Clinical trials: Clinical Study
Ependymoma
Single-agent Erlotinib in Patients Previously Treated With Oral Etoposide in Protocol OSI-774-205
Participants that were assigned to the oral etoposide treatment arm in protocol OSI-774-205 and either progressed while on study or discontinued due to unacceptable toxicity related to etoposide were allowed to participate in…
- Trial name
- NCT01247922
- Testing
- Erlotinib
- Where
- 21 sites in United States, Canada and 1 more
- Volunteers
- 4 people
- Sponsor
- OSI Pharmaceuticals
Recurrent Pericarditis
A Pilot Study of KPL-914 in Recurrent Pericarditis
The purpose of this study is to assess the preliminary efficacy and safety of KPL-914 treatment in participants with recurrent pericarditis.
- Trial name
- NCT03980522
- Testing
- KPL-914
- Where
- 14 sites in United States
- Volunteers
- 26 people
- Sponsor
- Kiniksa Pharmaceuticals (UK), Ltd.
Infection, Pulmonary Complications
Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis
RATIONALE: Antifungal therapy with voriconazole or amphotericin B may be an effective treatment for aspergillosis. It is not yet known whether voriconazole is more effective than amphotericin B in treating patients with…
- Trial name
- NCT00003031
- Testing
- amphotericin B deoxycholate, voriconazole
- Where
- 74 sites in United States, Australia and 13 more
- Volunteers
- 212 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Community-acquired Pneumonia
PCV13 Impact on Pneumococcal Nasopharyngeal Carriage Study
Prospective, observational, hospital based, nasopharyngeal carriage (NPC), vaccine effectiveness study Comparisons will be made in Filipino children, aged 8 weeks to ≤60 months of age at enrollment, who have been hospitalized…
- Trial name
- IMPACT (NCT05114902)
- Testing
- Nasopharyngeal swab
- Where
- Philippines
- Volunteers
- 451 people
- Sponsor
- Asian Foundation for Tropical Medicine Inc.
Anesthesia, Pain
Pupillometry Guided Remifentanil Administration In Pediatric Anesthesia
The aim of this prospective randomized study is to evaluate the impact of peroperative pupillometry monitoring on per and post-operative opioid consumption in pediatric anesthesia.
- Conditions
- Anesthesia, Pain, Child
- Trial name
- NCT02683837
- Testing
- Remifentanil, Pupillometry, Sevoflurane
- Where
- Switzerland
- Sponsor
- University Hospital, Geneva
Dermatitis, Atopic
Comparison Study Between Protopic (Tacrolimus Ointment) and Elidel (Pimecrolimus Cream) in Treating Pediatric Patients With Atopic Dermatitis
Comparison of Protopic Ointment to Elidel Cream to assess the safety and efficacy in pediatric patients with Atopic Dermatitis
- Trial name
- NCT00666159
- Testing
- tacrolimus ointment, pimecrolimus cream
- Where
- 12 sites in United States
- Volunteers
- 226 people
- Sponsor
- Astellas Pharma Inc
Hereditary Inclusion Body Myopathy, GNE Myopathy
GNE-Myopathy Disease Monitoring Program (GNEM-DMP): A Registry and Prospective Observational Natural History Study to Assess GNE Myopathy or Hereditary Inclusion Body Myopathy (HIBM)
HIBM is a severe progressive myopathy that typically presents in early adulthood as weakness in the distal muscles of the lower extremities and progresses proximally, leading to a loss of muscle strength and function, and…
- Conditions
- Hereditary Inclusion Body Myopathy, GNE Myopathy, Nonaka Disease, Quadriceps Sparing Myopathy (QSM)
- Trial name
- NCT01784679
- Where
- 5 sites in United States, Bulgaria and 3 more
- Volunteers
- 319 people
- Sponsor
- Ultragenyx Pharmaceutical Inc
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Busulfan in Treating Children and Adolescents With Refractory CNS Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the safety of delivering intrathecal busulfan in children and adolescents who…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Leukemia, Lymphoma
- Trial name
- NCT00006246
- Testing
- busulfan
- Where
- 8 sites in United States
- Volunteers
- 28 people
- Sponsor
- Pediatric Brain Tumor Consortium
Regenerative Inflammation
Regenerative Endodontic Treatment Using Sodium Hexametaphosphate (SHMP) For Necrotic Immature Permanent Anterior Teeth
evaluate clinically and radiographically regenerative potential of sodium hexametaphosphate (SHMP) on stem cells from the apical papilla for 18-month randomized controlled trial
- Trial name
- Regeneration (NCT07097688)
- Testing
- Sodium Hexametaphosphate (SHMP) Inorganic polyphosphates (poly[P]) are linear polymers of orthophosphate (Pi) residues linked by energy-rich phosphoranhydride bonds, Ithas multiple physiological funct
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ahmad Elheeny
Dental Caries, Child Behavior
Fluoride vs Probiotic Toothpaste for Caries Prevention
This clinical trial had two objectives. The first was to compare the effectiveness of 950 ppm fluoride toothpaste versus probiotic toothpaste in preventing dental caries in 4- to 5-year-old children.
