Clinical trials: Clotrimazole
Clotrimazole, Ovulen
Comparative Efficacy of Ovule vs Tablet
The study is focused to prove that the efficacy of a new Canesten formulation (ovule) is not inferior to the old Canesten formulation (tablet)
- Conditions
- Clotrimazole, Ovulen, Vulvovaginal Candidiasis
- Trial name
- NCT00755053
- Testing
- Clotrimazole, vaginal ovule, Clotrimazole, vaginal tablet
- Where
- 17 sites in Germany, Russia
- Volunteers
- 466 people
- Sponsor
- Bayer
Invasive Fungal Infections
Rezafungin Paediatric PK Study in Paediatric Subjects From Birth to <18 Years of Age
This study aimed to learn what levels of rezafungin were in the blood after dosing and how safe it was, in children and adolescents below 18 years old who were already receiving treatment for a fungal infection, a suspected…
- Trial name
- NCT05534529
- Testing
- Rezafungin Acetate
- Where
- 10 sites in Germany, Spain and 1 more
- Volunteers
- 32 people
- Sponsor
- Mundipharma Research Limited
Aspergillosis
To Determine Whether Galactomannan Test Will Help to Detect Fungal Infections Early and Hence Start Treatment Early
Chemotherapy lowers the white blood cell count or weakens the immune system for a long time. This puts the patients at a high risk of getting a serious fungal infection of the internal organs or blood.
- Trial name
- NCT00361517
- Testing
- Galactomannan antigen monitoring, Aspergillus PCR, blood draws, blood draws for GM monitoring
- Where
- Singapore
- Volunteers
- 47 people
- Sponsor
- Singapore General Hospital
Otomycosis
Efficacy and Safety Study of Miconazole Oil Versus Vehicle on Fungal Infection of the Ear Canal (Otomycosis)
This study involves two portions, a randomized, double-blind portion and an open-label portion, to evaluate the efficacy and safety of Miconazole oil 2% versus its Vehicle in the treatment of fungal infection of the outer ear…
- Trial name
- NCT04432376
- Testing
- miconazole 2% oil, vehicle oil
- Where
- 12 sites in United States
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- Hill Dermaceuticals, Inc.
Ulcerative Colitis, Pouchitis
Clotrimazole Enemas for Pouchitis in Children and Adults
Colectomy with creation of an ileal pouch (IPAA) is now the treatment of choice for patients with ulcerative colitis that is resistant to existing medical therapies.
- Conditions
- Ulcerative Colitis, Pouchitis, Ileitis, Inflammatory Bowel Disease
- Trial name
- CAPTURE (NCT00061282)
- Testing
- Clotrimazole
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Web
Bacterial Vaginosis, Candidiasis
Study of the Management of Vaginal Discharge in West African Using Single Dose Treatments
This randomised controlled trial aimed to verify whether directly observed single dose treatment (with tinidazole+fluconazole) would be as effective as the longer standard treatments (metronidazole for 7 days, plus vaginal…
- Conditions
- Bacterial Vaginosis, Candidiasis, Vaginitis
- Trial name
- NCT00313131
- Testing
- tinidazole+fluconazole vs metronidazole+clotrimazole
- Where
- 7 sites in Ghana, Guinea and 1 more
- Volunteers
- 1,524 people
- Sponsor
- Université de Sherbrooke
Pyothorax, Fungal Infection Lungs
Fungal Empyema Thoracis
Background: Fungal empyema thoracis is a rare but life-threatening pleural infection caused by fungal organisms such as Aspergillus and Candida species.
- Conditions
- Pyothorax, Fungal Infection Lungs, Pleural Empyema
- Trial name
- NCT07337993
- Testing
- pleural lavage followed by surgery, Decortication, Conservative Arm
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Health Sciences Lahore
Otomycosis, Antifungal Agents
Nanoparticle-Based Prunus Salicina Extract vs. Clotrimazole for Otomycosis
This randomized controlled superiority trial evaluates the anti-otomycotic efficacy of Prunus salicina methanolic extract in two formulations (standard drops and chitosan nanoparticle-based drops) compared to standard 1%…
- Trial name
- NCT07867223
- Testing
- Group A, Group B, Group C
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Deraya University
Candidiasis, Oral, HIV Infections
A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients With AIDS
To compare the efficacy, safety, and tolerance of fluconazole single daily capsule for 14 days versus clotrimazole troche 5 x daily for 14 days in the treatment of oropharyngeal candidiasis in patients with AIDS.
- Trial name
- NCT00002282
- Testing
- Clotrimazole, Fluconazole
- Where
- 17 sites in United States
- Sponsor
- Pfizer
Otomycosis
Efficacy of Pyodine Soaked Gelfoam vs Single Topical Application of Clotrimazole in Otomycosis Treatment
Background and Objectives To compare the efficacy of gel foam-soaked pyodine with a single topical application of clotrimazole ointment.
