Clinical trials: Child Development Disorders, Specific
Math Learning Disability, Child Development
Interventions in Mathematics and Cognitive Skills
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning…
- Conditions
- Math Learning Disability, Child Development, Developmental Disability, Learning Disabilities
- Trial name
- NCT05201534
- Testing
- Interventions in Mathematics and Cognitive Skills - Experimental, Interventions in Mathematics and Cognitive Skills - Active Comparator
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Stanford University
Electroencephalography, Child
Dexmedetomidine and Melatonin for Sleep Induction for EEG in Children
The aim of the study is to compare the effect of melatonin, given orally, dexmedetomidine, given intranasally, and dexmedetomidine given sublingually on sleep induction, sleep duration, their possible impact on vital functions…
- Conditions
- Electroencephalography, Child, Dexmedetomidine, Melatonin
- Trial name
- MeloDex (NCT04665453)
- Testing
- Electroencephalography, Monitoring of vital functions, Melatonin 0,1mg/kg oral syrup
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Autism, Asperger's Syndrome
Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety
Autism spectrum disorders affect as many as 1 out of 88 children and are related to significant impairment in social, adaptive, and school functioning.
- Conditions
- Autism, Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified, Generalized Anxiety Disorder
- Trial name
- NCT01919970
- Testing
- Cognitive Behavioral Therapy, Treatment as usual
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Developmental Delay Disorder, Intellectual Disability
Clinical Trial of the Dual Vector Base Editor for the Treatment of the CHD3-R1025W Mutation
To evaluate the safety, tolerability and preliminary efficacy study of a single intrathecal injection of the dual vector AAV-CHD3-R1025W base editor for the treatment of developmental disorders caused by the R1025W mutation in…
- Conditions
- Developmental Delay Disorder, Intellectual Disability, Rare Diseases
- Trial name
- NCT06860672
- Testing
- Dual vector DNA base editor
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Yongguo Yu
ALS, Autism Spectrum Disorder
Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products
This is an observational study of medical marijuana manufactured and dispensed by Ilera and given as standard treatment for a variety of approved serious medical conditions as defined by individual state law.
- Conditions
- ALS, Autism Spectrum Disorder, Cancer, Spasticity, Muscle
- Trial name
- Ilera (NCT03886753)
- Testing
- Registry, PK microsampling of blood
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Philadelphia
HIE - Hypoxic - Ischemic Encephalopathy, Language Delay
Speech of Kids After Neonatal Encephalopathy
The goal of this ambispective cohort study is to reveal the early indicators of delayed language development in children born with hypoxic-ischemic encephalopathy (HIE).
- Conditions
- HIE - Hypoxic - Ischemic Encephalopathy, Language Delay, Autism, ADHD - Attention Deficit Disorder With Hyperactivity
- Trial name
- SANE (NCT07136636)
- Where
- Hungary
- Volunteers
- 93 people
- Sponsor
- Semmelweis University
Developmental Dyslexia
Brain Stimulation With Combined Reading and Motor Training for Children With Dyslexia
This study examines whether combining non-invasive brain stimulation (tDCS) with an integrated reading-and-motor training program improves reading and phonological processing in 9-year-old boys with developmental dyslexia.
- Trial name
- NCT07781761
- Testing
- Active transcranial direct current stimulation (tDCS), Phonological awareness training, Non-targeted fine motor training
- Where
- Iran
- Volunteers
- 160 people
- Sponsor
- Shahid Beheshti University
Dyslexia, Developmental
Neurofunctional Correlates of the Behavioral Modifications Associated With Tachidino in Children With Developmental Dyslexia
Developmental dyslexia (DD) is the most common learning disorder. Multiple cognitive and sensory domains contribute to the etiology of DD and develop before reading acquisition.
- Trial name
- TACHIDINO (NCT05373576)
- Testing
- TACHIDINO
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Eugenio Medea
Language Development Disorders
Improving STEM Outcomes for Young Children With Language Learning Disabilities Via Telehealth
In this study the investigators focus on a subset of at-risk students who find the language of science to be a barrier to the learning of science. These are the nearly 3 million children in the U.S.
- Trial name
- NCT04775199
- Testing
- Language Intervention
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Karla McGregor
ICU Acquired Weakness
Development of an Early Warning Model for Intensive Care Unit-Acquired Weakness in Mechanically Ventilated Children
Acquired weakness (AW) is a common complication among patients in the Intensive Care Unit (ICU). It is a systemic muscle weakness and dysfunction associated with critical illness, often related to prolonged bed rest, mechanical…
- Trial name
- NCT07150637
- Testing
- ICU-AW
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Children's Hospital of Fudan University
Developmental Language Disorder, Language Disorders in Children
The Influence of Immersive Virtual Field Trips on Academic Vocabulary
The purpose of this study is to investigate an immersive virtual field trip (iVFT) on topic specific academic vocabulary for students with developmental language disorder (DLD).
