Clinical trials: Chest Syndrome
Aortic Dissection, Aortic Diseases
Antibiotic Prophylaxis for TEVAR
The infection rate of thoracic endovascular aortic repair (TEVAR) is unknown due to a lack of epidemiological data. The rate currently available comes from researches conducted decades ago, when open surgery was the standard of…
- Conditions
- Aortic Dissection, Aortic Diseases, Aortic Aneurysm, Thoracic, Coarctation of Aorta
- Trial name
- NCT05405790
- Testing
- thoracic endovascular aortic repair
- Where
- China
- Volunteers
- 457 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Respiratory Insufficiency of Prematurity
Level of Continuous Positive Airway Pressure (CPAP) in Preterm Infants After Extubation (L-CPAP Study)
Despite widely used of nasal CPAP in preterm infants, uncertainties regarding aspects of its application remain. Clinical indications vary greatly between institutions, especially when combined with varieties of systems, devices…
- Trial name
- L-CPAP (NCT00636324)
- Testing
- Nasal CPAP, level 7 to 9 cmH2O, Nasal CPAP, level 4 to 6 cmH2O
- Volunteers
- 23 people
- Sponsor
- Hamilton Health Sciences Corporation
Transient Tachypnea of the Newborn
Diagnosis of Transient Tachypnea of Newborn
Transient tachypnea of the newborn (TTN) is the most common cause of respiratory distress in fullterm newborn. TTN is a diagnosis of exclusion, It is primarily diagnosed based on medical history and typical clinical presentation.
- Trial name
- NCT05538780
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Thoracic Outlet Syndrome, Whiplash Injuries
Whiplash-induced Thoracic Outlet Syndrome Treated With Botulinum Toxin.
Whiplash injuries following car accident are common, it has been reported to affect 83% of individuals injured in traffic collisions (Yadla S, 2007).
- Trial name
- NCT05536570
- Testing
- IncobotulinumtoxinA 100 UNT
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- King, David, MD
Acute Coronary Syndrome, Chest Pain
Database of Patients Undergoing Cardiac Computed Tomographic Angiography at William Beaumont Hospital (CT DATABASE)
The purpose of the study is to establish an overarching database of information containing historical, demographical, clinical, and intermediate and long-term outcome data from all William Beaumont Hospital (WBH) patients…
- Trial name
- CTDATABASE (NCT00922662)
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Kavitha Chinnaiyan
Thoracic Insufficiency Syndrome (TIS)
Vertical Expandable Prosthetic Titanium Rib (VEPTR) for Thoracic Insufficiency Syndrome
The hypothesis of the study is that individuals with poor pulmonary function secondary to TIS will benefit from expansion thoracoplasty. The investigators specific aims are to: 1.
- Trial name
- VEPTR (NCT02241954)
- Testing
- Synthes VEPTR (Vertical Expandable Prosthetic Titanium Rib)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University Medical Center
Preterm Birth, Premature
Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm Newborns
Infants in the neonatal intensive care unit (NICU) may be lost due to risks such as being sensitive, frequent exposure to birth complications and being prone to infection.
- Conditions
- Preterm Birth, Premature, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
- Trial name
- therapy (NCT05036603)
- Testing
- chest physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sanko University
Asthma, Chest Syndrome
Clinical Characteristics, Treatment and Prognosis of Chest Tightness Variant Asthma
Asthma, abbreviation for bronchial asthma, is one of the common chronic airways disease that threatens human health. Typical symptoms of asthma are recurrent wheezing, shortness of breath, chest tightness and cough, usually…
- Conditions
- Asthma, Chest Syndrome, Clinical Anxiety, Clinical Depression
- Trial name
- NCT03237221
- Testing
- Treat patient according to Global Initiative for Asthma (GINA) guideline
- Where
- 34 sites in China
- Volunteers
- 76 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Aortic Arch, Aneurysm
Arch Size Study for Anatomical Variations
The aortic arch with a common origin of the innominate and left carotid artery (CILCA) prevalence in the general population is 13.6%.
