Clinical trials: Cardiovascular Function
Vascular Disease
Assessment of Short-term Effect of L-Citrulline on Endothelial Function and Vasodilation in Known CAD Patients
The purpose of this study is to determine the efficacy of oral L-Citrulline on endothelial function and vasodilation in patients with coronary artery disease(CAD) by evaluating the brachial artery diameter in the antecubital area…
- Trial name
- NCT02638727
- Testing
- L-Citrulline
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Congenital Heart Disease, Sedated for Cardiac Catheterization
Does Ketamine Attenuate Depression of Respiratory and Cardiac Functions
Normal cardiac and respiratory functions should be maintained during pediatric cardiac catheterization. Propofol has become a popular choice for sedation in children, however, it depresses cardiac and respiratory functions.
- Trial name
- NCT01501786
- Testing
- control, Ket10, Ket20
- Where
- Japan
- Volunteers
- 150 people
- Sponsor
- Ibaraki Children's Hospital
Dilated Cardiomyopathy
Simvastatin Therapy in Patients With Dilated Cardiomyopathy.
Dilated cardiomyopathy (DCM) is the most common childhood cardiomyopathy and is associated with significant early morbidity and mortality. About half of patients die or require heart transplantation within 5 years of diagnosis.
- Trial name
- SavDCM (NCT03775070)
- Testing
- Simvastatin
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- National Taiwan University Hospital
Heart Failure Congestive
Effect of omega3 on Congestive Heart Failure
In this double blinded study patients with resynchronization pacemaker- AICD were assigned to Omega3 and placebo randomly, results indicated that Omega3 had no more effect than placebo in mortality, BNP level and 6 minutes walk…
- Trial name
- NCT01227837
- Testing
- omga3
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Shiraz University of Medical Sciences
Fabry Disease
Registry of Fabry Disease - A Multicenter Observational Study
The purpose of this study is to compile a registry of patients with Fabry disease, an inherited metabolic disorder. In this disease, an enzyme called a-galactosidase A, which normally breaks down a lipid (fatty substance) called…
- Trial name
- NCT00055016
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cystic Fibrosis
Study of Ibuprofen to Preserve Lung Function in Patients With Cystic Fibrosis
OBJECTIVES: I. Determine the effect of different doses of ibuprofen on neutrophil (polymorphonuclear leukocyte; PMN) delivery to a mucosal surface (the oral mucosa) in patients with cystic fibrosis and healthy controls. II.
- Trial name
- NCT00004440
- Testing
- ibuprofen
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- FDA Office of Orphan Products Development
Tricuspid Atresia, Hypoplastic Left Heart Syndrome
Biomarker Study for Heart Failure in Children With Single Ventricle Physiology
The purpose of this study is to determine if children with heart disease where there is only one pumping chamber("ventricle") have proteins (biomarkers") in the blood that can be used to monitor the function of their heart.
- Conditions
- Tricuspid Atresia, Hypoplastic Left Heart Syndrome, Unbalanced AV Canal
- Trial name
- BHFSVP (NCT00571233)
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of California, San Francisco
Stroke
Mirror Therapy: Effects on Functional Recuperation of Severe Upper Limb Paresis After Stroke
After stroke, patients frequently suffer from arm or hand weakness. There are numerous rehabilitation methods to stimulate recovery, amongst which mirror therapy (MT).
- Trial name
- MT (NCT02949609)
- Testing
- Mirror Therapy, Control Therapy
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- University Hospital, Geneva
Congenital Heart Disease, Heart; Surgery, Heart, Functional Disturbance as Result
Just TRAC It! Transitioning Responsibly to Adult Care Using Smart Phone Technology
The Just TRAC It! study (Transitioning Responsibly to Adult Care using smart phone technology) is a randomized controlled trial designed to evaluate the impact of using smart phone technology in combination with the nurse led…
- Trial name
- NCT03429335
- Testing
- Teaching session, Just TRAC It!, MyHealth Passport
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- University of Alberta
Congenital Heart Disease, Telerehabilitation
The Effect of Telerehabilitation Exercises in Children With Congenital Heart Disease
This study aims to investigate the effects of functional inspiratory muscle training on physical performance and quality of life in pediatric patients with congenital heart disease.
- Conditions
- Congenital Heart Disease, Telerehabilitation, Functional Inspiratory Muscle Training
- Trial name
- CHD (NCT07854171)
- Testing
- Inspiratory Muscle Training, Functional Inspiratory Muscle Training
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Izmir Democracy University
Cardiovascular Diseases, Coronary Arterial Disease (CAD)
Virtual Reality-Supported Cardiac Rehabilitation: Psychological, Functional, and Physiological Perspectives
The study aims to evaluate the effectiveness of virtual reality-assisted cardiac rehabilitation compared to conventional cardiac rehabilitation in improving psychological outcomes-depression, stress, anxiety, and…
- Conditions
- Cardiovascular Diseases, Coronary Arterial Disease (CAD), Myocardial Disease, Heart Disease
- Trial name
- NCT06896318
- Testing
- Virtual Reality Therapy, Cardiac rehabilitation
- Where
- 2 sites in Poland
- Volunteers
- 60 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Stroke, Acute
Health Disparities in Stroke Patients and Their Families: a Longitudinal Multicenter Study (HDSS)
The meeting point of the patient and his/her immediate family with the health care system is complicated and traumatic. While having to deal with medicalization geared towards providing evidence-based and cost-effective medical…
- Trial name
- HDSS (NCT03330652)
- Where
- 4 sites in Israel
- Volunteers
- 600 people
- Sponsor
- Sheba Medical Center
Neonatal Seizure, Hypoxic-Ischemic Encephalopathy
Neonatal Seizure Registry - Developmental Functional EValuation
The NSR-DEV study is a longitudinal cohort study of around 280 Neonatal Seizure Registry participants that aims to evaluate childhood outcomes after acute symptomatic neonatal seizures, as well as examine risk factors for…
- Conditions
- Neonatal Seizure, Hypoxic-Ischemic Encephalopathy, Stroke, Intracranial Hemorrhages
- Trial name
- NSR-DEV (NCT04337697)
- Where
- 9 sites in United States
- Volunteers
- 188 people
- Sponsor
- University of California, San Francisco
Congenital Heart Disease, ICU Acquired Weakness
Muscle Catabolism and Outcomes in Children Following Cardiac Surgery
Background \& Significance. Children with congenital heart disease (CHD) have experienced improved postoperative survival shifting the focus away from minimizing mortality to curtailing morbidities.
- Conditions
- Congenital Heart Disease, ICU Acquired Weakness, Catabolic State
- Trial name
- MOCHI (NCT04998643)
- Testing
- Muscle ultrasound to estimate lean body mass
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Boston Children's Hospital
Walking, Cognitive Function
Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral Ischemia
The investigator(neurologist) has published a study in International Congress Series, in the 15th International Conference of Biomagnetism Vancouver Proceedings 2006,and Science Direct website, of 15 patients with brain ischemia…
- Trial name
- NCT00494689
- Where
- 2 sites in Singapore
- Volunteers
- 30 people
- Sponsor
- Devathasan Neurology Practice Pte Ltd
Cardiometabolic Health, Cognitive Function
The Effect of Oily Fish and Poultry on Children's Cardiometabolic Health and Cognitive Function
The purpose of FiSK Junior is to investigate whether intake of oily fish compared to poultry affects cardiovascular risk markers, cognitive function, and behaviour in healthy children.
- Trial name
- FiSK Junior (NCT02809508)
- Testing
- Oily fish, Poultry
- Where
- Denmark
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Varicose Veins of Lower Limb, Varicose Veins and Edema of Leg
Effects of Kinesio Taping Method on Functional Capacity and Quality of Life in Patients With Chronic Venous Disease
The purpose of this randomised and controlled study is to investigate the effects of Kinesio Taping method and compression stockings, combined with exercise therapy, on pain, edema, functional capacity and quality of life in…
- Conditions
- Varicose Veins of Lower Limb, Varicose Veins and Edema of Leg, Chronic Venous Hypertension Peripheral, Spider Veins
- Trial name
- NCT04148950
- Testing
- Kinesio Tape, Compression Stockings, Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Istanbul University
Central Nervous System Disease, Cerebrovascular Accident
Brain Processing of Language Meanings
This research trial will study discourse processing-that is, how the brain processes the meaning of language. It will examine, for example, how words and sentences are interpreted in cases where more than one meaning is possible.
- Conditions
- Central Nervous System Disease, Cerebrovascular Accident, Craniocerebral Trauma, Head Injury
- Trial name
- NCT00005004
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Congestive Heart Failure
Safety and Efficacy Study of Carvedilol to Treat Children With Congestive Heart Failure
The purpose of this study is to determine whether a new medicine, called carvedilol, improves symptoms and heart function in children who have congestive heart failure (diminished function of their heart muscle that pumps blood…
- Trial name
- NCT00052026
- Testing
- carvedilol
- Where
- 21 sites in United States
- Volunteers
- 161 people
- Sponsor
- Shaddy, Robert, M.D.
Fabry Disease
A Study of Migalastat in Fabry Disease
Fabry disease is a rare metabolic condition characterised by the widespread deposition of sphingolipids in multiple organ systems.
- Trial name
- GALAFAB (NCT03949920)
- Testing
- Migalastat
- Where
- 2 sites in United Kingdom
- Volunteers
- 21 people
- Sponsor
- Manchester University NHS Foundation Trust