Clinical trials: Cardiovascular Condition
Pain, Acute, Congenital Heart Disease
Transverse Thoracic Plane Block in the Pediatric Cardiac Patient
Postoperative pain after cardiothoracic surgery can be a significant problem interfering with recovery, yet difficult to manage due to the sedating effects of opiates.
- Trial name
- TTPPCT (NCT04138745)
- Testing
- Transverse Thoracic Plane Block
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Neurodevelopmental Disorders, Congenital Heart Disease
Altered Cerebral Growth and Development in Infants With Congenital Heart Disease
Background: Congenital heart disease (CHD) is the most frequent inborn defect with an incidence of 1 in 100 newborns per year, i.e. 800 children born in Switzerland per year.
- Conditions
- Neurodevelopmental Disorders, Congenital Heart Disease, Brain Injuries, Fetal Growth Retardation
- Trial name
- NCT04233775
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Cardiovascular Diseases, Heart Diseases
Diet Modification and Blood Pressure in Young People
To determine the effects of diet modification on blood pressure, blood cholesterol, and bone density in healthy young people.
- Trial name
- NCT00005167
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Intravascular Identification and Drug-Eluting Balloon Treatment of Vulnerable Lipid-Rich Plaques
Rationale: Two-thirds of intracoronary thrombi causing acute coronary syndrome (ACS) result from rupture of lipid-rich plaques (LRP).
- Trial name
- DEBuT-LRP (NCT04765956)
- Testing
- Drug-eluting balloon treatment
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Elasticum, Incomplete Pseudoxanthoma
The Characteristics of Backscattering With Depth in the Progression of Keratoconus
To investigate the variation in backscattering with depth between forme fruste keratoconus (FFKC), keratoconus, and normal eyes; to determine the backscattering changes in the characteristics of keratoconus progression; and to…
- Trial name
- NCT06050629
- Where
- China
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Phase 2, Radiotherapy-Induced Immune Priming
A Phase 2 Study of Radiotherapy-induced Immune Priming to Enhance Elranatamab (Elra) in Relapsed Refractory Multiple Myeloma (RRMM) With Extramedullary Disease (EMD) and Paramedullary Disease (PMD) "PRIME-EMD-PMD"
To learn if low doses of radiation therapy can help the drug elranatamab enhance the killing effect of the cancer cells.
- Conditions
- Phase 2, Radiotherapy-Induced Immune Priming, Elranatamab, Relapsed Refractory Multiple Myeloma (RRMM)
- Trial name
- NCT07382739
- Testing
- Elranatamab
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- M.D. Anderson Cancer Center
Age-related Macular Degeneration (AMD), Central Retinal Vein Occlusion (CRVO)
Evaluation of Physician Knowledge of Safety and Safe Use Information for Aflibercept in Canada
The primary objective of this study is to measure physician knowledge and understanding of the key safety information contained in the Eylea vial preparation instruction card, the intravitreal injection procedure video, and the…
- Conditions
- Age-related Macular Degeneration (AMD), Central Retinal Vein Occlusion (CRVO), Diabetic Macular Edema (DME)
- Trial name
- NCT02585401
- Testing
- Eylea (Aflibercept, VEGF Trap-Eye, BAY86-5321)
- Where
- Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Bayer
Autoimmune Diseases, Systemic Lupus Erthematosus (SLE)
Allogeneic CD19/BCMA CAR-T for B Cell-Related Autoimmune Disease
This is an exploratory, open-label, single-arm Phase 1 clinical study designed to evaluate the safety, tolerability, and preliminary efficacy of QT-219C.
- Conditions
- Autoimmune Diseases, Systemic Lupus Erthematosus (SLE), Multi-Drug Resistant Nephrotic Syndrome, IgA Nephropathy (IgAN)
- Trial name
- NCT07507201
- Testing
- UCAR T-cell
- Where
- China
- Volunteers
- 15 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Corneal Neovascularization
Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization
OBJECTIVES: I. Demonstrate the safety and efficacy of dihematoporphyrin derivative (DHP) in laser photodynamic therapy (PDT) in patients with corneal neovascularization. II.
- Trial name
- NCT00004430
- Testing
- Dihematoporphyrin derivative, prednisolone, Laser surgery
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Medical College of Hampton Roads
Chronic Heart Failure
Nurse-Led Education for Heart Failure Self-Care and Stability
Heart failure is a chronic condition that can lead to frequent hospitalizations and reduced quality of life. This study aims to evaluate whether a nurse-led, face-to-face educational intervention can improve clinical stability…
- Trial name
- EDUCATE (NCT07280728)
- Testing
- Nurse-Led Face-to-Face Educational Intervention (Teach-Back Method)
- Where
- Italy
- Volunteers
- 118 people
- Sponsor
- Azienda Socio Sanitaria Territoriale di Lodi
Heart Defects, Congenital
Rejuvenated, Washed Packed Red Blood Cells in Pediatric Cardiac Surgery
Blood transfusion is nearly always needed during open heart surgery in children less than 15 kg (35 pounds). The purpose of the red blood cells in the blood is to deliver oxygen to the organs and tissues of the body.
