Clinical trials: Cardiometabolic Health
In Utero Drug Exposure
Cardiometabolic Health of Children Exposed to Anti-retroviral Therapy (ART) in Utero
The Human Immunodeficiency Virus (HIV) has been recently linked to increased risk for cardiovascular diseases (CVDs). The prevalence of cardiovascular diseases and its risk factor, hypertension, are very high in African…
- Trial name
- ARTMOMSBABES (NCT04763668)
- Testing
- Pregnant HIV positive women on ARTs, Babies born to HIV positive mothers on ARTs
- Where
- South Africa
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Walter Sisulu University
Down Syndrome, Trisomy 21
Down Syndrome Metabolic Health Study
The purpose of this research study is to determine which measures best capture cardiovascular disease (CVD) risk and type 2 diabetes (T2DM) risk in children and adolescents with Down syndrome (DS).
- Trial name
- NCT01821300
- Where
- 2 sites in United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Sedentary Behavior, Physical Activity
MOVI-OLE! [Open Learning Environments]
This study will evaluate the effectiveness of MOVI-OLE! (Open Learning Environment), a school-based intervention designed to reduce sedentary time and enhance multiple aspects of child development, including cognitive function…
- Conditions
- Sedentary Behavior, Physical Activity, Cognitive Function, Mental Health
- Trial name
- MOVI-OLE! (NCT07103343)
- Testing
- MOVI-OLE intervention
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Overweight/Obesity, Puberty
Improving Health Among Disadvantaged Girls to Slow Pubertal Onset and Reduce Long-term Health Risks
This study is testing whether improving health in girls during the prepubertal period may slow the onset of puberty. This study will focus on prepubertal girls who have a high weight status (at or above the 85th percentile for…
- Conditions
- Overweight/Obesity, Puberty, Health Behavior, Cardiometabolic Health
- Trial name
- NCT07460544
- Testing
- Family-Based Treatment (FBT)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Washington
Dysbiosis, Cardiometabolic Health Indicators
Almonds, Gut Microbiome and Kids
This 8-week parallel-arm randomized controlled trial (N=70; ages 6-13) will determine the impact of daily almond butter consumption on gut microbiome composition and function, intestinal barrier integrity, and cardiometabolic…
- Trial name
- NCT07636850
- Testing
- Creamy Richards 100% Almonds! Creamy Natural Almond Butter, Cadbury Milk Chocolate Spread
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Florida State University
Vitamin D Deficiency
Impact of Vitamin D Supplementation on Cardiometabolic Risk Factors [The Daily D Health Study]
The purpose of this research is to determine what supplemental doses of vitamin D may be necessary to raise serum levels to optimal levels and how vitamin D supplementation and changes in vitamin D status impact cardiovascular…
- Trial name
- NCT01537809
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 691 people, healthy volunteers welcome
- Sponsor
- Tufts University
Maternal Cardiometabolic Health, Infertility
St Mary's Assisted Reproductive Technology and Cardiometabolic Health: Modifiable Targets for Multimorbidity Prevention (START-HEALThY)
The main causes of death in women are conditions affecting the heart and blood vessels (cardiovascular disease, CVD). Women who have difficulties getting pregnant (infertility) may be at increased risk, but the reasons for this…
- Conditions
- Maternal Cardiometabolic Health, Infertility, Assisted Reproductive Technology, Cardiovascular Health
- Trial name
- START-HEALThY (NCT07173569)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Cerebral Palsy
Telehealth Virtual Reality Gaming on Cardiometabolic Health Among Youth With Cerebral Palsy
The primary purpose of this study is to examine the preliminary efficacy of 12-weeks of home-based exercise using consumer available virtual reality gaming technology, compared with a 12 week wait-list control group.
- Trial name
- NCT05336227
- Testing
- Virtual Reality Exergaming
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Transgenderism, Insulin Sensitivity/Resistance
Puberty Suppression and Cardiometabolic Health
This observational study will evaluate the effect of puberty suppression on insulin sensitivity, metabolic rate and vascular health among transgender female youth at baseline and 6 months after initiation of a gondoatropin…
- Conditions
- Transgenderism, Insulin Sensitivity/Resistance, Endothelial Dysfunction, Vascular Stiffness
- Trial name
- NCT04482374
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Exercise Overtraining, Enjoyment
Interval Training and Cardio-metabolic Health in Overweight/Obese Girls
The main purpose of this study is to compare the impact of 12-week moderate-intensity interval training (MIIT) versus combined MIIT with high-intensity interval training (HIIT) on physical fitness, cardio metabolic, lipidomic…
- Conditions
- Exercise Overtraining, Enjoyment, Cardiometabolic Syndrome, Obesity
- Trial name
- NCT06538714
- Testing
- MIIT, MIIT + HIIT, Control group
- Where
- 2 sites in Tunisia
- Volunteers
- 45 people
- Sponsor
- Association Tunisienne d'Etude & de Recherche sur l'Athérosclérose
Physical Activity, Cardiometabolic Risk Factors
Going Places: A Multi-level Intervention to Improve Youth Transportation Efficacy and Physical Activity
Going Places is a community driven intervention to increase transportation self-efficacy among low-income youth, enabling access to community-based programs that promote physical activity and improve long term cardiometabolic…
- Conditions
- Physical Activity, Cardiometabolic Risk Factors, Cardiometabolic Health Indicators, Self-Efficacy
- Trial name
- Going Places (NCT07044375)
- Testing
- Going Places
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Duke University
Autism Spectrum Disorder (ASD), Cardiometabolic Health Indicators
This Study Will Evaluate Cardiorespiratory and Muscular Fitness to Examine Associations With Anthropometric Characteristics and Other Indicators of Cardiometabolic Risk Among Patients With or Without Autism Spectrum Disorder
The goal of this observational study is to evaluate cardiorespiratory and muscular fitness in children with obesity, with and without autism spectrum disorder (ASD), and examine how fitness relates to body measurements, body…
- Conditions
- Autism Spectrum Disorder (ASD), Cardiometabolic Health Indicators, Cardiometabolic Risk Factors, Metabolic Syndrome
- Trial name
- ROACH (NCT07804680)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Virginia
Bone Health, Muscle Function
Effects of Milk Protein and Vitamin D on Children's Growth and Health
The purpose of D-pro is to investigate the combined and separate effects of milk protein and vitamin D on bone health, growth, muscle function, body composition and cardiometabolic health in 6-8-year-old children.
- Conditions
- Bone Health, Muscle Function, Cardiometabolic Health, Appetite Regulation
- Trial name
- D-pro (NCT03956732)
- Testing
- Milk Protein (high), Vitamin D, Milk Protein (medium)
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity, Health Behavior
An Integrated Closed-loop Feedback System for Pediatric Cardiometabolic Disease
The high prevalence and burden of cardiometabolic disease underlie the urgent need to identify novel approaches to managing and preventing cardiometabolic disease and risk.
- Trial name
- STRIVE (NCT02659163)
- Testing
- mHealth wristband, mHealth scale, EMA
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy
Bioenergetic Phenotypes and Cardiometabolic Health
This research study is about how daily activities, behaviors, and fitness affect the health and function of blood cells and their mitochondria, which are the powerhouses of the cells.
- Trial name
- MI Energy (NCT04427462)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Exercise, Cerebral Palsy
RaceRunning for Young People With Moderate-to-severe Cerebral Palsy
Physical inactivity in people with cerebral palsy (CP) has been linked with increased risk of cardiometabolic disease. Exercise studies rarely include people with CP with severe walking impairments and assess the sustainability…
- Trial name
- NCT04034342
- Testing
- RaceRunning
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- Queen Margaret University
Dysbiosis, Cardiometabolic Health Indicators
Pulse Education and Children
This parallel-arm, randomized controlled trial will evaluate the effectiveness of a 6-week pulse-focused nutrition intervention in school-aged children (6-13 years).
- Conditions
- Dysbiosis, Cardiometabolic Health Indicators, Education on Feeding and Health Status, Gut Motility
- Trial name
- NCT07648446
- Testing
- Education Only, Education + Pulse Provision, Cooking Class
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Overweight and Obesity
Active Versus Passive Recovery During HIIT in Children With Overweight or Obesity
This study aims to evaluate the effects of a 12-week high-intensity interval training (HIIT) program with active versus passive recovery on physical performance, anthropometric characteristics, cardiometabolic parameters, and…
- Trial name
- NCT07861048
- Testing
- High-Intensity Interval Training with Active Recovery, High-Intensity Interval Training with Passive Recovery
- Where
- Tunisia
- Volunteers
- 30 people
- Sponsor
- High Institute of Sports and Physical Education of Kef
Polycystic Ovary Syndrome, Exercise
The Effects of High-intensity and Moderate-intensity Exercise on Polycystic Ovary Syndrome
This study will investigate the impact of high- and moderate-intensity exercise on the cardiometabolic and brain health of women with Polycystic Ovary syndrome (PCOS).
- Conditions
- Polycystic Ovary Syndrome, Exercise, Cerebrovascular Circulation
- Trial name
- NCT05394935
- Testing
- High-Intensity Exercise, Moderate-Intensity Exercise
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cardiff Metropolitan University
Cardiometabolic Health, Gastro-intestinal Wellbeing
Effects of Wholegrains on Children's Health (KORN)
KORN investigates the effects of wholegrain oat and rye intake on health and cognitive wellbeing in children with overweight.
- Conditions
- Cardiometabolic Health, Gastro-intestinal Wellbeing, Cognitive Function, Overweight
- Trial name
- NCT04430465
- Testing
- Grain products high in wholegrains from oat and rye, Grain products low in wholegrains
- Where
- Denmark
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen