Clinical trials: Cardiovascular Condition
Arrhythmia
Population Pharmacokinetics of Propafenone and Propranolol in Children Patients
The use of propafenone and propranolol in children during clinical treatment was depending mostly on experience. Besides, there was no recommended dose for children in drug instruction.
- Trial name
- NCT05463614
- Testing
- Propafenone and Propranolol
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shandong University
Diabetes Mellitus, Type 2, Coronary Disease
A Study Comparing Standard Care for Diabetes to Case-managed Care for Diabetes in Patients With Coronary Artery Disease
The purpose of this study is to compare two ways to treat patients with Type 2 Diabetes, Standard Care or Case-Managed Care. In-Patient Standard Care is guided by the assigned cardiologist and Out-Patient Standard Care by the…
- Trial name
- NCT00248352
- Testing
- Consultation with Endocrinologist, Counseling from Dietician, Counseling from Diabetes Educator
- Where
- Canada
- Volunteers
- 169 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Chronic Myeloid Leukemia, Acute Myelogenous Leukemia
Phase II Study Evaluating Busulfan and Fludarabine as Preparative Therapy in Adults With Hematopoietic Disorders Undergoing MUD SCT
The primary objective of this study is to assess the safety and efficacy of performing unrelated stem cell transplants using intravenous busulfan and fludarabine as preparative therapy and tacrolimus plus methotrexate as the GVHD…
- Conditions
- Chronic Myeloid Leukemia, Acute Myelogenous Leukemia, Myelodysplasia, Acute Lymphocytic Leukemia
- Trial name
- NCT00516152
- Testing
- Busulfan/Fludarabine phosphate/Tacrolimus/Methotrexate/G-CSF
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of California, San Francisco
High Blood Pressure
Home BP Monitoring
Most cases of high blood pressure in teens are missed for a number of reasons. One reason is that the most common way to make a diagnosis is to make three or more blood pressure measurements in a doctor's office on separate days.
- Trial name
- NCT05552547
- Testing
- Home Blood Pressure Machine, 24-Hour Blood Pressure Machine
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Cancer, Respiratory Failure
Multi-Disciplinary Treatment on the Anthropomorphism of Large Language Models
This retrospective clinical trial aims to better explore the potential of large language models in medicine by comparing the effectiveness of MDT consultations conducted by human doctors with those conducted by large language…
- Conditions
- Cancer, Respiratory Failure, Heart Diseases, Infections
- Trial name
- MDTALLM (NCT06627985)
- Testing
- GPT-4o, GPT-4o mini, MedicalGPT
- Where
- China
- Volunteers
- 300 people
- Sponsor
- North Sichuan Medical College
Heart Disease Congenital
The Swiss Registry for Heart Diseases in Children Living in Switzerland. SPHC
The Swiss Pediatric Heart Cohort aims to collect representative longitudinal data on all children diagnosed with a clinically relevant heart disease in Switzerland.
- Trial name
- SPHC (NCT04442685)
- Where
- Switzerland
- Volunteers
- 590 people
- Sponsor
- University Children's Hospital, Zurich
Atherosclerosis, Cardiovascular Diseases
Seasonal Variation of Blood Cholesterol Levels
To describe and delineate in a prospective study the nature and causes of seasonal variation of blood lipid levels in the general population.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00005385
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypoxic-Ischemic Encephalopathy
ANS Function in HIE Infants Treated With Therapeutic Hypothermia
After birth, babies that have suffered from oxygen deprivation may develop hypoxic-ischemic encephalopathy (HIE). Moderate or severe HIE has been associated with death or disability.
- Trial name
- NCT06730490
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Refractory Epilepsy, Arrhythmia
Cardiac Rhythm Abnormalities in Patients With Refractory Epilepsy at High Risk for Sudden Death
People with epilepsy are at a higher risk for sudden unexpected death than the general population. Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in this population, accounting for 10-50% of deaths for…
- Conditions
- Refractory Epilepsy, Arrhythmia, Sudden Death
- Trial name
- NCT00203333
- Testing
- Medtronic REVEAL
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Thomas Jefferson University
Thrombosis
Heparin and the Reduction of Thrombosis (HART) Trial
Heparin is frequently used in central venous catheters (CVCs) in post-operative cardiac patients. It remains unclear if a heparin infusion, compared to a normal saline infusion, prevents thrombosis of CVCs after surgery.
