Clinical trials: Cardiac Output, Low
Low Cardiac Output
Comparison of Techniques for Assessing Cardiac Output and Preload in Critically Ill Pediatric Patients
Each year in the United States more than 30,000 children are admitted to intensive care units. The majority of these children have some degree of heart instability during their stay, yet there is currently no routine way to…
- Trial name
- NCT00167440
- Where
- United States
- Sponsor
- University of Rochester
Low Cardiac Output Syndrome
Prophylactic Use of Levosimendan Versus Milrinone in Open Heart Surgery in Infants
Pediatric patients, especially infants undergoing open heart surgery have a predictable fall in cardiac index 6 to 18 hours after surgery, the so-called low cardiac output syndrome (LCOS).
- Trial name
- Levomil (NCT00549107)
- Testing
- Levosimendan, Milrinone
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Ludwig Boltzmann Gesellschaft
Low Cardiac Output Syndrome
Two Inodilators Postsurgery in Neonates
Congenital heart defects are the most prevalent group of congenital malformations in newborns. Surgery-related low cardiac output syndrome (LCOS) could be one of the reason for the unfavourable outcome of this population.
- Trial name
- NCT01576094
- Testing
- Milrinone, Levosimendan
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz
Heart Failure, Congenital Heart Defects
Right Ventricular Failure in Congenital Heart Defects
Usually, "heart failure" refers to myocardial insufficiency of the left ventricle. However, in patients with congenital heart defects, often predominantly the right ventricle is affected.
- Trial name
- NCT00266201
- Where
- 9 sites in Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Competence Network for Congenital Heart Defects
Congenital Cardiovascular Defects, Low Cardiac Output Syndrome
Levosimendan in Congenital Cardiac Surgery
Many pediatric patients undergoing cardiac surgery under cardiopulmonary bypass for repair of complex congenital malformations, require inotropic support for low cardiac output syndrome.
- Trial name
- NCT00695929
- Testing
- Levosimendan, Milrinone
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Congenital Heart Defect, Cardiopulmonary Bypass
Prognostic Markers of Inflammation in Infants Undergoing Cardiopulmonary Bypass
This study evaluates the effect of heart-lung bypass on babies undergoing cardiac surgery. The investigators want to learn more about the inflammation that exposure to bypass creates in the body by studying markers of…
- Conditions
- Congenital Heart Defect, Cardiopulmonary Bypass, Inflammatory Response, Low Cardiac Output Syndrome
- Trial name
- ProCard (NCT03143348)
- Testing
- Single blood draw, Multiple blood draws
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Oklahoma
Acute Coronary Syndrome, Cardiogenic Shock
Outcome of Patients Treated With IABP
Intra-Aortic Balloon Pumps (IABP) is a widely used and effective left ventricular adjuvant therapy. IABP is an inflatable device placed in the aorta that inflates with diastole and deflates with systole.
- Conditions
- Acute Coronary Syndrome, Cardiogenic Shock, Coronary Artery Disease, Heart Failure
- Trial name
- NCT04405856
- Testing
- Intra Aortic Balloon Pump
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Nanjing Medical University
Cardiac Output, High, Cardiac Output, Low
Hemodynamic Effects of Delayed Umbilical Cord Clamping in Full-term Newborns
The sequence of events at the time of delivery includes delivery of the infant, clamping of the umbilical cord, and lastly delivery of the placenta. There are some benefits for delayed cord clamping.
- Trial name
- NCT04358822
- Testing
- Delayed cord clamping
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Cairo University
Low Cardiac Output Syndrome
Levosimendan Administration in Neonates With Transposition of the Great Arteries
Calcium sensitizer drugs such as Levosimendan may exert anti-ischemic effect in addition to positive inotropic and anti-stunning effects mediated by the opening of ATP-sensitive potassium (KATP) channels.
