Clinical trials: Cardiac Defects
Congenital Heart Diseases, Cardiac Diseases
An International Multicenter, Multivendor Evaluation of the Free-Running Framework for Cardiac Function
This project aims to evaluate a new cardiac MRI technique called the Free-Running Framework (FRF), which could simplify and accelerate the process of acquiring cardiac images.
- Trial name
- FAST-CMR (NCT07613398)
- Where
- 20 sites in United States, Australia and 8 more
- Volunteers
- 300 people
- Sponsor
- Matthias Stuber
Postoperative; Dysfunction Following Cardiac Surgery
Oral Triiodothyronine for Infants Less Than 5 Months & Malnourished Children Undergoing Cardiopulmonary Bypass in Indonesia
Infants and children undergoing cardiac surgery require mechanical support for circulation called cardiopulmonary bypass. The artificial pump ensures that blood flow to the body is maintained during surgical procedure on the…
- Trial name
- I-TRICC (NCT02222532)
- Testing
- Tetronine
- Where
- Indonesia
- Volunteers
- 224 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Congenital Heart Disease
Dynamic Critical Congenital Heart Screening With Addition of Perfusion Measurements
The purpose of this study is to implement and externally validate an inpatient ML algorithm that combines pulse oximetry features for critical congenital heart disease (CCHD) screening.
- Trial name
- NCT05637814
- Testing
- SpO2/PIx Measurement and ML Algorithm
- Where
- 3 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Transposition of Great Vessels
Influence of Timing of Switch Operation in Transposition of Great Arteries
Transposition of great vessels are usually corrected by an arterial switch operation. This operation is often done during the first week of life as surgical delays lead to deconditioned left ventricle.
- Trial name
- NCT05160116
- Where
- Belgium
- Volunteers
- 151 people
- Sponsor
- Brugmann University Hospital
Congenital Heart Disease
The Effect of 3D Heart Modelling on Family Quality of Life and Surgical Success
Introduction and Objective: In recent years, 3D (three-dimensional) modeling has been added to traditional and effective diagnostic methods such as Computed Tomography (CT), Magnetic Resonance Imaging (MRI), and Echocardiography.
- Trial name
- NCT05852106
- Testing
- Surgical Simulation with 3D Heart Model and Parental Education with "Congenital Heart Disease Parent Education Booklet" and tailored 3D Heart Modeling
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Yeditepe University
Dwarfism, Turner's Syndrome
The Effects of Hormones in Growth Hormone-Treated Girls With Turner Syndrome
Turners Syndrome is a genetic condition in females that is a result of abnormal chromosomes. Patients with Turner syndrome are typically short, have abnormal physical features, and lack the physical changes normally associated…
- Trial name
- NCT00001343
- Testing
- Humatrope, Oxandrolone
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Heart Defect, Congenital, Executive Dysfunction
Executive Function Intervention for Children With Complex Congenital Heart Disease
Children with complex congenital heart disease (cCHD) nowadays survive thanks to medical advances into their teenage years and adulthood. However, many of them have difficulties with so-called executive functions.
- Trial name
- E-Fit Heart (NCT07692958)
- Testing
- E-Fit Intervention
- Where
- Switzerland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Bea Latal
Congenital Heart Defects
Cardiac Resynchronization Therapy in Congenital Heart Defects
The objective of this multicentre prospective therapeutic study is to evaluate the effects of CRT on the right and left ventricular function of patients with CHD in the medium and long term.
- Trial name
- CARE-CHD (NCT00450684)
- Testing
- Implantation and testing of CRT
- Where
- 16 sites in Austria, Germany
- Volunteers
- 55 people
- Sponsor
- Competence Network for Congenital Heart Defects
Congenital Heart Disease
Continuous Infusion Versus Bolus Dosing for Pain Control After Pediatric Cardiothoracic Surgery
The investigators hypothesize that intermittent bolus doses of morphine and midazolam can provide the same pain control after pediatric cardiothoracic surgery as bolus doses plus infusions while using smaller total doses of both…
- Trial name
- NCT02112448
- Testing
- continuous infusion, as needed dosing, Acetaminophen
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Wake Forest University Health Sciences
Congenital Heart Disease, Hypoplastic Left Heart Syndrome
Cold Heart Study: A Randomized Pilot Trial of Surfactant Therapy
This clinical trial is being done to see if giving surfactant (Curosurf®) will decrease the number of days that infants will need a breathing tube, decrease the days in the critical care unit and decrease the number of days…
- Trial name
- NCT04181255
- Testing
- Curosurf
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Michigan
Alagille Syndrome (ALGS)
A Study of TAK-625 for the Treatment of Alagille Syndrome (ALGS)
The main aim of the study is to check if TAK-625 improves symptoms of Alagille Syndrome (ALGS), side effect from the study treatment or TAK-625, and how much TAK-625 stays in their blood over time.
- Trial name
- NCT05543174
- Testing
- TAK-625
- Where
- 8 sites in Japan
- Volunteers
- 7 people
- Sponsor
- Takeda
Marfan Syndrome
Biological Collection for Marfan and Related Syndromes
The present study will establish a collection of biological samples from Marfan patients or with associated diseases to be used for research purposes only, with due respect for confidentiality.
- Trial name
- MARFANS (NCT04970459)
- Testing
- collection of samples of blood and urine
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Toulouse
Ventricular Septal Defect, Complete Atrioventricular Canal
Optical Tissue Identification for Myocardial Architecture
The goal of this study is to test the hypothesis that fiberoptic confocal microscopy (FCM) imaging during repair of common congenital heart defects is a useful adjunct for avoidance of conduction abnormalities.
- Conditions
- Ventricular Septal Defect, Complete Atrioventricular Canal, Tetralogy of Fallot With Pulmonary Stenosis
- Trial name
- OPTIMA (NCT04017975)
- Testing
- Fluorescite, Cellvizio 100 Series System with Confocal Miniprobes
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Aditya Kaza
Intellectual Disability, Rubinstein-Taybi Syndrome
Functional Tests to Resolve Unsolved Rare Diseases. Rares.
Rares diseases are a heterogeneous group of conditions which need important tools for diagnosis. The use of high-throughput sequencing is able to diagnose half of the patients.
- Conditions
- Intellectual Disability, Rubinstein-Taybi Syndrome, Cystic Fibrosis, Congenital Heart Defect
- Trial name
- RID (NCT05696912)
- Testing
- Ex-vivo approach concerning 25 patients, In-vitro approach concerning 25 patients
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Congenital Heart Disease, Fibrinolysis
Determination of the Minimal Concentration of Antifibrinolytics Required to Inhibit t-PA-activated Fibrinolysis
Lysine analogs, like tranexamic acid (TXA) or epsilon aminocaproic acid (EACA), are antifibrinolytic agents routinely administered in children undergoing different surgeries associated with a high bleeding risk (e.g.
- Conditions
- Congenital Heart Disease, Fibrinolysis, Rotational Thromboelastometry
- Trial name
- NCT02352675
- Testing
- Intraoperative Blood Sample
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Children's Hospital
Preterm, Ductus Arteriosus
Dynamic Changes of Ductus Arteriosus in < 31 Weeks Preterm Infants: an Observational Study
The ductus arteriosus quickly closes itself. is an important channel connecting the maternal fetal circulation before birth. After birth, this ductus arteriosus generally no longer has a physical function, so ductus arteriosus…
- Trial name
- PDA (NCT06950164)
- Testing
- observation group, control group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Fontan Procedure
Clinical Outcomes in Fenestrated Extra-Cardiac Fontan in Low Preoperative Risk Profiles
Evaluation of fenestration benefit in Extra-cardiac total cavo-pulmonary connection (Fontan procedure) in single ventricle anomaly, comparing clinical outcomes of patients with low preoperative risk profiles in prospective study
- Trial name
- NCT03503032
- Testing
- Extracardiac Fontan, Fontan fenestration
- Where
- Saudi Arabia
- Volunteers
- 62 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Congenital Heart Disease
Improving Motor Skill Development in Infants After Cardiac Surgery
The purpose of this study is to learn more about developmental behaviors and to examine changes in developmental progress related to motor activities among a group of infants who received open heart surgery within the first three…
- Trial name
- DAISY (NCT02700646)
- Testing
- Developmental recommendations, Standard care
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Michigan
Congenital Heart Disease, Pediatric ALL
HIIT in Youth With Congenital Heart Disease (MedBIKE)
Congenital heart disease (CHD), the most common birth defect, is present in nearly 1% of the population. CHD patients are associated with intense resource utilization and premature death in adulthood.
- Trial name
- NCT04575883
- Testing
- MedBIKE HIIT
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Alberta
Thiamine Deficiency, Congenital Heart Disease
Thiamine Influenced on Substrate Energy Effectiveness in Indonesian Children Undergoing Cardiopulmonary Bypass
This is a randomized, double-blind, controlled trial design. It was conducted with a main purpose of evaluating the effect of thiamine supplementation on serum lactate and lactate-pyruvate ratio after surgery as direct indicators…
- Conditions
- Thiamine Deficiency, Congenital Heart Disease, Cardiopulmonary Bypass
- Trial name
- NCT04453761
- Testing
- Neurobion
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
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