- Trial name
- NCT00779558
- Testing
- Heparin sulfate infusion at 10 units/kg/hour
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Stanford University
Ischemic Stroke
Speech and Language Therapy After Stroke
Our overall goal is to advance the state of functional brain imaging in aphasia, and then to apply the method to an intensive, imitation-based treatment for non-fluent aphasia.
- Trial name
- NCT00713050
- Testing
- Imitate Therapy
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of Chicago
Rare Diseases, Marfan Syndrome
Marfan Syndrome (MFS) and Facial Dysmorphism: Non-invasive 3D Assessment
The goal of this study observational prospective study is to define the facial morphological features associated with Marfan syndrome (MFS). The main qustion it aims to answer are: 1.
- Trial name
- FACE (NCT05702476)
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- IRCCS Policlinico S. Donato
Cardiovascular Diseases, Heart Diseases
Physical Fitness and Cardiovascular Mortality in Firefighters
To study prospectively the interrelationships among physical fitness, activity, other measured risk factors, coronary heart disease (CHD) and all-cause mortality in a cohort of 3,403 firefighters.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Hypertension
- Trial name
- NCT00005540
- Volunteers
- 3,403 people
- Sponsor
- University of Southern California
Macular Holes, Epiretinal Membrane
Intraoperative OCT Guidance of Intraocular Surgery II
The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes.
- Conditions
- Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment
- Trial name
- MIOCT (NCT03713268)
- Testing
- Microscope integrated optical coherence tomography
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Duke University
Atherosclerosis, Chlamydia Infections
Effects of Hormone Therapy on the Immune Systems of Postmenopausal Women With Chronic Infections
Hardening of the arteries (atherosclerosis) and heart disease are much more common in men than in women. However, as women grow older, especially after menopause the incidence of atherosclerosis and heart disease increases.
- Conditions
- Atherosclerosis, Chlamydia Infections, Cytomegalovirus Infections, Pneumonia, Bacterial
- Trial name
- NCT00001890
- Testing
- Estrogen therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Surgical Procedure, Non-cardiac, Cardiovascular Disease Patients
Perioperative Ischemia Versus Perioperative Bleeding During Non-cardiac Surgery in Cardiac Patients
The aim of the study is to analyze the present use of antithrombotic therapy on a large cohort of consecutive cardiacs undergoing non-cardiac surgery.
- Conditions
- Surgical Procedure, Non-cardiac, Cardiovascular Disease Patients, Perioperative Period
- Trial name
- PRAGUE-14 (NCT01897220)
- Where
- 2 sites in Czechia
- Volunteers
- 1,200 people
- Sponsor
- Charles University, Czech Republic
Complication Due to Immunization
Cardio-respiratory Events and Inflammatory Response After Primary Immunization in Preterm Infants
Background: Inflammation may depress respiration in neonates. The aim of this study was to establish a link between post-immunization inflammation and cardio-respiratory events (CRE).
- Trial name
- NCT02726178
- Testing
- Advil® Pediatric drops for infants
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Mitral Stenosis
Assessment of Right Ventricular Function in Patients With Severe Mitral Stenosis Before and After Balloon Mitral Valvuloplasty
To detect short-term impacts of successful balloon mitral valvuloplasty on right ventricular function
- Trial name
- NCT06067815
- Volunteers
- 30 people
- Sponsor
- Assiut University
Strabismus, Bradycardia
Strabismus Recovery With Proparacaine and Oculocardiac Reflex
Observational study to determine if topical anesthetic and intraoperative oculocardiac reflex influence post strabismus surgery recovery.
- Conditions
- Strabismus, Bradycardia, Nausea, Pain
- Trial name
- OCRprop (NCT03672435)
- Testing
- Topical Solution
- Volunteers
- 140 people
- Sponsor
- Alaska Blind Child Discovery
Hypoxemia, Ventilator Lung
Driving Pressure-guided Lung Protective Ventilation
The study, named as "The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial", aims to investigate whether driving…
- Trial name
- DPV (NCT06361420)
- Testing
- Driving pressure-guided positive end expiratory pressure, Optimal oxygenation-guided positive end expiratory pressure, Ventilation strategy
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Yong Lin, PhD
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