Clinical trials: Cardiac Output
Pediatric ALL
Pediatric Cardiac Output Monitoring Observational Study
To assess Cardiac Output Monitoring in pediatric subjects by comparing FloTrac and ClearSight system to intermittent thermodilution Swan-Ganz, in order to expand the indications of FloTrac, ClearSight and Swan-Ganz thermodilution…
- Trial name
- POGO (NCT04465370)
- Testing
- Hemosphere Advanced Monitoring System, ClearSight 1.5, Swan-Ganz Catheter, Flotrac, Foresight
- Where
- 3 sites in United States
- Volunteers
- 89 people
- Sponsor
- Edwards Lifesciences
Low Cardiac Output Syndrome
Levosimendan Administration in Neonates With Transposition of the Great Arteries
Calcium sensitizer drugs such as Levosimendan may exert anti-ischemic effect in addition to positive inotropic and anti-stunning effects mediated by the opening of ATP-sensitive potassium (KATP) channels.
- Trial name
- NCT01120106
- Testing
- levosimendan
- Where
- Italy
- Volunteers
- 63 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Hemodynamic Monitoring
UltraTrac Clinical Pilot Study
This single-center pilot study will evaluate the accuracy and feasibility of non-invasive cardiac output measurement using the UltraTrac device in pediatric patients aged 0-21 years undergoing standard-of-care diagnostic cardiac…
- Trial name
- ULTRA-CO (NCT07864714)
- Testing
- Noninvasive Hemodynamic Monitoring System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- AcQumen Medical, Inc.
Traumatic Brain Injury
Prediction of Neurological Outcome of Children After a Traumatic Brain Injury Based on an Integrated Predictive Model
This study aims to develop a integrated predictive model based on serum biomarkers, HRV, and an innovative computerized classifier output, to predict the patient long term neurological outcome after a moderate or severe TBI in…
- Trial name
- NCT04157634
- Testing
- Prognostication model
- Volunteers
- 70 people
- Sponsor
- St. Justine's Hospital
Ischemic Congestive Cardiomyopathy, Dilated Cardiomyopathy
Optimizing Left Ventricular Lead To Improve Cardiac Output
The purpose of this study is to determine if optimal lead placement, guided by the largest improvement in aortic flow measured by Doppler will: 1. Improve the way the heart's left ventricle functions 2.
- Conditions
- Ischemic Congestive Cardiomyopathy, Dilated Cardiomyopathy, Congestive Heart Failure
- Trial name
- CARE/VOLCANO (NCT01399801)
- Testing
- Doppler flow measurement, standard implantation of the LV lead
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Ann Marie Chikowski
Cardiac Output, Anesthesia
Non-invasive Cardiac Index in Children
This study investigates the level of agreement of two non-invasive cardiac output monitors (transthoracic echocardiography and electrical cardiometry) in young children under anesthesia.
- Conditions
- Cardiac Output, Anesthesia, Infant ALL
- Trial name
- NICIM (NCT06090396)
- Testing
- cardiac output monitoring with electrical cardiometry
- Where
- Switzerland
- Volunteers
- 55 people
- Sponsor
- Laszlo Vutskits
Hemodynamics
Electrical Velocimetry (ICON Cardiometry ) Assessment of Hemodynamic Changes During Pediatric Thoracoscopic Surgery
Advances in endoscopic equipment and technique have led to the use of minimally invasive thoracic surgery in an increasing number of pediatric surgical procedures.
- Trial name
- NCT04131699
- Testing
- Cardiotronic ICON continuous non-invasive cardiac output monitor.
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Cairo University
Rhabdomyolysis Linked to a Hereditary Disease of Metabolism
Evaluate the Effort Test as a Therapeutic Monitoring Tool in Acute Rhabdomyolyses
The prognosis of rhabdomyolyses related to hereditary diseases of metabolism is poor and treatments are only symptomatic. Rhabdomyolysis outbreaks are frequently precipitated by fever and fasting. They are unpredictable.
- Trial name
- EFFORHAB (NCT03802279)
- Testing
- Effort test, Functional tests on fibroblasts
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Output
Comparison of Techniques for Assessing Cardiac Output and Preload in Critically Ill Pediatric Patients
The ability to measure cardiac output (CO) accurately and reproducibly at frequent intervals remains elusive to the clinician caring for critically ill pediatric patients even though a large proportion of these children are known…
- Trial name
- GCH (NCT00853437)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Transonic Systems Inc.
Cardiac Output, Low, Cardiac Output, High
Non-invasive Continuous Cardiac Output Monitoring in Preterm Infants Study
This is an observational study in newborn term and preterm infants. The study will validate if non-invasive continuous cardiac output monitoring is feasible in newborn infants, if normative values can be constructed and what is…
- Conditions
- Cardiac Output, Low, Cardiac Output, High, Blood Pressure
- Trial name
- NICCOM (NCT04064177)
- Testing
- NICAS cardiac output monitor
- Where
- United Kingdom
- Volunteers
- 148 people
- Sponsor
- Imperial College Healthcare NHS Trust
Cardiac Diseases
Non-Invasive Determination of Cardiac Output by Inertgas Rebreathing Method
The cardiac output (CO) is an important parameter in the diagnosis and therapy of cardiac diseases. The current standard methods for the determination of the CO, however, are either invasive (e.g.
- Trial name
- NICO (NCT00479804)
- Testing
- inertgas rebreathing, spirometry, cardiac magnetic resonance imaging (CMR)
- Where
- Germany
- Volunteers
- 311 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Enhanced External Counterpulsation (EECP), Cardiac Output
Impact of Enhanced External Counterpulsation (EECP) on Cardiac Force Index
Regular exercise can prevent cardiovascular disease, but there is also a risk of sudden cardiac death. Exercise-related sudden death often occurs unconsciously and there is no relevant monitoring mechanism.
- Conditions
- Enhanced External Counterpulsation (EECP), Cardiac Output, Cardiac Force Index
- Trial name
- NCT05080023
- Testing
- Enhanced External Counterpulsation (EECP)
- Where
- 5 sites in Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Chi-Ming Chu
VCO2 Variation in Intensive Care as a Marker of Fluid Responsiveness, Cardiac Index Variation Transpulmonary Thermodilution in Patients on Controlled Ventilation With Shock
Cardiac Responsiveness Assessment by CO2
The increase of cardiac output resulting from increased blood volume (systolic ejection volume) during intravenous fluid administration defines a state of fluid responsiveness.
- Trial name
- CRAC (NCT05430880)
- Testing
- impact of fluid challenge on the cardiac index and CO2 respiratory parameters analysis (VCO2, EtCO2)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Pregnancy Related, Cardiac Output
Cardiac Flow Measurements in Pregnant Women by Non Invasive Techniques
the goal of this clinical trial is to compare the measurement of cardiac output, systolic ejection volume and vascular filling in pregnant women with the new non-invasive measurement techniques of the Index of contractility…
- Trial name
- NCT06114147
- Testing
- trans thoracic echocardiography measure, ICON measure, USCOM
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Low Cardiac Output
Comparative Study of Haemodynamic Changes After Spinal Anaesthesia in Non-obese and Pregnant Women
Obesity has become one of the most common risk factors in obstetric practice with serious anaesthetic implications. Obese pregnants have limited physiological reserves and cardiovascular co- morbidities when compared to non-obese…
- Trial name
- NCT02599376
- Testing
- LiDCOrapid
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Preterm Infant
Cardiorespiratory Effects of "Higher" Versus "Equivalent" CPAP Upon Extubation From High EAP in Preterm Infants
The aim of this study is to compare the cardiovascular and respiratory effects of "higher" versus "equivalent" CPAP pressures post-extubation from high endotracheal airway pressures (EAP), defined as at least 8 cm H2O (water), in…
- Trial name
- CO-PAP (NCT02528851)
- Testing
- Extubation from endotracheal mechanical ventilation to CPAP
- Volunteers
- 14 people
- Sponsor
- McMaster University
Congenital Heart Disease, Brain Injuries
Autologous Umbilical Cord Blood Treatment of Neonate With CHD
The aim of the study is to evaluate the feasibility and safety and efficacy of collecting and infusing autologous umbilical cord blood (UCB) in newborn infants with hypoplastic left heart syndrome (HLHS) and transposition of…
- Conditions
- Congenital Heart Disease, Brain Injuries, Low Cardiac Output Syndrome, Neonatal Disorder
- Trial name
- NCT03558269
- Testing
- Autlogous UCB infusion
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Severe Sepsis, Septic Shock
Comparison of Pediatric Septic Shock Treatment With and Without Central Venous Oxygen Saturation Monitoring
The purpose of this study was to compare ACCM/PALS guidelines performed with and without central venous oxygen saturation monitoring on the morbidity and mortality rate of children with severe sepsis and septic shock.
- Trial name
- NCT00407823
- Testing
- Central venous oxygen saturation continuous monitoring
- Where
- 2 sites in Brazil
- Volunteers
- 268 people
- Sponsor
- University of Sao Paulo
Low Cardiac Output Syndrome, Transposition of Great Vessels
Nitric Oxide During Bypass for Arterial Switch Operation
This trial will test if adding nitric oxide (NO) gas to the cardiopulmonary bypass (CPB) circuit in infants undergoing an arterial switch operation (ASO) for Transposition of the Great Arteries (TGA) changes the incidence of…
- Trial name
- NASO (NCT03661385)
- Testing
- Nitric Oxide
- Where
- 4 sites in Australia, Canada and 2 more
- Volunteers
- 300 people
- Sponsor
- Murdoch Childrens Research Institute
Heart Disease, Heart Failure
Investigating Systemic and Local Vascular Responses to Apelin in the Context of Renin-angiotensin Upregulation
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.
- Conditions
- Heart Disease, Heart Failure, Vasodilatation
- Trial name
- NCT00901719
- Testing
- Apelin, Acetylcholine, Sodium nitroprusside
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh