Clinical trials: Chemically-Induced Disorders, open to volunteers
Microbiome Analysis, Drug Abuse in Pregnancy
Alcohol and Cannabis Use Among Pregnant Slovenian Women
The aim of the study is to determine the prevalence of alcohol and drug use among Slovenian pregnant women. Alcohol and drug use during pregnancy has significant effects on the foetus and has short- and long-term health…
- Conditions
- Microbiome Analysis, Drug Abuse in Pregnancy, Alcohol Abuse in Pregnancy, Health Behavior, Risky
- Trial name
- NCT07456579
- Where
- Slovenia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Carbon Monoxide Poisoning, Myocardial Injury
CARbon monoxidE intoxiCatiOn in Korea: Prospective Cohort (CARE CO Cohort)
This prospective cohort study enrolls subjects who experience carbon monoxide (CO) poisoning. The purpose of the study is to evaluate therapeutic effects of various treatments and short and long-term outcomes in CO poisoned…
- Conditions
- Carbon Monoxide Poisoning, Myocardial Injury, Neurologic Deficits, Image, Body
- Trial name
- NCT04490317
- Testing
- Cardiac MRI, Hyperbaric oxygen therapy
- Where
- South Korea
- Volunteers
- 1,500 people
- Sponsor
- Wonju Severance Christian Hospital
Adverse Drug Reactions, Clinical Decision Support
Multi-Agent Collaborative ADR Prediction With Human-Machine Decision Comparison
This study develops a multi-agent collaborative prediction model to forecast adverse drug reactions using real-world clinical medical records.
- Trial name
- NCT07808866
- Testing
- Retrospective medical record data analysis only, no clinical intervention
- Where
- 2 sites in China
- Volunteers
- 20,000 people
- Sponsor
- Peking University Third Hospital
Substance Use, Binge Drinking
Substance Use Screening to Encourage Behavior Change Among Young People in Primary Care
This study evaluates whether completing a short screening questionnaire about health behaviours in the waiting room before a primary care consultation decreases excessive substance use in young people aged 14 to 24 years.
- Conditions
- Substance Use, Binge Drinking, Cannabis Use, Adolescent Behavior
- Trial name
- YP-HEALTH (NCT04146714)
- Testing
- Substance use questionnaire, Physical activity questionnaire
- Where
- Switzerland
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- Prof. Dagmar M. Haller
Occlusion
Assessment of the Occlusal Characteristics and Orthodontic Treatment Needs for Egyptian Children( 6-12)Years Old
The objective of this study is to assess the occlusal characteristics of Egyptian children 6-12 years old and their need for orthodontic treatment.
- Trial name
- NCT06402045
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Salma Hassan Widatalla Omar
Internalizing Disorders, Substance Use Disorders
Family Support Protocol for Adolescent Internalizing Disorders
This R34 will develop and test an adjunctive treatment protocol for addressing co-occurring internalizing disorders among adolescents enrolled in usual care for substance use problems.
- Trial name
- Fam-AID (NCT06413979)
- Testing
- Family Support Protocol for Adolescent Internalizing Disorders (Fam-AID)
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- The National Center on Addiction and Substance Abuse at Columbia University
Drug-induced Liver Injury
A Prospective Cohort Study on Drug-induced Liver Injury in China（DILI-P）
This is a multi-center, prospective, non-interventional cohort study . Its primary objectives are: 1. assess DILI patients' clinical characteristics, disease progression and influencing factors in clinical practice; 2.
- Trial name
- DILI-P (NCT02961413)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Drug Induced Liver Disease Study Group
Substance Use
Mindfulness-Based Substance Use Prevention (MINDS-UP)
The goal of this clinical trial is to test the feasibility, behavioral/neural mechanisms, and preliminary efficacy of "MINDfulness-based Substance Use Prevention Program," or "MINDS-UP", a novel substance use prevention…
- Trial name
- MINDS-UP (NCT06593470)
- Testing
- MINDS-UP, Prevention Plus Wellness
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Substance Use, Children
Testing and Evaluation of the Returning to the Land Intervention to Address and Prevent Substance Misuse
This study aims to test the Returning to the Land intervention in partnership with a tribal community. The program is designed to address caregiver substance use and child emotional and behavioral development.
- Conditions
- Substance Use, Children, Cultural Factors
- Trial name
- NCT07695818
- Testing
- Returning to the Land - Biodiverse Outdoor Setting, Control
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Crohn Disease, Ulcerative Colitis
Safety and Efficacy of Fecal Microbiota Transplantation
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease…
- Conditions
- Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome
- Trial name
- NCT04014413
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Chinese University of Hong Kong
Health Behavior, Wellness, Psychological
Teen Health Choices & Wellness
The goal of this observational study is to learn more about changes in health, wellness, and substance-use behaviors as teenagers get older.
