Clinical trials: Central Line Infection
CLABSI - Central Line Associated Bloodstream Infection, CRBSI - Catheter Related Bloodstream Infection
Neonatal Catheter Lock for Infection Prevention
For newborns admitted to Neonatal Intensive Care Units (NICUs), one of the main risk factors for late-onset sepsis is the presence of a central venous catheter (CVC), which is often essential for the administration of medications…
- Conditions
- CLABSI - Central Line Associated Bloodstream Infection, CRBSI - Catheter Related Bloodstream Infection, Neonatal Sepsis, Late-Onset
- Trial name
- Neo-CLIP (NCT07585188)
- Testing
- Taurolidine 2% lock, Normal saline lock
- Where
- Italy
- Volunteers
- 576 people
- Sponsor
- University of Turin, Italy
Plasmodium Falciparum Malaria (Uncomplicated)
A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combinations of 2 Anti-malarial Drugs (Asia)
A partially blinded randomised controlled non-inferiority trial comparing the efficacy, tolerability and safety of Triple ACTs artemether-lumefantrine + amodiaquine (AL+AQ) and artesunate- mefloquine+piperaquine (AS-MQ+PPQ) with…
- Trial name
- DeTACT-ASIA (NCT03939104)
- Testing
- Artemether-lumefantrine+amodiaquine, Artesunate-mefloquine+piperaquine
- Where
- 3 sites in Bangladesh, Cambodia
- Volunteers
- 103 people
- Sponsor
- University of Oxford
Infection
Community Central Line Infection Prevention Trial
The overall goal of this Community Central Line Infection Prevention (CCLIP) trial, supported by grant R01 HS022870 from the Agency for Healthcare Research and Quality, is to determine whether use of a promising new intervention…
- Trial name
- CCLIP (NCT02351258)
- Testing
- 70% Isopropyl alcohol embedded caps, Usual Care
- Where
- 16 sites in United States
- Volunteers
- 16 people
- Sponsor
- Johns Hopkins University
Central Line Bloodstream Infections
The Effectiveness of Silver Alginate (Algidex) Patch in the Prevention of Central Line Infections in Very Low Birth Weight Infants
The purpose of this study is to determine whether silver alginate (Algidex) patch is effective in the prevention of central line infections in very low birth weight infants.
- Trial name
- NCT00964093
- Testing
- Silver Alginate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor Research Institute
Central-line Associated Blood Stream Infections (CLABSI)
CLABSI Prevention With Tissue Adhesive
Our aim is to test the effect of tissue adhesive application at the Central-line exit-site on CLABSI rates in high-risk pediatric congenital heart disease patients.
- Trial name
- Cya-No-CLABSI (NCT05721677)
- Testing
- 2-octyl cyanoacrylate based topical skin adhesive
- Where
- Israel
- Volunteers
- 600 people
- Sponsor
- Rabin Medical Center
Infection
Study of Omiganan 1% Gel in Preventing Catheter Infections/Colonization in Patients With Central Venous Catheters
The purpose of this study is to determine whether treatment with topical omiganan is more effective than treatment with topical povidone-iodine in preventing local catheter site infections and catheter colonization in patients…
- Trial name
- NCT00231153
- Testing
- Omiganan 1% gel, Povidone-Iodine 10%
- Where
- 57 sites in United States, France and 2 more
- Volunteers
- 1,859 people
- Sponsor
- Cadence Pharmaceuticals
Peripherally Inserted Central Catheter, Umbilical Venous Catheter
Umbilical Venous Versus Peripherally Inserted Central Catheters in Neonates: A Prospective Cohort Study of Complications, Catheter Survival, and CLABSI"
This study aims to prospectively compare umbilical venous catheters (UVCs) and peripherally inserted central catheters (PICCs) in neonates, focusing on complications, catheter survival, and central line-associated bloodstream…
- Conditions
- Peripherally Inserted Central Catheter, Umbilical Venous Catheter, CLABSI - Central Line Associated Bloodstream Infection
- Trial name
- NCT07209670
- Testing
- peripherally inserted central catheter insertion, umbilical venous catheters insertion
- Volunteers
- 360 people
- Sponsor
- Assiut University
Infection
Developing and Maintaining a Central Venous Catheter Registry
It has been estimated that 90% of bloodstream infections associated with catheters, are due to CVCs, and that 500 to 4,000 patients in the United States die annually due to these bloodstream infections.
- Trial name
- NCT01165411
- Where
- United States
- Volunteers
- 4,530 people
- Sponsor
- Lehigh Valley Hospital
Central Lines in ICU Patients
Ethanol Lock for Prevention of Central Line-Associated Blood Stream Infections
Vascular access via central venous lines (CVL) is essential to the care of many patients in the intensive care setting. While the value of these lines for the management of critically ill patients is generally accepted, the…
- Trial name
- NCT01344590
- Testing
- Normal Saline, Ethanol 70% pharmaceutical grade
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
SIRS
Infections Related Central Venous Catheters
The purpose of this study is to clarify the relationship between SIRS (Systemic inflammatory response syndrome) and the infection associated with the use of central venous catheters at Critical Care center in National Defense…
- Trial name
- CVL (NCT00554021)
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- National Defense Medical College, Japan
Device Related Infection, Vascular Access Complication
The IVCare Adaptive Platform Trial
The IVCare trial is a multicentre adaptive platform study evaluating interventions to prevent infections and other complications associated with central venous access devices (CVADs) in patients with newly inserted or existing…
- Conditions
- Device Related Infection, Vascular Access Complication, Device Related Sepsis, Catheter Infection
- Trial name
- NCT07587593
- Testing
- Connectors/Caps Domain - Standard of Care, Curos™, ClearGuard™ HD
- Volunteers
- 2,500 people
- Sponsor
- The University of Queensland
Catheter-Related Infections
Heparin Versus Taurolidine to Bloodstream Infection Prevention Related in Central Venous Catheter in Children
Clinical trial, that aim is evaluation of the use of taurolidine and heparin in the prevention of bloodstream infection in venous catheter in children with intestinal failure.
- Trial name
- NCT02515201
- Testing
- Taurolidine, Heparin
- Volunteers
- 20 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Staphylococcal Infections
Vancomycin Study: Treatment of Catheter Related Bloodstream Infection Caused by Coagulase Negative Staphylococcus
Patients admitted into the Intensive Care Unit (ICU) have an intravenous (IV) catheter (small plastic tube) placed in their vein.
- Trial name
- NCT00175370
- Testing
- Vancomycin
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Infection
Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter
RATIONALE: Giving the antibiotic teicoplanin by infusion and allowing bacteria to be exposed to the antibiotic for a longer period of time may be effective in preventing or controlling septicemia.
- Trial name
- NCT00024453
- Testing
- teicoplanin
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 1,360 people
- Sponsor
- Children's Cancer and Leukaemia Group
Bacterial Infection, Benign Neoplasm
Chlorhexidine Gluconate Cleansing in Preventing Central Line Associated Bloodstream Infection and Acquisition of Multi-drug Resistant Organisms in Younger Patients With Cancer or Undergoing Donor Stem Cell Transplant
This randomized phase III trial studies chlorhexidine gluconate cleansing to see how well it works compared to control cleansing in preventing central line associated bloodstream infection and acquisition of multi-drug resistant…
- Conditions
- Bacterial Infection, Benign Neoplasm, Malignant Neoplasm, Methicillin-Resistant Staphylococcus Aureus Infection
- Trial name
- NCT01817075
- Testing
- Chlorhexidine Gluconate Skin Cleanser, Laboratory Biomarker Analysis, Mild Soap Skin Cleanser
- Where
- 59 sites in United States, Canada and 1 more
- Volunteers
- 177 people
- Sponsor
- Children's Oncology Group
Blood Stream Infections, Skin Diseases, Infectious
Topical Antibiotics for Prevention of Intensive Care Unit (ICU) Central Line Infections
The purpose of the study is to determine if the overall central venous catheter related infection rate can be reduced by the application of Polysporin Triple Therapy ointment to the insertion site.
- Trial name
- ToPICL (NCT00990392)
- Testing
- Polysporin Triple Therapy ointment, Petroleum Jelly
- Where
- Canada
- Sponsor
- Fraser Health
Acquired Immunodeficiency Syndrome, BK Virus Infection
Cytotoxic T Lymphocytes in Treating Patients With Malignancies With BK and/or JC Virus
This phase II trial studies how well donor cytotoxic T lymphocytes work in treating patients with malignancies with BK and/or JC virus.
- Conditions
- Acquired Immunodeficiency Syndrome, BK Virus Infection, Human Immunodeficiency Virus, JC Virus Infection
- Trial name
- NCT02479698
- Testing
- Allogeneic BK-specific Cytotoxic T-lymphocytes, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Central Line-associated Bloodstream Infection (CLABSI)
Central Line-associated Bloodstream Infection Prevention Using TauroLock-Hep100 in Pediatric Oncology Patients.
The goal of this assessor blinded randomized controlled trial is to compare a lock solution containing taurolidine, citrate and heparin to a heparin only lock solution for the prevention of central line associated bloodstream…
- Trial name
- CATERPILLAR (NCT05740150)
- Testing
- TauroLock-Hep100 (taurolidine 1.35%, citrate 4%, heparin 100 IU/mL), Heparin lock (heparin 100 IU/mL)
- Where
- Netherlands
- Volunteers
- 462 people
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Central Line Associated Bloodstream Infections (CLABSI), Bone Marrow Transplant
Parafilm to Prevent CLABSI in Pediatric Patients Undergoing HCT
The purpose of this study is to see if applying parafilm as an external barrier on the central line in children having a bone marrow transplant helps to prevent central line associated bloodstream infection(s) and also to assess…
- Trial name
- NCT02575079
- Testing
- Parafilm
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Emory University
Neonatal Infection
Impact of a Multi-infusion Strategy in Neonatology on the Rate of Central Line-associated Bloodstream Infections
The management of premature infants hospitalized in neonatal units requires the simultaneous intravenous (IV) infusion of several drugs and parenteral nutrition solutions, when oral administration is impossible or unsuitable.
- Trial name
- EDELVAISS (NCT06656104)
- Testing
- Reference strategy, Experimental strategy
- Where
- 3 sites in France
- Volunteers
- 569 people
- Sponsor
- Hospices Civils de Lyon