Clinical trials: Cleft Palate +/- Lip
Cleft Lip and Palate
Tissue Engineered Constructs for Alveolar Cleft Repair
Description of the research question In children undergoing unilateral alveolar cleft reconstruction, would stem cells carried on collagen scaffold provide bone of a good quality and quantity if compared to autogenous bone…
- Trial name
- NCT03563495
- Testing
- tissue engineered group, autogenous bone graft group
- Volunteers
- 10 people
- Sponsor
- Cairo University
Toothbrushing, Gingivitis
Effectiveness of Dual Light Electric Toothbrush vs. Manual Toothbrush in Orthodontic Patients Undergoing Oral Surgery
The study is a randomized clinical trial to compare the effectiveness of a dual light ultrasonic toothbrush on periodontal health in orthodontic patients undergoing surgery.
- Conditions
- Toothbrushing, Gingivitis, Cleft Lip and Palate
- Trial name
- NCT06122805
- Testing
- Toothbrush
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Cleft Lip and Palate
Evaluation of the Effect of Prosthetic Management for Congenital Cleft Lip and Palate Infants on the Middle Ear Function
Aim of the study was to evaluate the effect of feeding appliance for congenital cleft lip and palate infants on the middle ear function
- Trial name
- NCT06075069
- Testing
- Feeding appliance
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Cleft Lip, Cleft Palate
Effects of AlignBabyCleft (ABaCleft)
Since the appearance of presurgical infant orthopedic (PSIO) as a treatment for patients with cleft lip and palate ( CLP) , numerous techniques have been described with the aim of aligning the displaced alveolar segments and…
- Trial name
- (ABaCleft) (NCT05357092)
- Testing
- Appliance. Orthodontic appliance to carry out dentoalveolar movement
- Volunteers
- 30 people
- Sponsor
- Universidad Complutense de Madrid
Palatal Expansion Technique, Cleft Lip and Palate
MARPE in Patients With Cleft Lip and Palate
The objective of this randomized controlled study will be to evaluate the dental and skeletal effects of maxillary protraction with a facemask, associated with MARPE and Class III elastics in patients with unilateral cleft lip…
- Conditions
- Palatal Expansion Technique, Cleft Lip and Palate, Class III Malocclusion, Skeletal Malocclusion
- Trial name
- NCT04354116
- Testing
- Rapid maxillary expansion, Maxillary Protraction
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Pontifícia Universidade Católica de Minas Gerais
Clift Lip, Cleft Palate
Description of Pain in Pediatric Patients With Cleft Lip and Palate Undergoing Alveolar Grafting Using Two Surgical Strategies: Stem Cells and Autogenous Iliac Crest Bone (Pain Evaluation in Children Undergoing Alveolar Grafting: Stem Cells vs. Iliac Crest Bone)
Study Objective The objective of this study was to evaluate and compare postoperative pain and hospital costs in pediatric patients with cleft lip and palate undergoing alveolar bone grafting surgery.
- Conditions
- Clift Lip, Cleft Palate, Alveolar Bone Loss, Postoperative Pain
- Trial name
- NCT07734974
- Testing
- Autogenous Iliac Crest Bone Grafting, Bioengineered Alveolar Grafting (SHED + Scaffold)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital Sirio-Libanes
Cleft Lip and Palate
Effectiveness of Nasal-alar Elevator Combined With Taping Vs. Taping Alone on Improving the Nose Esthetics and Maxillary Arch Dimensions in Infants With Unilateral Complete Cleft Lip and Palate
This randomized trial is designed to assess the effectiveness of nasal elevator as a presurgical infant orthopedics on improvement of nose esthetics vs taping alone.
- Trial name
- NCT04331379
- Testing
- Nasal Elevator, Taping Alone
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cleft Palate, Cleft Lip
Perioperative Respiratory Adverse Events in Cleft Lip and Palate Surgery: Incidence, Risk Factors, and Clinical Scoring
Cleft lip and palate surgeries present unique anesthetic challenges due to shared airway access with the surgical field, frequent anatomical abnormalities, and a predominantly infant and toddler population.
- Conditions
- Cleft Palate, Cleft Lip, Laryngospasm, Bronchospasm
- Trial name
- NCT07651904
- Testing
- Standard General Anesthesia per Institutional Protocol
- Volunteers
- 150 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Cleft Lip, Cleft Palate
Oral Cleft Prevention Program
The purpose of this study is to asses if taking 4 mg of folic acid per day at preconception and during the first three months of pregnancy decreases the risk of having a child with cleft lip and palate compared to 0.4 mg folic…
- Trial name
- NCT00397917
- Testing
- Folic acid: 4 mg versus 0.4 mg per day
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- University of Iowa
Bottle Feeding
The Effect of the Usage of Squeezable vs Standard Bottles After Cleft Palate Surgery on the Feeding Process of Infants
This study aims to examine the effect of the usage of squeezable bottles and standard bottles on the feeding process of infants with CLP after cleft palate surgery.
