Clinical trials: Cardiovascular Biomarkers
Adrenal Gland Neoplasm, Hypertension
Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks
Background: The adrenal gland makes the hormone aldosterone. This helps regulate blood pressure. An adrenal gland tumor that makes too much aldosterone can cause high blood pressure and low potassium.
- Conditions
- Adrenal Gland Neoplasm, Hypertension, Bone Diseases, Metabolic, Cardiovascular Disease
- Trial name
- NCT03374215
- Where
- United States
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Exercise
The Munich Cardiovascular Adaptation in Young Athletes Plus Study
The aim of the 3-year longitudinal study is to investigate the cardiovascular system's response to training loads in young athletes.
- Trial name
- MuCAYAplus (NCT06259617)
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Ventricular Dysfunction, Asthma in Children
Evaluation of Cardiac Biomarkers and Ventricular Function in Asthmatic Children
Evaluation of cardiac biomarkers and the left and right ventricular systolic and diastolic function in asthmatic children in Assuit university hospital
- Trial name
- NCT05985720
- Volunteers
- 50 people
- Sponsor
- Assiut University
Acute Brain Injury, Traumatic Brain Injury
Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury
Acute brain injury (ABI) is a leading cause of death and long-term disability in children. Diagnosis depends on fast neuroimaging, and head computed tomography (CT) is the bedside reference standard despite exposing the…
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Hydrocephalus
- Trial name
- CUPID-Peds (NCT07772323)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Virginia Commonwealth University
Cardiac Arrest
Circulating Biomarkers Predict Neurological Outcome After Cardiac Arrest
Prediction of clinical outcome after cardiac arrest is clinically important.Early prognostication after successful cardiopulmonary resuscitation is difficult, and there is a need for novel methods to estimate the extent of brain…
- Trial name
- CABNO (NCT02297776)
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai 10th People's Hospital
Congenital Heart Disease
Copeptin- Relevance as a Perioperative Marker in Pediatric Cardiac Surgery
This study evaluates the relevance of Copeptin in children with congenital heart disease undergoing cardiac surgery with the need of cardiopulmonary bypass. Three blood samples are taken of each patient.
- Trial name
- NCT03316508
- Where
- Austria
- Volunteers
- 81 people
- Sponsor
- Claudia Herbst
Hypoxic Ischaemic Encephalopathy (HIE), Asphyxia
BiHiVE2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy.
Despite recent advances in the care of mothers and newborn infants, many infants (approximately 20 per 1000 live births) continue to need resuscitation at birth.
- Trial name
- BiHiVE2 (NCT02019147)
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University College Cork
Preeclampsia, Pregnancy Related
Use of Lumella-glycosylated Fibronectin for Diagnosis of Preeclampsia
women with symptoms of preeclampsia from antenatal clinic or triage will be offered Lumella test along with traditional blood tests. If Lumella test is positive which will be compared with the traditional blood test results.
- Conditions
- Preeclampsia, Pregnancy Related, Hypertension
- Trial name
- Lumella (NCT06085001)
- Testing
- Lumella finger prick blood test
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Croydon University Hospital
Sickle Cell Disease
Study of Biological Markers in Children With Sickle Cell Disease
Sickle cell disease is associated with significant morbi-mortality hence the interest in an early and targeted care. At present, there is no plasmatic marker able to identify infants at higher risk of developping severe…
- Trial name
- NCT04839159
- Testing
- Blood sampling
- Where
- 3 sites in Belgium
- Volunteers
- 41 people
- Sponsor
- Queen Fabiola Children's University Hospital
Fabry's Disease
Early Detection and Follow-Up of Patients With Fabry's Disease
This research project will serve on the enhancement of early detection, diagnosis and follow-up of patients with Fabry Disease, through new biomarkers identification. This could have straight clinical impact on: 1.
