Clinical trials: Cardiac Disease
Congenital Heart Disease
Proposal for Parental Guidance and Early Stimulation in Children With Congenital Heart Disease: Randomized Trial
Problem: With the increased survival rate of children with congenital heart disease, other health problems, in addition to the clinic, have emerged, such as the risks of developmental delay to which these children are exposed.
- Trial name
- NCT04152330
- Testing
- Early stimulation protocol on neuropsychomotor development of children with congenital heart disease
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Diastolic Heart Failure
Perhexiline Therapy in Heart Failure With Preserved Ejection Fraction Syndrome
Up to half of all patients with clinical features of heart failure are found to have normal heart pumping function. Recently the investigators have shown that a drug called perhexiline markedly improved exercise capacity and…
- Trial name
- NCT00839228
- Testing
- Perhexiline
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Aberdeen
Heart Failure
Comparison Between Internal and External Chest Impedance Measurement
To compare two methods of chest impedance: the Medtronics Optivol Measurement via CRT pacemakers for patients with heart failure and external non-invasive measurement
- Trial name
- NCT01296282
- Testing
- Medronics CRT Optivol Impedance Measurement, External Thoracic Impedance Measurement
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hillel Yaffe Medical Center
Postoperative Chylothorax, Congenital Heart Disease
Propranolol Treatment for Postoperative Chylothorax
Postoperative chylothorax is a serious complication after open heart surgery for pediatric patients with congenital heart disease (CHD).
- Conditions
- Postoperative Chylothorax, Congenital Heart Disease, Open Heart Surgery, Chylothorax
- Trial name
- NCT06833320
- Testing
- Propranolol Hydrochloride
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- June Wu
Congenital Heart Defects
Congenital Heart Disease GEnetic NEtwork Study (CHD GENES)
Congenital heart defects (CHD) are the most common major human birth malformation, affecting ~8 per 1,000 live births. CHD are associated with significant morbidity and mortality, and are second only to infectious diseases in…
- Trial name
- CHD GENES (NCT01196182)
- Where
- 15 sites in United States, United Kingdom
- Volunteers
- 32,000 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Ischemic Heart Disease
Ranolazine for Improving Symptoms of Palpitations
Patients with ischemic heart disease often report multiple symptoms, including angina and palpitations. Ranolazine has antiarrhythmic effects which are largely a result of the drug's effect on multiple ion channels.
- Trial name
- RYPPLE (NCT01495520)
- Testing
- Ranolazine
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Congenital Heart Disease in Children
Cardiac Simulator for Surgical Planning
The goal of this clinical trial is to learn if a computer software program (cardiac simulator) for surgical planning will lead to improvements in patient care by decreasing the incidence of unsuccessful interventions and…
- Trial name
- NCT06373705
- Testing
- Cardiac simulator
- Volunteers
- 275 people
- Sponsor
- Stanford University
Cardiac Transplant Failure, Cardiac Transplant Rejection
Outcomes AlloMap Registry: the Long-term Management and Outcomes of Heart Transplant Recipients With AlloMap Testing
The objective of this registry is to observe short and long term clinical outcomes in heart transplant recipients who receive regular AlloMap testing as part of allograft rejection surveillance.
- Conditions
- Cardiac Transplant Failure, Cardiac Transplant Rejection, Heart Diseases
- Trial name
- OAR (NCT01833195)
- Where
- 36 sites in United States
- Volunteers
- 2,444 people, healthy volunteers welcome
- Sponsor
- CareDx
Congenital Heart Disease, Single-ventricle
Clinical Characteristics and Associations of the "Good Fontan" Patient
This study aims to determine what are some of the clinical characteristics and associations of Fontan patients who are doing well, as well as how accurate cardiology providers are at predicting the likelihood of future adverse…
- Trial name
- NCT03470428
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Boston Children's Hospital
Aortic Valve Stenosis
Early neo2 Registry of the Acurate neo2 TAVI Prosthesis
The Early neo2 registry will study up to 500 patients treated with the updated Boston Acurate neo2 TAVI prosthesis at various European hospitals.
- Trial name
- NCT04810195
- Testing
- Boston Scientific Acurate neo2 TAVR device
- Where
- 4 sites in Denmark, Germany and 1 more
- Volunteers
- 554 people
- Sponsor
- Andreas Rück
Respiratory Disease
The Effect of Vitamin E Supplementation on Hospital Stay Duration in Non-cyanotic Heart Disease Children With Lower Respiratory Tract Infections
Congenital heart disease can lead to serious health issues, particularly an increased risk of infections, specifically respiratory infections. Lower respiratory tract infections are the fifth leading cause of death globally.
- Trial name
- NCT06926712
- Testing
- Vitamin E
- Volunteers
- 260 people
- Sponsor
- Assiut University
Alagille Syndrome
Characterization of Pulmonary Artery Stenoses in Alagille Syndrome - a Medical Record Review
Patients who have Alagille Syndrome (AGS) also frequently have blockages (or "stenoses") of their pulmonary arteries. Little is known about the degree or variability of these stenoses, or the effect of this disease on the right…
- Trial name
- NCT01515631
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stanford University
Pain, Acute, Congenital Heart Disease
Transverse Thoracic Plane Block in the Pediatric Cardiac Patient
Postoperative pain after cardiothoracic surgery can be a significant problem interfering with recovery, yet difficult to manage due to the sedating effects of opiates.
- Trial name
- TTPPCT (NCT04138745)
- Testing
- Transverse Thoracic Plane Block
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Neurodevelopmental Disorders, Congenital Heart Disease
Altered Cerebral Growth and Development in Infants With Congenital Heart Disease
Background: Congenital heart disease (CHD) is the most frequent inborn defect with an incidence of 1 in 100 newborns per year, i.e. 800 children born in Switzerland per year.
- Conditions
- Neurodevelopmental Disorders, Congenital Heart Disease, Brain Injuries, Fetal Growth Retardation
- Trial name
- NCT04233775
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Cardiovascular Diseases, Heart Diseases
Diet Modification and Blood Pressure in Young People
To determine the effects of diet modification on blood pressure, blood cholesterol, and bone density in healthy young people.
- Trial name
- NCT00005167
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Intravascular Identification and Drug-Eluting Balloon Treatment of Vulnerable Lipid-Rich Plaques
Rationale: Two-thirds of intracoronary thrombi causing acute coronary syndrome (ACS) result from rupture of lipid-rich plaques (LRP).
- Trial name
- DEBuT-LRP (NCT04765956)
- Testing
- Drug-eluting balloon treatment
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Heart Failure
Nurse-Led Education for Heart Failure Self-Care and Stability
Heart failure is a chronic condition that can lead to frequent hospitalizations and reduced quality of life. This study aims to evaluate whether a nurse-led, face-to-face educational intervention can improve clinical stability…
- Trial name
- EDUCATE (NCT07280728)
- Testing
- Nurse-Led Face-to-Face Educational Intervention (Teach-Back Method)
- Where
- Italy
- Volunteers
- 118 people
- Sponsor
- Azienda Socio Sanitaria Territoriale di Lodi
Acute Kidney Injury
Effects of Oral Protein Load on Kidney Function in Patients Undergoing Cardiac Surgery
Acute kidney injury (AKI) occurs in approximately one-third of patients undergoing cardiac surgery (CS), and represents one of the most significant negative predictors of patient outcome in this population.
- Trial name
- NCT03102541
- Testing
- None intervention
- Volunteers
- 214 people
- Sponsor
- University of Giessen
Heart Defects, Congenital
Rejuvenated, Washed Packed Red Blood Cells in Pediatric Cardiac Surgery
Blood transfusion is nearly always needed during open heart surgery in children less than 15 kg (35 pounds). The purpose of the red blood cells in the blood is to deliver oxygen to the organs and tissues of the body.
- Trial name
- NCT02485366
- Testing
- Rejuvesol, Cardiac surgery
- Where
- United States
- Sponsor
- Duke University
Electroencephalogram, Postoperative Delirium
Correlation of Electroencephalogram With Postoperative Delirium During Cardiac Surgery
The purpose of this study is to explore characteristic changes of EEG epileptiform discharges in patients under CPB and correlation with POD
- Trial name
- NCT04943939
- Where
- China
- Volunteers
- 60 people
- Sponsor
- General Hospital of Ningxia Medical University
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