- Trial name
- NCT05062798
- Testing
- Standart bottle, Squeezable bottle
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Cleft Lip, Cleft Palate
Follow Ups of Parents With Infants With Cleft Lip and Palate
In Norway, 100-120 children are born with CLP (1.9 per 1,000 live births) each year. Parents of infants with CLP need information and support, especially with feeding immediately after birth. These needs are often not met.
- Trial name
- NCT02415361
- Testing
- Cleft lip and palate
- Where
- Norway
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Cleft Lip and Palate
Use of Computer Aided Design and 3D Printing for Anesthesiology Management in a Pediatric Patient With Cleft Facial Defect (3D Obturator) - Pilot Trial
Congenital malformations of the orofacial area are the most common congenital malformations in children with an incidence of 1.8 children with orofacial cleft per 1000 healthy births in the Czech Republic.
- Trial name
- Pilobtur (NCT04422964)
- Testing
- 3D Obturator
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Brno University Hospital
Kallmann Syndrome, Hypogonadotropic Hypogonadism
Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate
The purpose of this study is to explore the genetic basis of reproductive disorders and cleft lip and/or palate.
- Conditions
- Kallmann Syndrome, Hypogonadotropic Hypogonadism, Hypothalamic Amenorrhea, Polycystic Ovarian Syndrome
- Trial name
- NCT01601171
- Where
- Switzerland
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cleft Lip
Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment
Alveolar bone grafting (ABG) is an essential part of the surgical management of cleft lip and palate patients. This procedure could obliterate oronasal fistula, stabilize dental arch, offer bone matrix for adjacent teeth…
- Trial name
- NCT02454998
- Testing
- orthodontic treatment
- Volunteers
- 24 people
- Sponsor
- Chang Gung Memorial Hospital
Cleft Lip Palate, Cleft Lip, Unilateral, Complete
Nasoalveolar Molding for Egyptian Cleft Lip Palate Infants
The cleft lip and palate (CLP) is the commonest craniofacial anomaly worldwide. Nasoalveolar molding (NAM) therapy has emerged in the management of CLP as an early presurgical intervention to provide symmetry to severely deformed…
- Trial name
- EgyCleft (NCT03029195)
- Testing
- Nasoalveolar molding therapy
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Serous Otitis, Tympanic Membrane Perforation
Otological Study of Facial Cleft Patients Over 10 Years of Age (Excluding Isolated Cleft Lip) (EFEOF)
Studies published on the placement of transtympanic ventilatory tubes in children with cleft palate show heterogeneous results, highlighting the need for a new study with strong statistical power and long-term follow-up to…
- Conditions
- Serous Otitis, Tympanic Membrane Perforation, Retraction Pocket, Cholesteatoma
- Trial name
- EFEOF (NCT06738927)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Brest
Cleft Lip and Palate
Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infants With / Without Vacuum Formed Nasoalveolar Molding Aligners : A Controlled Clinical Trial
Newborns with unilateral cleft lip/ palate will be treated pre-surgically by Vacuum formed aligners in order to evaluate its effect on Nasoalveolar complex.
- Trial name
- NCT03011489
- Testing
- Vacuum formed aligners
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cleft Lip and Palate
How Does Orthognathic Surgery Affect Jaw and Neck Motor Function?
In a prospective longitudinal study design, details in jaw-neck kinematics and electromyography (EMG) activity changes in patients (women and men) referred for surgical correction of basal relations between the maxilla and…
- Trial name
- NCT05876169
- Testing
- Orthognathic surgery
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Umeå University
Cleft Lip and Palate
Alveolar Cleft Hard- and Soft Tissue Reconstruction With an Autogenous Tooth Derived Particulate Graft
The present study aims at clinical and radiographic evaluation of the safety and efficacy of Bonmaker ATB powder combined with a novel split thickness papilla curtain flap in the treatment of alveolar cleft defects.
- Trial name
- NCT05971914
- Testing
- Autogenous tooth derived particulate graft and a novel split thickness papilla curtain flap
- Where
- Hungary
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Cleft Lip and/or Palate, Speech Disorder
Neural Changes After Speech Therapy in Patients With Cleft Palate: A Brain Imaging Study
Cleft palate is one of the most common maxillofacial congenital malformations, which results in severe speech disorders. Compensatory articulation disorder, also known as non-oral articulation disorder (NOA), is considered as the…
- Conditions
- Cleft Lip and/or Palate, Speech Disorder, Speech Therapy, Brain
- Trial name
- fMRI-Speech-CP (NCT07330687)
- Testing
- Structured Speech Training for Decompensation
- Where
- China
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Shufan Zhao