Clinical trials: Cardiac Disorder
Atrial Septal Defects
Safety and Effectiveness Study of the Solysafe Septal Occluder
Prospective mono-center clinical study to evaluate the safety and effectiveness of an intracardiac septal closure device in patients with atrial septum defect (ASD)
- Trial name
- NCT00353509
- Testing
- Device Closure of a Septal Defect
- Where
- Serbia
- Sponsor
- Carag AG
Pulmonary Hypertension
PHIRST-1: Tadalafil in the Treatment of Pulmonary Arterial Hypertension
The purpose of this study is to evaluate the safety and effectiveness of tadalafil for the treatment of pulmonary arterial hypertension.
- Trial name
- NCT00125918
- Testing
- tadalafil
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 406 people
- Sponsor
- Eli Lilly and Company
Heart Transplant, Periodontitis
Effect of Non-Surgical Periodontal Therapy on Inflammation in Heart Transplant Recipients
Heart transplant recipients frequently exhibit chronic low-grade systemic inflammation, which can contribute to allograft dysfunction and cardiovascular complications.
- Conditions
- Heart Transplant, Periodontitis, Gingivitis, Systemic Inflammation
- Trial name
- NCT07791927
- Testing
- Full-mouth periodontal debridement
- Volunteers
- 20 people
- Sponsor
- Baskent University
Alagille Syndrome
A Maralixibat Expanded Access Program for Patients With Cholestatic Pruritus Associated With Alagille Syndrome (ALGS)
An open-label, single-arm, multi-centre program providing treatment access to ALGS patients with cholestatic pruritus in the US.
- Trial name
- NCT04530994
- Testing
- maralixibat
- Where
- 14 sites in United States
- Sponsor
- Mirum Pharmaceuticals, Inc.
Cardiopulmonary Bypass, Congenital Defects
Aprotinin in Neonates Undergoing Cardiopulmonary Bypass
This is a retrospective chart review study. The purpose of this study is to review our experience at Children's Healthcare of Atlanta in neonates receiving aprotinin.
- Conditions
- Cardiopulmonary Bypass, Congenital Defects, Hemostasis
- Trial name
- NCT00469742
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- Children's Healthcare of Atlanta
Alagille Syndrome
Efficacy and Safety of Odevixibat in Patients With Alagille Syndrome
Double-blind, randomized, placebo-controlled, Phase 3 study to investigate the efficacy and safety of odevixibat compared to placebo in Patients with Alagille Syndrome.
- Trial name
- ASSERT (NCT04674761)
- Testing
- Odevixibat
- Where
- 32 sites in United States, Belgium and 11 more
- Volunteers
- 52 people
- Sponsor
- Albireo
Body Weight, Obesity
Meta-analysis of the Nordic Dietary Pattern on Cardiometabolic Risk and Cardiovascular Outcomes
The Nordic Diet is a dietary pattern rich in traditional Nordic foods, including berries, grains, and fatty fish common in northern Europe.
- Conditions
- Body Weight, Obesity, Overweight and Obesity, Obesity, Abdominal
- Trial name
- NCT04094194
- Testing
- Nordic diet
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cardiovascular Diseases, Heart Diseases
Comparison of Hematocrit Levels in Infant Heart Surgery
The purpose of this study is to compare the effects of diluted hematocrit (HCT) levels of 35% versus 25% during hypothermic cardiopulmonary bypass (CPB) in infants with d-transposition of the great arteries, a malformation of the…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Heart Defects, Congenital, Transposition of Great Vessels
- Trial name
- NCT00006183
- Testing
- Cardiopulmonary Bypass with Two Different Intra-Operative Hematocrits, Thoracic Surgery
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Anesthesia, Infant
Dopamine Versus Norepinephrine Under General Anesthesia
Participants under general anesthesia will be randomly treated with an adjusted dose dopamine or norepinephrine to elevate 10% of mean arterial pressure.
- Conditions
- Anesthesia, Infant, Congenital Heart Disease, Hemodynamic Instability
- Trial name
- NCT04536194
- Testing
- norepinephrine, dopamine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
Pulmonary Atresia With Intact Ventricular Septum, Congenital Heart Disease
Prognostic Model of Postnatal Circulation in Pulmonary Atresia-critical Stenosis With Intact Ventricular Septum
Pulmonary atresia (PA)/critical stenosis (CS) with intact ventricular septum (PA/CS-IVS) is a rare congenital heart disease (CHD), that presents heterogeneously.
- Conditions
- Pulmonary Atresia With Intact Ventricular Septum, Congenital Heart Disease, Fetal Cardiac Disorder
- Trial name
- NCT07095829
- Testing
- No intervention
- Where
- 2 sites in Spain, Sweden
- Volunteers
- 150 people
- Sponsor
- Hospital Universitario 12 de Octubre
Heart Failure, Heart Failure (for Example, Fluid Overload)
Molecular Underpinnings of Heart Failure, Integrative Multi-Omics, and Non-Coding RNA Profiling
The main objective of the study is to achieve a comprehensive phenotyping of patients with heart failure, combining detailed clinical characterization with in-depth molecular profiling.
