Clinical trials: Cardiovascular Condition
Breast Cancer, Leukemia
High-Dose Chemotherapy, Total-Body Irradiation, and Autologous Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Hematologic Cancer or Solid Tumors
RATIONALE: Radiation therapy uses high-energy x-rays to damage cancer cells. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
- Conditions
- Breast Cancer, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00060255
- Testing
- busulfan, carboplatin, carmustine
- Where
- United States
- Volunteers
- 451 people
- Sponsor
- Roswell Park Cancer Institute
Patent Foramen Ovale
Post Market Clinical Follow-up Study of IrisFITTM PFO (Patent Foramen Ovale) Occluder
The purpose of the study is to collect more data about performance and safety of the device called "IrisFITTM PFO occluder". This data will be used to help more patients who will accept treatment with this device in the future.
- Trial name
- PFO (NCT02882815)
- Testing
- IrisFIT PFO Occluder
- Where
- 3 sites in Germany, Ireland
- Volunteers
- 85 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Abdominal Aortic Aneurysm, Endoleak
Contrast-enhanced Ultrasound in Follow-up After Endovascular Aneurysm Repair
X-ray computed tomography imaging (CT) is routinely used in follow-up after endovascular aneurysm repair (EVAR). Contrast-enhanced ultrasound (CEUS) has been shown to give accurate information about endoleak after EVAR.
- Trial name
- NCT01843335
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Norwegian University of Science and Technology
Atrial Fibrillation, Tachycardia, Ventricular
Ajmaline Utilization in the Diagnosis and Treatment of Cardiac Arrhythmias
The study evaluates 3 different populations: It is an open, randomized, parallel-group study comparing the effectiveness of intravenous (iv) ajmaline with currently used antiarrhythmic drugs in the acute treatment of : 1.
- Conditions
- Atrial Fibrillation, Tachycardia, Ventricular, Brugada Syndrome
- Trial name
- AJUAR (NCT00702117)
- Testing
- flecainide, ajmaline, procainamide
- Where
- 4 sites in Spain
- Volunteers
- 123 people
- Sponsor
- Hospital Clinic of Barcelona
Univentricular Heart
Aesculus Hippocastanum L. on Fontan Circulation
Patients after the Fontan operation at a single institution will be randomized to receive a standardized extract of Aesculus hippocastanum L. (horse chestnut) or placebo for 4 months in a crossover clinical trial.
- Trial name
- NCT04035317
- Testing
- Aesculus Hippocastanum / Horse Chestnut
- Where
- Brazil
- Sponsor
- Casa Espirita Terra de Ismael
Obesity, Diabetes Mellitus, Type 2
Study of the Potential of a Macronutrient Balanced Normocaloric Diet to Treat Lifestyle Diseases
One of today's major health problem in the western world is related to lifestyle. Lifestyle diseases include obesity, type 2 diabetes, cardiovascular diseases and different types of cancers.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Cardiovascular Diseases
- Trial name
- NCT01278121
- Testing
- Diet A, Diet B
- Where
- Norway
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Hypotension, Neonatal Hypotension
Appropriate Dosage of Vasopressor in Neonates and Infants
In this study, the investigators will evaluate cerebral blood flow before and after drug infusion using ultrasound to suggest blood pressure criteria and dosage of ephedrine, a vasopressor, to maintain adequate cerebral blood…
- Conditions
- Hypotension, Neonatal Hypotension, Intraoperative Complications
- Trial name
- NCT06257316
- Testing
- EPHEDrine Hydrochloride 5 mg/ml
- Volunteers
- 132 people
- Sponsor
- Seoul National University Hospital
Cardiovascular Diseases, Pre-Eclampsia Onset Less Than 37 Weeks (Diagnosis)
Postnatal Enalapril to Improve Cardiovascular fUnction Following Preterm Pre-eclampsia
This is a double blind randomised controlled feasibility study investigating the effect of postnatal enalapril on cardiovascular function in women who have had preterm pre-eclampsia.
- Trial name
- PICk-UP (NCT03466333)
- Testing
- Enalapril Maleate
- Where
- United Kingdom
- Volunteers
- 118 people
- Sponsor
- Manchester University NHS Foundation Trust
Heart Defects, Congenital
DEX vs SEVO in Congenital Heart Surgery
Anesthesia-related neurotoxicity in the developing brain is still a concern although evidence in humans is debatable. Moreover, it is unclear whether repeated and/or prolonged exposures are harmless and whether their effects are…
- Trial name
- DEXLOSNeuro (NCT05369949)
- Testing
- DEX group, Control group
- Volunteers
- 150 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Duchenne Muscular Dystrophy, Cardiomyopathy
HOPE-Duchenne (Halt cardiomyOPathy progrEssion in Duchenne)
Male participants with cardiomyopathy secondary to Duchenne muscular dystrophy (DMD) meeting all inclusion and no exclusion criteria will be randomized. All participants will be at least 12 years of age.
