Clinical trials: Cerebrospinal Fluid
Attention Deficit and Disruptive Behavior Disorder, Attention Deficit Disorder With Hyperactivity
Biological Markers in Attention Deficit/Hyperactivity Disorder (ADHD)
The purpose of this study is to evaluate individuals with Attention Deficit/Hyperactivity Disorder (ADHD) to learn more about the genetics of the disease. This study is part of other ongoing studies of individuals with ADHD.
- Trial name
- NCT00001206
- Where
- United States
- Volunteers
- 347 people
- Sponsor
- National Institute of Mental Health (NIMH)
Alzheimer Disease
Amyloid Beta-peptide 1-40 and Alzheimer's Disease
The combined measurement of Ab42 and tau protein (total and phosphorylated) in the spinal fluid has been shown to be promising in the diagnosis of Alzheimer's disease (AD), and has justified its inclusion new diagnostic criteria.
- Trial name
- ADAB40 (NCT02770482)
- Testing
- spinal fluid collection
- Where
- France
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Multiple Sclerosis, Neuromyelitis Optica
Immunologic Biomarker Profile of Cerebrospinal Fluid
The aim of this study was the describe the Immunologic biomarker profile of cerebrospinal fluid in multiple sclerosis patients
- Trial name
- BIOMOG (NCT04202055)
- Testing
- Biomarker analysis
- Where
- France
- Volunteers
- 165 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Ataxia Telangiectasia
Oxidative Stress, Low Grade Inflammation, Tissue Breakdown and Biomarkers in Cerebrospinal Fluid of A-T
Ataxia telangiectasia (A-T) is a rare devastating human recessive disorder characterized by progressive cerebellar ataxia, immunodeficiency, chromosomal instability, and cancer susceptibility.
- Trial name
- NCT02285348
- Testing
- Lumbar puncture
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Neuropathic Pain
Identifying Biomarkers and Changes in Cerebrospinal Fluid Collected Pre and Post Spinal Cord Stimulation in Subjects Suffering From Chronic Refractory Pain Conditions
This is a single center exploratory study in subjects suffering from chronic refractory pain to identify cellular, molecular and protein biomarkers within cerebrospinal fluid (CSF).
- Trial name
- CSF-STIM (NCT03986255)
- Testing
- Lumbar Puncture
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Hydrocephalus, Ventriculoperitoneal Shunt Infection
Efficacy and Cost-Effectiveness of Topical Vancomycin Powder in Preventing Pediatric Ventriculoperitoneal Shunt Infections Across Different Etiologies
Objectives Primary: To measure the reduction in VP shunt infection rates using topical vancomycin powder. Secondary: To compare efficacy across different Etiological Strata (Congenital, Post-hemorrhagic, post-inflammatory).
- Conditions
- Hydrocephalus, Ventriculoperitoneal Shunt Infection, Surgical Site Infection (SSI), Cerebrospinal Fluid Shunt Infection
- Trial name
- NCT07547826
- Testing
- Topical Vancomycin Powder, Standard Perioperative Care
- Where
- Egypt
- Volunteers
- 164 people
- Sponsor
- Assiut University
Pharmacokinetics of Celecoxib in Children
CELECOXIB Plasma and Cerebral Spinal Fluid Pharmacokinetics in Children
Celecoxib is effective for reducing postoperative pain in adults. Children use celecoxib more rapidly than adults and require higher doses. Celecoxib is partially metabolized in the liver by a certain enzyme.
- Trial name
- NCT01344200
- Testing
- Celecoxib
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Children's Hospital of Eastern Ontario
Hydrocephalus
Strata Programmable CSF Shunt Valve Study
The treatment of hydrocephalus is the most time consuming, and arguably the most important role of the pediatric neurosurgical service at most children's' hospitals.
- Trial name
- NCT02737163
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Johns Hopkins All Children's Hospital
Hydrocephalus
Longitudinal Measurements of Flow in Cerebrospinal Fluid Shunts With a Wireless Thermal Anisotropy Measurement Device
This study evaluates the performance of a device for non-invasively assessing cerebrospinal fluid (CSF) shunt flow. Patients with an existing implanted shunt will wear the device to acquire longitudinal data.
- Trial name
- NCT06086561
- Testing
- Thermal Anisotropy Measurement Device
- Where
- 4 sites in United States
- Volunteers
- 130 people
- Sponsor
- Rhaeos, Inc.
Cerebral Palsy, Multiple Sclerosis
Measuring Signatures in the Fluid Surrounding the Spinal Cord in Patients Who Have Problems With Intrathecal Drug Delivery
The purpose of this study is to record signatures from the fluid surrounding the spinal cord from people who have an implanted drug infusion system.