- Trial name
- NCT02485366
- Testing
- Rejuvesol, Cardiac surgery
- Where
- United States
- Sponsor
- Duke University
Aortic Valve Stenosis, Regurgitation, Aortic
Comparison of the Balloon-Expandable Edwards Valve and Self-Expandable CoreValve Evolut R or Evolut PRO System for the Treatment of Small, Severely Dysfunctional Surgical Aortic Bioprotheses. The 'LYTEN' Trial
The treatment with transcatheter aortic valve implantation (TAVI) of patients with small (≤23mm) surgical bioprostheses remains a challenge due to the increased transvalvular residual gradients and high rates of severe…
- Conditions
- Aortic Valve Stenosis, Regurgitation, Aortic, Prosthesis Failure
- Trial name
- NCT03520101
- Testing
- TAVI_ViV procedure with Edwards valve, TAVI_ViV procedure with CoreValve system
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Kawasaki Disease, Coronary Artery Aneurysm
Rivaroxaban for Children Aged Over 2 Years With Giant Coronary Artery Aneurysms After Kawasaki Disease
Based on population pharmacokinetic model-based simulation, a 15 mg-equivalent, age-, and bodyweight-adjusted dosing regimen for Chinese children with giant coronary artery aneurysms after acute Kawasaki disease was proposed.
- Trial name
- RIVA-KG (NCT05643651)
- Testing
- Rivaroxaban Oral Tablet [Xarelto], Aspirin or Clopidogrel, Warfarin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Children's Hospital of Fudan University
Congenital Heart Disease
Assessing Neurodevelopment in Congenital Heart Disease.
Congenital heart disease (CHD) is the most prevalent congenital malformation affecting 1 in 100 newborns per year. Children with CHD are a known risk population for brain injury, with neurodevelopmental alterations shown over…
- Trial name
- NEUROHEART (NCT02996630)
- Testing
- Sonography, Magnetic Resonance Imaging, Bailey Test
- Where
- Spain
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Cardiovascular Diseases, Heart Diseases
Diet, Insulin Resistance, and Cardiovascular Risk
To elucidate dietary factors that elevate risk for cardiovascular disease (CVD) in conjunction with insulin resistance.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Insulin Resistance, Hyperinsulinism
- Trial name
- NCT00005530
- Sponsor
- University of South Carolina
Pulmonary Hypertension
Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients With Pulmonary Arterial Hypertension (PAH)
The study will assess the effect of bosentan on pulmonary vascular resistance and exercise capacity in sickle cell disease (SCD) patients diagnosed with pulmonary arterial hypertension.
- Trial name
- NCT00310830
- Testing
- Bosentan
- Volunteers
- 14 people
- Sponsor
- Actelion
Myocardial Infarction, ST Elevation Myocardial Infarction
Early Discharge Pathway Registry
Despite the year-on-year decrease, coronary artery disease (CAD) still remains one of the leading causes of mortality worldwide.
- Conditions
- Myocardial Infarction, ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction
- Trial name
- NCT06040528
- Where
- 2 sites in United Kingdom
- Volunteers
- 20,000 people
- Sponsor
- Queen Mary University of London
Atherosclerosis, Cardiovascular Diseases
Understanding the Genetic and Hereditary Basis of Atherosclerosis
Atherosclerosis is a condition that occurs when fatty deposits build up along the inner walls of arteries. New strategies are needed to prevent and treat atherosclerosis.
- Trial name
- NCT00344292
- Where
- 4 sites in United States
- Volunteers
- 2,763 people
- Sponsor
- Wake Forest University Health Sciences
Persistent Ductus Arteriosus
Clinical Trial to Evaluate Two Guidelines for the Administration of Ibuprofen in the Treatment of Persistent Ductus Arteriosus Eco-guided: Impact in the Intestinal Prognosis
Persistent ductus arteriosus (DA) is a common entity in the premature newborn and is associated with high morbidity and mortality. There is still controversy about which is the best treatment for its closure.
- Trial name
- IBU24h-EchoG (NCT04282941)
- Testing
- Ibuprofen in continuous (24 hours) iv infusion and EchoG, IV bolus Ibuprofen slow (15 minutes) and EchoG
- Where
- 3 sites in Spain
- Volunteers
- 180 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
eHealth, Coronary Artery Disease
Effectiveness of eHealth on the Self-management of Health Status and QOL Among CAD Patients
This article uses the smart medical case management tracking system, combined with various terminal devices to fully record the measured data (pulse, blood pressure) for case home care tracking to prevent the occurrence and…
- Conditions
- eHealth, Coronary Artery Disease, Quality of Life, Self-management
- Trial name
- NCT04146766
- Testing
- eHealth
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Defense Medical Center, Taiwan
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