Clinical trials: Cavitated Caries
Proximal Caries
Effect of Self-Assembling Peptides on the Progression of Non-Cavitated Proximal Caries
The aim of this randomized controlled, double-blinded, split-mouth clinical trial was to evaluate the efficacy of self-assembling peptide P11-4 solution (Curodont™ Repair) with fluoride varnish on the progression of non-cavitated…
- Trial name
- NCT04776785
- Testing
- Curodont™ Repair, MI Varnish™, Profluorid® Varnish
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Dental Caries, Early Caries Lesion
Effect of Ozone Therapy on Remineralization of Initial Caries Lesions in Children
Initial caries lesions can be managed using non-invasive treatment approaches that promote remineralization and prevent lesion progression.
- Trial name
- OZONE-CARIES (NCT07671651)
- Testing
- Ozone Therapy, other
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Neslihan Atmaca
Prevention
MI and PreviDent Varnish on Non Cavitated Interproximal Lesions.
Fluoride products are proven to be cost effective in preventing dental caries. Newer Fluoride products have been released in the market with different components that may have an impact on the clinical and radiographic outcome…
- Trial name
- NCT03925740
- Testing
- MI Varnish, PreviDent Varnish, 1.23% APF
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- King Abdulaziz University
Fissure Sealants, Oral Hygiene Orientation
Efficacy of Sealants in Cavitated Enamel Lesions on Occlusal Surfaces in Children
The aim of this study is to evaluate the efficacy of oral hygiene orientation singly, compared to resin-based sealants in controlling occlusal cavitated enamel lesions on primary and permanent molars.
- Trial name
- SLM1661 (NCT02617940)
- Testing
- fissure sealant, oral hygiene orientation
- Where
- Brazil
- Volunteers
- 546 people
- Sponsor
- Faculty Sao Leopoldo Mandic Campinas
Dental Caries, Dental White Spot
Effect of Light Curable Resin Modified Glass Ionomer Varnish on Non-Cavitated Proximal Carious Lesions' Progression
The standard-of-care preventive measures to stop early tooth decay from becoming worse is by fluoride application, diet counseling, and oral hygiene instructions. This standard way is not always successful.
- Trial name
- NCT03685058
- Testing
- Light curable resin modified glass ionomer varnish, standard-of-care preventive measures
- Where
- Saudi Arabia
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Early Childhood Caries
A Clinical Trial of Silver Diamine Fluoride to Arrest Early Childhood Caries in Young Children
Silver diamine fluoride (SDF) is an antibiotic liquid that has the potential to arrest Early Childhood Caries in young children and delay treatment until children can be seen in outpatient settings.
- Trial name
- NCT04054635
- Testing
- Silver diamine fluoride
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- University of Manitoba
Dental Caries, Tooth Demineralization
"Comparison of the Effects of Resin Infiltrant, Fluoride Varnish, and the Combined Application of Resin Infiltrant and Fluoride Varnish on Primary Molars in the Treatment of Proximal Non-Cavitated Carious Lesions in Children."
Purpose: This randomized controlled clinical trial aimed to compare the effectiveness of fluoride varnish, resin infiltrant, and their combination in treating superficial proximal carious lesions in primary molars of children…
- Conditions
- Dental Caries, Tooth Demineralization, Pediatric Dentistry, Molar, Deciduous
- Trial name
- NCT07112963
- Testing
- Fluoride Varnish
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Sacide Duman
Fissure Sealant
Retention Rate and Caries Preventive Effect of Self Etch Giomer Based Fissure Sealant
With limited evidence-based information in literature about using giomer based pit and fissure sealant(BeautiSealant) in non-cavitated pits and fissures in permanent molars, it is beneficial to evaluate the newly introduced…
- Trial name
- NCT05336162
- Testing
- Self etch giomer based fissure sealant (BeautiSealant, Shoufu, USA)
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries, Non-cavitated Occlusal Caries
Detection of Non-cavitated Occlusal Caries Lesions by Visual Inspection, LF, QLF and NILT
This study aims to evaluate and compare the diagnostic accuracy of visual examination using ICDAS-II and three adjunctive optical methods-laser fluorescence (LF), near-infrared light transillumination (NILT), and quantitative…
- Trial name
- NCT07532291
- Testing
- Diagnostic assessment of occlusal caries
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Neslihan Atmaca
Dental Caries, White Spot Lesions
QLF and Digital Imaging for Caries Activity Assessment After Orthodontic Treatment
This prospective longitudinal observational study aims to evaluate the diagnostic performance and agreement of Smartphone photography, intraoral 3D imaging, Quantitative Light-Induced Fluorescence Digital (QLF-D), and ICDAS…
- Conditions
- Dental Caries, White Spot Lesions, Caries Lesion Activity, Post-Orthodontic Enamel Demineralization
- Trial name
- NCT07608471
- Volunteers
- 30 people
- Sponsor
- Universidad El Bosque, Bogotá
Dental Caries
Non-restorative Cavity Control in Anterior Cavitated Caries Lesion of Primary Teeth
Background: Studies have questioned the necessity of restoring cavitated carious lesion on primary teeth, once the control of biofilm is the most important factor to arrest these lesions.
