Clinical trials: Chronobiology
Sleep Disorders
Efficacy and Safety of Circadin® in the Treatment of Sleep Disturbances in Children With Neurodevelopment Disabilities
The purpose of this study is to establish the efficacy and safety of Circadin in children with neurodevelopmental disorders and to determine the dose, this randomized, placebo-controlled study is planned to evaluate the efficacy…
- Trial name
- NCT01906866
- Testing
- Circadin 2/5/10 mg
- Where
- 28 sites in United States, Finland and 3 more
- Volunteers
- 125 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Narcolepsy, Obstructive Sleep Apnea
The Nuvigil and Provigil Pregnancy Registry
The primary objective of the Nuvigil/Provigil Pregnancy Registry is to characterize the pregnancy and fetal outcomes associated with Nuvigil and Provigil exposure during pregnancy.
- Conditions
- Narcolepsy, Obstructive Sleep Apnea, Shift Work Sleep Disorder
- Trial name
- NCT01792583
- Testing
- Modafinil/armodafinil
- Where
- United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Cephalon, Inc.
Breast Feeding, Exclusive, Hospitalization
The Effect of Chronobiologic Feeding Model on Circadian Rhythm in Newborns
This study was planned to evaluate the effect of "feeding model with chronobiologic approach" on circadian rhythm, growth and physiologic parameters of newborns.
- Conditions
- Breast Feeding, Exclusive, Hospitalization, Feeding Patterns
- Trial name
- NCT05923437
- Testing
- Feeding model group with a chronobiological approach
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Selcuk University
Preterm, Chronobiology
The Effect of Oral Feeding Model With a Chronobiological Approach in Neonates
The ideal food for healthy term babies as well as preterm babies and sick term babies is breast milk. There are many studies showing that the composition of breast milk can vary from mother to mother, according to the baby's…
- Conditions
- Preterm, Chronobiology, Human Milk/Breastfeeding, Bottle Feeding
- Trial name
- NCT06821672
- Testing
- Chronobiological Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Bilgi University
Sleep Disorders, Circadian Rhythm
Early Development of Sleep-wake Cycles in Premature Infants and Its Impact on Neurodevelopmental Outcome
Due to the development of neonatal intensive care the number of surviving premature infants increased significantly. The immature brain undergoes a fair amount of external stimuli, which have a great impact on later cognitive…
- Trial name
- SWC (NCT01774318)
- Testing
- aEEG and conventional EEG measurement
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Anemia, Sickle Cell, Sickle Cell Disease
Preventing Sickle Cell Kidney Disease
Untreated hypertension and renal injury are risk factors for increased morbidity and mortality in sickle cell disease, yet early markers of progressive disease have not been identified and therapies to prevent the development of…
- Conditions
- Anemia, Sickle Cell, Sickle Cell Disease, Kidney Disease, Hypertension
- Trial name
- NCT02373241
- Testing
- Losartan
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Enuresis, Nocturnal, Ganglion
Ganglion Cell Thickness in Enuresis Nocturna
The precise role of the intrinsic circadian regulatory mechanism behind the pathogenesis of enuresis is not fully understood, but in theory, circadian rhythm irregularity may be the primary pathogenic mechanism not only for…
- Conditions
- Enuresis, Nocturnal, Ganglion, Circadian Rhythm Disorders
- Trial name
- NCT05126732
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Izmir Bakircay University
Bipolar Disorder
Circadian Rhythm Dysregulation in Offspring of Parents With Bipolar Disorder
This study aims to 1) investigate the differences and variances in circadian rhythms at several levels, including physical activity, dim light melatonin onset, diurnal patterns of cortisol, and body temperature between the…
- Trial name
- NCT03656302
- Where
- Hong Kong
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Smith-Magenis Syndrome, Autism Spectrum Disorder
Smith Magenis Syndrome and Autism Spectrum Disorders
Autism Spectrum Disorders (ASD) are a neurodevelopmental disorder. Their prevalence is estimated at around 0.4% of the general population worldwide.
- Trial name
- SMS/TSA (NCT05116904)
- Testing
- Assessment
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Smith-Magenis Syndrome (SMS)
Natural History Study of Smith-Magenis Syndrome
This study will examine how a rare disease called Smith-Magenis syndrome (SMS) affects people and how they change over time. SMS is caused by a small chromosome 17p11.2 deletion (missing piece).
- Trial name
- NCT00013559
- Where
- United States
- Volunteers
- 593 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Circadian Dysregulation
Maintaining Behavior Change: A 6-year Follow-up of Adolescent 'Night-owls'
A follow-up of a cohort of participants recruited for a prior study will be conducted. In the prior study, 10-18 years olds were provided one of two treatments to improve the sleep of adolescent night-owls.
