Clinical trials: Cardiovascular Disorder
Infant, Premature, Hypoperfusion in Newborn
Monitoring of Systemic or Organ Perfusion for Preterm Infants
To investigate biomarker reflects systemic or specific organ perfusion well, we are going to the observational comparison study using several hemodynamic monitoring methods in the premature infants.
- Conditions
- Infant, Premature, Hypoperfusion in Newborn, Necrotizing Enterocolitis of Newborn, Sepsis Newborn
- Trial name
- NCT03136172
- Testing
- NIRS (near Infra-red spectroscopy)
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Inha University Hospital
Stroke
Women's Estrogen for Stroke Trial (WEST)
To determine if estrogen hormone replacement therapy reduces the risk of stroke or death in postmenopausal women who have already had stroke or a transient ischemic attack (TIA).
- Trial name
- NCT00026039
- Testing
- estrogen
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Acute Myeloid Leukemia, Multiple Myeloma
Study of CAR T-cell Therapy in Acute Myeloid Leukemia and Multiple Myeloma
The purpose of this first-in-man Phase I-IIa study is to evaluate the safety and antitumor activity of autologous CD44v6 CAR T-cells in patients with acute myeloid leukemia (AML) and multiple myeloma (MM).
- Trial name
- NCT04097301
- Testing
- MLM-CAR44.1 T-cells at day 0 Single intravenous infusion
- Where
- 3 sites in Czechia, Italy
- Volunteers
- 8 people
- Sponsor
- AGC Biologics S.p.A.
Hereditary Angioedema
C1 Esterase Inhibitor in Hereditary Angioedema (HAE)(Extension Study)
Hereditary angioedema (HAE) is a rare disorder characterized by congenital lack of functional C1 esterase inhibitor. If not treated adequately, the acute attacks of HAE can be life-threatening and may even result in fatalities…
- Trial name
- NCT00292981
- Testing
- C1 Esterase Inhibitor
- Where
- 14 sites in United States, Canada
- Volunteers
- 57 people
- Sponsor
- CSL Behring
Short Stature
Vosoritide for Selected Genetic Causes of Short Stature
Short stature can be caused by a number of genetic etiologies, many of which directly affect the growth plate. The FGFR3/CNP pathway is central to growth of the chondrocyte.
- Trial name
- NCT04219007
- Testing
- Vosoritide
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Andrew Dauber
Congenital Heart Defects, Neurodevelopmental Disorder
Characterization and Support for Neurodevelopmental Disorders Associated With Congenital Heart Defects
The leading cause of birth defects, Congenital Heart Defects (CHD) affect 12 million people worldwide and 41,000 newborns/year in Europe. It's a major cause of life-long morbidity and mortality, and a crucial public health issue.
- Trial name
- CATAMARAN Ped (NCT06442592)
- Testing
- Blood sampling, Assessment of neurodevelopment (CA), Assessment of neurodevelopment (Nantes)
- Where
- 5 sites in France
- Volunteers
- 1,206 people
- Sponsor
- Nantes University Hospital
Multiple Myeloma
Transcriptomics and Epigenetics Analysis in Drug-Resistance of Multiple Myeloma
Multiple Myeloma (MM) is the more common hematological neoplastic disease second only to Hodgkin lymphoma. In MM patients, mutated genes are mainly KRAS (23%), NRAS (20%), FAM46C (11%), DIS3 (11%) e TP53 (8%).
- Trial name
- TEDROMM (NCT05888636)
- Testing
- ChIP-seq, NGS, ATAC-seq
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Regina Elena Cancer Institute
Atherosclerosis, Cardiovascular Diseases
Non-Traditional Cardiovascular Risk Factors in Type 2 Diabetes Mellitus - Ancillary to VA Study of Glycemic Control
To test whether novel cardiovascular risk factors are related to the presence and development of atherosclerosis and macrovascular events in Type 2 diabetes mellitus and to determine whether intensive glucose lowering therapy…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Diabetes Mellitus, Non-insulin Dependent
- Trial name
- NCT00021944
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Bradycardia; Syncope, Bradyarrhythmia
Temporary Transvenous Pacemaker Placement by Intracavitary Electrocardiogram Monitoring
Traditional temporary pacing catheter insertion by intracavitary electrocardiogram (IC-ECG) monitoring which only monitoring tip polar, the negative one.
- Conditions
- Bradycardia; Syncope, Bradyarrhythmia, Brady-tachy Syndrome, Tachycardia Bradycardia
- Trial name
- NCT04905199
- Testing
- Temporary transvenous cardiac pacing
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hunan Provincial People's Hospital
Sudden Cardiac Death
CIQTP Prolongation : Role and Mechanism in Sudden Cardiac Death
Despite major progress in molecular and phenotypic characterization of primary electrical disorders, many (aborted) sudden cardiac deaths (SCD) occur in young victims without identifiable abnormalities.
- Trial name
- IQARE-SCD (NCT03387072)
- Testing
- Non interventional study
- Where
- 4 sites in France
- Volunteers
- 394 people
- Sponsor
- Nantes University Hospital
Preterm Birth, Coagulation Protein Disorders
Stratifying Risk for Intracerebral Haemorrhage
This study aims to investigates the role of gestational age on the prevalence of coagulation factors and components of the complement system in preterm- (≤32+0 weeks) and term neonates (≥37+0 weeks) and their role for the…
- Conditions
- Preterm Birth, Coagulation Protein Disorders, Coagulation Disorder Neonatal
- Trial name
- NEW_STRATEGI (NCT04140812)
- Testing
- mass spectrometry (LC-MS/MS)
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hypertension
Dose Ranging, Safety and Tolerability of TOPROL-XL® Extended-Release Tablets in Hypertensive Pediatric Subjects
This was a 4-week, multicenter, double-blind, placebo-controlled, randomized, parallel-group study to determine the antihypertensive dose range, efficacy, safety and tolerability of TOPROL-XL ® (metoprolol succinate)…
- Trial name
- 307A (NCT00255528)
- Testing
- metoprolol succinate
- Where
- 31 sites in United States, Dominican Republic
- Volunteers
- 144 people
- Sponsor
- AstraZeneca
Sickle Cell Anemia, Sickle Cell Disease
Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose
The CADRE study is a multinational observational cohort of patients with sickle-cell disease (SCD) in five west and central sub-Saharan African countries.
- Trial name
- CADRE (NCT03114137)
- Where
- 13 sites in Cameroon, Côte d’Ivoire and 4 more
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Cardiologie et Développement
Antiplatelet Therapy, Hemorrhagic Infarction
Early Antiplatelet Therapy After Hemorrhagic Infarction in Acute Ischemic Stroke Treated With Intravenous Thrombolysis (HITs)
Previous study showed that the proportions of hemorrhagic Infarction after intravenous thrombolysis were 24.2% and 32.5% in the control group and the alteplase group, and most of them were asymptomatic.
- Trial name
- NCT04624295
- Testing
- Early aspirin Therapy, Non-Early aspirin Therapy
- Where
- China
- Volunteers
- 294 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ischemic Stroke
Predictive Role of KLK10 and Other Neuroinflammatory Molecules on Clinical Outcomes of AIS
This study aims to investigate the dynamic changes and differential expression characteristics of neuroinflammatory molecules such as kallikrein-related peptidase 10 (KLK10), soluble triggering receptor expressed on myeloid cells…
- Trial name
- NCT06549972
- Testing
- Acute Ischemic Stroke
- Where
- China
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Hypoxic-Ischemic Encephalopathy, Asphyxia
Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns
This is a prospective, randomized, double-blind, placebo controlled, single center study to compare low dose hydrocortisone vs placebo in systemic low blood pressure during hypothermia treatment in asphyxiated newborns.
- Trial name
- CORTISoL (NCT02700828)
- Testing
- Hydrocortisone
- Where
- Hungary
- Volunteers
- 32 people
- Sponsor
- Semmelweis University
Low Cardiac Output Syndrome
Prophylactic Use of Levosimendan Versus Milrinone in Open Heart Surgery in Infants
Pediatric patients, especially infants undergoing open heart surgery have a predictable fall in cardiac index 6 to 18 hours after surgery, the so-called low cardiac output syndrome (LCOS).
- Trial name
- Levomil (NCT00549107)
- Testing
- Levosimendan, Milrinone
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Ludwig Boltzmann Gesellschaft
Heart Failure
Beta-Blockers in Heart Failure: Pharmacy-level Intervention Comparison
The overall objective of the proposed pilot study is to begin evaluation of two methods for promoting adherence to guidelines for beta-blocker therapy in heart failure.
- Trial name
- NCT01002456
- Testing
- Level 1: (provide site-specifi information), Level 2 (Provide site- and patient-specific information)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- US Department of Veterans Affairs
Coronary Artery Disease
Essen Coronary Artery Disease Registry
The ECAD registry is a registry of patients undergoing coronary angiography at the West German Heart and Vascular Center. The registry anticipates to determine predictors of patient outcome after coronary angiography.
- Trial name
- ECAD registry (NCT04196712)
- Where
- Germany
- Volunteers
- 55,000 people
- Sponsor
- University Hospital, Essen
Brain Tumor, Vascular Lesion
Factor XIII and Pulmonary Embolism in Neurosurgical Patients
Two studies (Gerlach et al. 2000; Gerlach et al. 2002) described the impact of factor XIII on the risk of prospective hemorrhage for patients undergoing craniotomy.
- Conditions
- Brain Tumor, Vascular Lesion, Factor XIII Deficiency, Pulmonary Embolism
- Trial name
- NCT01106937
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Ludwig-Maximilians - University of Munich
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