Clinical trials: Cervical Lesion
Cervical Cancers, Vulvar Cancer
A Study of V503 (A Multivalent Human Papillomavirus [HPV] L1 Virus-Like Particle [VLP] Vaccine) in Preadolescents and Adolescents (V503-002)
This study will evaluate the immunogenicity and tolerability of V503 (a multivalent human papillomavirus [HPV] L1 virus-like particle [VLP] vaccine) in preadolescent and adolescent participants between 9 and 15 years old and…
- Conditions
- Cervical Cancers, Vulvar Cancer, Vaginal Cancer, Genital Lesions
- Trial name
- NCT00943722
- Testing
- V503
- Volunteers
- 3,074 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Adhesion
Dentin Treatments for Restorations of Cervical Lesions Non-Carious
The surface of non-carious cervical lesions (LCNC) is a challenge to adhesive systems, it presents a dentin layer sclera hypermineralized, presence of bacteria and lack of mechanical retention, so this study aimed to evaluate the…
- Trial name
- NCT02434601
- Testing
- Treatment of Dentin Surface, Dentin Surface, Treatment
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Premalignant Lesion, Oral Cancer
Diagnostic Accuracy of Mobile Phone Imaging Compared to Conventional Clinical Examination for Oral Cancer Screening
The aim of study is to evaluate the sensitivity and specificity of using mobile phone photographs versus conventional clinical examination as a screening tool for early detection of oral cancer.
- Trial name
- NCT06060288
- Testing
- Diagnosis by mobile phone imaging
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Cairo University
Evaluation of New Tissue Biomarkers for Cervical Cancer
Biomarkerscreening in Cervical Cancer and Its Preinvasive Lesions
The following trial is a multicenter and prospective research trial of the colposcopy unit of luebeck university and the national research center in Borstel, Germany.
- Trial name
- NCT02238990
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Luebeck
Cervical Cancer
Evaluation of the Cancer Tracking System (CATSystem)
Cervical cancer contributes to significant preventable mortality in Kenya where less than 20% of women are screened. The Cancer Tracking System (CATSystem) is a web-based, algorithm generated tool to promote guideline adherent…
- Trial name
- CATSystem (NCT06286462)
- Testing
- Cancer Tracking System (CATSystem)
- Where
- 10 sites in Kenya
- Volunteers
- 6,600 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Cervical Cancer, Cervical Precancerous Lesions
Trial of Two Versus Three Doses of Human Papillomavirus (HPV) Vaccine in India
The primary study hypothesis wasthat a two-dose human papillomavirus (HPV) vaccine regimen would offer similar immunogenicity and protection as that of a three-dose regimen to girls against persistent HPV infection and cervical…
- Trial name
- NCT00923702
- Testing
- Prophylactic quadrivalent HPV vaccine Merck (Gardasil®)
- Where
- 8 sites in India
- Volunteers
- 22,729 people, healthy volunteers welcome
- Sponsor
- Partha Basu
Oral Cavity Squamous Cell Carcinoma, Saliva Altered
Salivary Ap4A, SCCA, TROP2 in Oral Cancer Patients
According to the World Health Organization, oral cancer (OC) is the eighth most common cancer in the world with a five year survival rate of 50%.
- Conditions
- Oral Cavity Squamous Cell Carcinoma, Saliva Altered, Precancerous Lesions
- Trial name
- OCSALTM (NCT03529604)
- Testing
- Saliva sampling, ELISA, HPLC
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Potentially Malignant Lesions, Oral Lichen Planus
Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions
The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.
- Conditions
- Potentially Malignant Lesions, Oral Lichen Planus, Leukoplakia, Oral
- Trial name
- NCT05730855
- Testing
- Real-time Polymerase Chain Reaction technique
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University
HPV, HIV Infections
Gut and Vaginal Microbiota Profile Study for HIV Women
Women Living with HIV Infection （WLHIV）are intended to acquire HPV infection which usually contributes to variable cervical lesions.
