Clinical trials: Chemically-Induced Disorders
Anxiety, Adolescent Development
Adverse Adolescent Pathways to Substance Use
Purpose: This 5-year R01 study will elucidate the role of maturational change across adolescence in neural connectivity and physiological stress responses in the relationship between anxiety and adverse pathways to substance use…
- Conditions
- Anxiety, Adolescent Development, Substance Use
- Trial name
- APSU (NCT06977178)
- Testing
- Trier Social Stress Test
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Pharmaceutical Services, Medication Errors
Effect and Associated Factors of the Clinical Pharmacy Model in the Incidence of Medical Errors
Medication errors are considered by WHO to be a subject that requires attention at all levels of care, in order to reduce the serious and preventable damage related to medication.
- Conditions
- Pharmaceutical Services, Medication Errors, Drug-Related Side Effects and Adverse Reactions, Outcome Assessment (Health Care)
- Trial name
- EACPharModel (NCT03338725)
- Testing
- Clinical pharmacy model
- Where
- Colombia
- Volunteers
- 720 people
- Sponsor
- Universidad de Antioquia
Drug-Related Side Effects and Adverse Reactions
Investigation of Serious Adverse Events Following Vaccination Against Yellow Fever: Emphasis on Genetic Basis and Biological Markers
It concerns an investigation aiming to investigate genetic biological(s) marker(s) which allow to identify individuals who have risk of serious adverse events to the yellow fever vaccine.
- Trial name
- NCT03938597
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Tobacco Use Disorder, Smoking Cessation
Mobile Health (mHealth) Application for Smoking Cessation Among Adolescents in Indonesia
This mixed-methods study develops and evaluates a mobile health (mHealth) application for smoking cessation among Indonesian adolescents aged 13-15 years.
- Conditions
- Tobacco Use Disorder, Smoking Cessation, Adolescent Smoking
- Trial name
- NCT07198828
- Testing
- mHealth Smoking Cessation Application, Paper-based Control Materials
- Where
- Indonesia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Gadjah Mada University
Brain and Central Nervous System Tumors, Drug/Agent Toxicity by Tissue/Organ
Treating Patients With Recurrent PCNSL With Carboplatin/BBBD and Adding Rituxan To The Treatment Regimen
RATIONALE: Monoclonal antibodies, such as rituximab, can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells.
- Conditions
- Brain and Central Nervous System Tumors, Drug/Agent Toxicity by Tissue/Organ, Lymphoma, Thrombocytopenia
- Trial name
- NCT00074165
- Testing
- Rituxan, Cyclophosphamide, Etoposide
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- OHSU Knight Cancer Institute
Effect of Drug, Toxicity, Drug
Apatinib Plus IE Chemotherapy (Ifosfamide and Etoposide) for Relapsed or Refractory Osteosarcoma
Apatinib has led to positive responses in the treatment of osteosarcoma refractory to first-line chemotherapy. However, apatinib demonstrates only short-lived activity, and the disease control of musculoskeletal lesions is worse…
- Trial name
- AIEO (NCT04824352)
- Testing
- apatinib
- Where
- 2 sites in China
- Volunteers
- 44 people
- Sponsor
- Peking University People's Hospital
Cannabis Use, Alcohol Use, Unspecified
CARS: Cannabis and Alcohol Reduction Study
The study will test a computerized treatment with subjects ages 13-17 years who are seeking treatment for alcohol and/or cannabis use. Follow-up assessments will be conducted at one- and three-months following treatment.
- Conditions
- Cannabis Use, Alcohol Use, Unspecified, Substance Use, Substance Use Disorders
- Trial name
- CARS (NCT05486234)
- Testing
- modified Approach-Avoidance Task (mAAT), which aims to modify automatic approach bias, modified Approach-Avoidance Task (mAAT) that does not aim to modify automatic approach bias.
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Medical University of South Carolina
Substance Use Disorders, Parent-Child Relations
MIO-CPP to Improve the Well-being, Permanency, and Safety Outcomes for Young Children at Risk of or in Out-of-home Placement in Philadelphia and Bucks Counties, and Affected by Maternal Substance Use
The goal of the project is to improve child well-being, permanency, and safety, and reduce the risk for involvement in the child welfare system for families with children pre-birth to five years who are affected by parental…
- Conditions
- Substance Use Disorders, Parent-Child Relations, Parent Child Abuse
- Trial name
- NCT04294134
- Testing
- MIO-CPP
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Children's Hospital of Philadelphia
Substance Use, Substance Abuse
Family Engagement, Cross-System Linkage to Substance Use Treatment for Juvenile Probationers -- Phase 3
Developed from adapting and combining two evidence-based programs, Project CONNECT (a linkage-to-services program that targets barriers within the probation and substance abuse treatment systems) and TIES (a program that teaches…
- Conditions
- Substance Use, Substance Abuse, Substance Use Disorders, Substance-Related Disorders
- Trial name
- NCT03048552
- Testing
- Family CONNECT
- Volunteers
- 22 people
- Sponsor
- New York State Psychiatric Institute
ADHD, Cannabis Use Disorder
Delayed-Release, Extended-Release Methylphenidate (Jornay PM) for Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder and Cannabis Use Disorder
The goal of this clinical trial is to look at how delayed-release, extended-release methylphenidate (Jornay PM), an FDA-approved medication for the treatment of Attention-Deficit Hyperactivity Disorder (ADHD), works to treat ADHD…
- Trial name
- NCT07838311
- Testing
- Delayed-release, extended-release methylphenidate
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Massachusetts General Hospital
Alcohol Drinking, Alcohol Use Disorder
Contributing Factors of Solitary Drinking Among Adolescents and Young Adults
A convenience sample of 40 solitary drinkers aged between 10 and 24 will be invited to complete a structured questionnaire and a individual semi-structured interviews.
