Clinical trials: Clinical Course
Urinary Tract Infection, Cellulitis
Clinical Efficacy of Stopping Oral Antibiotics When Symptoms Stop, Compared to 'Finishing the Course'
The aim of the StopStop@HITH study is to see if stopping antibiotics when symptoms stop is as good as finishing the course of antibiotics.
- Conditions
- Urinary Tract Infection, Cellulitis, Respiratory Tract Infections, Lymphadenitis
- Trial name
- StopStop@HITH (NCT07532941)
- Testing
- Antibiotics for duration of symptoms, Antibiotics for duration of prescribed course
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- Murdoch Childrens Research Institute
Influenza
Biomarkers for the Prognosis of Influenza in Children
Context: Seasonal influenza affects 2.5 to 3 million people each year in France, resulting in 1500 to 2000 severe cases seen in intensive care units.
- Trial name
- BMIG (NCT03231995)
- Testing
- Collection of nasopharyngeal specimen collected at D0, D1, D2 and D5.
- Where
- 2 sites in France
- Volunteers
- 145 people
- Sponsor
- Hospices Civils de Lyon
Tuberculosis, HIV Infections
Brief Rifapentine-Isoniazid Evaluation for TB Prevention (BRIEF TB)
HIV-infected people have an increased risk of developing active tuberculosis (TB). At the time the study was designed, the standard course of treatment for TB was 6 to 9 months of isoniazid (INH).This study compared the safety…
- Trial name
- NCT01404312
- Testing
- Rifapentine (RPT), Isoniazid (INH), Pyridoxine (Vitamin B6)
- Where
- 45 sites in United States, Botswana and 8 more
- Volunteers
- 3,000 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Non IgE Mediated Food Allergy, Food Protein-Induced Enteropathy
Non-Immunoglobulin E-mediated Food Allergies in Children
Non-IgE-mediated gastrointestinal food allergies (non-IgE-GIFA) are an evolving web of clinical conditions characterized by subacute and/or chronic symptoms and include food protein-induced enterocolitis syndrome (FPIES), food…
- Conditions
- Non IgE Mediated Food Allergy, Food Protein-Induced Enteropathy, Food Protein-Induced Proctocolitis, Food Protein-Induced Enterocolitis Syndrome
- Trial name
- NIGEFA (NCT04462978)
- Testing
- Non IgE-mediated food allergy
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Federico II University
Celiac Disease
Effect of Addition of Short Course of Prednisolone to Gluten Free Diet in Naive Celiac Disease Patients
Withdrawal of gluten, the culprit antigen, is the definite treatment for celiac disease. Weeks to months after gluten withdrawal from the diet before the clinical manifestations, histological features start improving.
- Trial name
- CD (NCT01045837)
- Testing
- Prednisolone and Gluten free diet, Gluten free diet
- Where
- India
- Volunteers
- 33 people
- Sponsor
- All India Institute of Medical Sciences
Covid19, SARS CoV 2 Infection
COVID-19: A Scope Research on Epidemiology and Clinical Course
Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) 2 infection and the associated coronavirus disease 2019 (COVID-19) are the most recent international health threat challenging our ability to protect populations, to…
- Conditions
- Covid19, SARS CoV 2 Infection, Sequelae of; Infection
- Trial name
- COVID-Scope (NCT05046769)
- Where
- Portugal
- Volunteers
- 5,000 people
- Sponsor
- Instituto de Saude Publica da Universidade do Porto
Self Harm, Borderline Personality Disorder
Predictors of Clinical Course and Treatment Response in DBT Programmes
The project is a collaboration between The National Centre for Suicide Research and Prevention (NSSF) and clinical units with Dialectical Behaviour Therapy (DBT) programmes.
- Trial name
- NCT04318899
- Testing
- Dialectical Behaviour Therapy adapted for adolescents (DBT-A), Dialectical Behaviour Therapy - Standard version (DBT)
- Where
- 5 sites in Norway
- Volunteers
- 250 people
- Sponsor
- Oslo University Hospital
Chronic Liver Disease
Observational Clinical Study of the Natural Course and Long-term Prognosis of Patients With Chronic Liver Disease
Chronic liver disease is a global public health problem. Without timely diagnosis and treatment, chronic liver disease can progress to hepatitis, liver fibrosis, and cirrhosis, while causing a variety of complications such as…
- Trial name
- NCT05653830
- Where
- China
- Volunteers
- 50,000 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Tuberculosis
Asymptomatic TB With Innovative Modified Short-course Regimens
This study is a randomized controlled trial among asymptomatic tuberculosis individuals aiming to assess whether the standard treatment duration can be shortened to 17 weeks without increasing the types or doses of…
- Trial name
- SWIFT (NCT06153069)
- Testing
- Four-month regimen, Three-month regimen, Standard regimen
- Where
- 5 sites in China
- Volunteers
- 426 people
- Sponsor
- Huashan Hospital
Critical Illness
Effect of Immune-enhancing Enteral Nutrition on Immunomodulation in Critically Ill Patients
To determine whether high-protein (24% of total calorie from protein) enteral nutrition of immune modulating nutrients (eg, ω-3 fatty acids and antioxidants) enriched with β-glucan stimulates immune functions compared with…
- Trial name
- NCT02569203
- Testing
- standard enteral nutrition, high-protein enteral nutrition of immune modulating nutrients enriched with β-glucan, high-protein enteral nutrition of immune modulating nutrients without β-glucan
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Osteonecrosis, Acute Lymphoblastic Leukaemia
Osteonecroses in Pediatric Patients With ALL
Nowadays approximately 80% of children and adolescents with acute lymphoblastic leukaemia (ALL) or lymphoblastic lymphoma (LBL) can be cured and become long-term survivors.
