Clinical trials: Cardiac Defects
Tetrology of Fallot
Comparison of Mid-term Results of Total Correction of TOF Between Preservation of PV and Trans-annular Patch.
To compare of mid-term results of total correction of tetralogy of fallot between preservation of pulmonary valve and trans-annular patching , thus avoiding PV regurgitation during TOF repair , this will determine the value of…
- Trial name
- NCT03732742
- Testing
- TOF repair with trans-annular patch VS preservation of PV
- Volunteers
- 50 people
- Sponsor
- Assiut University
Heart Septal Defects, Ventricular, Atrioventricular Septal Defect
Aberrations in Carnitine Homeostasis in Congenital Heart Disease With Increased Pulmonary Blood Flow
Infants with congenital heart disease and increased pulmonary blood flow have altered carnitine homeostasis that is associated with clinical outcomes; and L-carnitine treatment will attenuate these alterations and improve…
- Trial name
- L-carn (NCT01825369)
- Testing
- IV L-carnitine
- Where
- United States
- Sponsor
- University of California, San Francisco
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Univentricular Heart
Factors Associated With Normal Exercise Capacity in Patients With Single Ventricle
The congenital heart disease (CHD) is the firts cause of congenital birth defects. Medical and surgical advances completely changed the epidemiology of CHD.
- Trial name
- SV (NCT04026542)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Montpellier
Congenital Heart Disease, Tetralogy of Fallot
Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development
The study team will use small pieces of human hearts which are removed as part of a required surgical procedure to study different objectives.
- Trial name
- NCT00243776
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Emory University
QT Prolongation
QT Interval in Athletes
QT interval prolongation occurs in athletes and causes concerns, as it may indicate the life-threatening long QT syndrome (LQTS).
- Trial name
- ERAS (NCT05759260)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 869 people
- Sponsor
- Istituto Auxologico Italiano
Genetic Disorder, Noonan Syndrome
Post Marketing Surveillance on Long-term Use With Norditropin® (Short Stature Due to Noonan Syndrome)
The purpose of this study is to collect information about safety and effectiveness for long term use of Norditropin®. Participants will attend the medical institution according to usual practice and receive medical care, as…
- Trial name
- NCT03435627
- Testing
- Somatropin
- Where
- 22 sites in Japan
- Volunteers
- 71 people
- Sponsor
- Novo Nordisk A/S
Congenital Heart Disease
Effectiveness of a Transition Program for Adolescents With Congenital Heart Disease in the Transition to Adulthood
This study is part of a larger research project known as Swedish Transition Effects Project Supporting Teenagers with chrONic mEdical conditionS (STEPSTONES).
- Trial name
- NCT02675361
- Testing
- Transition program
- Where
- 7 sites in Sweden
- Volunteers
- 189 people
- Sponsor
- Göteborg University
Turner Syndrome
Defining the Optimal Hormonal Replacement Therapy in Turner Syndrome
The purpose of this study is to examine whether a larger dosage of estrogen than the one used today will secure the development of a normal sized uterus and increase the strength of the bones in girls and young women with Turner…
- Trial name
- NCT00134745
- Testing
- estradiol
- Where
- Denmark
- Volunteers
- 43 people
- Sponsor
- Line Cleemann
Patent Ductus Arteriosus
Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus
The purpose of this pilot trial is to study efficacy and safety of simultaneous intravenous (iv) ibuprofen/indomethacin and paracetamol medications in the closure of patent ductus arteriosus (PDA) in preterm infants.
- Trial name
- PAI (NCT03648437)
- Testing
- Paracetamol 10Mg/mL, 0.45% Sodium Chloride, Ibuprofen
- Where
- 4 sites in Finland
- Volunteers
- 22 people
- Sponsor
- University of Oulu
Congenital Heart Disease
Coronary Artery Assessement by TEE in Congenital Heart Disease
This study aims to establish normal coronary artery pulse Doppler flow patterns and velocities using transoesophageal echocardiography (TEE) in patients with a variety of congenital heart disease.
