Clinical trials: Chronic Brain Injury
Cerebral Palsy
Early Childhood Constraint Therapy in Cerebral Palsy
This is a prospective interventional study involving young children who will all receive non-invasive, passive assessments of sensory and motor function.
- Trial name
- APPLES (NCT02567630)
- Testing
- Soft Mitt Constraint Therapy for Sensory/Motor Impairment in Cerebral Palsy
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Cerebral Palsy
Robotic Exoskeleton Gait Training in Adolescents With Cerebral Palsy
The study design will consist of a cohort of adolescents and young adults with cerebral palsy (CP) that will undergo a gait training protocol.
- Trial name
- NCT05158218
- Testing
- Robotic Exoskeleton Gait Therapy, Physical Therapy
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Father Flanagan's Boys' Home
Cognitive Dysfunction, Acquired Brain Injury
Fareon Open Label Device Clinical Trial
The purpose of this study is to assess the safety and feasibility of an at-home MMT treatment in patients with cognitive dysfunction related to acquired brain injury, Long COVID, traumatic brain injury, myalgic encephalomyelitis…
- Conditions
- Cognitive Dysfunction, Acquired Brain Injury, Traumatic Brain Injury
- Trial name
- NCT07600320
- Testing
- Fareon device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cerebral Palsy, Osteoporosis
Influence of Verticalization on Bone Mineral Density and Biological Parameters of Bone Remodeling in Children With Severe Cerebral Palsy
Low bone mineral density affects 77% of children with severe cerebral palsy (GMFCS IV \& V) with an increased fracture risk of 4%. One strategy supposed to improve bone mineral density is verticalisation with static devices.
- Conditions
- Cerebral Palsy, Osteoporosis, Bone Mineral Density, Bone Remodeling Disorder
- Trial name
- CPABONE (NCT04761666)
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cerebral Palsy Spastic Diplegia
Comparison of the Effects of Vojta and Bobath Treatment on Gait and Balance in Diplegic Cerebral Palsy
This study aims compare the effects of Vojta verses Bobath therapy on gait in children with diplegic cerebral palsy and to compare the effects of Vojta versus Bobath therapy on balance in children with diplegic cerebral palsy.
- Trial name
- NCT06757101
- Testing
- Vojta Therapy, Bobath Therapy, Combined Vojta and Bobath Therapy
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Riphah International University
Cerebral Palsy (CP)
Intensive Rehabilitation Program for Upper Limb in Children and Adolescents With Cerebral Palsy
Cerebral palsy is the most common motor disability in children. Individuals with CP often experience significant difficulties in the use of their upper limbs, which affects their autonomy and quality of life.
- Trial name
- NCT07285837
- Testing
- Intensive Rehabilitation
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Fondation Ellen Poidatz
Cerebral Palsy (CP), Hand Functions
Hand-10 Questionnaire in Children With Unilateral Cerebral Palsy
A Turkish version of the Hand-10 (unabbreviated) questionnaire has been developed, but its validity and reliability in cerebral palsy has not yet been proven.
- Trial name
- NCT06887530
- Testing
- Hand-10 questionnaire and ABILHAND-kids questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Gazi University
Spastic Hemiplegic Cerebral Palsy
The Effect of Mirror Therapy on Cerebral Re-organization, Functional Motor Skills, and Quality of Life in Hemiplegic Cerebral Palsy
The purpose of this study is to investigate brain reorganization, functional motor development, level of daily living activity and quality of life of upper extremity mirror therapy in children with spastic hemiplegic cerebral…
- Trial name
- NCT03612128
- Testing
- control group, intervention group
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Hacettepe University
Spastic/Dystonic Quadriplegia, Cerebral Palsy (CP)
Outcomes of Neurosurgical Tone Management
Patients with spastic/dystonic quadriplegia (GMFCS IV/V) are often severely disabled by their tone, and require surgical tone management to improve quality of life, allow for better function, improve comfort, and range of motion.
- Trial name
- NCT07817745
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Spastic Diplegia
Phase II Randomized Study of Selective Dorsal Rhizotomy and Physiotherapy Vs Physiotherapy Alone for Spastic Diplegia
OBJECTIVES: I. Assess the efficacy and safety of selective dorsal rhizotomy and physiotherapy compared with physiotherapy alone in improving gross motor function and reducing spasticity in children with spastic diplegia.