- Trial name
- HOPE (NCT02485938)
- Testing
- Allogeneic Cardiosphere-Derived Cells (CAP-1002)
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Capricor Inc.
Stroke, Stroke, Acute
Data Collection of Patients Admitted to the Stroke Unit
The purpose of this prospective observational study is to create a database in which data will be collected from every patient admitted to the Stroke unit and who has explicitly given his or her informed consent for this data…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- PRODA-STROKE (NCT04956185)
- Where
- Belgium
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Ghent
Congenital Heart Disease
Effect of Feeding With Nutrient Dense Formula in Malnourished Infants and Children With Congenital Heart Defects
Infants with congenital heart disease (CHD) are usually born with a normal weight but develop malnutrition over time, and about 20-50% of these children are usually malnourished. Malnutrition in these patients is multifactorial.
- Trial name
- NCT04795076
- Testing
- Infant formula
- Where
- Iran
- Volunteers
- 65 people
- Sponsor
- Shahid Beheshti University
Diabetic Retinopathy
Prevention of Onset and Transition to an Advanced Form of Diabetic Retinopathy in Children
The primary goal of the project is to create a normative database from data collected from a healthy pediatric population. A secondary aim is to compare normative data with data from pediatric patients with pre-existing type 1…
- Trial name
- NCT05615740
- Testing
- Optical coherence tomography (OCTA)
- Where
- Czechia
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- University Hospital Ostrava
Congenital Disorders
Outcomes of Children With Congenital Single Ventricle Heart
Congenital heart disease affects 1 in 100 newborn babies each year and more than 2,000,000 Americans have a congenital heart defect.
- Trial name
- NCT00266968
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Healthcare of Atlanta
Traumatic Brain Injury
Interacting Together Everyday: Recovery After Childhood Traumatic Brain Injury (TBI) "I-InTERACT
The purpose of this study is to test an on-line intervention for families of young children who have experienced moderate or severe traumatic brain injury (TBI).
- Trial name
- I-InTERACT (NCT01056146)
- Testing
- Internet-based Interacting Together Everyday: Recovery After Childhood TBI, Internet Resources Comparison
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pulmonary Hypertension
Giessen Pulmonary Hypertension Registry and Biobank
Giessen Pulmonary Hypertension Registry and Biobank
- Trial name
- NCT04145024
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- University of Giessen
Obesity (Disorder)
AI-INFORMED PEER-MENTORING BEHAVIORAL INTERVENTION FOR OBESITY AND CARDIOVASCULAR DISEASE PRIMARY PREVENTION IN YOUTH
The goal of this clinical trial is to learn if an AI-based peer-mentoring works to prevent obesity in adolescents and young adults.
- Trial name
- PeerMentorOBCV (NCT07505459)
- Testing
- AI-informed behavioral intervention, Standard behavioral intervention, Health Education
- Where
- 3 sites in Greece, Italy and 1 more
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- Aikaterini Karaivazoglou
Sickle Cell Anemia
Longitudinal Changes in Exercise Capacity in Children and Young Adults With Sickle Cell Anemia
The purpose of this study is to use comprehensive exercise testing to examine longitudinal changes in exercise capacity over a 2 year period in children and young adults with sickle cell anemia.
- Trial name
- NCT01558076
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Patent Ductus Arteriosus
Ibuprofen vs. Continuous Indomethacin in the Treatment of PDA
The purpose of this study is to determine whether closure of the PDA in premature neonates using IV ibuprofen vs continuous IV indomethacin has different side effects, eg.
- Trial name
- NCT00485160
- Testing
- Continuous indomethacin, ibuprofen
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Shaare Zedek Medical Center
Hereditary Angioedema (HAE)
Efficacy and Safety Study of DX-88 to Treat Acute Attacks of Hereditary Angioedema (HAE)
The purpose of this study is to determine if a subcutaneous dose of DX-88 (ecallantide; an investigational product) is safe and relieves symptoms of HAE in patients suffering from moderate to severe acute attacks of HAE.
- Trial name
- NCT00262080
- Testing
- ecallantide, Phosphate Buffer Saline (PBS),
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Shire
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