Clinical trials: Chronic Illness
Human Immunodeficiency Virus (HIV)
ComBaCaL HIV Prevention TwiCs
This cluster-randomized intervention is embedded in the ComBaCaL (Community-Based Chronic disease care Lesotho) cohort study (EKNZ ID AO_2022-00058, clinicaltrials.gov ID NCT05596773, Lesotho NH-REC ID 210-2022), a platform for…
- Trial name
- CoPrev (NCT07581600)
- Testing
- CoPrev model, Referral to the nearest responsible health facility
- Where
- 2 sites in Lesotho, Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Diabetes Mellitus, Type 2, Coronary Disease
A Study Comparing Standard Care for Diabetes to Case-managed Care for Diabetes in Patients With Coronary Artery Disease
The purpose of this study is to compare two ways to treat patients with Type 2 Diabetes, Standard Care or Case-Managed Care. In-Patient Standard Care is guided by the assigned cardiologist and Out-Patient Standard Care by the…
- Trial name
- NCT00248352
- Testing
- Consultation with Endocrinologist, Counseling from Dietician, Counseling from Diabetes Educator
- Where
- Canada
- Volunteers
- 169 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Chronic Granulomatous Disease
Gene Therapy for Chronic Granulomatous Disease
X-linked Chronic Granulomatous Disease (CGD) is an inherited disorder caused by an abnormal gene that fails to make the protein known as gp91 phox.
- Trial name
- NCT00394316
- Testing
- Phagocyte Oxidase Subunit Transduced CD34 Hematopoietic Stem Cells
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Hepatitis, Hepatitis B
Efficacy and Safety of Clevudine Compared With Adefovir in Patients With Chronic Hepatitis Due to Hepatitis B Virus
The objectives of this study are to compare in nucleoside treatment-naïve subjects, the efficacy and safety of clevudine 30 mg once daily versus adefovir 10 mg once daily, each as monotherapy, for 48 weeks, 72 weeks, and 96 weeks.
- Trial name
- QUASH2 (NCT00496158)
- Testing
- Clevudine, Adefovir
- Where
- 119 sites in United States, Argentina and 9 more
- Sponsor
- Pharmasset
Chronic Myeloid Leukemia
CML Pediatric ITK Response According to Molecular Identification at Diagnosis
Treatment of chronic myeloid leukemia (CML) has been revolutionized by tyrosine kinase inhibitor (TKI). Nevertheless, case of failure and suboptimal response are still observed even in children.
- Trial name
- CML Piramid (NCT05605379)
- Testing
- Next Generation Sequencing (DNA and RNA)
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Bordeaux
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Outcome of Patients With Primary Aldosteronism
Majority of patients with hypertension have primary hypertension (without an underlying cause). Primary aldosteronism (PA) is the most common cause of secondary hypertension, and can be found in 5-10% of patients locally.
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral), Adrenalectomy; Status
- Trial name
- PA_Outcome (NCT04428827)
- Testing
- Unilateral adrenalectomy in patients with unilateral disease
- Where
- Singapore
- Volunteers
- 600 people
- Sponsor
- Changi General Hospital
Aortic Valve Disease, Chronic Kidney Disease
Preventing contrAst Induced Nephropathy After TranscathEter Aortic Valve Replacement
Chronic kidney disease (CKD) and (subsequent) acute kidney injury are frequent in patients undergoing transcatheter aortic valve implantation (TAVI).
- Conditions
- Aortic Valve Disease, Chronic Kidney Disease, Contrast Induced Nephropathy, Acute Kidney Injury
- Trial name
- PANTER (NCT03121053)
- Testing
- sodium bicarbonate, hypotone saline
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- St. Antonius Hospital
Chronic Obstructive Pulmonary Disease
The Effects of Pulmonary Rehabilitation on Bone Mineral Density in Patients Diagnosed With Chronic Obstructive Pulmonary Disease
Exercise has been reported to lead to improvements in Bone Mineral Density (BMD), however studies looking into the effects of exercise on BMD in Chronic Obstructive Pulmonary Disease (COPD) patients are still very limited.
- Trial name
- NCT05871671
- Testing
- Pulmonary Rehabilitation, Control
- Volunteers
- 80 people
- Sponsor
- University of Malta
Acute Renal Failure, Chronic Renal Failure
How Much Reliable iv Calcium for the Treatment of Hyperkalemia?
Hyperkalemia is a common problem in the emergency services and one of the life threatening metabolic emergencies. Calcium, insulin, beta adrenoceptor agonists, bicarbonate, diuretics, sodium polystyrene sulfonate and lastly…
- Trial name
- NCT02672930
- Testing
- Electrocardiogram (ECG)
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people
- Sponsor
- Haseki Training and Research Hospital
Chronic Obstructive Airway Disease
Continuous Versus Interval Walking Training in Patients With COPD - a Pilot Study
This study will investigate the effects of interval walking training versus continuous walking training in patients with chronic obstructive pulmonary disease.
- Trial name
- NCT02209207
- Testing
- Treadmill, walking training
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Fever, COPD
The Application of a Wireless Sensor Technology for Vital Statistics in CHILDREN AND ADULTS
The primary outcome for this project will be the development of a small, non-invasive wireless sensor that is linked to a conventional computer that can be used in health care for monitoring of acute and chronic health problems.
- Conditions
- Fever, COPD, Obesity, Congenital Heart Disease
- Trial name
- NCT01845506
- Testing
- Cardiorespiratory monitor, Wireless pressure sensor
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cancer
External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Indinavir and ritonavir may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT00637637
- Testing
- indinavir sulfate, ritonavir, radiation therapy
- Where
- 3 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Oncology Institute of Southern Switzerland
Von-Hippel Lindau, Kidney Disease, Chronic
Contrast-enhanced Ultrasound as a Screening Tool for Kidney Cancer in Patients With Von-Hippel Lindau
The purpose of this study is to determine if contrast-enhanced ultrasound can detect abnormal features of kidney lesions in patients with Von-Hippel Lindau with the same accuracy as conventional ultrasound and contrast-enhanced…
- Trial name
- CEUS-VHL (NCT03907657)
- Testing
- Perflutren lipid microsphere, Sulfur hexafluoride lipid microspheres
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Acute Lymphoblastic Leukemia, Acute Myeloblastic Leukemia
Natural Killer Index From Hematopoietic Stem Cell Graft
Numerous studies about the potential role of NK alloreactive during a n hematopoietic stem cells graft are based on genotypical analyses of the KIR receptors and on genotypic incompatibilities between KIR and HLA for couple…
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloblastic Leukemia, Chronic Myeloid Leukemia
- Trial name
- NCT00435864
- Testing
- Blood test
- Where
- France
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Chronic Kidney Disease (CKD), Secondary Hyperparathyroidism
A Study of PLS240 in Pediatric Participants With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis
Approximately 56 participants who are 1 month old to 17 years old will be enrolled in this study. The total duration for this study will be 38 weeks (or up to 42 weeks when participants require a washout period due to prior…
- Trial name
- NCT07890584
- Testing
- PLS240, Standard of Care
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Pathalys Pharma
Pulmonary Disease, Chronic Obstructive
Development and Feasibility Testing of Digital Theory-based Pursed Lip Breathing in Stable Patients With COPD
The goal of this pre-post design clinical trial is to develop a digital, theory-based Pursed Lip Breathing intervention protocol software system installed on smartphones (DT-PLB) and to preliminarily evaluate its feasibility and…
- Trial name
- NCT06063733
- Testing
- Digital pursed lip breathing intervention
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Manchester Metropolitan University
Leukemia, Myeloid, Chronic-Phase
Therapy of Early Chronic Phase CML With Gleevec
The goal of this clinical research study is to see if imatinib mesylate (Gleevec, STI571) can improve CML in chronic phase. Objectives: Primary Objective: To increase the proportion of patients achieving a complete cytogenetic…
- Trial name
- NCT00048672
- Testing
- Gleevec
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Obstructive Pulmonary Disease
Gas Usage for Those With COPD Who Experience Low Oxygen Levels During Activities Only
Several studies have described the use of supplemental oxygen during exertion or activities of daily living (ambulatory oxygen) in study populations that have different characteristics.
- Trial name
- NCT00546299
- Testing
- oxygen
- Volunteers
- 27 people
- Sponsor
- West Park Healthcare Centre
End Stage Renal Disease
A Study of Drug-Induced Kidney Disease
The purpose of this study is to identify incidence of Chinese herb nephropathy in a medical center
- Trial name
- NCT00729014
- Where
- Taiwan
- Volunteers
- 2,000 people
- Sponsor
- National Taiwan University Hospital
Chronic Illness
You.Mind! | Boosting First-line Mental Health Care for Youngsters Suffering From Chronic Conditions With Mindfulness
Adolescents with chronic conditions often experience high levels of stress, anxiety and depression and reduced quality of life. Mindfulness-Based Interventions (MBI) have been found to improve emotional distress in clinical and…
- Trial name
- NCT04359563
- Testing
- Mindfulness-Based Intervention
- Where
- Belgium
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- KU Leuven
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.