Clinical trials: Clinical Features
NGLY1 Deficiency
NGLY1 Natural History
N-glycanase 1 (NGLY1) Deficiency (OMIM #615273) is an ultra-rare, autosomal recessive disorder caused by loss of function variants in NGLY1 gene.
- Trial name
- NCT06122766
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Baylor College of Medicine
Paraganglioma, Pheochromocytoma
Development of a Predictive Model for the Risk of Metastatic Disease in PPGLs, a Retrospective Cohort Study
Phaeochromocytomas and paragangliomas (PPGLs) are tumours of the adrenal medulla and extra-adrenal sympathetic nervous system, some which can become metastatic. It is a very rare disease and the tumours are often detected late.
- Conditions
- Paraganglioma, Pheochromocytoma, Genetic Predisposition to Disease, Pathology
- Trial name
- PPGL-Pred (NCT04788927)
- Where
- 2 sites in Denmark
- Volunteers
- 400 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Creutzfeldt-Jakob Disease (CJD) | Prion Disease
CLIME-CJD: A Multimodal Study
Creutzfeldt-Jakob disease (CJD) is a rare and rapidly progressive neurological disorder. This study aims to describe and summarize the key features of CJD by looking back at medical records of patients who were diagnosed with CJD…
- Trial name
- NCT07589283
- Testing
- No Interventions
- Where
- China
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Rickettsial Disease
Causes of Fever in Bangladeshi Patients
Background: The clinical features and prevalence of tropical rickettsial illnesses such as murine and scrub typhus in Bangladesh are unknown.
- Trial name
- NCT02339259
- Testing
- Observation
- Where
- Bangladesh
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Immune-Mediated Necrotizing Myopathy
Juvenile Autoimmune Necrotizing Myopathies
Autoimmune necrotizing myopathies (AINM) in adult patients are characterized by severity of muscle damage, presence of necrosis with little inflammation on muscle biopsy and anti-HMGCR or anti-SRP auto-antibodies.
- Trial name
- MYONECPED (NCT04295785)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Central Hospital, Nancy, France
Bronchospasm
Bronchospasm During Anesthetic Induction: Study of Clinical Characteristics and Treatments Administered According to Etiology
Bronchospasm during anaesthesia is a rare but potentially life-threatening event. They are classically part of IgE-dependent anaphylaxis but can also occur as an independent clinical entity, triggered by inflammatory factors such…
- Trial name
- NCT05025709
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Central Hospital, Nancy, France
Stem Cell Transplantation
Pipeline Integrating Gut Metagenome Data, Host Immunogenetic Characteristics and Clinical Gut Inflammatory Biomarkers
The combined analysis of microbiome, immunological parameters and host genetics in patients has potential for applying personalized approaches of prevention, diagnostics or therapy in the future.
- Trial name
- ImMiGeNe (NCT02940093)
- Testing
- Stem cell transplantation
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Sickle Cell Anemia, Sickle Cell β+ or β0 Thalassemia
Sickle Cell Anemia - A Comparative Study Between Three Ethnical Communities, a Multicenter Study
The purpose of this study is to take advance of the presence of two different cohorts of SCA patients in one country, the first group included SCA patients from Bedouin Arab origin that lives in Israel for more than one century…
- Trial name
- NCT01905787
- Where
- 4 sites in United States, Israel
- Volunteers
- 300 people
- Sponsor
- HaEmek Medical Center, Israel
Calcaneonavicular Coalition
Evaluation of Clinical Features and Surgical Outcomes of the Too Long Anterior Process in Children
Calcaneonavicular coalition represents approximately 1% of the population between 8 and 12 years. They are manifested by repeated ankle sprains or by pain.
- Trial name
- NCT04894942
- Testing
- American Orthopaedic Foot and Ankle Society Score (AOFASS)
- Where
- France
- Volunteers
- 11 people
- Sponsor
- University Hospital, Limoges
SARS-CoV-2 Viral Kinetics and Host Immune Responses
Understanding COVID-19
This single-center prospective observational study will examine immune responses to to SARS-CoV-2 and how they correlate with its virological characteristics and clinical manifestations in infected patients.