- Trial name
- NCT04847713
- Testing
- extraction of blood samples
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Clinico Universitario de Santiago
Cardiomyopathy
Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy
The objective of this study is to collect information on patients with cardiomyopathy (CM) due to mutations in the MYBPC3 gene, to evaluate their disease course, burden of illness, risk factors for this disease, and the quality…
- Trial name
- MyCLIMB (NCT05112237)
- Where
- 29 sites in United States, Canada and 2 more
- Volunteers
- 200 people
- Sponsor
- Tenaya Therapeutics
Heart Failure，Congestive
Effects of Furosemide Plus Small HSS in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF)
The investigators sought to evaluate the effectiveness of treatment with furosemide + HSS in terms of reduction of serum levels of some chosen markers of heart failure and the response in terms of these markers at a compensated…
- Trial name
- NCT04628325
- Testing
- Furosemide
- Where
- 2 sites in Italy
- Volunteers
- 136 people
- Sponsor
- University of Palermo
Nitrous Oxide Abuse
Biological Diagnosis and Monitoring of Chronic Nitrous Oxide Abuse
There is a toxicity linked to the chronic use of nitrous oxide, leading to neurological disorders such as combined sclerosis of the spinal cord.
- Trial name
- BALON (NCT05540561)
- Testing
- blood collection
- Where
- 8 sites in France
- Volunteers
- 356 people
- Sponsor
- University Hospital, Lille
Pregnancy, Gestational Diabetes
Behavior of Biomarkers During Pregnancy and Lactation Through a Biological Multi-paradigm Model: BECOME Study Protocol
Background Despite of advances in research, at the moment, various points related to the physiology of gestation and the etiology of severe diseases that can be developed in the course of it remain unknown.
- Conditions
- Pregnancy, Gestational Diabetes, Hypertension, Obesity
- Trial name
- BECOME (NCT02811172)
- Testing
- BEhavior of biomarkers during pregnanCy and lactatiOn
- Where
- Spain
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Myocarditis
Risk Stratification Value of Biomarkers in Patients With Myocarditis
The aim of this study is to collect clinical data and biological specimens from patients with myocarditis and construct a predictive model for the prognosis of myocarditis.
- Trial name
- FORWARD (NCT06010199)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Sturge-Weber Syndrome
Innovative Approaches to Gauge Progression of Sturge-Weber Syndrome
This study has three aims that hope to expand the knowledge on the cause of Sturge-Weber Syndrome (SWS) and improve clinical care of Sturge-Weber Syndrome patients.
- Trial name
- NCT01425944
- Where
- 7 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Congenital Heart Disease, Pulmonary Arterial Hypertension
Biomarkers in Pediatric Congenital Heart Disease and PAH
Nowadays, biomarkers are broadly used in clinical practice. Blood-derived biomarkers fulfil an important role in the field of cardiology. However, most biomarkers have been investigated for adult left ventricular disease.
- Trial name
- NCT04130243
- Testing
- Blood test
- Where
- Netherlands
- Volunteers
- 380 people
- Sponsor
- University Medical Center Groningen
Children, Chronic Renal Failure
Effect of Strict Blood Pressure Control and ACE-Inhibition on Progression of Chronic Renal Failure in Pediatric Patients
In children with chronic kidney disease, progression to end-stage renal failure is associated with high patient morbidity and poor quality of life.
- Conditions
- Children, Chronic Renal Failure, Hypertension, Acquired Kidney Disease
- Trial name
- ESCAPE (NCT00221845)
- Testing
- ACE Inhibition, Intensified Blood Pressure Control, Add-on Angiotensin Receptor Blockade
- Where
- 33 sites in Czechia, France and 10 more
- Volunteers
- 400 people
- Sponsor
- Heidelberg University
Circulatory Failure
NeoAdapt 2: An Observational Study Investigating Novel Biomarkers in the Evaluation and Treatment of Neonatal Circulatory Insufficiency
Circulatory failure can affect up to 50% of premature infants that are admitted to neonatal intensive care. This can be because their heart muscle is not developed enough to send blood to vital organs such as the brain.
- Trial name
- NCT02051855
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Pediatric Hypertension, Primary Hypertension
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Children With Newly Diagnosed Hypertension
Childhood hypertension is associated with early endothelial dysfunction and an increased risk of future cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial…
- Conditions
- Pediatric Hypertension, Primary Hypertension, Endothelial Dysfunction
- Trial name
- HYPER-endoEV-c (NCT07728643)
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek