Clinical trials: Chronic Constipation
Chronic Functional Constipation
Effectiveness & Safety of Promelaxin® Microenemas Against Macrogol 4000 P.O. in Chronic Constipation in Children 6-48 Months
The study is aimed at the efficacy and safety evalutation of the study treatments through a 2-weeks study period and the subsequent follow-up-
- Trial name
- NCT02751411
- Testing
- micro-enema with Promelaxin, Macrogol 4000
- Where
- 4 sites in Italy
- Volunteers
- 158 people
- Sponsor
- Aboca Spa Societa' Agricola
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Fecal Calprotectin Collection Protocol
The primary objective is to obtain stool samples from subjects diagnosed with , and displaying signs and/or symptoms of IBD and/or IBS will be evaluated in this study.
- Conditions
- Inflammatory Bowel Diseases, Irritable Bowel Syndrome, Ulcerative Colitis, Crohn Disease
- Trial name
- CALFE (NCT03143517)
- Testing
- Stool collection
- Where
- 13 sites in United States
- Volunteers
- 240 people
- Sponsor
- DiaSorin Inc.
Constipation - Functional
Effect and Safety of the Dietary Supplement Mannite in Pediatric Patients With Chronic Functional Constipation
Functional constipation is a widely prevalent pediatric issue, with a prevalence in some studies as high as 32.2%. Treatment consists of a combination of behavioral and pharmacological interventions (mainly, administration of…
- Trial name
- MANNAPED (NCT06404853)
- Testing
- Manna
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Chronic Constipation
Anorectal Manometery in Pediatric Chronic Refractory Constipation
Anorectal manometry and high-resolution anorectal manometry (HRAM) are becoming the investigation of choice for understanding the pathophysiology of chronic constipation with or without fecal incontenance in children in many…
- Trial name
- NCT06543979
- Testing
- lubiprostone , single arm, biofeed back sessions, botox injection
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Cerebral Palsy
Effects of Core Stability Program on Abdominal Endurance in Wheelchair Bound Cerebral Palsy
This study aims to evaluate the effects of a Core Stability Program on abdominal endurance and constipation severity in wheelchair-bound children with cerebral palsy.
- Trial name
- NCT07764952
- Testing
- Core Stability Program, traditional Physiotherapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Cerebral Palsy
Chronic Constipation With Cerebral Palsy
This study was performed to evaluate posture, sleep, physical activity and quality of life in individuals with chronic constipation Cerebral Palsy.
- Trial name
- NCT04588766
- Testing
- constipation group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Bartın Unıversity
Chronic Idiopathic Constipation, Functional Constipation
Botulinum Toxin Injection Versus Anal Myectomy in Management of Idiopathic Constipation
Chronic idiopathic constipation is most common cause of Constipation in childhood with numerous cases in Egypt. Numerous conservative measures were tried but many fail.
- Trial name
- NCT02361749
- Testing
- Botulinum Toxin, Anal Myectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Constipation, Constipation Chronic Idiopathic
A Pilot Study to Explore the Role of Gut Flora in Chronic Constipation
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding chronic constipation
- Conditions
- Constipation, Constipation Chronic Idiopathic, Constipation - Functional, Constipation (Excl Faecal Impaction)
- Trial name
- NCT04148248
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Chronic Constipation
To Determine the Effect of Forlax® Treatment in Children With Chronic Constipation Who May Also Suffer From Soiling/ Faecal Incontinence.
The purpose of this study is to determine whether Forlax® is more effective than placebo in relieving chronic constipation in children who may also suffer from soiling or faecal incontinence.
- Trial name
- NCT00255372
- Testing
- PEG 4000 (Forlax®)
- Where
- 2 sites in Thailand
- Volunteers
- 88 people
- Sponsor
- Ipsen
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Chronic Constipation, Hirschsprung's Disease
Endoscopic Mucosal Resection (EMR) for Diagnosis of Hirschsprung's Disease
The purpose of this study is to compare the diagnostic yield with endoscopic mucosal resection (EMR) in hirschsprung's disease versus that of standard rectal suction biopsy.
