Clinical trials: Central Line Infection
Central Line-Associated Bloodstream Infection
Ethanol Lock Therapy for Treatment and Secondary Prophylaxis of Central Line-Associated Bloodstream Infection
Use of long-term central venous access devices (including tunneled lines and ports) can be associated with development of bloodstream infection caused by build-up of bacteria or fungus on the inside of the device, called central…
- Trial name
- NCT01472965
- Testing
- ethanol
- Where
- 2 sites in United States, Australia
- Volunteers
- 95 people
- Sponsor
- St. Jude Children's Research Hospital
Central Line Associated Bloodstream Infections (CLABSI), Bone Marrow Transplant
Parafilm to Prevent CLABSI in Pediatric Patients Undergoing HCT
The purpose of this study is to see if applying parafilm as an external barrier on the central line in children having a bone marrow transplant helps to prevent central line associated bloodstream infection(s) and also to assess…
- Trial name
- NCT02575079
- Testing
- Parafilm
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Emory University
Bacterial Infection, Benign Neoplasm
Chlorhexidine Gluconate Cleansing in Preventing Central Line Associated Bloodstream Infection and Acquisition of Multi-drug Resistant Organisms in Younger Patients With Cancer or Undergoing Donor Stem Cell Transplant
This randomized phase III trial studies chlorhexidine gluconate cleansing to see how well it works compared to control cleansing in preventing central line associated bloodstream infection and acquisition of multi-drug resistant…
- Conditions
- Bacterial Infection, Benign Neoplasm, Malignant Neoplasm, Methicillin-Resistant Staphylococcus Aureus Infection
- Trial name
- NCT01817075
- Testing
- Chlorhexidine Gluconate Skin Cleanser, Laboratory Biomarker Analysis, Mild Soap Skin Cleanser
- Where
- 59 sites in United States, Canada and 1 more
- Volunteers
- 177 people
- Sponsor
- Children's Oncology Group
Infection
Study of Omiganan 1% Gel in Preventing Catheter Infections/Colonization in Patients With Central Venous Catheters
The purpose of this study is to determine whether treatment with topical omiganan is more effective than treatment with topical povidone-iodine in preventing local catheter site infections and catheter colonization in patients…
- Trial name
- NCT00231153
- Testing
- Omiganan 1% gel, Povidone-Iodine 10%
- Where
- 57 sites in United States, France and 2 more
- Volunteers
- 1,859 people
- Sponsor
- Cadence Pharmaceuticals
Catheter-Related Infections, Central Venous Catheters
Advanced Dressings for CVC Infection Prevention in PICU
Randomised, single-blind clinical trial comparing chlorhexidine gluconate-impregnated transparent dressings versus conventional transparent dressings in the prevention of central venous catheter-related bloodstream infections…
- Conditions
- Catheter-Related Infections, Central Venous Catheters, Bloodstream Infection, Pediatric Intensive Care Units
- Trial name
- NCT07175116
- Testing
- 3M™ Tegaderm™ Antimicrobial Transparent Dressing (chlorhexidine gluconate-impregnated), Conventional transparent polyurethane dressing
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- University of Seville
Bloodstream Infection
Ethanol Locks for the Treatment of Central Venous Line Infections
Ethanol Locks as an Adjunct Treatment for Central Venous Line Infections Purpose To evaluate the effectiveness of a 70% ethanol lock solution when used as an adjunct therapy with antibiotics to treat central venous line…
- Trial name
- NCT00680459
- Testing
- 70% ethanol, heparin flush solution
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Baystate Medical Center
CLABSI - Central Line Associated Bloodstream Infection
Sodium Citrate 4% Locking Solution for Children Requiring Home Parenteral Nutrition
This study an open label prospective observational cohort study to evaluate the safety and efficacy of sodium citrate 4% locking solution in preventing central line associated blood stream infection in children requiring long…
- Trial name
- NCT04756427
- Testing
- Sodium Citrate 4% Inj Syringe 3Ml
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Central Line Fungal Infections
Antifungal Locks to Treat Fungal-related Central Line Infections
The purpose of this study is to evaluate the usefulness of antifungal lock therapy with liposomal amphotericin B (Ambisome), in combination with systemic antifungal(s), in patients with catheter-related blood stream infections…
- Trial name
- NCT00936910
- Testing
- amphotericin B liposomal (Ambisome)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Bill McGhee
Central Line Complication, Central Line Infection
Innovative Central Line Securement Device in the Pediatric Population
This study involves evaluating pediatric patients with central lines to determine differences in line complications and quality of life in those with a novel central line securement device (wrap) as compared to those who use a…
- Conditions
- Central Line Complication, Central Line Infection, Central Line-Associated Infection, Central Line Sepsis
- Trial name
- NCT04522778
- Testing
- Wearable Central Line Securement Device (Vest), Traditional Securement Dressing
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Ryan St. Pierre-Hetz
Fever
Procalcitonin Levels in Patients With Fever and a Central Line
Procalcitonin (PCT) is one of many inflammatory markers which rises in response to infection. Many studies have shown this marker to be more indicative of a patient's clinical course in comparison to other inflammatory markers…
- Trial name
- NCT01175005
- Volunteers
- 62 people
- Sponsor
- Phoenix Children's Hospital
Central Venous Catheter Thrombosis, Central Venous Catheter Associated Bloodstream Infection
t-PA Prophylaxis to Prevent Catheter-associated Thrombosis and Infection
The purpose of this pilot study is to test feasibility of concept, consent and enrollment rates, and mechanics of study designed to assess if intra-catheter dwells of tissue plasminogen activator (t-PA) is effective in decreasing…
- Trial name
- TOPCAT (NCT03672006)
- Testing
- alteplase (recombinant t-PA), Heparin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Central Line-associated Bloodstream Infection (CLABSI), Ventilator Associated Pneumonia
Safe Critical Care: Testing Improvement Strategies
One group of hospitals participated in a collaborative approach for healthcare quality improvement while another group was provided only a tool kit.
- Trial name
- NCT00975923
- Testing
- Collaborative Group, Tool Kit
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Vanderbilt University
Infection
Community Central Line Infection Prevention Trial
The overall goal of this Community Central Line Infection Prevention (CCLIP) trial, supported by grant R01 HS022870 from the Agency for Healthcare Research and Quality, is to determine whether use of a promising new intervention…
- Trial name
- CCLIP (NCT02351258)
- Testing
- 70% Isopropyl alcohol embedded caps, Usual Care
- Where
- 16 sites in United States
- Volunteers
- 16 people
- Sponsor
- Johns Hopkins University
Childhood Cancer, Central Venous Catheters
Identification and Treatment of Clinically Silent Catheter-Related Deep Vein Thrombosis in Children With Cancer
The primary hypothesis of this study is that occult catheter-related DVT in children with cancer is common and directly contributes to development of serious catheter complications, specifically bacteremia/fungemia and/or…
- Conditions
- Childhood Cancer, Central Venous Catheters, Deep Vein Thrombosis, Catheter-related Infection
- Trial name
- DVT (NCT00633061)
- Testing
- Enoxaparin
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of Texas Southwestern Medical Center