- Conditions
- Cerebral Palsy, Multiple Sclerosis, Traumatic Brain Injury, Spinal Cord Injury
- Trial name
- NCT01117090
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- MedtronicNeuro
CSF Leak
The Paediatric EVICEL® Neuro Study
The purpose of this study is to evaluate the safety and efficacy of EVICEL® when used for suture-line sealing in dura-mater closure in elective or urgent paediatric cranial neurosurgery to provide intraoperative watertight…
- Trial name
- NCT02309645
- Testing
- EVICEL® Fibrin Sealant, Sutures Only
- Where
- 7 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Ethicon, Inc.
Spinal Cord Injuries
Cerebrospinal Fluid (CSF) Drainage and Cytokine Profiling in the Treatment of Acute Spinal Cord Injury (SCI)
The overall purpose of this pilot study is to evaluate CSF drainage as a potential neuroprotective strategy after acute spinal cord injury (SCI).
- Trial name
- NCT00135278
- Testing
- CSF Drainage, No CSF Drainage
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- University of British Columbia
Glaucoma Open-Angle
Normal Tension and Chronic Open Angle Glaucoma and Cerebrospinal Fluid Composition
Normal tension glaucoma (NTG) and chronic open angle glaucoma (COAG) occurring progressively with optimal conventional or intraocular pressure reducing surgery are still unsolved problems in ophthalmology.
- Trial name
- NCT00306657
- Testing
- Optic nerve sheath fenestration
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Kantonsspital Aarau
Hydrocephalus
Flow Detection in Open and Closed Shunt Valve Periods
This study is evaluating a new, noninvasive device designed to detect whether cerebrospinal fluid (CSF) is flowing through a surgically implanted shunt.
- Trial name
- NCT07478926
- Testing
- Rhaeos Shunt Monitoring System
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Rhaeos, Inc.
Hydrocephalus
Assessment of CSF Shunt Flow With Thermal Measurements B
This study evaluates the performance of a non-invasive thermal measurement device for assessing CSF shunt flow. Patients with an existing implanted shunt and symptoms of shunt malfunction will be evaluated with the study device.
- Trial name
- STEALTH (NCT05432986)
- Testing
- Thermal Anisotropy Measurement Device
- Where
- 10 sites in United States
- Volunteers
- 141 people
- Sponsor
- Rhaeos, Inc.
Infection, Meningitis
Pediatric Infectious Disease Precision Medicine Using Sequencing Evaluation of CSF
Prospective, multi-site, study to evaluate the diagnosis rate of DNA and RNA sequencing of cerebrospinal fluid for identification of pathogens directly in patients who have already had a spinal tap to evaluate for infection and…
- Trial name
- PIPSEC (NCT03796546)
- Where
- 3 sites in United States
- Volunteers
- 71 people
- Sponsor
- IDbyDNA, Inc.
Adolescent Idiopathic Scoliosis
Evaluation of Cerebrospinal Fluid Flow in Adolescent Idiopathic Scoliosis
Adolescent Idiopathic Scoliosis (AIS) is the most frequent spinal deformity in adolescence, but its etiology remains unknown. Recent publications suggest a link between ciliopathy and AIS.
- Trial name
- MEDULLOSCOL (NCT04760808)
- Testing
- Baseline Clinical Examination, Initial 3T MRI of the Brain and Spine, 6-month Follow-up Clinical Examination
- Where
- 2 sites in France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Intracranial Hemorrhages, Prematurity
Neurophysiology and Anatomy of Severe Intraventricular Hemorrhage (IVH)
Currently, when premature infants develop severe intraventricular hemorrhage (IVH), a type of intracerebral bleed, there are no proven therapeutic interventions to prevent the devastating consequences of this event.
- Trial name
- NCT00817310
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University
Guillain-Barré Syndrome, Miller Fisher Syndrome
International Guillain-Barré Syndrome Outcome Study
International GBS Outcome Study (IGOS) is a study conducted by the members of the Inflammatory Neuropathy Consortium (INC) and Peripheral Nerve Society (PNS) on disease course and outcome in Guillain-Barré syndrome (GBS).
- Trial name
- IGOS (NCT01582763)
- Where
- 138 sites in United States, Argentina and 19 more
- Volunteers
- 2,000 people
- Sponsor
- Erasmus Medical Center
Meningitis Enterovirus
Characterization of Cytokines Expression During Enterovirus Meningitis in Paediatric Populations.
Enteroviruses (EV) are the most frequent cause of acute meningitis in the paediatric population. Detection of enterovirus in cerebrospinal fluid (CSF) specimens by Polymerase Chain Reaction (PCR) is the gold standard diagnostic…
- Trial name
- Bledi-Cytokine (NCT04711876)
- Testing
- Cytokine level in blood and CSF
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Clermont-Ferrand