- Trial name
- NCT01120106
- Testing
- levosimendan
- Where
- Italy
- Volunteers
- 63 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Cardiac Output, Low, Cardiac Output, High
Non-invasive Continuous Cardiac Output Monitoring in Preterm Infants Study
This is an observational study in newborn term and preterm infants. The study will validate if non-invasive continuous cardiac output monitoring is feasible in newborn infants, if normative values can be constructed and what is…
- Conditions
- Cardiac Output, Low, Cardiac Output, High, Blood Pressure
- Trial name
- NICCOM (NCT04064177)
- Testing
- NICAS cardiac output monitor
- Where
- United Kingdom
- Volunteers
- 148 people
- Sponsor
- Imperial College Healthcare NHS Trust
Low Cardiac Output
Comparative Study of Haemodynamic Changes After Spinal Anaesthesia in Non-obese and Pregnant Women
Obesity has become one of the most common risk factors in obstetric practice with serious anaesthetic implications. Obese pregnants have limited physiological reserves and cardiovascular co- morbidities when compared to non-obese…
- Trial name
- NCT02599376
- Testing
- LiDCOrapid
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Congenital Heart Disease, Brain Injuries
Autologous Umbilical Cord Blood Treatment of Neonate With CHD
The aim of the study is to evaluate the feasibility and safety and efficacy of collecting and infusing autologous umbilical cord blood (UCB) in newborn infants with hypoplastic left heart syndrome (HLHS) and transposition of…
- Conditions
- Congenital Heart Disease, Brain Injuries, Low Cardiac Output Syndrome, Neonatal Disorder
- Trial name
- NCT03558269
- Testing
- Autlogous UCB infusion
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Low Cardiac Output Syndrome, Transposition of Great Vessels
Nitric Oxide During Bypass for Arterial Switch Operation
This trial will test if adding nitric oxide (NO) gas to the cardiopulmonary bypass (CPB) circuit in infants undergoing an arterial switch operation (ASO) for Transposition of the Great Arteries (TGA) changes the incidence of…
- Trial name
- NASO (NCT03661385)
- Testing
- Nitric Oxide
- Where
- 4 sites in Australia, Canada and 2 more
- Volunteers
- 300 people
- Sponsor
- Murdoch Childrens Research Institute
Low Cardiac Output Syndrome, Cardiac Surgical Procedures
Prophylactic Use of Milrinone After Congenital Heart Surgery in Infants
This randomized, multi-center, double-blinded, placebo-controlled study is designed to evaluate the efficacy and safety of milrinone compared with placebo in participants after corrective surgery for congenital heart disease.
- Conditions
- Low Cardiac Output Syndrome, Cardiac Surgical Procedures, Infant
- Trial name
- NCT03823781
- Testing
- Milrinone, Normal saline
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Shanghai Children's Medical Center
Acute Heart Failure
FranceLEVO - Zimino Registry (FZR)
The French National Authority for Health (Haute Autorité de santé) requested a registry study to obtain post-market surveillance data to describe baseline clinical profiles, management and outcome of patients treated with…
- Trial name
- FZR (NCT04252404)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Arcothova
Aortic Coarctation, Cardiac Output, Low
Correlation of Cardiac Index Measured by the PRAM Method With NIRS and Lactate Levels in Pediatric Aortic Coarctation Surgery
This prospective observational study aims to evaluate the correlation between cardiac index measured by the MostCare™ system (Pressure Recording Analytical Method, PRAM) and cerebral/renal regional oxygen saturation measured by…
- Trial name
- MostCare-Ped (NCT07568431)
- Testing
- MostCare (PRAM), Near-Infrared Spectroscopy (NIRS), Arterial Blood Gas with Lactate
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Konya City Hospital
Healthy
Determination of Variances in Exhaled Nitric Oxide Output in Normal Healthy Male Volunteers Consuming High and Low Nitrate/Nitrite Diets
This study will determine whether and how nitrites and nitrates in the diet affect the level of nitric oxide gas that is breathed out in air.
- Trial name
- NCT00027157
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiac Output, Low
Corticosteroids in Postoperative Critically Ill Neonates With Low Cardiac Output Syndrome With Congenital Heart Disease
Babies having heart surgery often have problems after surgery with their blood pressure and getting enough blood to their bodies.
- Trial name
- Corti (NCT00590018)
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Baylor College of Medicine
Apnea of Prematurity, Preterm Birth
Hemodynamic Responses to Cardio-respiratory Events in Preterm Infants
Intermittent episodes of hypoxemia and/or bradycardia, also defined as cardio-respiratory events (CRE) are very frequent in preterm infants and may result in transient hypoxia and hypoperfusion of target organs, with possible…
- Conditions
- Apnea of Prematurity, Preterm Birth, Patent Ductus Arteriosus, Hypoxia, Brain
- Trial name
- NCT04184245
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Shock, Sepsis
Hemodynamic Evaluation of Preload Responsiveness in Children by Using PiCCO
The purpose of this study is To assess the value of dynamics (SVV, PPV) and static indices (GEDVI, ITBVI, CVP) of preload and its combination with contractility (CI,SV, ventricular power, dP/dtmax, CFI, GEF) and lung water…
- Conditions
- Shock, Sepsis, Systemic Inflammatory Response Syndrome, Low Cardiac Output
- Trial name
- PreloaDren (NCT01157299)
- Where
- 7 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitario La Paz