- Conditions
- Aortic Arch, Aneurysm, Dissection, Aortic
- Trial name
- NCT06235619
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele
Sickle Cell Disease, Vaso-occlusive Crisis
A Study of Varespladib Infusion in Subjects With Sickle Cell Disease.
The purpose of this study is to determine the effectiveness of A 001 infusion in preventing acute chest syndrome in sickle cell disease (SCD) subjects with vaso-occlusive crisis, fever, and elevated serum C-reactive protein (CRP).
- Trial name
- IMPACTS-2 (NCT01522196)
- Testing
- Varespladib
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Anthera Pharmaceuticals
Aorta Dissection, Aorta Aneurysm
Hybrid Operation in Thoracic Aortic Dissection
The purpose of this study is to investigate the short to mid term efficacy and safety of different hybrid operations who had complex aortic lesions, such as ascending aortic/arch aneurysm, pseudo-aneurysm, Stanford Type A…
- Trial name
- NCT01500395
- Testing
- Hybrid operation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xijing Hospital
Acute Chest Syndrome, Sickle Cell Disease
Ultrasound Acute Chest Syndrome Sickle Cell Disease
Feasibility and reliability of ultrasound in the inpatient hematology setting.
- Trial name
- POCUS (NCT06880679)
- Testing
- Point of Care Ultrasound
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Indiana University
Pain Crisis
Natural History of Sickle Cell Disease
This study is not a treatment protocol and no experimental treatments are involved. Study participants may be seen as needed for clinical, translational and basic research studies, or as medically indicated.
- Trial name
- NCT00081523
- Where
- 3 sites in United States
- Volunteers
- 3,500 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Thoracic Aortic Aneurysm, Penetrating Aortic Ulcer
Zenith Thoracic Alpha (ZTA) Post-Market Data Collection
This study aims to gather real-world clinical data demonstrating the continued safety and performance of the a marketed stent graft (Zenith® Alpha Thoracic Endovascular Graft [ZTA]) and collect longer term follow-up to better…
- Trial name
- NCT06094127
- Testing
- Endovascular aortic treatment
- Where
- 10 sites in France, Germany and 2 more
- Volunteers
- 300 people
- Sponsor
- Cook Research Incorporated
Cancer
Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor
RATIONALE: When irradiated lymphocytes from a donor are infused into the patient they may help the patient's immune system kill cancer cells.
- Trial name
- NCT00161187
- Testing
- therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Neonatal Respiratory Distress Syndrome, PreTerm Neonate
MINImising Total Radiation EXposure in Preterm Infants
Being born too early (preterm birth) is the leading cause of death in children world-wide. In Australia, 97% of very preterm babies who are admitted to Neonatal Intensive Care Units need breathing support after birth to survive.
- Trial name
- MINI T-Rex (NCT06975189)
- Testing
- Lung ultrasound group, Standard Care
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- Western Health, Australia
Sickle Cell Disease
A Phase 1 Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest Syndrome
Sickle cell disease is a genetic red blood cell disorder characterized by vaso-occlusion from sickling of red blood cells, that can lead to pain or organ complications such as acute chest syndrome.
- Trial name
- NCT02697240
- Testing
- Intravenous citrulline
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Mississippi Medical Center
Lung Injury, Acute, Respiratory Distress Syndrome, Adult
Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant
The purpose of this study is to determine the effectiveness of etanercept in the treatment of patients with sub-acute lung injury following a bone marrow transplant.
- Conditions
- Lung Injury, Acute, Respiratory Distress Syndrome, Adult, Bronchiolitis Obliterans
- Trial name
- NCT00141726
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan Rogel Cancer Center
Thoracic Outlet Syndrome
First Rib Resection Versus Avulsion for Thoracic Outlet Syndrome
The management of thoracic outlet syndrome can be either surgical or nonsurgical. Fewer than 20% of patients experience benefits from nonsurgical treatments.
- Trial name
- NCT06095700
- Testing
- first rib resection, First rib avulsion
- Where
- Iraq
- Volunteers
- 50 people
- Sponsor
- University of Sulaimani