- Trial name
- NCT07579403
- Testing
- Fluoride toothpaste, Probiotic Toothpaste, Control Toothpaste
- Where
- China
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Qingdao University
Narcolepsy in Children
Pediatric Cohort Study
Narcolepsy is a rare disease that affects 0.05% of the general population. It is characterized by a dysregulation of the sleep wake regulation that leads to uncontrolled sleep episode during day and a disorganized sleep during…
- Trial name
- COSACM (NCT04561427)
- Testing
- Study of Sleep architecture in children with narcolepsy
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Neonatal Bradycardia, Hypoxemia of Newborn
Bradycardia Recognition and Detection in Young Infants Part-I
This prospective cohort study will determine the diagnostic accuracy of the Owlet OSS 3.0 monitor for the detection of episodes of bradycardia and/or hypoxemia among infants.
- Trial name
- BRADY-I (NCT05774470)
- Testing
- Owlet OSS 3.0
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Alabama at Birmingham
Type 1 Diabetes
Verapamil In Preclinical Type 1 Diabetes
Type 1 diabetes (T1D) is preceded by a presymptomatic phase featured by the presence of islet autoantibodies (aAbs) without (Stage 1) or with (Stage 2) dysglycemia.
- Trial name
- VIP-1 (NCT07880769)
- Testing
- Verapamil 120 Mg/24 Hours Oral Capsule, Extended Release, blood sampling, EKG and cardiological evaluation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tilapia Fish Skin in Burn Coverage
Burn Coverage of Burn by Tilapia Fish Skin
The goal of this experimental study is to compare TFS and regular dressings as coverage for acute thermal burns. The main question it aims to answer is: Is TFS effective in treating thermal burns? burn induction was done on…
- Trial name
- TFS (NCT06549569)
- Testing
- TFS
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Aswan University
Vaccines, Pneumococcal
Study to Evaluate a 13-valent Pneumococcal Conjugate Vaccine in Infants.
The purpose of this study is to assess the safety, tolerability and immunogenicity of a 13-valent pneumococcal conjugate (13vPnC) vaccine compared to Prevenar (7vPnC), when given concomitantly with routine pediatric vaccinations…
- Trial name
- NCT00368966
- Testing
- 13-valent Pneumococcal Conjugate Vaccine, 7-valent Pneumococcal Conjugate Vaccine
- Where
- 41 sites in Spain
- Volunteers
- 619 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Retinoblastoma
Efficacy Study of Lucentis in the Treatment of Retinoblastoma
This study will evaluate the clinical efficacy of intravitreal injections of Ranibizumab (Lucentis) together with chemotherapy in the treatment of Retinoblastoma as compared to chemotherapy alone.
- Trial name
- NCT01899066
- Testing
- Lucentis, chemotherapy, chemotherapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-sen University
Mumps
Safety Study of Live Attenuated Mumps Vaccines in Junior High School Students Under 14 Years Old
This study of live attenuated mumps vaccines is an observational study in which active monitoring and passive monitoring were combined to conduct safety observation.The live attenuated mumps vaccines manufactured by Sinovac…
- Trial name
- NCT05145166
- Testing
- Safety group
- Where
- 3 sites in China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Sinovac (Dalian) Vaccine Technology Co., Ltd.
Pediatric General Anesthesia With Endotracheal Tube
Ultrasound Study of the Airway to Predict Endotracheal Tube Size in Anesthetized Pediatric Patients
The purpose of this study is to determine whether ultrasound study of the airway to predict endotracheal tube size in anesthetized pediatric patients better than the tube size formula
- Trial name
- NCT02321956
- Testing
- Ultrasound
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
TBI (Traumatic Brain Injury)
Brain Development in Young Children Following Mild Traumatic Brain Injury - Pilot Study
Concussions (also known as mild traumatic brain injury) are common in young children. In some children, they can lead to short- and long-term difficulties.
- Trial name
- KAOUENN (NCT06024122)
- Testing
- IRM exam
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, ANCA-Associated Glomerulonephritis
Stratified Therapy on Pediatric AAGN
Clinical information of children with ANCA-associated nephritis admitted to Children's Hospital Affiliated to Chongqing Medical University and partner centers from January 1, 2023 to December 31, 2023 was collected: To evaluate…
- Trial name
- STPARS (NCT05969522)
- Testing
- GlucoCorticoid
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Wang Mo
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