- Conditions
- Osteonecrosis, Acute Lymphoblastic Leukaemia, Lymphoblastic Lymphoma
- Trial name
- OPAL (NCT01619124)
- Where
- 25 sites in Germany
- Volunteers
- 400 people
- Sponsor
- Klinik für Kinder-Onkologie, -Hämatologie und Klinische Immu
Staphylococcus Aureus Pneumonia, Lung Diseases
Mucoid Staphylococcus Aureus in Cystic Fibrosis Airways
Recently, the investigators described a new mucoid phenotype of Staphylococcus aureus cultured from the airways of cystic fibrosis (CF) patients.In this observational study, the investigators plan to determine the prevalence of…
- Conditions
- Staphylococcus Aureus Pneumonia, Lung Diseases, Cystic Fibrosis, Lung Function Decreased
- Trial name
- mucostaph (NCT04171583)
- Where
- 13 sites in Austria, Germany
- Volunteers
- 628 people
- Sponsor
- University Hospital Muenster
Steroid-Dependent Nephrotic Syndrome
Compare Efficacy and Safety of Repeated Courses of Rituximab to That of Maintenance Mycophenolate Mofetil Following Single Course of Rituximab Among Children With Steroid Dependent Nephrotic Syndrome
The aim of the RITURNS II study is to evaluate the efficacy and safety of Repeat courses of Rituximab to that of maintenance Mycophenolate Mofetil following single course of Rituximab in maintaining remission over 24 months among…
- Trial name
- RITURNS II (NCT03899103)
- Testing
- Rituximab, Mycophenolate Mofetil
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Nilratan Sircar Medical College
Adrenoleukodystrophy
Effect of Glycerol Trierucate on Clinical Course of Adrenoleukodystrophy
OBJECTIVES: I. Evaluate the clinical efficacy of combination glyceryl trierucate and glyceryl trioleate (Lorenzo's Oil) therapy in boys with X-linked adrenoleukodystrophy. II.
- Trial name
- NCT00004418
- Testing
- glyceryl trierucate/glyceryl trioleate
- Where
- 2 sites in United States
- Volunteers
- 126 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Schizophrenia, Psychotic Disorders
Dimensional and Developmental Profiles of Psychosis in Children and Adolescents
Five collaborating sites in France will study the broad spectrum of schizophrenia in children and adolescents. Patients will be studied with diagnostic interviews, developmental histories, dimensional clinical ratings…
- Trial name
- PSYDEV (NCT04370730)
- Testing
- clinical, neuroimaging and DNA assessments
- Where
- 6 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Psuedomas Infection, Cystic Fibrosis
The Role of Bacteria and Genetic Variations in Cystic Fibrosis
This study will examine 1) the role of hereditary factors in cystic fibrosis; i.e., the relationship of the disease to specific gene variations, and 2) the role of bacterial products involved in lung infections substances…
- Trial name
- NCT00043225
- Where
- 4 sites in United States
- Volunteers
- 76 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Nephronophthisis
Nephronophthisis : Clinical and Genetic Study
to describe evolution of Nephronophthisis
- Trial name
- NEPHAER (NCT01022957)
- Testing
- genetic diagnosis
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Glioblastoma (GBM)
Personalized Targeted Glioblastoma Therapies by ex Vivo Drug Screening: Advanced Brain Tumor TheRApy Clinical Trial In Patients Scheduled for shOrt Course radiatioN
Patients will receive in addition to standard histology analysis also the PDC- based drug screening.
- Trial name
- ATTRACTION (NCT07627334)
- Testing
- CBmed drug screening platform
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Severe Preeclampsia
Effectiveness Study of Short Course of Magnesium Sulfate for Severe Preeclamsia
Magnesium sulfate is the ideal drug for seizures prophilaxis in preeclampsia. The ideal duration of this treatment after delivery is still to be established.
- Trial name
- MgSO4 (NCT01408979)
- Testing
- Magnesium sulfate 12 hours, Magnesium sulfate 24 hours
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Melanoma
Serial Tumour Biopsies and Blood Biomarkers in Melanoma
Recent advances in understanding how cancer develops and spreads have led to effective new treatments and improved outcomes for patients with melanoma.
- Trial name
- NCT04493723
- Testing
- Surgery, Venepuncture
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- The Christie NHS Foundation Trust