- Trial name
- BIOCARDIUM-HF (NCT07158086)
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Zurich
Congenital Heart Disease
Dexmedetomidine Neuroprotection in Pediatric Cardiac Surgery
Neurodevelopmental disability is the most significant complication for survivors of infant surgery for congenital heart disease.
- Trial name
- NCT04484922
- Testing
- Dexmedetomidine, Normal saline
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
Williams-Beuren Syndrome, Micro-duplication 7q11.23 Syndrome
Quantification of Elastin Markers Synthesis in Williams-Beuren Syndrome and 7q11.23 Micro-duplication Syndrome
Introduction: Williams-Beuren syndrome is a rare genetic disorder caused by a 7q11.23 microdeletion. The phenotype associates vasculopathy (arterial stenosis, hypertension), dimorphism and intellectual disability.
- Conditions
- Williams-Beuren Syndrome, Micro-duplication 7q11.23 Syndrome, Vasculopathy
- Trial name
- ELAST7 (NCT04051086)
- Testing
- Physical examination and Urine and blood samples, Urine and blood samples
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Intracardiac and Septal Defects, Valve and Anulus Repair
Prospective and Non-randomized Registry of CardioCel 3D
Post-market, prospective, multi-centre, open-label, registry designed to collect prospective safety and performance data on the use of CardioCel in patients with cardiovascular disorders and in accordance with local standard of…
- Conditions
- Intracardiac and Septal Defects, Valve and Anulus Repair, Great Vessel Reconstruction, Peripheral Vessel Reconstruction
- Trial name
- NCT04175327
- Testing
- CardioCel implantation
- Where
- 6 sites in Germany, Italy and 2 more
- Volunteers
- 200 people
- Sponsor
- LeMaitre Vascular
Q Fever
Safety Evaluation of a Q-fever Vaccine, NDBR 105
The purpose of this study is to evaluate the safety of Q Fever vaccine, NDBR 105, and collect data on incidence of occupational Q Fever infection in at risk personnel.
- Trial name
- NCT00584454
- Testing
- Q Fever Vaccine (NDBR 105
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Atrial Fibrillation
Manual Compared to Magnetic Navigation in Ablation for Atrial Fibrillation
The purpose of this study is to compare manual and magnetic navigation in ablation for atrial fibrillation.
- Trial name
- NCT01407588
- Testing
- Magnetic navigation, Ablation performed with manual navigation
- Where
- Norway
- Volunteers
- 51 people
- Sponsor
- Norwegian University of Science and Technology
Acute Coronary Syndromes
Registry of Acute Coronary Syndromes in the Lazio Region of Italy
The NET-SCA Registry has been designed to document and evaluate the clinical epidemiology and current management of Acute Coronary Syndromes in the Lazio Region of Italy.
- Trial name
- NET-SCA (NCT01216462)
- Where
- 8 sites in Italy
- Volunteers
- 3,000 people
- Sponsor
- San Filippo Neri General Hospital
Physicians' Practice Patterns, Coronary Heart Disease
From Research to Practice - Lipid Management for Low HDL-Cholesterol
The overall purpose of this project is to improve the clinical outcomes of veterans with ischemic heart disease (IHD) through implementation of evidence-based lipid management, with a particular focus on veterans whose primary…
- Trial name
- NCT00057044
- Testing
- education and reminder
- Where
- United States
- Volunteers
- 11,700 people
- Sponsor
- US Department of Veterans Affairs
Congenital Heart Disease
The CHAPTER II Study - Congenital Heart Adolescents Participating in Transition Evaluation Research
Transition is the planned movement of teens with chronic conditions from child-centered to adult-oriented healthcare. National bodies have published detailed guidelines about the importance of helping teens move to adult…
- Trial name
- NCT01723332
- Testing
- Educational, Self management
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- University of Alberta
Arrhythmias, Cardiac
An Observational Post-marketing Study Using Commercially Approved Biosense Webster (BWI) Medical Devices for the Treatment of Participants With Cardiac Arrhythmias
The purpose of this study is to prospectively collect clinical data evaluating the ongoing safety and performance during routine-use standard cardiac arrhythmia mapping and/or ablation procedures while using commercial Biosense…
- Trial name
- SECURE (NCT04750798)
- Testing
- BWI Medical Device, Varipulse Catheter, Dual Energy THERMOCOOL SMARTTOUCH SF Catheter
- Where
- 47 sites in Austria, Belgium and 13 more
- Volunteers
- 8,000 people
- Sponsor
- Biosense Webster, Inc.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.