Clinical trials: Chemically-Induced Disorders
Posttraumatic Stress Disorder, Alcohol Use Disorders
CAP: Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders
The proposed study will examine the efficacy of doxazosin in the treatment of PTSD and alcohol use disorder or substance use disorders.
- Trial name
- Doxazosin (NCT02500602)
- Testing
- doxazosin
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- VA Office of Research and Development
Human Immunodeficiency Virus, Risk Reduction
Building Mobile HIV Prevention and Mental Health Support in Low-resource Settings
The purpose of this research study is to provide help and support for mental health and human immunodeficiency virus (HIV) risk reduction among Romanian gay and bisexual men.
- Conditions
- Human Immunodeficiency Virus, Risk Reduction, Alcohol Abuse, Depression, Anxiety
- Trial name
- NCT03912753
- Testing
- Comunică, Education Attention Control
- Where
- Romania
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Columbia University
Substance Use
Unidos Against ATOD Use Intervention Trial
Adolescent alcohol tobacco and drug (ATOD) use is a major public health concern, with rates for Latino middle school youth higher than other ethnic groups.
- Trial name
- TWC (NCT03642106)
- Testing
- Unidos Se Puede
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Lead Poisoning
Randomized Study of Succimer (Dimercaptosuccinic Acid) on Growth of Lead-Poisoned Children
OBJECTIVES: Compare growth of lead-poisoned children receiving succimer (dimercaptosuccinic acid; DMSA) plus standard treatment to those receiving standard treatment only.
- Trial name
- NCT00004838
- Testing
- succimer
- Volunteers
- 175 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Substance Use, Stress
Automating Peer Learning to Reduce Alcohol Use and Related Deviant Behavior in Secondary School
Deviant peer affiliation is one of the most important predictors of alcohol use in adolescence. These affiliations arise when socially marginalized youth self-aggregate and reinforce alcohol use and other deviant activity (i.e.…
- Conditions
- Substance Use, Stress, Relation, Interpersonal, Bullying
- Trial name
- PeerLearning (NCT04478240)
- Testing
- PeerLearning.net
- Where
- United States
- Volunteers
- 924 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Anxiety, Adolescent Development
Adverse Adolescent Pathways to Substance Use
Purpose: This 5-year R01 study will elucidate the role of maturational change across adolescence in neural connectivity and physiological stress responses in the relationship between anxiety and adverse pathways to substance use…
- Conditions
- Anxiety, Adolescent Development, Substance Use
- Trial name
- APSU (NCT06977178)
- Testing
- Trier Social Stress Test
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Substance-Related Disorders
Rapid Benzodiazepine Detoxification Using Flumazenil - 1
The purpose of this study is to verify the hypothesis that the benzodiazepine antagonist, flumazenil, will reduce acute benzodiazepine withdrawal.
- Trial name
- NCT00000246
- Testing
- Flumazenil
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Cigarette Smoking-Related Carcinoma
Electronic Cigarette Use During Pregnancy
Aim 1: To compare the overall toxicant exposure in pregnant women who use electronic cigarettes (e-cigs, vapor, e-liquid, e-juice, vape, vaping devices) compared to women who smoke conventional cigarettes. Aim 2.
- Trial name
- NCT03480373
- Where
- 6 sites in United States
- Volunteers
- 182 people
- Sponsor
- UConn Health
Opioid-Related Disorders, Alcohol-Related Disorders
Medication-Assisted Treatment Implementation in Community Correctional Environments (MATICCE)
The goal of this study is to see whether or not a strategic planning process is able to introduce and sustain improvements in the working relationship between probation/parole departments and community-based addiction treatment…
- Trial name
- MATICCE (NCT01344122)
- Testing
- KPI training only, KPI plus OLI
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Nicotine Dependence
Prize Reinforcement for Smoking Cessation
Nicotine dependence is prevalent in society, cigarette smoking is associated with several known health risks, and most dependent individuals find it very difficult to stop smoking cigarettes.
- Trial name
- NCT00865254
- Testing
- Standard Treatment, Traditional Contingency Management, Early Enhanced Contingency Management
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Alcohol or Other Drugs Use
Brief Substance Use Intervention for Youth in Teen Court
Youth involved in the juvenile justice system have multiple problems, including an earlier onset of alcohol and drug use and higher rates of alcohol and drug use than their peers in the general population.
- Trial name
- NCT01464554
- Testing
- Usual care, Project Free Talk
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- RAND
Homelessness, Substance Use Disorder (SUD)
Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing
The Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) Program provides subsidized permanent housing with case management to homeless-experienced Veterans (HEVs).
- Trial name
- CARE-VASH (NCT07141394)
- Testing
- Medication for Addiction Treatment (MAT), Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)
- Where
- United States
- Volunteers
- 7,908 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Substance Use
Peer-to-peer Tobacco and ENDS Prevention
In Phase I, the REAL media Plus prototype will be developed and a usability test conducted among students and teachers. In Phase II a group randomized trial will be conducted among 27 high schools to evaluate the effects of REAL…
- Trial name
- PPSM (NCT03491865)
- Testing
- REAL media Plus curriculum
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Real Prevention, LLC
Substance Abuse, Adolescent Behavior
An Evaluation of JUST Court in Yuma County, AZ
Arizona has created a pilot program for juvenile probationers called Juveniles under Supervision and Treatment (JUST), which includes swift and certain, but modest responses, to technical violations of the terms of juvenile…
- Conditions
- Substance Abuse, Adolescent Behavior, Juvenile Delinquency Unspecified
- Trial name
- JUST (NCT02449057)
- Testing
- JUST
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Pepperdine University
Alcohol Drinking, Binge Drinking
An Animation- Versus Text-based Computer-tailored Game Intervention to Prevent Alcohol Consumption in Adolescents
This study consists in the design, implementation and evaluation of an animation (Alerta Alcohol 2.0)- versus text-based (Alerta Alcohol) computer-tailored game intervention aimed to prevent alcohol consumption and binge drinking…
- Conditions
- Alcohol Drinking, Binge Drinking, Adolescent Behavior
- Trial name
- NCT04853628
- Testing
- Alerta Alcohol, Alerta Alcohol 2.0
- Where
- Spain
- Volunteers
- 2,625 people, healthy volunteers welcome
- Sponsor
- University of Seville
Complete Obstruction
Primary Anastomosis After Left Colectomy in Emergency Cases
The aim of this study is to know the outcome of primary anastomosis after left colectomy in emergency cases regarding early post operative complication like surgical site infection , ileus, incidence of leakage, restoration of…
- Trial name
- NCT07026201
- Testing
- colectomy with primary anastomosis
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Ain Shams University
Opioid Use Disorder
EMS-Initiated Buprenorphine
This is a multisite EMS study that will first conduct a sequence of pragmatic, prehospital field studies to provide preliminary feasibility, acceptability, and safety data for refinement and enhancement of a subsequent single-arm…
- Trial name
- EMS BUP (NCT07475728)
- Where
- 3 sites in United States
- Volunteers
- 495 people
- Sponsor
- Yale University
Organic, Including Symptomatic, Mental Disorders, Substance Use
Exploring the Comorbidity Between Mental Disorders and General Medical Conditions
Mental disorders have been shown to be associated with a number of general medical conditions (also referred to as somatic or physical conditions).
- Conditions
- Organic, Including Symptomatic, Mental Disorders, Substance Use, Schizophrenia, Mood [Affective] Disorders
- Trial name
- COMO-GMC (NCT03847753)
- Testing
- Organic Disorders, Substance Use Disorders, Schizophrenia Disorders
- Volunteers
- 5,940,299 people
- Sponsor
- University of Aarhus
Drug Hypersensitivity, Penicillin Allergy
Drug Challenges Without Prior Skin Testing
The investigators are conducting a prospective study to determine the safety and outcomes of placebo-controlled graded drug challenges without prior skin testing in patients with a low-risk history of antibiotic hypersensitivity…
- Conditions
- Drug Hypersensitivity, Penicillin Allergy, Antibiotic Allergy
- Trial name
- NCT03158831
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Envenomation, Snakebite, Envenomation
Clinical Profile and Antivenom Use in Hump-nosed Pit Viper Bites in Kerala, South India: A Review.
Several controversies exist in Hypnale bite management in Kerala. Even though leading bodies like WHO recommend against using antivenom for hypnale bites, many physicians still administer antivenom for snakebites even when the…
- Trial name
- NCT05954806
- Testing
- Antivenom Snakes
- Where
- India
- Volunteers
- 41 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
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