Clinical trials: Chemically-Induced Disorders
Substance Abuse, Intimate Partner Violence (IPV)
SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Families
This study aims to prevent syndemic health conditions by decreasing acculturative stress and promoting resilience via SER Familia (Salud, Estrés y Resilencia en Familias/ Health, Stress, and Resilience in Families), a…
- Conditions
- Substance Abuse, Intimate Partner Violence (IPV), HIV Infections, Depression
- Trial name
- SER Familia (NCT06627764)
- Testing
- SER Familia
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Duke University
Violence, Alcohol Abuse
Tailored Teen Alcohol and Violence Prevention in the Emergency Room (ER)
This study is designed to address both alcohol misuse and violence among adolescents ages 14-18 seeking care in an urban emergency department (ED).
- Trial name
- NCT00251212
- Testing
- Adapted Motivational Interviewing & Skills Training
- Volunteers
- 3,694 people
- Sponsor
- University of Michigan
Lysosomal Acid Lipase Deficiency, Wolman Disease
Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Sebelipase Alfa in Children With Growth Failure Due to Lysosomal Acid Lipase Deficiency
This was an open-label, repeat-dose, intra-participant dose-escalation study of SBC-102 (sebelipase alfa) in children with growth failure due to lysosomal acid lipase (LAL) Deficiency.
- Trial name
- NCT01371825
- Testing
- Sebelipase alfa (SBC-102)
- Where
- 7 sites in United States, Egypt and 3 more
- Volunteers
- 9 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Substance Abuse
Adolescent Involvement in Parental Substance Abuse Treatment
Given the reciprocal nature of parent-child interaction, involvement of the adolescent in their mother's substance abuse treatment plan might be associated with reductions in adult relapse and improvements in child functioning.
- Trial name
- NCT01576393
- Testing
- Home-based Family Therapy, office-based family therapy, WHE
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Fetal Alcohol Spectrum Disorders
CIFASD 5 tDCS and Cognitive Training
This is a randomized placebo-controlled trial of cognitive training with transcranial direct current stimulation (tDCS) for children and adolescents (ages 8 - 17 years) with prenatal alcohol exposure (PAE).
- Trial name
- NCT05456321
- Testing
- Active tDCS, Cognitive Training
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Minnesota
Pain, Postoperative, Orthognathic Surgery
Personalization of Opioid Prescription Following Orthognathic Surgery
This study aims to investigate pain management and satisfaction following orthognathic surgery, which is a type of surgery that corrects jaw and facial bone issues.
- Conditions
- Pain, Postoperative, Orthognathic Surgery, Opioid Use, Patient Satisfaction
- Trial name
- NCT05708521
- Testing
- Personalization of dose and frequency and instituting a tapering protocol of hydromorphone post-orthognathic surgery, Standardized dose and frequency of hydromorphone with no tapering post-orthognathic surgery
- Where
- Canada
- Volunteers
- 201 people
- Sponsor
- Nova Scotia Health Authority
Substance-related Disorders, Alcohol-Related Disorders
LaunchPad: Supporting Healthy Decisions and Preventing Drug Use After High School
LaunchPad is an online substance use prevention program for high school seniors. The program is designed to help seniors develop skills and make informed decisions as they transition from high school to young adulthood.
- Conditions
- Substance-related Disorders, Alcohol-Related Disorders, Tobacco Use Disorder, Marijuana Use
- Trial name
- NCT07655609
- Testing
- Introduction, Norms re: Protective Behavior Strategies (PBS), Life Skills
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Prevention Strategies, LLC
Poisoning
Pesticide Exposure Pathways for Farmworker Children
This project is aimed at better understanding how children living in agricultural environments are exposed to pesticides, and how such exposures can be prevented or reduced.
- Trial name
- NCT00013754
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Substance-Related Disorders, Alcohol-Related Disorders
Computer-delivered Psychosocial Intervention for Adolescent Substance Use Disorders
The purpose of this study is to develop and evaluate the acceptability and preliminary efficacy of a web-based, skills training program for adolescents with substance use disorders.
- Conditions
- Substance-Related Disorders, Alcohol-Related Disorders, Marijuana Abuse
- Trial name
- NCT00957775
- Testing
- Usual care, Computer-delivered ACRA
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- National Development and Research Institutes, Inc.