- Trial name
- NCT04194502
- Testing
- Transesophageal echocardiogram (TEE)
- Where
- Canada
- Volunteers
- 118 people
- Sponsor
- The Hospital for Sick Children
Cyanotic Congenital Heart Disease, Right Ventricular Outflow Tract Obstruction
RVOT Stenting Versus Surgical RV-PA Conduit in Cyanotic Adults
This prospective observational cohort study aims to compare clinical and hemodynamic outcomes of percutaneous right ventricular outflow tract stenting versus surgical right ventricle-to-pulmonary artery conduit placement in…
- Trial name
- NCT07866911
- Volunteers
- 30 people
- Sponsor
- Assiut University
Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder
Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)
This is a research protocol that will examine Hematopoietic Stem Cell Transplantation (HSCT) using a reduced conditioning regimen (RIC) with total body Irradiation (TBI) in those diagnosed with Common Variable Immunodeficiency…
- Conditions
- Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder, Immune Dysregulation, DiGeorge Syndrome
- Trial name
- CVID/PIRD (NCT07284641)
- Testing
- Hematopoietic stem cell transplant (HSCT)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Paul Szabolcs
Idiopathic Pulmonary Arterial Hypertension, Cardiomyopathy
Comparison of Inhaled Nitric Oxide and Oxygen in Participants Reactivity During Acute Pulmonary Vasodilator Testing
The primary purpose of this study is to compare the number of participants with reversible pulmonary hypertension (vasoreactivity) due to nitric oxide for inhalation and oxygen as compared to 100% oxygen.
- Trial name
- NCT00626028
- Testing
- Nitric Oxide for inhalation, Oxygen, Nitric Oxide plus Oxygen
- Where
- 18 sites in United States, France and 3 more
- Volunteers
- 136 people
- Sponsor
- Mallinckrodt
Atrial Septal Defect, Patent Foramen Ovale
Post Market Registry of the CBSO
Multi centre, international, post market registry to monitor the clinical performance and safety of an atrial septal closure device with biodegradable framework in patients with clinically significant atrial septum defect (ASD)…
- Trial name
- CBSO Registry (NCT04105595)
- Testing
- Septal defect closure
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- atHeart Medical
Patent Ductus Arteriosus
Comparative Study of Efficacy and Safety of Oral Ibuprofen and Intravenous Ibuprofen in Closure of Patent Ductus Arteriosus in Very Low Birth Weight Infants
it is a prospective randomized simple-blinded pilot trial with the principal aim to compare efficacy and tolerance between oral ibuprofen and intravenous ibuprofen in early curative closure of PDA in very low birth weight…
- Trial name
- NCT00642330
- Testing
- oral ibuprofen, intravenous ibuprofen
- Where
- Tunisia
- Volunteers
- 62 people
- Sponsor
- Hopital La Rabta
Hypoplastic Left Heart Syndrome
Hypoplastic Left Heart Syndrome: Subendocardial Viability After Norwood Palliation
This project has several objectives ranging from clinical data analysis to computational simulations as listed below: 1. Retrospective review of all patients with HLHS treated surgically and followed medically at the IRCCS…
- Trial name
- HLHS (NCT05709275)
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- IRCCS Policlinico S. Donato
Growth Hormone Disorder, Growth Hormone Deficiency in Children
Observational Prospective Study on Patients Treated With Norditropin®
This observational study is conducted globally. The aim of the study is to investigate the effectiveness and safety of real-life treatment with Norditropin®.
- Conditions
- Growth Hormone Disorder, Growth Hormone Deficiency in Children, Adult Growth Hormone Deficiency, Genetic Disorder
- Trial name
- NCT00960128
- Testing
- somatropin
- Where
- 23 sites in Argentina, Belgium and 21 more
- Volunteers
- 21,249 people
- Sponsor
- Novo Nordisk A/S
Calprotectin, Cyanotic Heart Disease
Monitor Faecal Calprotectin Concentration in Infants With Heart Defects
Infants born with heart problems are at risk of developing gut disease due to reduced blood flow to the intestines which can result in poor weight gain, surgery and even death.
- Trial name
- NCT03255564
- Testing
- feacal calprotectin concentration
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Heart Disease
Sildenafil in Single Ventricle Patients
Patients with single ventricle anatomy undergo staged surgical palliation. The result is an "in series" circulation with pulmonary blood flow and cardiac output directly related to pulmonary vascular resistance.
- Trial name
- NCT01169519
- Testing
- Sildenafil by injection
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Duke University
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