- Trial name
- EDGE (NCT00671684)
- Testing
- Endoscopic Mucosal Resection (EMR)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Chronic Constipation With Overflow, Encopresis With Constipation and Overflow Incontinence
Sacral Neuromodulation in Children and Adolescents
The purpose of this study is to assess the efficacy of neuromodulation for treatment of chronic constipation and fecal incontinence in pediatric patients and to evaluate the differences between the invasive vs.
- Conditions
- Chronic Constipation With Overflow, Encopresis With Constipation and Overflow Incontinence, Hirschsprung's Disease, Anorectal Malformations
- Trial name
- NCT04713085
- Testing
- Invasive Sacral Neuromodulation, Non-invasive Sacral Neuromodulation
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Functional Constipation (FC)
This is a Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study of the Efficacy and Safety of 2 Weight-based Treatment Groups of Plecanatide Versus Placebo in Children and Adolescent Participants 6 to Less Than 18 Years of Age With FC
The goal of this clinical trial is to learn if plecanatide can treat functional constipation in children and adolescents aged 6 to less than 18 years.
- Trial name
- Trulance (NCT07723924)
- Testing
- plecanatide
- Where
- 29 sites in United States
- Volunteers
- 180 people
- Sponsor
- Bausch Health Americas, Inc.
Cerebral Palsy, Constipation
Effect of Transcutaneous Electrical Stimulation on Constipation
Cerebral palsy (CP) is a group of non-progressive neurological disorders that affect body movement, muscle coordination, and posture .It is caused by damage in developing brain, usually before or during birth, but can also occur…
- Trial name
- NCT06198244
- Testing
- Transcutaneous Electrical Nerve Stimulation(TENS), Baseline Treatment
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Constipation
Abdominal Massage With TENS on Parasacral Versus Sacral Area on Symptom,Severity & QOL in Chronic Constipation Females.
Constipation is Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders…
- Trial name
- NCT06303011
- Testing
- Transcutaneous Electrical Nerve Stimulator, TENS on para sacral area with Abdominal Massage
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Chronic Constipation With Overflow, Encopresis With Constipation and Overflow Incontinence
Non-invasive Sacral Nerve Stimulation in Children and Adolescents With Chronic Constipation
The purpose of this study is to assess the efficacy of additional neuromodulation for treatment of chronic constipation in pediatric patients
- Conditions
- Chronic Constipation With Overflow, Encopresis With Constipation and Overflow Incontinence, Hirschprung's Disease, Anorectal Malformations
- Trial name
- NCT04710433
- Testing
- Non-invasive Neuromodulation, Medical and Behavioral Therapy
- Where
- Germany
- Volunteers
- 59 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD)
Indiana University Gastrointestinal Motility Diagnosis Registry
Develop a registry (list of patients) with accurate clinical motility diagnosis. This registry will help the doctors to identify the patients with specific disease conditions.
- Conditions
- Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD), Gastroparesis, Functional Vomiting
- Trial name
- NCT04506593
- Testing
- no intervention
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Indiana University
Constipation Chronic Idiopathic, Cystic Fibrosis
Maralixibat in Patients With Cystic Fibrosis and Constipation
Chronic constipation is common in children with cystic fibrosis (CF), likely due to impaired chloride channel function that reduces intestinal secretions.
- Trial name
- NCT06413368
- Testing
- Maralixibat 9.5 MG/ML [Livmarli]
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Los Angeles
Chronic Constipation
Effect of Propofol on Internal Anal Sphincter Pressure During ARM
Background and Aim: An anorectal manometry (ARM) is a common test in the evaluation of outlet obstruction in constipation. In children under 6 yo, anesthesia is often used for patient comfort and compliance.
- Trial name
- NCT01793753
- Testing
- Propofol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Cerebral Palsy, Constipation
Constipation in Children With Cerebral Palsy
Constipation is a common problem in children with cerebral palsy and may negatively affect daily activities, quality of life, and family well-being.
- Conditions
- Cerebral Palsy, Constipation, Physical Activity
- Trial name
- NCT07466914
- Testing
- Observational assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Lokman Hekim University