- Trial name
- CEPECO2 (NCT03785730)
- Testing
- Non-restorative cavity control - NRCC group, Restoration with resin composite - RCR group
- Where
- Brazil
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Universidade Ibirapuera
Dental Caries in Children
Clinical and Radiographic Evaluation of Injectable Composite Versus Packable Composite in Restoring of Primary Molars
This randomized clinical trial aims to compare the clinical and radiographic performance of injectable composite versus packable composite in restoring cavitated primary molars in children aged 4 to 8 years.
- Trial name
- NCT07239154
- Testing
- packable composite, injectable composite
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Eslam samy abdel monaem kalboush
Caries, Dental
Accuracy Of Sopro-Life Camera In Comparison With ICDAS II For Detection Of Initial Caries
This study will be conducted to assess diagnostic predictive values of a light induced fluorescence intraoral camera versus those of the visual-tactile assessment method according to modified ICDAS-II criteria in clinical
- Trial name
- NCT03586713
- Testing
- light induced fluorescence camera
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Development and Validation of a Multi-Mineral Fluoride Mouthrinse
The primary goals of this project are to determine the anticaries benefits of a prototype multi-mineral mouthrinse containing 225 ppm fluoride and 30 ppm of a Ca through the remineralization of enamel white-spots (non-cavitated…
- Trial name
- NCT00642252
- Testing
- Fluoride
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana Nanotech, LLC
Cavities of Teeth
Effectiveness of Silver Diamine Fluoride (SDF) in Arresting Cavitated Caries Lesions
This trial is a Phase III, multisite, randomized, placebo-controlled trial, with two parallel groups. The groups are SDF or placebo and they are applied every 6 months.
- Trial name
- NCT03649659
- Testing
- Silver Diamine Fluoride
- Where
- 3 sites in United States
- Volunteers
- 830 people
- Sponsor
- University of Michigan
Initial Caries, Arrested Dental Caries
Early Caries Lesion Management Observational Study
The purpose of this observational study is to assess the effectiveness of Curodont Repair Fluoride Plus (CRFP) compared to other tooth-specific treatments (silver diamine fluoride (SDF), sealants, or other FDA-approved…
- Conditions
- Initial Caries, Arrested Dental Caries, Cavitated Caries, Dental Caries
- Trial name
- ELMO (NCT04933331)
- Testing
- Curodont Repair Fluoride Plus, Silver Diamine Fluoride, Glass Ionomer Sealant
- Where
- 4 sites in United States
- Volunteers
- 744 people, healthy volunteers welcome
- Sponsor
- CareQuest Institute for Oral Health
Dental Caries
Effects of Different Remineralization Agents on the Progression of Non-Cavitated Approximal Carious Lesions in Primary Teeth: A Randomized Clinical Trial
Dental caries is a highly prevalent disease in children. Contemporary caries management emphasizes minimally invasive approaches that aim to arrest or reverse non-cavitated lesions rather than remove tooth structure.
- Trial name
- REMİN-PRİMARY (NCT07431463)
- Testing
- P11-4 + NaF Varnish, Silver diamine fluoride, NaF Varnish Alone
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Izmir Katip Celebi University