Clinical trials: Closed-Loop
Diabetes Mellitus, Type 1
International Diabetes Closed Loop (iDCL) Trial: Research Site Training Protocol
The objective of the study is for clinical staff to gain experience using the proposed artificial pancreas system named inControl and the inControl Cloud and assess 24/7 in-home usability prior to initiating a large randomized…
- Trial name
- NCT02844517
- Testing
- Artificial Pancreas
- Where
- 10 sites in United States, France and 2 more
- Volunteers
- 43 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
Artificial Pancreas and Remote Monitoring During a T1DM Youth Ski Camp
An early feasibility study that will test the efficacy of the Tandem t:slim X2 with Control-IQ and Dexcom Continuous Glucose System G6 in a winter/ski camp environment.
- Trial name
- NCT03369067
- Testing
- Tandem t:slim X2 with Control-IQ Technology + Dexcom G6, Dexcom CGM G5, Continuous Subcutaneous Insulin Infusion
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- University of Virginia
Type1diabetes
Assessment of Two Insulin Pump Insulin Delivery Systems in Type 1 Diabetes.
This is a study of the Minimed 670G 4.0 insulin pump, assessing the efficacy of the Advanced Hybrid Closed Loop (AHCL) algorithm in controlling blood glucose levels in Type 1 Diabetes.
- Trial name
- NCT04073576
- Testing
- AHCL, SAP+PLGM
- Where
- New Zealand
- Volunteers
- 60 people
- Sponsor
- Christchurch Clinical Studies Trust Ltd
Insulin Pump Therapy
Closed Loop Pumps vs. Traditional Open Loop Pumps in Managing Blood Glucose Levels in T1DM Patients Fasting in Ramadan.
Our proposed study aims to build upon the existing findings by conducting a first-of-its-kind randomized controlled trial (RCT) that directly compares Advanced Hybrid Closed Loop (AHCL) and open-loop insulin delivery (OLID)…
- Trial name
- HybridRam (NCT06416202)
- Testing
- Advanced hybrid closed loop insulin pump, Open Loop Insulin Delivery system
- Where
- Saudi Arabia
- Volunteers
- 75 people
- Sponsor
- King Fahad Medical City
Acute Respiratory Failure, Pediatric Respiratory Distress Syndrome
Closed-loop Synchronization Versus Conventional Synchronization
A prior research indicated that asynchrony between the patient and ventilator occurred in 33 percent of 19,175 breaths, and was seen in every patient.
- Trial name
- CHESTSIPP (NCT05731024)
- Testing
- close-loop synchronization controller with SPONT mode, Conventional synchronization settings with SPONT mode
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Parkinson's Disease (PD)
Closed-Loop Therapeutic Refinement Using Local Field Potentials in Parkinson's Disease
This multi-center pilot study compares conventional DBS (cDBS) and adaptive DBS (aDBS) in Parkinson's disease patients using the Medtronic Percept™ system.
- Trial name
- CTRL-PD (NCT07105280)
- Testing
- Optimized conventional DBS, Optimized adaptive DBS
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- HagaZiekenhuis
Type 1 Diabetes
Closed-loop Control of Overnight Glucose Levels in Adults and Adolescents With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT01905020
- Testing
- Carbohydrate-rich meal, Exercise
- Where
- 3 sites in Canada
- Volunteers
- 28 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes Mellitus
Safety and Efficacy of Overnight Closed Loop in Children With Type 1Diabetes Mellitus in Luxembourg
The purpose of this study is to validate current algorithms and evaluate safety and efficacy of overnight closed loop insulin delivery (FlorenceD2 system) in children with type 1 diabetes between 6 - 12 years of age in Luxembourg…
- Trial name
- NCT02099409
- Testing
- FLORENCED2
- Where
- 2 sites in Luxembourg
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier du Luxembourg
Type 1 Diabetes
Effect of Metabolic Control at Onset of Diabetes on Progression of Type 1 Diabetes
The purpose of this study is to find out if very tight blood glucose control from the onset of Type 1 Diabetes can preserve beta cell function.
- Trial name
- NCT00891995
- Testing
- Closed loop, Home glucose monitoring, Insulin pump
- Where
- 5 sites in United States
- Volunteers
- 71 people
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes Mellitus
Safety Evaluation of the Advanced Hybrid Closed Loop (AHCL) System
This study is a Safety Evaluation of the Advanced Hybrid Closed Loop (AHCL) System in Type 1 Adult and Pediatric Subjects.
- Trial name
- NCT03959423
- Testing
- AHCL insulin pump system
- Where
- 17 sites in United States
- Volunteers
- 288 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes
Comparison of an Artificial Pancreas Versus Threshold Low Glucose Suspend in Type 1 Diabetic Children
The objective of this study is to assess the efficacy of an Artificial Pancreas system which includes a Control-To-Range algorithm, versus standard Insulin Pump Therapy with Threshold Low glucose Suspend feature.
- Trial name
- SHAN (NCT02509429)
- Testing
- Insulin therapy (aspart, lispro ou glulisine) with Control-to-Range algorithm, Insulin therapy ((aspart, lispro ou glulisine) withThreshold Low Glucose Suspend
- Where
- 4 sites in France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Montpellier
Type1 Diabetes Mellitus
The Insulin-Only Bionic Pancreas Bridging Study- Pediatric Transitional Study
The iLet is a closed-loop delivery system that can be used in insulin-only, bihormonal, or glucagon-only configurations. Previous studies have utilized a phone-based bionic pancreas.
- Trial name
- NCT04112069
- Testing
- iLet Bionic Pancreas insulin-only configuration with Humalog or Novolog, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Type1 Diabetes
Hybrid Closed Loop Therapy and Verapamil for Beta Cell Preservation in New Onset Type 1 Diabetes (CLVer): Extension Study
The purpose of this extension study is to continue to follow the participants who completed the CLVer RCT for up to 3 additional years.
- Trial name
- CLVerEx (NCT06177691)
- Where
- 6 sites in United States
- Volunteers
- 77 people
- Sponsor
- Jaeb Center for Health Research
Mechanical Ventilation
Ventilation With ASV Mode in Children
ASV mode of ventilation is an automatic mode with closed-loop control used for mechanical invasive ventilation in intubated patients. It has been studied in adult patients but not in children.
- Trial name
- NCT03930147
- Testing
- ASV ventilation
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Lausanne Hospitals
Type 1 Diabetes
Safety of Artificial Pancreas Therapy in Preschoolers, Age 2-6
A single-arm, multi-center, clinical study to assess the safety profile of the Tandem t:slim X2 with Control-IQ system in children with T1D aged 2-6 years old under free living condition
- Trial name
- NCT04084171
- Testing
- Tandem t:slim X2 with Control-IQ Technology + Dexcom G6
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Type 1 Diabetes
Hybrid Closed-Loop Hotel Studies With Medtronic PID Controller
The primary objective of this study is to evaluate the safety and efficacy of the Medtronic hybrid closed-loop (HCL) system utilizing the proportional-integral-derivative algorithm with insulin feedback (PID-IFB) optimized to…
- Trial name
- NCT02280863
- Testing
- Medtronic Hybrid Closed-loop System - Android Platform, Medtronic Hybrid Closed-loop Integrated System
- Where
- 3 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Stanford University
Type1 Diabetes
Hybrid Closed Loop Therapy and Verapamil for Beta Cell Preservation in New Onset Type 1 Diabetes
Randomized trial of youth aged 7-<18 years with newly diagnosed stage 3 type 1 diabetes (T1D) to assess the effect of both (1) near-normalization of glucose concentrations achieved through use of a hybrid closed loop (HCL) system…
- Trial name
- CLVer (NCT04233034)
- Testing
- HCL, verapamil 120mg tablet, non-HCL
- Where
- 6 sites in United States
- Volunteers
- 113 people
- Sponsor
- Jaeb Center for Health Research
Anesthesia
Use of Closed-loop Anesthesia in Pediatric Patients
To compare manual administration of propofol and remifentanil and dual closed-loop using bispectral index as the control variable during pediatric anesthesia
- Trial name
- LoopPed (NCT00778505)
- Testing
- Propofol, remifentanil
- Where
- 2 sites in France
- Volunteers
- 45 people
- Sponsor
- Hopital Foch
Type 1 Diabetes Mellitus
Development of Algorithms for a Hypoglycemic Prevention Alarm: Closed Loop Study
This research study, Development of Algorithms for a Hypoglycemic Prevention Alarm, is being conducted at Stanford University Medical Center and the University of Colorado Barbara Davis Center.
- Trial name
- NCT00884611
- Testing
- Predictive Low Glucose Suspend Algorithm ON, Predictive Low Glucose Suspend Algorithm OFF
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Acute Lung Injury
Driving Pressures in a Closed-loop and a Conventional Mechanical Ventilation Mode
In mechanically ventilated patients, driving pressure (ΔP) assess the strain applied to the respiratory system and is related to ICU mortality.
- Trial name
- NCT04541199
- Testing
- closed loop, conventional
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Dr. Behcet Uz Children's Hospital