- Trial name
- NCT00004751
- Testing
- Surgery, Physical therapy
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spastic Cerebral Palsy, Dysarthria
Lateral Cord Magnetic Stimulation For Refractory Spastic Cerebral Palsy
Lateral cord stimulation (LCS) was discovered by the author as the producer of an average threshold increase for abnormal muscle contraction responses, in experimental pathological conditions, as described and referred.
- Trial name
- NCT03676439
- Testing
- Magnetic Spinal Stimulation
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Sociedad Argenttina de Neuromodulación
Cerebral Palsy, Functioning
Effects of Action Observation Therapy and Mirror Therapy in Children With Unilateral Cerebral Palsy
The aim of this study was to examine the effects of action observation therapy and mirror therapy on upper extremity functions in children with unilateral cerebral palsy.
- Conditions
- Cerebral Palsy, Functioning, Upper Extremity Problem
- Trial name
- NCT05951829
- Testing
- Action Observation Therapy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Cerebral Palsy
Usability and Effectiveness of the ATLAS2030 Exoskeleton in Children With Cerebral Palsy
The main objective of this study is to assess the usability and efficacy of receiving therapy with the peaditric exoskeleton ATLAS 2030in children with gait impairment due to a cerebral palsy condition.
- Trial name
- NCT05551364
- Testing
- ATLAS 2030 exoskeleton
- Where
- 6 sites in Spain
- Volunteers
- 30 people
- Sponsor
- MarsiBionics
Physical Disability, CP (Cerebral Palsy)
Evaluating the Impacts of a Single Session of Robot Assisted Gait Training With a Trexo
Early use of robotic gait trainers have shown many benefits, however why these benefits occur and how to maximize them is unknown.
- Conditions
- Physical Disability, CP (Cerebral Palsy), Developmental Disability
- Trial name
- NCT06407219
- Testing
- Robot Assisted Gait Training
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Cerebral Palsy, Lower Urinary Tract Symptoms
Incontinence and MRI Results in Children with Cerebral Palsy
More than 50 % of children and adults with cerebral palsy experience lower urinary tract symptoms (LUTS). This can negatively influence quality of life of the child and the total social environment.
- Trial name
- NCT05060211
- Testing
- Vancouver symptom score for dysfunctional elimination syndroms, Magnetic resonance imaging
- Where
- Belgium
- Volunteers
- 125 people
- Sponsor
- University Hospital, Ghent
Spastic Cerebral Palsy
INcobotulinumtoxina in ChIldren Upper and Lower Limb sPasticITy (INCIPIT)
Prospective, open-label, non-randomized, single-arm, dose titration, phase II study. The study will consist of three injection cycles. In each, an injection visit is followed by an observation period of 12 to 20 weeks.
- Trial name
- INCIPIT (NCT05340439)
- Testing
- IncobotulinumtoxinA 100 UNT [Xeomin]
- Volunteers
- 30 people
- Sponsor
- Universita di Verona
Cerebral Palsy, Spina Bifida
A Peer E-mentoring Intervention to Improve Employment
Despite the strong business case of hiring people with disabilities, a significant proportion of youth with disabilities leave high school and neither work nor continue their education and are unprepared to meet the demands of a…
- Conditions
- Cerebral Palsy, Spina Bifida, Juvenile Arthritis, Spinal Cord Injury
- Trial name
- NCT02522507
- Testing
- Empowering youth towards employment
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Cerebral Palsy
Effects of Associated Impairments on Activity and Participation in Children With Cerebral Palsy
This study will investigate the effects of associated impairments on the activity levels and social participation of school-aged children with Cerebral Palsy (aged 6-12) and their impact on their families' quality of life and…
- Trial name
- NCT06944171
- Where
- Turkey (Türkiye)
- Volunteers
- 107 people
- Sponsor
- Hacettepe University
Cerebral Palsy
PedBot Ankle Rehablitation
The primary objective of the study is to determine engagement with use and adherence to a home exercise program with our PedBotHome ankle rehabilitation device.
- Trial name
- NCT05825508
- Testing
- ankle robot
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's National Research Institute
Spastic Diplegia, Cerebral Palsy
Effect of Core Stability Training on Segmental Trunk Control and Quality of Life in Children with Cerebral Palsy
Spastic diplegia is a common shape of cerebral palsy that significantly affects trunk control and quality of life in children. Core stability training (CST) has been utilized as a potential intervention to improve the trunk…
- Trial name
- NCT06822296
- Testing
- Physical Therapy, Designed rehabilitation program
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University