- Trial name
- NCT04329546
- Testing
- NA (no intervention)
- Where
- Switzerland
- Volunteers
- 86 people
- Sponsor
- University Hospital, Geneva
Hydatid Cyst, Hepatic
Epidemiological Study of Hydatid Cyst in Najaf City, Iraq
Background Cystic echinococcosis (hydatid cyst) is a significant zoonotic disease endemic to Iraq. Understanding the localized clinical and epidemiological trends is vital for improving surgical outcomes and public health…
- Trial name
- Hydatid cyst (NCT07369674)
- Where
- Iraq
- Volunteers
- 350 people
- Sponsor
- Al-Kafeel University
Infective Endocarditis
Characteristics of Infective Endocarditis in East China
This was a retrospective observational study of consecutive cases of definite or possible infective endocarditis (IE) as per the modified Duke criteria between January 2008 and December 2015, which was performed at the Second…
- Trial name
- NCT04977518
- Testing
- no intervention
- Volunteers
- 183 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Asthma
A Study Evaluating Disease Characteristics and Outcomes in Participants With Asthma in Routine Clinical Practice
The main aim of the study to describe the characteristics of participants with asthma across the spectrum of disease severity, including sociodemographic and clinical characteristics, treatment and disease burden, biomarkers, and…
- Trial name
- AIRITY (NCT07556159)
- Testing
- Procedure: Investigational Procedures
- Where
- 83 sites in United States, Canada and 4 more
- Volunteers
- 2,500 people
- Sponsor
- Sanofi
ADHD, Probiotics
Effect of Probiotics on ADHD
Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder. Gut microbiome dysbiosis may be associated with the pathophysiology of ADHD.
- Conditions
- ADHD, Probiotics, Gut Microbiota, Psychiatry
- Trial name
- NCT04958460
- Testing
- BF688
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Wang Liang-Jen
Type 2 Diabetes
A Clinical Study Comparing the Pharmacokinetics and Pharmacodynamic Characteristics of Insulin Degludec Injection (RD15003) and Insulin Degludec Injection (Tresiba®) in Healthy Subjects
To evaluate the single-dose subcutaneous injection of insulin degludec injection (Tresiba®) listed by Novo Nordisk in China as a reference drug, the insulin degludec injection provided by Dongguan Dongyang Sunshine…
- Trial name
- NCT05576298
- Testing
- Insulin degludec injection, RD15003, Insulin degludec, Tresiba
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Inborn Errors of Metabolism
Retrospective Study of Adult Patients With Inborn Errors of Metabolism in Switzerland
This is a retrospective study aimed at establishing a database of the current health of adult patients with IEM in the French-speaking part of Switzerland. .
- Trial name
- NCT03534752
- Where
- Switzerland
- Volunteers
- 220 people
- Sponsor
- University of Lausanne
Hepatocellular Carcinoma
The AI Prognostic Assessment and Pathological Basis Research of Early HCC After Minimally Invasive Treatment
The study evaluates artificial intelligence method based on multimodal magnetic resonance imaging (MRI) images and clinical data in preoperative prediction of prognosis in early hepatocellular carcinoma (HCC) patients treated…
- Trial name
- NCT04299919
- Testing
- Minimally invasive treatment, Hepatectomy
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Delayed Puberty
Delayed Puberty in Boys; Clinical and Biochemical Characteristics and Effect of Testosterone Treatment
To evaluate the phenotype and biochemical characteristics of boys referred for delayed puberty, to describe the frequency of associated co-morbidities and diseases, to evaluate the diagnostic criteria and the effect of…
- Trial name
- NCT02034487
- Testing
- retrospective data collection
- Where
- Denmark
- Volunteers
- 451 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Eating Disorders
Characteristics and Importance of Physical Activity in Women With Anorexia Nervosa
This study will determine the importance and the level of physical activity among women with anorexia nervosa, both during inpatient treatment and 1 year after hospital discharge.
- Trial name
- NCT00917423
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Coronavirus
Clinical Features of Suspected and Confirmed Patients of 2019 Novel Coronavirus Infection
Outbreak of 2019 Novel Coronavirus infection started in Wuhan and quickly spread to the world. Suspected patients were isolated and treated in our department.
- Trial name
- NCT04279782
- Testing
- Comprehensive treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University