- Conditions
- HPV, HIV Infections, Vaginal Microbiota
- Trial name
- NCT05996016
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Uterine Cervical Cancer
Evaluation of Long-term HPV Vaccine Efficacy
Summary For ethical and practical reasons pre-licensure clinical efficacy phase III trials for GSK Biologicals' HPV-16/18 LI VLP AS04 vaccine used cervical intraepithelial grade 2 and above (CIN2+) lesions as surrogate efficacy…
- Trial name
- NCT01393470
- Testing
- Screening for cervical cancer
- Where
- 15 sites in Finland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Tampere University
Cervical Precancerous Lesions, Cervical Cancer
TS Triage of HR-HPV Positive Population and Its Accuracy Study
A prospective study assessing TS accuracy in HR-HPV+ women, influencing factors, and 1-year follow-up of false-positives versus biopsy.
- Trial name
- NCT07777094
- Testing
- Colposcopy and cervical biopsy, Follow-up of TS false-positive patients
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nantong University
Non-carious Cervical Lesion
Prevalence of Non-Carious Cervical Lesions in Patient With Gingival Recession and Associated Risk Factors
The study aims at determining the prevalence of non carious cervical lesions in patients with gingival recession in Egyptian population and associated risk factors including gingival biotype, keratinized tissue width, gingival…
- Trial name
- NCT05170529
- Where
- Egypt
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Potentially Malignant Lesions, Oral Cancer
Sensitivity and Specificity of Serum and Salivary CYFRA21-1 in the Detection of Malignant Transformation in Oral Potentially Malignant Mucosal Lesions (Diagnostic Accuracy Study)
The study is designed to measure serum and salivary CYFRA21-1 levels using enzyme linked immunosorbent assay (ELISA) in patients with oral malignancy, oral potentially malignant lesions, and control subjects to evaluate the…
- Trial name
- CYFRA21-1 (NCT03686020)
- Testing
- Enzyme Linked Immunosorbent assay (ELISA)
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Restoration Failure
Evaluation of Adhering Flowable Composite With and Without Adhesive Vs Flowable in Cervical Lesions
With limited evidence-based information in literature about using self-adhering flowable composite in conservative class V restorations, it was found beneficial to evaluate the newly introduced material using a randomized…
- Trial name
- NCT03859284
- Testing
- flowable resin composite, self adhering flowable, self adhering flowable with adhesive
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Leukoplakia
Analyzing Handprint Patterns to Predict Oral Cancer Risks: A Comparative Study
Aims: To evaluate the qualitative and quantitative parameters of finger and palmar dermatoglyphic patterns in patients with oral premalignant and malignant lesions OBJECTIVES: 1.
- Trial name
- QQA-FPD-PMML (NCT06256809)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- King Khalid University
Oral Cancer, Diagnoses Disease
Exfoliated Cytology in Detection of Oral Premalignant and Malignant Lesions
Micronuclei have been used since 1937 as an indicator of genetic toxic exposure due to their association with chromosomal alterations.
- Trial name
- NCT04955197
- Testing
- exfoliated cytology
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cairo University
Early Esophageal Cancer or Precancerous Lesions Treated With Endoscopic Resection
The Cohort Study of Early Esophageal Cancer or Precancerous Lesions Treated With Endoscopic Resection
Endoscopic Submucosal Dissection (ESD) is currently the main method of treatment of early esophageal cancer and precancerous lesions.
- Trial name
- NCT03377972
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Cancer Risk, Cancer Predisposition Syndrome
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member…
- Conditions
- Cancer Risk, Cancer Predisposition Syndrome, Hereditary Cancer Prediction, Childhood Cancer Survivors
- Trial name
- NCT05463796
- Testing
- Samples
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Induction of Labor Affected Fetus / Newborn
Nitroglycerin Skin Patches for Facilitating Cervical Ripening: A Randomized Controlled Trial
This study aims to establish the efficacy of transdermal glyceryl trinitrate as a nitric oxide donor in addition to dinoprostone for induction of cervical ripening in the third trimester through progression in the Bishop's score…
- Trial name
- NCT03320187
- Testing
- Nitroderm TTS, Dinoprostone
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital