Clinical trials: Child Mortality
Tuberculosis
Isoniazid Prophylaxis With Concomitant Cotrimoxazole in HIV-infected Children
The study involves use of isoniazid and cotrimoxazole as strategies for preventing infections in HIV-infected children and reducing mortality.
- Trial name
- NCT00330304
- Testing
- Isoniazid, Cotrimoxazole
- Where
- 2 sites in South Africa
- Volunteers
- 450 people
- Sponsor
- University of Cape Town
Measles Infection
Additional Measles Vaccine at 4 Months of Age
Overall objective: To conduct a randomised controlled trial (RCT) to examine whether an early two-dose measles vaccination (MV) strategy at 4 and 9 months will reduce child mortality compared with the WHO strategy of one dose of…
- Trial name
- NCT01486355
- Testing
- Measles vaccine
- Where
- Guinea-Bissau
- Sponsor
- Bandim Health Project
Pesticide Exposure
Incidence and Mortality of Childhood Cancer Among Children of Farmer Pesticide Applications
Previous studies have estabished pesticide exposure as a possible risk factor for childhood cancer. The Agricultural Health Study (AHS), a prospective cohort study of pesticide exposure among 51,000 pesticide applicators in North…
- Trial name
- NCT00339378
- Where
- 3 sites in United States
- Volunteers
- 21,985 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Child Rearing, Adolescent Development
Follow-up of Families in Early Preventive Intervention
This project supports the post-third-grade assessment of 693 children and their families who were enrolled in a randomized trial of a program of prenatal and infancy home visitation by nurses that was epidemiologically and…
- Conditions
- Child Rearing, Adolescent Development, Reproductive Behavior, Risk Reduction Behavior
- Trial name
- MemphisYear9 (NCT00438516)
- Testing
- nurse home visitation
- Where
- United States
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Mortality, Morbidity
Birth Cohort in Coast Province, Kenya
In 2010, 7.6 million children under the age of five died worldwide and yet the causes of only 2.7% (0.205 million) of these deaths were medically certified.
- Conditions
- Mortality, Morbidity, Child Development, Child Behaviour
- Trial name
- NCT02448615
- Where
- 2 sites in Kenya
- Volunteers
- 283 people
- Sponsor
- The Hospital for Sick Children
Mortality, Resistance Bacterial
Azithromycin for Child Survival in Niger: Mortality and Resistance Trial
The MORDOR trial found that biannual distribution of azithromycin to children 1-59 months old reduced child mortality. The World Health Organization (WHO) released conditional guidelines for this intervention, which include…
- Conditions
- Mortality, Resistance Bacterial, Child, Only
- Trial name
- AVENIR (NCT04224987)
- Testing
- Azithromycin
- Where
- Niger
- Volunteers
- 864,493 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Children, Anaesthesia
NEonate-Children sTudy of Anaesthesia pRactice IN Europe Epidemiology of Morbidity and Mortality in Neonatal Anaesthesia
To study the 30-day morbidity and mortality after neonatal anaesthesia, and predictive factors that can be responsible for poor outcome.
- Trial name
- NECTARINE (NCT02350348)
- Where
- 10 sites in Belgium, Denmark and 7 more
- Volunteers
- 5,500 people
- Sponsor
- European Society of Anaesthesiology
Maternal-Child Health Services, Health Service Utilization
Integrated Community Based Health Systems Strengthening Preliminary Study in Kozah Togo
This preliminary study aims to inform the design and delivery of the integrated facility and community-based health systems strengthening (ICBHSS) model in four Kozah District health facilities over a period of 48 months.
- Trial name
- ICBHSS-Kozah (NCT03773913)
- Testing
- ICBHSS model
- Where
- Togo
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Integrate Health
Fever
Biomarkers of Mortality and Morbidity in Children Hospitalized With Fever
The objective of this study is to identify clinically informative biomarkers of host defense pathways with potential utility as diagnostic and prognostic tools among children hospitalized with acute febrile illness in a…
- Trial name
- NCT04726826
- Testing
- Diagnostic and prognostic biomarkers
- Where
- Uganda
- Volunteers
- 2,500 people
- Sponsor
- University of Alberta
Nutrition
Community Trial of Zinc Supplementation on Preschool Child Mortality and Morbidity in Southern Nepal
The purpose of this study is to determine whether daily supplementation of young children in Nepal with either zinc, iron-folic acid, or both can reduce mortality and morbidity.
- Trial name
- NCT00109551
- Testing
- zinc sulphate dietary supplement, iron sulphate-folic acid dietary supplement
- Where
- 3 sites in United States, Nepal
- Volunteers
- 58,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Child Mortality
Infant Mortality Reduction by the Mass Administration of Azithromycin
This trial will investigate the supplementation of azithromycin distribution to the "Child Health Days" platform in Burkina Faso for child mortality reduction.
- Trial name
- MIRAMA (NCT04716712)
- Testing
- Azithromycin
- Where
- 3 sites in United States, Burkina Faso
- Volunteers
- 694,400 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pediatric Dilated Cardiomyopathy
A Study of Impact of Anemia on Morbidity and Mortality in Children With Dilated Cardiomyopathy
Dilated cardiomyopathy is a heart muscle disorder characterized by systolic dysfunction and dilation of the left or both ventricles.Dilated cardiomyopathy can develop in people of any age or ethnicity, although it is more common…
- Trial name
- NCT03214757
- Testing
- treatment of anemia.
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diarrhea
Antibiotics for Children With Severe Diarrhoea
Although the current World Health Organization (WHO) recommended management package for acute diarrhoea (ORS, zinc and feeding advice) has contributed to significant reductions in diarrhoea associated mortality, over half a…
- Trial name
- ABCD (NCT03130114)
- Testing
- Azithromycin
- Where
- 7 sites in Bangladesh, India and 5 more
- Volunteers
- 8,268 people
- Sponsor
- World Health Organization
Neonatal Death, Mental Competency
Survive and Thrive Boa Vista Early Childhood Program
The proposed project will tackle the two most salient problems for children under 5 in Brazil: the continued high rates of neonatal mortality, and the large disparities in early childhood development.
- Trial name
- STBV (NCT03386747)
- Testing
- Home visits to improve parenting behaviors, Center based parenting groups
- Where
- Brazil
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Malaria,Falciparum, Feasibility
Malaria Vaccine Pilot Evaluation
The RTS,S/AS01 malaria vaccine is being introduced sub-nationally in phased pilot introductions through the EPI programmes in Malawi Ghana and Kenya.
- Conditions
- Malaria,Falciparum, Feasibility, Safety, Mortality
- Trial name
- MVPE (NCT03806465)
- Testing
- Feasibility survey, Sentinel hospital surveillance, Community mortality surveillance
- Where
- 3 sites in Ghana, Kenya and 1 more
- Volunteers
- 30,124 people, healthy volunteers welcome
- Sponsor
- Rafiq OKINE
Measles Vaccination, Oral Polio Vaccine
Vaccine Campaign Effects on General Hospital Admissions and Mortality Among Children
The world is set on eradicating measles and polio infections in the coming decade. Once both infections are under control, campaigns with measles and oral polio vaccines will be phased out.
- Conditions
- Measles Vaccination, Oral Polio Vaccine, Non-specific/Heterologous Effects of Vaccines, Mortality
- Trial name
- RE-CAMP (NCT03460002)
- Testing
- Measles vaccine, Oral polio vaccine
- Where
- Guinea-Bissau
- Volunteers
- 28,612 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Childhood Illness
Community-Integrated Management of Childhood Illness (IMCI) Programme Evaluation
The proposed four-year randomized study will attempt to test the hypothesis that community-based child health interventions in conjunction with facility-based IMCI will improve child care practices, nutritional status and child…
- Trial name
- NCT00979797
- Testing
- Community-based interventions to promote maternal and child health
- Where
- Bangladesh
- Volunteers
- 140,000 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Reproductive, Maternal, Newborn, and Child Health, Integrated, Community-Health Systems
Implementing an Integrated RMNCH Intervention by Community Health Workers in Achham and Dolakha: National Pilot
The investigators will conduct a cluster-controlled, stepped wedge implementation science trial of a bundled reproductive, maternal, neonatal, and child healthcare (RMNCH) delivery intervention within an approximate population of…
- Trial name
- NCT03371186
- Testing
- Community Health Worker, Continuous Surveillance, CB-Integrated Management of Newborn and Childhood Illness
- Where
- 2 sites in Nepal
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Possible
Septic Shock, Sepsis, Severe
As an Early Indicator Biomarker of Prognosis and Mortality in Children With Sepsis and Septic Shock: suPAR
The sepsis and septic shock remain major causes of child morbidity and mortality, despite the use of modern antibiotics and resuscitation therapies.
- Trial name
- suPAR (NCT04459572)
- Testing
- suPAR
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ege University
Severe Malaria
Clinical Prediction Models for Pediatric In-Hospital Death Risk in Congolese Severe Malaria Children Using Machine Learning Based-Algorithms
The goal of this observational study is to optimize the management of severe childhood malaria, based on understanding and controlling the severity factors of the disease in Congolese children aged 2 to 9 years (the age group at…
- Trial name
- NCT07355426
- Testing
- Puncture of the radial artery for instant arterial blood gaz as well as for venous biochemistry
- Where
- Democratic Republic of the Congo
- Volunteers
- 100 people
- Sponsor
- University of Kinshasa