- Trial name
- NCT05242575
- Testing
- The information provided in the iVFT and control book parallel one another.
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Salus University
Developmental Dyscalculia
tRNS Combined to Cognitive Training in Children With Dyscalculia
The present study grounds on the absence of evidence-based treatment in individuals with developmental dyscalculia (DD). At this topic, the present study will explore the potential effect of transcranial random noise stimulation…
- Trial name
- NCT04242680
- Testing
- Brainstim DLPFC, Brainstim PPC, Cognitive Training
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Anxiety Disorders in Youth With Autism, Asperger's Syndrome, and Pervasive Developmental Disorder Not Otherwise Specified
Cognitive Behavioral Therapy (CBT) for Anxiety Disorders in Autism: Adapting Treatment for Adolescents
Comorbid anxiety disorders affect as many as 80% of youth with autism spectrum disorders, causing substantial distress and impairment over and above the autism spectrum diagnosis alone.
- Trial name
- NCT01177969
- Testing
- Cognitive-Behavioral Therapy, Wait-list
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Intellectual Developmental Disorder, Malformations
The Belgian Genome Resource to Resolve Rare Diseases
Whole-exome (WES) or whole-genome sequencing (WGS) are recommended as first- or second-tier molecular tests for patients with developmental disorders (DD), but the clinical utility of WGS continues to be debated.
- Conditions
- Intellectual Developmental Disorder, Malformations, Dysmorphia, Developmental Delay (Disorder)
- Trial name
- BeSolveRD (NCT07051213)
- Testing
- Whole exome sequencing, Whole genome Sequencing
- Where
- Belgium
- Volunteers
- 567 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Learning Disorders, Specific, Developmental Disability
Using a New Calibrated Tool in Specific Language and Learning Disorders : the BMTi
The group of experts at HAS has defined the places of first and second-line workers in specific disorders of development and learning, as defined in the international diagnostic classifications International Classification of…
- Trial name
- ValidBMTI (NCT03919357)
- Testing
- BMT-i
- Where
- 16 sites in France, Martinique
- Volunteers
- 229 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Language Disorders in Children
Let's Know!2: Language-focused Intervention for Children at Risk of Comprehension Difficulties
In the proposed project, the investigators will conduct a multisite randomized controlled trial (RCT) to determine the efficacy of Let's Know!2, a small-group, language focused comprehension intervention, on children's lower- and…
- Trial name
- LK!2 (NCT05133479)
- Testing
- Let's Know! small-group or TierL 2 Intervention
- Where
- 2 sites in United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Autism Spectrum Disorder, Autism
Mitochondrial Dysfunction in Autism Spectrum Disorder
Researchers at Arkansas Children's Hospital Research Institute are conducting a study about mitochondrial function in children. The study involves up to 5 visits to Arkansas Children's Hospital with fasting blood draws…
- Conditions
- Autism Spectrum Disorder, Autism, Mitochondrial Disease, Developmental Delay
- Trial name
- Mito (NCT02000284)
- Where
- United States
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Genetic Disease, Neurologic Disorder
Use of Long Read Genome Sequencing in Patients Suffering From Neurodevelopmental Troubles
Patients with neurodevelopmental diseases and their families need to identify the genetic cause of the disease to allow for recognition of the disability, genetic counseling, and possible hope for participation in therapeutic…
- Conditions
- Genetic Disease, Neurologic Disorder, Developmental Delay Disorder, Growth Disorders
- Trial name
- HiFi-NDD (NCT05643274)
- Where
- 5 sites in France
- Volunteers
- 10 people
- Sponsor
- Nantes University Hospital
Developmental Dyslexia
Comparing the Efficacy of tDCS and tRNS to Improve Reading Skills in Children and Adolescents With Dyslexia
The present study grounds on the absence of evidence-based treatment in individuals with developmental dyslexia (DD). At this topic, the present study will explore the potential effect of transcranial random noise stimulation…
- Trial name
- NCT05832060
- Testing
- Active tDCS, Active tRNS
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bambino Gesù Hospital and Research Institute
Developmental Delay Disorder, Repetitive Transcranial Magnetic Stimulation (rTMS)
Repetitive Transcranial Magnetic Stimulation Combined With Language Training for Language Disorders in Children With Global Developmental Delay
This study explores a safe and effective new approach to improve language function in children with Global Developmental Delay (GDD).
- Conditions
- Developmental Delay Disorder, Repetitive Transcranial Magnetic Stimulation (rTMS), Global Developmental Delay, Language Disorders in Children
- Trial name
- NCT07369960
- Testing
- Transcranial magnetic stimulation, individualized language training
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xiangya Hospital of Central South University