- Trial name
- NCT05337488
- Testing
- questionnaire with interview
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Recurrent Tonsillitis, Obstructive Sleep Apnea
Post-operative Pain Control After Pediatric Adenotonsillectomy
Adenotonsillectomy is one of the most common surgical procedures performed in the pediatric population in the United States. It is generally a well-tolerated procedure with post-operative bleeding risk ranging from 3-5% in…
- Conditions
- Recurrent Tonsillitis, Obstructive Sleep Apnea, Sleep Disordered Breathing, Adverse Reaction to Drug
- Trial name
- NCT02296840
- Testing
- Ibuprofen, Hydrocodone-Acetaminophen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Emory University
Urolithiasis, Urologic Diseases
Effectiveness of Drainage by PCN vs. JJ in Patients With Symptoms of Obstructive Kidney Disease Caused by Urolithiasis
To investigate the effectiveness of percutaneous nephrostomy catheter placement versus retrograde double J catheter placement in patients with symptoms of obstructive kidney disease (with either infection and/or pain and/or…
- Conditions
- Urolithiasis, Urologic Diseases, Urinary Calculi, Urinary Obstruction
- Trial name
- STONE (NCT04594161)
- Testing
- Percutaneous Nephrostomy, Double J catheter
- Where
- Netherlands
- Volunteers
- 204 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Substance-Related Disorders, Sexually Transmitted Diseases
Adolescent Drug and HIV Prevention in South Africa
The purpose of this trial is to test the effectiveness of a classroom-based prevention program (HealthWise: Learning Life Skills for Young Adults) to reduce the risk of HIV/AIDS and STIs, as well as substance use, among…
- Trial name
- NCT00336180
- Testing
- HealthWise South Africa curriculum
- Where
- South Africa
- Volunteers
- 7,695 people, healthy volunteers welcome
- Sponsor
- Penn State University
Fetal Alcohol Syndrome, Attention Deficit Hyperactivity Disorder (ADHD)
Open-Label Study of the Long Term Tolerability and Safety of Atomoxetine in Children With FASD and ADD/ADHD
Determine if atomoxetine is safe and well tolerated by children with fetal alcohol syndrome.
- Trial name
- B4Z-US-050 (NCT00418262)
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Oklahoma
Drug Induced Liver Injury
Drug-Induced Liver Injury (DILI) Network Retrospective
The purpose of this study is to establish retrospectively a nationwide registry of patients who have suffered drug-induced liver injury (DILI), and to collect, immortalize, and store serum, DNA, and lymphocytes from these…
- Trial name
- ILIAD (NCT00360646)
- Where
- 6 sites in United States
- Volunteers
- 400 people
- Sponsor
- Duke University
Alcoholic Liver Disease
Gut Mycobiome Profile in Alcoholic Liver Disease.
The fecal mycobiome, which refers to the community of fungi that resides in the human gut, is an important component of the gut microbiome.
- Trial name
- NCT05793190
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Risk Behavior, Substance Abuse
Juvenile Offender HIV Prevention and Drug Abuse Services
This study will determine the clinical effectiveness, moderators and mechanisms of change, and economic impact of an integrative, family-based intervention that concurrently targets change in HIV/Sexually Transmitted Disease…
- Conditions
- Risk Behavior, Substance Abuse, Delinquency
- Trial name
- Day Treatment (NCT01922297)
- Testing
- Day Treatment MDFT-HIV, Day Treatment SAU
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Miami
Attention Deficit Disorder With Hyperactivity, Marijuana Abuse
Atomoxetine for Treating Marijuana-Abusing Adolescents Who Have Attention Deficit Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder (ADHD) is common among adolescents seeking treatment for marijuana dependence. The purpose of this study is to determine the use of atomoxetine in treating adolescents who abuse marijuana…
- Trial name
- NCT00142961
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- New York State Psychiatric Institute
Neonatal Intensive Care Unit, Medication Errors
Drug-Related Problems in Neonatal Patients
Drug-related problems in newborn babies have been reported with a rate of 4-30%. It is estimated that the higher rates of these problems in hospitalized children under the age of two are related to the variety of drugs used and…
- Conditions
- Neonatal Intensive Care Unit, Medication Errors, Drug-Related Problems, Adverse Drug Event
- Trial name
- NCT04899960
- Testing
- Clinical Pharmacist Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 512 people
- Sponsor
- Hacettepe University
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