Clinical trials: Circadian Dysregulation
Dementia, Alzheimer Disease
Multidisciplinary Expert System for the Assessment & Management of Complex Brain Disorders
The Multidisciplinary Expert System for the Assessment \& Management of Complex Brain Disorders (MES-CoBraD) is an interdisciplinary project combining Real-World Data (RWD) from multiple clinical and consumer sources through…
- Conditions
- Dementia, Alzheimer Disease, Epilepsy, Sleep Disorder
- Trial name
- MES-CoBraD (NCT05171725)
- Testing
- EEG,PSG, biosample collection (blood and CSF), neuropsychological testing
- Where
- 4 sites in Greece, Israel and 2 more
- Volunteers
- 635 people, healthy volunteers welcome
- Sponsor
- Neurological Institute of Athens
Shift-work Disorder, Insomnia
SHIFTPLAN: an RCT Investigating the Effect of a Shift Work Intervention on Fatigue, Sleep and Health.
Shift work is associated with disturbed life rhythms resulting from chronic exposure to circadian misalignment and sleep restriction, with long-term participation in most shift schedules causing serious health problems.
- Conditions
- Shift-work Disorder, Insomnia, Fatigue, Mental Health Issue
- Trial name
- SHIFTPLAN (NCT05452096)
- Testing
- Education program and ergonomic schedulling
- Volunteers
- 176 people
- Sponsor
- University Hospital, Antwerp
Non-24-Hour Sleep-Wake Disorder
Withdrawal Study to Demonstrate the Maintenance Effect in the Treatment of Non-24-Hour Sleep-Wake Disorder
The purpose of this study is to evaluate the maintenance effect and safety of 20 mg tasimelteon versus placebo in subjects suffering from Non-24-Hour Sleep-Wake Disorder.
- Trial name
- NCT01430754
- Testing
- tasimelteon
- Where
- 22 sites in United States
- Volunteers
- 20 people
- Sponsor
- Vanda Pharmaceuticals
Hypohidrotic Ectodermal Dysplasia
Impact of Dysregulation of Core Body Temperature on Sleep in Patients With Hypohidrotic Ectodermal Dysplasia
The aim of the study is to compare sleep efficiency by means of actigraphy in patients with hypohidrotic ectodermal dysplasia with healthy controls.
- Trial name
- DEH-Somno (NCT05378932)
- Testing
- Actigraphy, Recording of proximal and distal skin temperature and temperature of the bedroom, Questionnaires assessing subjective sleep quality
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Inflammatory Bowel Diseases, Circadian Dysregulation
Circadian Rhythms in Patients With IBD or Celiac Disease Upon Diagnosis and Medical Follow-up
patients 6-25 years old upon diagnostic evaluation will be recruited . study population will comprise of two groups: newly diagnosed IBD patients/ Celiac disease and healthy controls.
- Trial name
- NCT03662646
- Testing
- no intervention performed- observational only
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Circadian Dysregulation, Light Exposure
Feasibility of Light Therapy in the Pediatric Intensive Care Unit (ICU)
The goal of this clinical trial is to understand how easy or difficult it is for critically ill children (4-17 years old) to have light therapy while in the pediatric ICU.
- Conditions
- Circadian Dysregulation, Light Exposure, Pediatric Critical Illness
- Trial name
- NCT07384585
- Testing
- Light Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Laura Beth Kalvas
Enuresis, Nocturnal, Ganglion
Ganglion Cell Thickness in Enuresis Nocturna
The precise role of the intrinsic circadian regulatory mechanism behind the pathogenesis of enuresis is not fully understood, but in theory, circadian rhythm irregularity may be the primary pathogenic mechanism not only for…
- Conditions
- Enuresis, Nocturnal, Ganglion, Circadian Rhythm Disorders
- Trial name
- NCT05126732
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Izmir Bakircay University
Circadian Rhythm Disorders, Sleep
The Effects of Bright Light Exposure on ICU Nurses
In the majority of intensive care units, nurses work 12 hour shifts that consist of days and nights. Shift work outside of 6am-6pm has been reported to cause fatigue, induce sleep disorders, and cause metabolic disturbances.
- Trial name
- NCT03331822
- Testing
- Bright Light
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Pittsburgh
Bipolar Disorder
Circadian Rhythm Dysregulation in Offspring of Parents With Bipolar Disorder
This study aims to 1) investigate the differences and variances in circadian rhythms at several levels, including physical activity, dim light melatonin onset, diurnal patterns of cortisol, and body temperature between the…
- Trial name
- NCT03656302
- Where
- Hong Kong
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Cystic Fibrosis
Circadian Rhythm Disorders in Children With Cystic Fibrosis Under CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Modulators
Cystic fibrosis (CF) is a rare disease affecting one out of 4,500 newborns in France (INSERM 2021). Despite major advances in patient care over the past two decades, with significant improvements in life expectancy, cystic…
- Trial name
- CHRONO-MUCO (NCT06370962)
- Where
- 3 sites in France
- Volunteers
- 180 people
- Sponsor
- Hospices Civils de Lyon
Circadian Dysregulation
Maintaining Behavior Change: A 6-year Follow-up of Adolescent 'Night-owls'
A follow-up of a cohort of participants recruited for a prior study will be conducted. In the prior study, 10-18 years olds were provided one of two treatments to improve the sleep of adolescent night-owls.
- Trial name
- NCT05098782
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Circadian Rhythm Disorders
Managing Sleep-wake Disruption Due to Hospitalisation: the Circadian Care Project
Sleep is regulated by the interaction of homeostatic and circadian processes. The homeostatic process determines sleep propensity in relation to sleep-wake history, the circadian one is responsible for the alternation of high/low…
- Trial name
- CircadianCare (NCT05228444)
- Testing
- CircadianCare
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University Hospital Padova
Circadian Dysrhythmia, Sleep Disturbance
PICU-related Sleep and Circadian Dysregulation Pilot Study
A single center pilot trial investigating the feasibility of using actigraphy and salivary melatonin levels to measure the sleep and circadian rhythm of critically ill children aged 3 to 6 years old.
- Conditions
- Circadian Dysrhythmia, Sleep Disturbance, Critical Illness, Children, Only
- Trial name
- NCT06505447
- Testing
- Daytime light exposure, Daytime restricted feeding
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- State University of New York at Buffalo
Circadian Rhythm Sleep Disorder, Circadian Rhythm Disorder Caused by Drug
Changes in Circadian Rhythm After Anaesthesia in Children
In this study the investigators will examine the effect of general anesthesia and surgery on sleep duration and sleep quality in children, using questionnaires and a sleep diary.
- Conditions
- Circadian Rhythm Sleep Disorder, Circadian Rhythm Disorder Caused by Drug, Circadian Rhythm Sleep Disorder, Jet Lag Type, Jet Lag
- Trial name
- CLOCKSkids (NCT05618405)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Sleep, Circadian Rhythm Disorders
Sleep Timing, Eating and Activity Measurement Study
There is strong reason to believe that sleep promotion during adolescence could yield long-term health rewards; the investigators' data show that, when they get more sleep, Morning Larks have impressively reduced intake of…
- Conditions
- Sleep, Circadian Rhythm Disorders, Dietary Habits
- Trial name
- STEAM (NCT04992611)
- Testing
- Sleep Extension (Early), Sleep Extension (Late)
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati