Clinical trials: Chronic Rhinosinusitis
Chronic Sinusitis, Adenoid Disease - Chronic
Management of Pediatric Chronic Rhinosinusitis in Asthmatic Children
The objectives of this study would be to determine the most effective management for pediatric patients with chronic rhinosinusitis and asthma who fail medical management.
- Trial name
- NCT03336671
- Testing
- Endoscopic Sinus surgery, Adenoidectomy
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Voice Disorders in Children
Effect of Chronic Rhinosinusitis on Voice of Children
Evaluation of the effect of chronic rhinosinusitis on the laryngeal mucosa and voice quality in children. This is important to know factors affecting voice disorders
- Trial name
- NCT03696693
- Testing
- acoustic vocal analysis
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cystic Fibrosis, Chronic Rhinosinusitis
Nasal Inhalation of Dornase Alfa (Pulmozyme) in Patients With Cystic Fibrosis and Chronic Rhinosinusitis
Rhinosinusitis disorders are often associated with Cystic Fibrosis. They can restrict quality of life enormously and give cause to repeated ENT surgery.
- Trial name
- NCT00265434
- Testing
- Pulmozyme
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- University of Jena
Chronic Sinusitis, Radiology
Research on Identifying and Treatment Prognosis of Chronic Rhinosinusitis Based on Image and Sequencing Data
This project focuses on researching chronic rhinosinusitis in patients, employing image processing techniques and molecular biology methods to jointly determine the research objectives: 1. Investigating heterogeneity. 2.
- Conditions
- Chronic Sinusitis, Radiology, Pathology, Surgery
- Trial name
- NCT05983003
- Testing
- endoscopic sinus surgery
- Where
- China
- Volunteers
- 3,500 people
- Sponsor
- Zheng Liu
Cystic Fibrosis, Rhinosinusitis
Nasal Inhalation of Pulmozyme in Patients With Cystic Fibrosis and Chronic Rhinosinusitis
Rhinosinusitis disorders are often associated with Cystic Fibrosis. They can restrict quality of life enormously and give cause to repeated ENT surgery.
- Trial name
- NCT00534079
- Testing
- Dornase alfa (Pulmozyme), isotonic saline
- Where
- 2 sites in Germany
- Volunteers
- 23 people
- Sponsor
- University of Jena
Chronic Sinusitis
Results of Endoscopic Sinus Surgery in Management of Ophthalmological Complications of Chronic Rhino Sinusitis
Investigate the clinical features of orbital complications of sinusitis in the Egyptian population, and observed that certain ophthalmological manifestations and outcomes were significantly associated with disease stage
- Trial name
- NCT04617223
- Testing
- Endoscopic sinus evacuation
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Tanta University
Cystic Fibrosis, Rhinosinusitis
Sino-nasal Inhalation of Sodium Chloride 6,0% in Patients With Cystic Fibrosis and Chronic Rhinosinusitis
Rhinosinusitis disorders are almost regularly associated to Cystic Fibrosis (CF). The basic defect in CF is a dysfunction of chloride channels in exocrine glands which equally concerns upper airway mucosa.
- Trial name
- NCT01086839
- Testing
- sodium chloride 6%, sodium chloride 0,9%
- Where
- 11 sites in Germany
- Volunteers
- 69 people
- Sponsor
- University of Jena
Chronic Rhinosinusitis
The Sinonasal Outcome Test - 22, Validated for Danish Patients
Introduction: Chronic rhinosinusitis (CRS) is a significant health problem increasing in both incidence and prevalence. It calls into attention consensus about diagnosing, assessing symptoms and treatment of patients with CRS.
- Trial name
- NCT01254916
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- Odense University Hospital
Chronic Sinusitis
Clinical Study to Improve Diagnosis and Treatment of Sinusitis
Chronic rhinosinusitis (CRS) is the most common chronic medical condition that affects Americans between 18-44 years of age. While significant advances have been made in the understanding of the molecular pathogenesis underlying…
- Trial name
- NCT00962689
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Ohio State University
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
International Severe CRSwNP Registry 2024-2028
The objective of the study is to collect real-life data worldwide, which already have been collected in national databases, to merge the data and the knowledge with the focus of better care for the individual patients, more…
- Trial name
- INVENT (NCT06617754)
- Testing
- Biologic drugs
- Where
- Denmark
- Volunteers
- 3,000 people
- Sponsor
- Vibeke Backer
URTI, Bronchiolitis
Assessement of Effectiveness of Seawater Nasal Sprays on Sinonasal Symptoms
The purpose of this post-market clinical investigation is to assess in a real-life setting, the effectiveness, usage, tolerance, safety and satisfaction of 4 isotonic and hypertonic seawater-based CE-marked nasal sprays.
- Conditions
- URTI, Bronchiolitis, COVID - 19, Allergic Rhinitis
- Trial name
- SeaBridge (NCT07262450)
- Testing
- Respimer® Hygiene-Prevention -Baby, kids, adults, Respimer® Hygiene-Prevention Kids, adults, Respimer® Decongestion Baby, kids, adults
- Where
- 32 sites in France
- Volunteers
- 1,065 people
- Sponsor
- Laboratoire de la Mer
Conscripts, Military Induction Board
Prevalence of ENT Diseseas
The aim of the present study will be to evaluate in conscripts at the military induction board the prevalence of rhinosinusitis, the prevalence of HPV vaccinations, the prevalence of hearing impairments and the prevalence of…
- Conditions
- Conscripts, Military Induction Board, ENT Disease, Rhinosinusitis Chronic
- Trial name
- PrENT (NCT06105346)
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Rhinitis + Sinusitis, Pediatric Chronic Rhinosinusitis
Study for the Management of Pediatric Chronic Rhinosinusitis With or Without Balloon Sinuplasty
Chronic rhinosinusitis, a common diagnosis in children, remains a poorly understood disease. Adenoidectomy (surgery to take out the adenoid pads- infection fighting glands in the back of the throat) is performed since the adenoid…
- Trial name
- NCT01990820
- Testing
- Acclarent Relieva Balloon Sinuplasty, Adenoidectomy + Maxillary Sinus Irrigation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Endeavor Health
Chronic Rhinosinusitis (CRS), Exacerbations
Effect of Pleuran on the Clinical Course of Patients With Chronic Rhinosinusitis
The goal of this clinical research is to learn if Imunoglukan P4H® as an add-on therapy to the standard of care treatment according to the EPOS guidelines (intranasal corticosteroids and saline irrigation) can help to prevent CRS…
- Conditions
- Chronic Rhinosinusitis (CRS), Exacerbations, Respiratory Tract Infections (RTI), Antibiotic Prophylaxis
- Trial name
- EPCCOR (NCT07460934)
- Testing
- Imunoglukan P4H® capsules
- Where
- 5 sites in Czechia, Slovakia
- Volunteers
- 85 people
- Sponsor
- Pleuran, s.r.o.
Chronic Rhinosinusitis (Diagnosis)
Effect of Post-operative Ibuprofen After Surgery for Chronic Rhinosinusitis
Endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) is a common procedure in the US, with about 250,000 cases performed annually.
- Trial name
- NCT03055507
- Testing
- Ibuprofen 400 mg, Acetaminophen 650 mg, OxyCODONE 5 Mg Oral Tablet
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Washington
Sinusitis
Immunologic Aspects of the Pathogenesis of Chronic Sinusitis in Children
Chronic sinusitis is a common pediatric disease; it ranks among the top five infectious diseases of the upper respiratory tract. Its treatment is limited and may be due largely in part to a lack of understanding of its cause.
- Trial name
- NCT00004638
- Testing
- pathogenesis study
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Sinusitis
Sinus Balloon Dilation in Pediatric Patients
Safety and effectiveness of sinus balloon dilation in patients 2-21 years old.
- Trial name
- NCT02278484
- Testing
- XprESS device and PathAssist confirmation tools
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Entellus Medical, Inc.
Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)
Chronic Otitis Media With Effusion in Chronic Sinusitis With Polyps
The relationship between otitis media with effusion (OME) and chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unclear.
- Trial name
- NCT03975842
- Testing
- Sinonasal and otologic evaluation
- Volunteers
- 80 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Chronic Rhinosinusitis
Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis
Chronic sinusitis is reported to be one of the most widespread disorders in the United States. It can be caused by a variety of reasons such as allergy, infection and/or defects in T-cells which help regulate immune function.
- Trial name
- NCT00396162
- Testing
- probiotic containing L.rhamnosus R0011 strain
- Volunteers
- 77 people
- Sponsor
- University of Michigan
Chronic Rhinosinustis With Polyps
Ciclesonide vs Fluticasone Nasal Sprays in Nasal Poplyposis
This study is designed to compare ciclesonide nasal spray once daily with fluticasone propionate aquas nasal spray BD, which is commonly prescribed in patients with nasal polyposis, in order to relieve symptoms of these patients.
- Trial name
- NCT02665806
- Testing
- Ciclesonide, Fluticasone
- Volunteers
- 32 people
- Sponsor
- Tehran University of Medical Sciences