Tobacco Use Disorder, Smoking Cessation
Mobile Health (mHealth) Application for Smoking Cessation Among Adolescents in Indonesia
This mixed-methods study develops and evaluates a mobile health (mHealth) application for smoking cessation among Indonesian adolescents aged 13-15 years.
- Conditions
- Tobacco Use Disorder, Smoking Cessation, Adolescent Smoking
- Trial name
- NCT07198828
- Testing
- mHealth Smoking Cessation Application, Paper-based Control Materials
- Where
- Indonesia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Gadjah Mada University
Cardiac Toxicity, Sarcoma
Combination Chemotherapy Before and After Surgery in Treating Patients With Osteosarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy before surgery may shrink the tumor so that it can be removed during surgery.
- Trial name
- NCT00019864
- Testing
- filgrastim, cisplatin, dexrazoxane hydrochloride
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Cancer Institute (NCI)
Liver Diseases
DILIN - Prospective Study
The purpose of this study is to identify individuals who have suffered a liver injury arising as an idiosyncratic reaction to a prescription drug or a complementary and alternative medicine.
- Trial name
- NCT00345930
- Where
- 6 sites in United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Adolescent Problem Behavior, Truancy; Unsocialized
Substance Use Interventions for Truant Adolescents
This study evaluates a brief motivation-building intervention for parents and teens to reduce truancy and substance use. It is hypothesized that the motivational intervention will result in better outcomes compared to an…
- Conditions
- Adolescent Problem Behavior, Truancy; Unsocialized, Marijuana Abuse, Truancy; Socialized
- Trial name
- GOALS (NCT03655574)
- Testing
- Motivational + Family Check-up (MET+FCU), Psychoeducation
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Brown University
Temporomandibular Joint Dysfunction Syndrome
Analysis of Clinical Data of Patients With Temporomandibular Joint Disorder
According to our previous research and clinical observation results, the motor function of the oral, maxillofacial and cervical body is closely related to the occlusal contact.
- Trial name
- NCT05780827
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Posttraumatic Stress Disorder, Substance Use Disorders
Treating Violence-related PTSD and Substance Risk in Low-income, Urban Adolescents
This project will provide initial feasibility and efficacy data for the implementation of Narrative Exposure Therapy (NET) to urban, at-risk youth.
- Trial name
- POWER-NET (NCT03737383)
- Testing
- Narrative Exposure Therapy
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
DNA Sequencing
Ivermectin Neurotoxicity and ABCB1 Gene Mutations
The study report a unique case of severe intoxication in a child treated with oral ivermectin to prevent scabies infection. The ABCB1 gene sequencing found the child compound heterozygote for two nonsense mutations, one in each…
- Trial name
- NCT04174469
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Montpellier
Allergy Drug, Allergic Reaction
Preoperative Survey to Evaluate Patient Allergy
The study will only involve identification of the listed allergies from the electronic medical record and investigation into the symptoms that prompted this allergy listing.
- Conditions
- Allergy Drug, Allergic Reaction, Pediatric, Surgery
- Trial name
- NCT05670756
- Testing
- Survey
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Nationwide Children's Hospital
Substance Abuse, Mindfulness
Master Mind Program Evaluation Study
The purpose of this study is to conduct a randomized controlled trial to evaluate the efficacy of the Master Mind program, a mindfulness education substance abuse prevention program.
- Trial name
- MasterMind (NCT03212066)
- Testing
- Master Mind
- Where
- United States
- Volunteers
- 518 people, healthy volunteers welcome
- Sponsor
- Innovation Research & Training
PTSD - Post Traumatic Stress Disorder, Substance Use
CBITS-RTM Pilot Study
This pilot study, conducted in partnership with juvenile detention centers, evaluates an adapted CBITS-RTM intervention delivered in a detention school setting.
- Trial name
- NCT07682441
- Testing
- Adapted Cognitive Behavioral Intervention for Trauma in Schools (CBITS) with a Racial Trauma Module (RTM)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Francisco
Liver Cancer, Ototoxicity
Cisplatin With or Without Sodium Thiosulfate in Treating Young Patients With Stage I, II, or III Childhood Liver Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- SIOPEL6 (NCT00652132)
- Testing
- cisplatin, sodium thiosulfate
- Where
- 16 sites in United Kingdom
- Volunteers
- 116 people
- Sponsor
- University of Birmingham
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