- Trial name
- NCT06339294
- Testing
- Clotrimazole Cream, Povidone-Iodine
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Fungal Infection
Alternate Day Micafungin: A PK Study in Pediatric Patients
The purpose of this study is to examine the pharmacokinetics of micafungin when it is given on an every other day schedule. The study will determine if every other day micafungin will provide drug exposure equivalent to daily…
- Trial name
- NCT00842504
- Testing
- Micafungin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Invasive Fungal Infections
Expanded Access to Fosmanogepix for Patients With Serious or Life-threatening Invasive Fungal Infections
The EAP is intended to provide a treatment option for patients with proven or probable serious or life-threatening invasive fungal infection (in accordance with the EORTC-MSGERC criteria) who have exhausted their treatment…
- Trial name
- NCT06433128
- Testing
- Fosmanogepix solution for infusion, Fosmanogepix 400 mg tablets
- Sponsor
- Basilea Pharmaceutica
Otomycosis
Phase III Efficacy and Safety Study of Miconazole Oil for Otomycosis
The goal of this clinical trial is to prove the that miconazole oil works well on fungal infections of the ears, by comparing the drug with a placebo.
- Trial name
- NCT05660382
- Testing
- Miconazole (2%) oil and mineral oil
- Where
- 7 sites in United States
- Volunteers
- 112 people
- Sponsor
- Hill Dermaceuticals, Inc.
Oral Lichen Planus
Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus
Oral Lichen Planus (OLP) is an autoimmune, chronic inflammatory mucocutaneous disease characterized by pain and burning sensation.
- Trial name
- NCT03026478
- Testing
- Betamethasone Dipropionate, Clobetasol Propionate
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Garlapati Komali
Immunocompromised, Bone Marrow Transplant
A Pharmacokinetic Study of Pediatric Micafungin Prophylaxis
The purpose of this research study is to examine the pharmacokinetics (the process by which a drug is absorbed, distributed, metabolized, and eliminated by the body) of micafungin when it is given at 5mg/kg dose to…
- Conditions
- Immunocompromised, Bone Marrow Transplant, Cancer
- Trial name
- Micafungin (NCT02057289)
- Testing
- Micafungin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Diaper Rash
Prospective Two-Year Study to Assess Miconazole Nitrate Resistance in Neonates and Infants
The purpose of this study is to determine whether repeated use of 0.25% miconazole nitrate ointment in newborns and infants with a yeast infection in the diaper area causes the yeast to become resistant to the drug.
- Trial name
- NCT00702507
- Testing
- 0.25 % Miconazole Nitrate Ointment
- Where
- 8 sites in United States, Dominican Republic and 2 more
- Volunteers
- 200 people
- Sponsor
- Stiefel, a GSK Company
Intra-abdominal Perforation
the Influence of Prophylactic and Empirical Anti-fungal Treatment in Severe Sepsis Patients With Perforations
This prospective intended to observe the influence of prophylactic and empirical anti-fungal treatment on Severe Sepsis patients with perforations.
- Trial name
- NCT02941068
- Testing
- fluconazole and caspofungin
- Volunteers
- 223 people
- Sponsor
- Nanjing PLA General Hospital
Invasive Fungal Infections
Comparative Study of Micafungin (FK463) Versus Placebo as Prophylactic Antifungal Therapy in the ICU
The purpose of this study is to determine the efficacy and safety of intravenous micafungin versus placebo as prophylactic therapy for invasive fungal infections in patients in the intensive care unit considered to be at high…
- Trial name
- NCT00048750
- Testing
- Micafungin
- Where
- 48 sites in United States, Canada
- Volunteers
- 104 people
- Sponsor
- Astellas Pharma Inc
Acute Lymphoblastic Leukaemia, Acute Myeloid Leukaemia
Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression
The purpose of this study is to understand the safety, tolerability, efficacy, pharmacokinetic (PK), pharmacodynamic (PD), and preliminary efficacy of orally administered AZD3632 in participants with advanced haematologic…
- Conditions
- Acute Lymphoblastic Leukaemia, Acute Myeloid Leukaemia, Higher-risk Myelodysplastic Syndromes
- Trial name
- MOMENTUM (NCT07155226)
- Testing
- AZD3632, Posaconazole
- Where
- 30 sites in United States, Australia and 7 more
- Volunteers
- 85 people
- Sponsor
- AstraZeneca
Otomycosis
Comparative Efficacy of Topical Clotrimazole Versus 2% Salicylic Acid in Otomycosis
Otomycosis is a fungal infection of the outer ear canal that commonly causes itching, discomfort, discharge, and a feeling of blockage in the ear.
- Trial name
- NCT07535424
- Testing
- clotrimazole, 2% Salicylic Acid
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Mayo Hospital Lahore