Clinical trials: Clear Aligner Therapy
White Spot Lesions, Demineralization
Comparative Effectiveness of Remineralization Agents on Attachment-Associated Demineralization in Clear Aligner Patients
Background/ Objectives: Clear aligner attachments increase the risk of white spot lesions (WSL), with a 35.5% incidence in adolescents. The number of anterior attachments is an independent risk factor (OR=2.192).
- Conditions
- White Spot Lesions, Demineralization, Dental Caries, Orthodontic Treatment
- Trial name
- NCT07229105
- Testing
- GC Tooth Mousse, Nano-Hydroxyapatite Gel, Sodium Fluoride varnish
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bezmialem Vakif University
White Spot Lesion
The Role of Fluoride Varnish Application in Preventing White Spot Lesions During Clear Aligner Treatment: A Controlled Split-Mouth Study
aim of study: is to compare the effect of the fluoride varnish application on the prevention of white spot lesions (WSLs) during clear aligner therapy Design Details: Each participant will have one side of the mouth assigned to…
- Trial name
- NCT07319884
- Testing
- White spot lesion with fluoride varnish application, White spot lesion without fluoride varnish application
- Where
- Egypt
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Malocclusion
FM Technique in Orthodontic Clear Aligner Therapy: A Single-Arm Clinical Study
This trial tests whether a new method (FM) for moving back teeth can shorten clear-aligner treatment. All participants use FM, which moves the canine and first molar back together instead of one tooth at a time like the standard…
- Trial name
- NCT07896369
- Testing
- Clear aligners with FM (Fluid Move) design
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
White Spot Lesion
Evaluation of Enamel Demineralization During Clear Aligner Orthodontic Treatment
Development of white spot lesions (enamel demineralization) will be evaluated quantitatively during clear aligner orthodontic treatment compared to conventional fixed appliances using quantitative light induced fluorescence (QLF)
- Trial name
- NCT04107012
- Testing
- Orthodontic treatment with clear aligner
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Malocclusion, Angle Class II
Therapeutic Effects of Class II Elastics on Aligners in Different Vertical Skeletal Patterns
The objective is to compare the dento-alveolar therapeutic effects of wearing class II inter-arch traction elastics on aligners versus multi-brackets in an adult population.
- Trial name
- NCT05853211
- Testing
- Aligner and inter-arch elastics
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Tooth Movement
Evaluation of Treatment Outcome of Lower Incisors Crowding Using Clear Aligners With Laser Acceleration .
The present study will be performed to evaluate the effect of low-level laser therapy (LLLT) on the rate of orthodontic tooth movement through the correction of lower incisors crowding using clear aligners
- Trial name
- NCT06526871
- Testing
- Low-Level Laser acceleration, clear aligner therapy
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Huda Abdelhakim
Angle Class I Maloclussion, Dental Crowding
Orthodontic Treatment Outcomes of Self Ligating System Compared to Clear Aligner System
This study is a multi-center, prospective, parallel-group randomized controlled trial designed to compare the orthodontic treatment outcomes of a passive self-ligating bracket system (Damon Ultima) versus a clear aligner system.
- Trial name
- NCT07638397
- Testing
- self ligating bracket, Clear aligner
- Where
- Iraq
- Volunteers
- 42 people
- Sponsor
- University of Baghdad
Malocclusion, Esthetics, Dental
Effect of Finishing Clear Aligner Marginal Termination Design (Supragingival vs Juxtagingival) on Aligner Color Stability After 14 Days of Wear: A Split-Mouth Study
The goal of this clinical study is to learn whether the gumline edge design of a finishing orthodontic clear aligner affects how much the aligner's color changes after 14 days of wear.
- Trial name
- SPECTRO-ALIGN (NCT07628491)
- Testing
- Tri-layer thermoplastic finishing clear aligner
- Where
- Romania
- Volunteers
- 50 people
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Composite Resins, Clear Aligner Therapy
Surface Wear of Clear Aligner Attachment Composites
The aim of this study is to investigate the amount of surface wear that may occur during treatment with different composite materials used for clear aligner attachments.
- Trial name
- NCT07812220
- Testing
- GC Aligner Connect, VOCO AlignerFlow LC
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Marmara University
Periodontal Diseases, Malocclusion
Influence of Finishing Clear Aligner Marginal Termination Design on Subgingival Periodontal Microbiota During Orthodontic Treatment: A Split-Mouth Study.
The goal of this clinical trial is to learn whether the edge design of a finishing orthodontic clear aligner at the gumline affects the bacteria living in the groove between the tooth and the gum (the gingival sulcus) in patients…
- Conditions
- Periodontal Diseases, Malocclusion, Oral Health
- Trial name
- PATHO-ALIGN (NCT07533058)
- Testing
- CA Pro tri-layer finishing clear aligner (SCHEU-DENTAL GmbH)
- Where
- Romania
- Volunteers
- 36 people
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Crowding, Tooth, Tipped Tooth or Teeth
Efficacy and Effectiveness of Two Types of Aligners Based on Stratification by Type of Movement
The purpose of this study is to evaluate the biomechanical behaviour of direct-printed and thermoformed aligners in different tooth movements, creating a biomechanical planning protocol based on a stratification of tooth…
- Conditions
- Crowding, Tooth, Tipped Tooth or Teeth, Rotation of Tooth, Malocclusion, Angle's Class
- Trial name
- NCT06516185
- Testing
- direct-printed aligner, thermoformed aligner
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Universidad Complutense de Madrid
Juvenile Idiopathic Arthritis, Malocclusion, Angle Class II
Mandibular Advancement Clear Aligner Treatment in Juvenile Idiopathic Arthritis Subjects
There is currently no information on how mandibular advancement therapy could influence three-dimensionally the condylar and mandibular morphology in growing patients affected by Juvenile Idiopathic Arthritis (JIA).
- Trial name
- NCT05467579
- Testing
- Device: orthodontic - mandibular advancement clear aligner
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Genova
Masseter Muscle Activity, Anterior Temporalis Muscle Activity
Orthodontic Clear Aligners Vs Conventional Fixed Appliance's Impact on Muscular Activities Among Adults Using SEMG (Surface Electromyography)
This clinical trial goal is to evaluate the difference in masticatory activities in adult patients treated with clear aligners compared to conventional fixed appliances treatment.
- Trial name
- NCT06699290
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Riyadh Elm University
Crowding of Anterior Maxillary Teeth
Clear Aligner Treatment With and Without Low Level Laser Therapy for Upper Incisor Crowding
The goal of this clinical trial is to assess the effect of Low Level Laser Therapy (LLLT) on Upper Incisor Crowding using Clear Aligner Treatment (CAT).
- Trial name
- NCT06493721
- Testing
- Clear Aligner Treatment, Low level laser
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Tooth Discoloration
Bleaching Procedures Performed During Treatment With Brackets and Clear Aligners
The aim of this study is to compare the effectiveness of different whitening methods used during orthodontic treatment with fixed appliances and clear aligners.
- Trial name
- NCT06716827
- Testing
- In-office bleaching system, Laser-assisted bleaching, Home-bleaching
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Ahmet Yağcı
Malocclusion, Crowded Teeth
Factors Affecting Attachment Loss in Clear Aligner Treatment
This prospective clinical study evaluated the incidence of composite attachment loss in patients undergoing clear aligner treatment and identified patient-, tooth-, and treatment-related factors associated with attachment…
- Conditions
- Malocclusion, Crowded Teeth, Attachment
- Trial name
- NCT07352644
- Testing
- Clear Aligners with Composite Attachments
- Where
- Turkey (Türkiye)
- Volunteers
- 4 people
- Sponsor
- Bezmialem Vakif University
Composite Resins, Clear Aligner Therapy
Color Stability and Fluorescence Properties of Two Aligner Attachment Composites
This split mouth study aims to evaluate whether 2 different composite materials used for making clear aligner attachments change color over time and do they have different fluorescent characteristics when illuminated with…
- Trial name
- NCT07806214
- Testing
- GC Aligner Connect, VOCO AlignerFlow LC
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Marmara University
Malocclusion, Angle Class I
Predictability of Part-time Wearing of Removable Clear Aligner Therapy Versus Full Time
14 Patients with mild to moderate crowding and spacing will be selected according to inclusion criteria. Treatment planning will be done on Maestro® software. An impression will be taken and scanned by an extra-oral scanner.
- Trial name
- NCT06253286
- Testing
- clear aligner treatment for orthodontics patients
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Distalization, Class II Malocclusion
Comparison of Distalization of Maxillary First and Second Molars Between a Miniscrew Implant Supported Device and Clear Aligners.
The goal of this randomized clinical trial is to compare distalization of maxillary first and second molars achieved with a device supported with mini screw implants in the palate (Advanced Molar Distalization Appliance, AMDA®)…
- Conditions
- Distalization, Class II Malocclusion, Aligner Therapy, Distalization by Miniscrews
- Trial name
- NCT07040176
- Testing
- Upper molar distalization
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Aristotle University Of Thessaloniki
Skeletal Class III Malocclusion
Skeletal and Dentoalveolar Effects of Functional Clear Aligner Therapy in Growing Patient With Skeletal Class III Malocclusion
The purpose of this study is to evaluate the skeletal, dentoalveolar \& soft tissue effects of functional clear aligner therapy in growing patient with Skeletal class III malocclusion.
- Trial name
- NCT07703007
- Testing
- Functional Clear Aligner
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Mansoura University