Clinical trials: Cardiovascular Condition
Diabetic Foot Ulcer
Orthotic Treatment of Diabetic Foot Ulcers
The United States Department of Veterans Affairs spends an estimated $1.5 billion a year on healthcare for patients with diabetes. The prevalence and complications of diabetes increase with age.
- Trial name
- NCT05094037
- Testing
- Removable cam walker boot, Counseling
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- VA Office of Research and Development
Deep Vein Thrombosis
Limited Compression Ultrasound by Emergency Physicians to Exclude Deep Vein Thrombosis
Deep vein thrombosis is a common condition seen in the Emergency Department. Standard of care for diagnosis of DVT includes a combination of a clinical pre-test probability rule known as Well's criteria, D-dimer blood testing…
- Trial name
- NCT01007045
- Where
- 2 sites in Canada
- Volunteers
- 227 people
- Sponsor
- Queen's University
Hypertension, Pulmonary
Inflammatory Biomarkers of Pediatric Pulmonary Hypertension
To investigate if the inflammatory protein, high mobility group box 1 (HMGB1), along with other inflammatory mediators, is elevated in pediatric patients with congenital heart disease (CHD) and pulmonary hypertension as compared…
- Trial name
- NCT03581695
- Testing
- Blood test
- Where
- Canada
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Deep Vein Thrombosis
D-Dimer Vs Serial Compression Ultrasound Study
To determine whether d-dimer testing can be used to simplify and reduce the costs of the diagnostic approach to patients with clinically suspected deep vein thrombosis
- Trial name
- NCT00182351
- Testing
- D-dimer, Serial Compression Ultrasound
- Where
- 3 sites in Canada
- Volunteers
- 810 people
- Sponsor
- Hamilton Health Sciences Corporation
Hyperparathyroidism, Hypercalcemia
Study of 1.25 mmol/L Calcium Dialysate on Mineral Metabolism in Haemodialysis Patients.
A prospective, randomized, controlled multicenter trial to evaluate 1.25 mmol/L (physiological) vs. 1.5 mmol/L calcium dialysate on serum markers of mineral metabolism, secondary hyperparathyroidism and cardiovascular…
- Trial name
- NCT00744302
- Testing
- physiological (1.25 mmol/L ) calcium dialysate
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Sun Yat-sen University
Carotid Stenosis
Risk Prediction Model for Cerebrovascular Events in Carotid Artery Stenosis
Atherosclerotic carotid artery stenosis is a major cause of stroke, and early identification of high-risk patients combined with surgical intervention can significantly reduce stroke risk.
- Trial name
- NCT06452173
- Testing
- Plasma, carotid high-resolution magnetic resonance imaging
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Tiantan Hospital
Thrombosis
A Study of the Safety and Pharmacokinetics of Apixaban Versus Vitamin K Antagonist (VKA) or Low Molecular Weight Heparin (LMWH) in Pediatric Subjects With Congenital or Acquired Heart Disease Requiring Anticoagulation
To investigate the safety and pharmacokinetics of apixaban in children with congenital or acquired heart disease who have a need for anticoagulation.
- Trial name
- NCT02981472
- Testing
- Apixaban, Vitamin K Antagonist (VKA), Low Molecular Weight Heparin (LMWH)
- Where
- 46 sites in United States, Argentina and 12 more
- Volunteers
- 192 people
- Sponsor
- Bristol-Myers Squibb
Intracranial Aneurysm, Pipeline Embolization Device
Post Market Multi-Center Retrospective Research on Embolization of Intracranial Aneurysms With Pipeline Embolization Device in China
Pipeline TM embolization device launched to China in 2014, and has been widely used to treat large width IA. Therefore, it is necessary to collect and analysis the clinical data to evaluate effectiveness and safety of its usage…
- Trial name
- PLUS (NCT03831672)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Neurosurgical Institute
Hypoxic-Ischemic Encephalopathy, Asphyxia Perinatal
Identification of a Pool of miRNA to Improve Early Management of Perinatal Asphyxia and Hypoxic Ischemic Encephalopathy
Hypoxic-ischemic encephalopathy is the most common cause of neurological damage in the neonatal period. It has an incidence of about 1.5-2.5% of livebirths in developed countries.
- Trial name
- NCT05986994
- Testing
- Metabolic acidosis, microRNA, Hypothermia
- Where
- 2 sites in Italy
- Volunteers
- 45 people
- Sponsor
- Ospedale Buon Consiglio Fatebenefratelli
Intra-operative Hypotension, Carotid Stenosis
Effect of Blood Pressure on rSO2 in Carotid Endarterectomy (CEA)
Carotid endarterectomy (CEA) is the recommended treatment for symptomatic high degree stenosis of the internal carotid artery (ICA).