- Trial name
- NCT05098782
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Stroke, Ischemic Attack, Transient
Sleep Disorders Managed and Assessed Rapidly in Transient Ischemic Attack (TIA) and In Early Stroke
The aim of the investigators was to determine whether the immediate management of any detected sleep disorders can improve outcomes in patients who have had a transient ischemic attack (TIA) or minor stroke.
- Conditions
- Stroke, Ischemic Attack, Transient, Sleep Disorders, Sleep Apnea Syndromes
- Trial name
- SMARTIES (NCT01528462)
- Testing
- Expedited Treatment of Sleep Disorders
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- Sunnybrook Health Sciences Centre
Williams Syndrome, Angelman Syndrome
Study of Phenotype and Genotype Correlations in Patients With Contiguous Gene Deletion Syndromes
OBJECTIVES: I. Investigate phenotype and genotype correlations in patients with Smith-Magenis syndrome (SMS) associated with del(17p11.2). II.
- Conditions
- Williams Syndrome, Angelman Syndrome, Prader-Willi Syndrome, Shprintzen Syndrome
- Trial name
- NCT00004351
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Infant Sleep Problems, Circadian Rhythm
Chrononutrition in Preterm Infants: a Randomised Controlled Trial of Time-matched Breast Milk Feeding and Its Effects on Sleep and Circadian Development
This study investigates whether the timing of feeding expressed breast milk influences infant sleep and circadian (day-night) development in preterm infants.
- Conditions
- Infant Sleep Problems, Circadian Rhythm, Neurodevelopment
- Trial name
- NCT07533578
- Testing
- Chronobiologically Timed Feeding of Expressed Breast Milk, Usual Feeding Practice (Untimed Expressed Breast Milk)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Luzerner Kantonsspital
Circadian Dysregulation, Light Exposure
Feasibility of Light Therapy in the Pediatric Intensive Care Unit (ICU)
The goal of this clinical trial is to understand how easy or difficult it is for critically ill children (4-17 years old) to have light therapy while in the pediatric ICU.
- Conditions
- Circadian Dysregulation, Light Exposure, Pediatric Critical Illness
- Trial name
- NCT07384585
- Testing
- Light Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Laura Beth Kalvas
Delayed Sleep Phase Syndrome
Randomized Controlled Trial on the Treatment Effects of Melatonin and Light Therapy on Delayed Sleep Phase Syndrome
In this study the investigators will examine the effects of melatonin and light therapy on delayed sleep phase syndrome in adolescents 16 up to 20 years old.
- Trial name
- NCT00834886
- Testing
- Melatonin, Bright light
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- University of Bergen
Mental Disorder in Adolescence, Insomnia
Promoting Sleep and Physical Activity Among Adolescent Psychiatric Patients
Mental health disorders pose a significant burden on adolescent populations globally, often accompanied by sleep disturbances. Emerging evidence suggests that addressing sleep issues can improve mental health outcomes, while…
- Conditions
- Mental Disorder in Adolescence, Insomnia, Delayed Sleep-Wake Phase Disorder
- Trial name
- SLEEPAC (NCT06407258)
- Testing
- SLEEPAC
- Where
- 2 sites in Switzerland
- Volunteers
- 140 people
- Sponsor
- Christin Lang
Angelman Syndrome, Smith-Magenis Syndrome
Ghrelin in Patients With a Rare Disease Associated With Intellectual Disability, and Hyperphagia, and/or Overweight, and/or Obesity
A significantly higher proportion of patients with rare diseases (RD) with intellectual disability (ID), present hyperphagia, overweight or obesity, compared to the general population.
- Conditions
- Angelman Syndrome, Smith-Magenis Syndrome, X Fragile Syndrome, Epilepsy
- Trial name
- HOGRID (NCT04768803)
- Testing
- acylated and unacylated ghrelin dosages
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Toulouse
Circadian Rhythm Disorders, Sleep
The Effects of Bright Light Exposure on ICU Nurses
In the majority of intensive care units, nurses work 12 hour shifts that consist of days and nights. Shift work outside of 6am-6pm has been reported to cause fatigue, induce sleep disorders, and cause metabolic disturbances.
- Trial name
- NCT03331822
- Testing
- Bright Light
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Pittsburgh
Sleep, Sleep Disorders, Circadian Rhythm
Effects of Delayed School Start Times on Sleep, Mental Health, and Academic Performance Among Norwegian Adolescents
The aim is to investigate whether later school start times have positive effects on high school students' sleep patterns, mental health and daytime functioning.
- Conditions
- Sleep, Sleep Disorders, Circadian Rhythm, Psychiatric Disorder, Sleepiness, Daytime
- Trial name
- NCT06657482
- Testing
- Delayed school start time
- Where
- Norway
- Volunteers
- 583 people, healthy volunteers welcome
- Sponsor
- University of Bergen