Clinical trials: Cardiac Diseases Requiring Surgery
Cardiac Diseases Requiring Surgery
Correlation of Estimated Continuous Cardiac Output (esCCO) and TEE in Pediatric Cardiac Surgery
The purpose of this study is to determine the measuring accuracy of the truly non-invasive method estimated continuous cardiac output (esCCO) against the reference method transesophageal echocardiography in pediatric cardiac…
- Trial name
- NCT01865994
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- Heidelberg University
Acquired Bleeding Disorder, Cardiac Surgery Requiring Cardiopulmonary Bypass
Activated Recombinant Human Factor VII Following Cardiac Bypass Surgery for Paediatric Congenital Heart Disease
This trial is conducted in Oceania. The aim of this trial is to investigate the efficacy of activated recombinant human factor VII and standard treatment compared with standard haemostatic replacement therapy in cardiopulmonary…
- Trial name
- NCT01562574
- Testing
- activated recombinant human factor VII
- Where
- Australia
- Volunteers
- 82 people
- Sponsor
- Novo Nordisk A/S
Primary Condition: Heart Defects Requiring Surgery With CPB
Heparin Management During Cardiopulmonary Bypass in Children
We propose a comparison between between our standard ACT based heparin management protocol for children undergoing CPB and a patient-specific heparin concentration-based heparin management protocol.
- Trial name
- NCT00146653
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Congenital Disorders
Biomarkers for Detection of Brain Ischemia
Brain injury occurs in one-quarter to one-half of congenital heart defect infants during the perioperative period. A blood test using a biomarker to diagnose brain injury would be important.
- Trial name
- NCT00490295
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Congenital Heart Disease, Oral Aversion
Nasal vs. Oral Intubation for Neonates Requiring Cardiac Surgery
Often, infants struggle to feed orally after surgery for congenital heart disease and may require supplemental feeding interventions at discharge.
- Trial name
- NCT05378685
- Testing
- Endotracheal intubation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Virginia
Children in Cardiac Intensive Care Requiring Surgery for Congenital Heart Disease
Antibiotics Distribution Study in Peripheral Compartments: Contribution of Microdialysis
Postoperative mediastinitis is an important cause of postoperative morbidity in children. The main objective of this study is to describe the distribution of cefazolin, using as surgical antibiotic prophylaxis, in the mediastinal…
- Trial name
- Antimidis (NCT07327502)
- Testing
- Microdialysis probe placement, Microdialysis and Plasma samples
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aortic Stenosis
PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis
To establish the safety and effectiveness of the Edwards SAPIEN 3 Transcatheter Heart Valve (THV) in patients with severe, calcific aortic stenosis who are at low operative risk for standard aortic valve replacement.
- Trial name
- P3 (NCT02675114)
- Testing
- SAVR, SAPIEN 3 THV
- Where
- 77 sites in United States, Australia and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Edwards Lifesciences
Congenital Heart Disease in Children, Neuroprotection
Cerebrum and Cardiac Protection With Allopurinol in Neonates With Critical Congenital Heart Disease Requiring Cardiac Surgery With Cardiopulmonary Bypass
Neurodevelopmental impairment due to delayed brain development and brain injury is a fundamental problem in children with critical congenital heart disease (CCHD).
- Trial name
- CRUCIAL (NCT04217421)
- Testing
- Allopurinol, Mannitol
- Where
- 4 sites in Netherlands
- Volunteers
- 236 people
- Sponsor
- dr. M.J.N.L. Benders
Heart Defects, Congenital
NIRS Guidance Trail in Children's Heart Surgery
Heart surgery in young children involves some risks. This study looks at a new type of monitor that may reduce these risks. Near Infrared Reflectance Spectroscopy (NIRS) aims to measure if enough blood reaches vital organs in the…
- Trial name
- NIRS (NCT02157597)
- Testing
- NIRS based management, Control
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cardiac Surgery Requiring Cardiopulmonary Bypass, Brain Injury
The Association Between Tau & GFAP and Postoperative Neurological Impairment in Patients Undergoing Cardiac Surgery
Patients born with heart defects often undergo surgical procedures on a heart lung machine. With improvements in medical and surgical management, their survival has significantly improved, but their brain insult has not been paid…
- Conditions
- Cardiac Surgery Requiring Cardiopulmonary Bypass, Brain Injury, Congenital Heart Defect
- Trial name
- NCT06899971
- Testing
- Collecting discarded blood samples
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Sepsis, Cancer, Heart Attack, Heart Failure, Abdominal Surgery, Trauma, Diabetes, Lung Disease, Gynaecology, Fertility, Cardiac Surgery,
Medical Record Study on Adverse Events Requiring a Higher Level of Care in Flemish Hospitals
An adverse event (AE) is defined as unintended injury or complication, which results in disability, death or prolongation of hospital stay, and is caused by healthcare management (including omissions) rather than the patient's…
- Trial name
- NCT02044718
- Where
- Belgium
- Volunteers
- 878 people
- Sponsor
- Hasselt University
Heart Defects, Congenital
Motor Development of Children That Have Surgery as Newborns for Complex Congenital Heart Disease
Infants requiring surgery in the neonatal period for complex congenital heart diseases are at risk for developmental problems. For infants with congenital heart diseases with admixture physiology and single ventricles, optimal…
- Trial name
- NCT02781545
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Wake Forest University Health Sciences
Kidney Failure, Acute
Fenoldopam in Pediatric Cardiac Surgery
The purpose of this study is to determine whether fenoldopam infusion during cardiopulmonary bypass in young children with congenital heart disease is able to reduce indicators of acute kidney injury (biomarkers reduction…
- Trial name
- NCT00982527
- Testing
- Fenoldopam
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute