Clinical trials: Central Visual Impairment
Amblyopia
Early Detection and Prevention of Amblyopia and Visual Impairment Through Systematic Pediatric Vision Screening
Amblyopia, characterized by reduced visual acuity, develops in childhood due to insufficient sensory stimulation of the affected eye.
- Trial name
- FALSSE (NCT07112560)
- Testing
- Standard screening procedure for amblyopia, New amblyopia screening method using a virtual reality headset.
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Preterm Less Than 32wks With IVH, WMI/PVL, Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE
Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates
Cerebral/Cortical Visual Impairment (CVI) is the leading cause of childhood visual impairment in the United States and other industrialized countries.
- Trial name
- CVI (NCT07275021)
- Testing
- Prospective Clinical and Neurodevelopmental Data Collection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Cerebral Visual Impairment
A Computerized, Adaptive Therapeutic Gaming Approach Training Visual Perceptual Skills in Children With CVI
This clinical trial aims to compare the effectiveness of our adaptive, therapeutic game to the effectiveness of the same game, without the adaptive component.
- Trial name
- iVision2_WP3 (NCT05014503)
- Testing
- Adaptive Therapeutic gaming, Non-adaptive Therapeutic gaming
- Where
- Belgium
- Volunteers
- 73 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Visual Impairment, Cerebral Visual Impairment
Promoting Psychophysical Well-being in Children and Adolescents With Visual Impairment
Visual impairment (VI) has significant implications not only for visual functioning, but also for the motor development, psychological well-being, and social participation of children and adolescents.
- Conditions
- Visual Impairment, Cerebral Visual Impairment, Visual Impairments
- Trial name
- VIPPSTAR_UNITN (NCT07703150)
- Testing
- Adapted Physical Activity Programme
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Università degli Studi di Trento
Intermittent Exotropia
Visual Perceptual Learning Based Digital Therapeutics for Stereopsis in Intermittent Exotropia
This study evaluates the efficacy and safety of visual perceptual learning for improving stereopsis in intermittent exotropia. Half of participants will receive visual perceptual training using the Nu.T.
- Trial name
- NCT06117813
- Testing
- Nu.T, No-Treatment Control
- Where
- 6 sites in South Korea
- Volunteers
- 54 people
- Sponsor
- Nunaps Inc
Vision, Low
eSight Eyewear Quality of Life and Efficacy Study
The "eSight Quality of Life and Efficacy Study" (eQUEST) is a prospective cohort study intended to demonstrate the functional vision and Quality of Life (QoL) improvement provided by eSight Eyewear to persons with significant…
- Trial name
- eQUEST (NCT02616900)
- Testing
- eSight Eyewear
- Where
- 6 sites in United States, Canada
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- eSight Corporation
Visual Impairment, Cerebral Visual Impairment
Body Image, Identity Development, and Social Media Use Among Youth With Visual Impairment: A Single Case Intervention Study
1. Introduction This 3-week single case intervention study is funded by the Horizon Europe Research Program and is part of the VIPPSTAR project (Project 101156763 - VIPPSTAR "Visually Impaired children and adolescents: bridging…
- Conditions
- Visual Impairment, Cerebral Visual Impairment, Visual Impairments
- Trial name
- VIPPSTAR_G3KUL (NCT07741500)
- Testing
- Body image intervention
- Where
- 2 sites in Belgium
- Volunteers
- 15 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Retinopathy of Prematurity (ROP), Prematurity Complications
Retinopathy of Prematurity - Visual Function and Retinal Structure
Children born prematurely may develop a characteristic retinal disease named retinopathy of prematurity (ROP). This disease could lead to retinal detachment and blindness.
- Conditions
- Retinopathy of Prematurity (ROP), Prematurity Complications, Cerebral Visual Impairment, Visual Field Defect
- Trial name
- NCT07427719
- Where
- Norway
- Volunteers
- 140 people
- Sponsor
- Oslo University Hospital
Macular Edema (ME)
To Assess the Efficacy and Safety of Intravitreal Ranibizumab in People With Vision Loss Due to Macular Edema
To evaluate the efficacy and safety of 0.5 mg Ranibizumab intravitreal injections in adult patients with visual impairment due to macular edema (ME).
- Trial name
- NCT01846299
- Testing
- Ranibizumab
- Where
- 61 sites in Australia, Belgium and 17 more
- Volunteers
- 181 people
- Sponsor
- Novartis Pharmaceuticals
Age-related Macular Degeneration
Visual Remapping to Aid Reading With Field Loss
Reading performance in patients with Central Vision Loss and age matched controls with artificial scotomas will be measured with and without different kinds of remapping of missing text to different parts of the visual field.
- Trial name
- NCT03848663
- Testing
- Traditional Remapping, Personalized Remapping
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Homonymous Hemianopsia
Ongoing Effect of Expansion Prisms Following the Discontinuation of Use on Visual Field Enlargement and Retrograde Ganglion Cell Degeneration in Homonymous Hemianopia Patients
The goal of this observational study is to learn about the long-term effects of Pelli prism in Hemianopia patients who take Prisms for awareness of the area they cannot see.
- Trial name
- NCT06674369
- Testing
- Peli prism for hemianopia
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Okan University
Myopia, Quality of Life
Functional Vision and Quality of Life in a Modern Society - With Emphasis on Myopia and Cerebral Visual Impairment Among Youth
Society has become increasingly digital, and many everyday services have been replaced by digital self-service solutions. This puts greater demands on our vision and our ability to interpret what we see.
- Trial name
- NCT07653074
- Testing
- ophthalmological examination
- Where
- Sweden
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Headache, Urinary Incontinence
Pediatric Patient Experience on a Diagnostic Path
The trial will determine the impact of an information- and education-focused interventions on the anxiety levels, and patients' experiences as well as satisfaction of patients aged 10-14 and their caregivers during the MR…
- Conditions
- Headache, Urinary Incontinence, Growth Deficiency, Visual Impairment
- Trial name
- NCT05199363
- Testing
- Information leaflet, Educational movie, Demonstration
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Children's Memorial Health Institute, Poland
Amblyopia, Amblyopia Unilateral
Non-invasive Induction of Metaplasticity for Amblyopia
The goal of this clinical trial is to determine the efficacy of flicker therapy as an adjunct therapy to treat amblyopia beyond the critical period in adolescents and adults aged 14-40 years who have amblyopia of ≥3 lines of…
- Conditions
- Amblyopia, Amblyopia Unilateral, Amblyopia, Anisometropic, Amblyopia Strabismic
- Trial name
- NIMA (NCT07846397)
- Testing
- Flicker
- Volunteers
- 10 people
- Sponsor
- Boston Children's Hospital
Central Visual Impairment
Peripheral Reading
The purpose of this study is to evaluate reading performance in the visual periphery by simulating central vision loss using a computer-controlled gaze-contingent display with an eye tracker.
- Trial name
- NCT03640130
- Testing
- Gaze-contingent text enhancement
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Houston
Amblyopia, Amblyopia Unilateral
Valproate for the Treatment of Residual Amblyopia
The goal of this clinical trial is to determine the efficacy of valproate as an adjunct therapy to treat amblyopia beyond the critical period in children aged 8-17 years who have amblyopia of ≥3 lines of interocular…
- Conditions
- Amblyopia, Amblyopia Unilateral, Amblyopia, Anisometropic, Amblyopia Strabismic
- Trial name
- VARA (NCT07226141)
- Testing
- Valproate, Patch
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Boston Children's Hospital
Age Related Macular Degeneration, Central Retinal Vein Occlusion
Ziv-aflibercept in Eyes With Retinal Diseases and Poor Vision-phase I
Aflibercept is FDA approved and the same molecule is available as hyperosmolar for oncology (cost 800 USD for 4ml) and isoosmolar for Ophthalmology (cost 1,770 USD for 0.05ml injection).
- Trial name
- ZIV (NCT02173873)
- Testing
- ziv-aflibercept drug
- Where
- Lebanon
- Volunteers
- 100 people
- Sponsor
- Rafic Hariri University Hospital
Visual Impairment, Amblyopia
Developing Better Computerised Vision Tests (CVTV)
Clinical vision measurements usually involve printed charts with an eye care professional interpreting patient responses to generate a score. Those scores determine the need for or outcome of treatment.
- Conditions
- Visual Impairment, Amblyopia, Macular Degeneration, Ophthalmic Disease
- Trial name
- CVTV (NCT06224751)
- Testing
- Near logMAR letter acuity, Near LogMAR word acuity, Red Green Stereoacuity
- Where
- United Kingdom
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Choroidal Neovascularization (CNV)
Assess the Efficacy/Safety of Intravitreal Ranibizumab in Patients With Vision Loss Due to Choroidal Neovascularization.
This study was conducted to evaluate the efficacy and safety of 0.5 mg ranibizumab in adult and adolescent patients with visual impairment due to choridal neovascularization (CNV).
- Trial name
- NCT01840410
- Testing
- Ranibizumab
- Where
- 59 sites in Australia, Canada and 19 more
- Volunteers
- 183 people
- Sponsor
- Novartis Pharmaceuticals
Vision Loss Partial, Hemianopia
Effect of Visual Retraining on Visual Loss Following Visual Cortical Damage
This project is intended to collect data using standard clinical tests and psychophysics to quantify the effect of visual cortical damage on the structure of the residual visual system, visual perception, spatial awareness, and…
- Conditions
- Vision Loss Partial, Hemianopia, Hemianopia Homonymous, Quadrantanopia
- Trial name
- NCT05098236
- Testing
- Training in the Blind Field, Training in the Sighted Field
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University of Rochester