- Trial name
- NCT01451294
- Testing
- Administration of phenylephrine, Administration of ephedrine
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- G.J. de Borst
Hereditary Angioedema
A Study of Icatibant (TAK-667) in Japanese Children and Teenagers With Acute Attacks of Hereditary Angioedema
The main aim of the study is to check for side effects from icatibant in children and teenagers with hereditary angioedema (HAE).
- Trial name
- NCT04654351
- Testing
- TAK-667
- Where
- 3 sites in Japan
- Volunteers
- 2 people
- Sponsor
- Takeda
Hypoplastic Left Heart Syndrome (HLHS)
National Collaborative to Improve Care of Children With Complex Congenital Heart Disease
The purpose of this initiative is to improve care and outcomes for infants with HLHS by expanding the NPC-QIC national registry to gather clinical care process, outcome, and developmental data on infants with HLHS between…
- Trial name
- NPC-QIC (NCT02852031)
- Testing
- Collaborative Learning Network
- Where
- 63 sites in United States, Canada and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Heart Failure
Effects of Losartan on Insulin Resistance in Patients With Heart Failure
The purpose of this study is to evaluate the effects of losartan, an ARB, on glucose metabolism and inflammatory cytokines in CHF patients treated with ACE inhibitors.
- Trial name
- NCT00663377
- Testing
- losartan
- Volunteers
- 16 people
- Sponsor
- Tottori University Hospital
Abdominal Aortic Aneurysm, Surgery
Aneurysm Diameter and Surgical Outcome
Aneurysm diameter is an important risk for rupture and related death in affected patients. This study will evaluate whether aneurysms size may even influence post procedural outcomes both in open surgical repair and in…
- Conditions
- Abdominal Aortic Aneurysm, Surgery, Outcome, Fatal
- Trial name
- ADASO (NCT04422054)
- Testing
- Open Surgery, Endovascular Surgery
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Catanzaro
Pre-Eclampsia, Intrauterine Growth Restriction
PEPPI Study: Identification of Women at Risk for Placental Dysfunction
The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a…
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Polycystic Ovary Syndrome, Iron-deficiency
- Trial name
- NCT06115122
- Testing
- Pre-eclampsia screening program
- Where
- Finland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Congenital Heart Disease (CHD), Hypoxic Encephalopathy
Early Detection of Brain Injury After Congenital Heart Surgery in Infants
Infants with congenital heart disease undergoing cardiac surgery with extracorporeal circulation are at risk for perioperative hypoxic-ischaemic brain injury.
- Trial name
- NCT07424976
- Testing
- Observational study: blood analisys, EEG, MRI
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Congenital Heart Disease, Open Heart Surgery
Localized Evidence of Cytokine Adsorption Therapy During Pediatric Cardiac Surgery: A Single Center Randomized Controlled Trial (LEAT)
The Localized Evidence of Cytokine Adsorption Therapy (LEAT) study is a prospective, randomized controlled trial conducted at the Institut Jantung Negara in Malaysia.
- Conditions
- Congenital Heart Disease, Open Heart Surgery, Cardiopulmonary Bypass, Endocarditis Acute and Subacute
- Trial name
- LEAT (NCT07771491)
- Testing
- Hemoadsorption (Jafron HA-60/HA380)
- Volunteers
- 120 people
- Sponsor
- Norfaniza Zabidi
Cardiovascular Disease, Aortic Valve Stenosis
Evaluating the Risk of Cognitive Impairment After Surgical and Transcatheter Aortic Valve Replacement
The investigators are conducting a pilot study to compare cognitive outcomes among Veterans with severe aortic valve stenosis who are scheduled to undergo either aortic valve replacement.
- Conditions
- Cardiovascular Disease, Aortic Valve Stenosis, Cognitive Assessments, Valve Surgery
- Trial name
- CAVIAR (NCT02971020)
- Testing
- Observational/Cognitive Assessment
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Minnesota Veterans Medical Research and Education Foundation
Respiratory Distress Syndrome
Phase III Randomized, Double-Blind, Placebo-Controlled Study of Antenatal Thyrotropin-Releasing Hormone in Pregnant Women With Threatened Premature Delivery
OBJECTIVES: I. Evaluate the effect of thyrotropin-releasing hormone (TRH) on the severity of initial lung disease and occurrence of chronic lung disease when given antenatally to women with threatened premature delivery. II.
- Trial name
- NCT00004778
- Testing
- betamethasone, dexamethasone, thyrotropin-releasing hormone
- Volunteers
- 1,090 people
- Sponsor
- National Center for Research Resources (NCRR)
Cerebral Palsy, Developmental Delay
SmarToyGym: Smart Detection of Atypical Toy-oriented Actions in At-risk Infants
The study aims to develop a SmarToyGym where sensitized, wireless toys are strategically hung and placed within reach of infants to elicit toy-oriented body and arm/hand movements.
- Conditions
- Cerebral Palsy, Developmental Delay, Stroke, Fine Motor Delay
- Trial name
- NCT02813889
- Testing
- SmarToyGym
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
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