- Conditions
- Health Behavior, Wellness, Psychological, Substance Use
- Trial name
- THC&W (NCT06822569)
- Testing
- Cue reactivity paradigm
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Brown University
Opiate-Related Disorders, Opiate Use Disorder
MedSMA℞T Mobile ED
The goal of this clinical trial is to learn if a new smartphone-based intervention can help with factors related to opioid misuse in parents and adolescent/early adult children.
- Conditions
- Opiate-Related Disorders, Opiate Use Disorder, Opioid
- Trial name
- NCT06848504
- Testing
- MedSMA℞T Mobile
- Where
- 3 sites in United States
- Volunteers
- 244 people
- Sponsor
- Olufunmilola Abraham
Substance-Related Disorders, Adverse Childhood Experiences
Evaluating an Adverse Childhood Experience-Targeting Advocate Model of a Substance Use Prevention Program
Primary Objective: Conduct a rigorous evaluation of a prevention-based intervention designed to mitigate the harms of adverse childhood experiences (ACEs) exposure and prevent future ACEs, substance use, and overdose within 36…
- Trial name
- NCT06236100
- Testing
- Strengthening Families Program + Family Advocate, Strengthening Families Program
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- RTI International
Adverse Drug Reaction (ADR)
National Active Surveillance Network and Pharmacogenomics of Adverse Drug Reactions in Children
The purpose of the study is (1) to identify and collect samples from children and adults who take drugs and have adverse drug reactions AND children and adults who take drugs and do not experience any adverse drug effects; (2) to…
- Trial name
- NCT00414115
- Where
- Canada
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Sleep
Circadian Rhythms and Homeostatic Sleep Drive and Their Effect on Reward and Cognitive Control Systems in Adolescents
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their…
- Trial name
- CARRS-P1 (NCT05336084)
- Testing
- Ultradian sleep/wake protocol
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Mother-Child Relations, Substance Use
Optimizing Mental Health for Infants Exposed to Early Adversity: A Comparison of Breaking the Cycle and Maxxine Wright
The goal of this clinical trial is to compare the effectiveness of the Breaking the Cycle (BTC) and Maxxine Wright (MW) programs in substance-involved mothers and their children.
- Trial name
- NCT05768815
- Testing
- Breaking the Cycle Program, Maxxine Wright Program
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University of Ottawa
Neoplasms
Determinants of Physical Activity Level in Pediatric Oncological Patients Treated With Cardiotoxic Therapy - a Study Protocol
Cancer treatment in children is generally effective, but unfortunately, it often comes with side effects-unwanted negative impacts.
- Trial name
- NCT06256068
- Volunteers
- 300 people
- Sponsor
- Medical University of Warsaw
Drug Induced Liver Injury
Drug-Induced Liver Injury (DILI) Network Retrospective
The purpose of this study is to establish retrospectively a nationwide registry of patients who have suffered drug-induced liver injury (DILI), and to collect, immortalize, and store serum, DNA, and lymphocytes from these…
- Trial name
- ILIAD (NCT00360646)
- Where
- 6 sites in United States
- Volunteers
- 400 people
- Sponsor
- Duke University
Obesity, Adolescent, Healthy Nutrition
Wakaya: Rising Up for Choctaw Youth Health
Investigators will conduct a two-group randomized waitlist-control trial to assess the efficacy of the Wakaya: Rising Up for Choctaw Youth Health program on improving physical activity, reducing sedentary behaviors and improving…
- Conditions
- Obesity, Adolescent, Healthy Nutrition, Sedentary Behavior, Drug Abuse
- Trial name
- Wakaya (NCT05818384)
- Testing
- Wakaya: Rising Up for Choctaw Youth Curriculum
- Where
- 2 sites in United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University of Washington
Neoplasm, Breast, Heart Failure
Breast Cancer Long-term Outcomes on Cardiac Functioning: a Longitudinal Study
Rationale: In addition to surgery, effective breast cancer (BC) treatment typically requires chemotherapy, radiotherapy, or both.
- Conditions
- Neoplasm, Breast, Heart Failure, Cardiotoxicity, Ventricular Dysfunction
- Trial name
- BLOC-II (NCT05851053)
- Testing
- Echocardiography
- Where
- Netherlands
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen