Clinical trials: Cognitive Functions
Cognitive Function
Efficacy and Safety of Eriobotyra Japonica Lindley Extract on Improvement of Cognitive Function
The investigators performed a 12-week, randomized, double-blind, placebo-controlled human trial to evaluate the efficacy and safety of Eriobotyra Japonica Lindley Extract on improvement of Memory Function.
- Trial name
- NCT01734200
- Testing
- Eriobotyra Japonica Lindley Extract
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Focal Epilepsy
The Effects on Cognitive Function of Levetiracetam (Keppra®) Compared to Carbamazepine (Tegretol®, Carmazepine®) as Monotherapy for Children With Partial Seizure; A Multicentric Randomized Controlled Study
Unlike the first generation antiepileptic medications, newer drugs for epilepsy such as levetiracetam are reported to have less adverse effect in children but not many studies have systematically reviewed the subject.
- Trial name
- NCT02208492
- Testing
- Levetiracetam, Carabamazepine
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Yonsei University
Sleep, Sleep Restriction
The Cognitive and Metabolic Effects of Sleep Restriction in Adolescents
The aim of this study is to examine the neurobehavioural and glucose metabolic responses to two successive cycles of sleep restriction and recovery in adolescents, and to determine the benefits of napping on cognitive…
- Trial name
- NFS4 (NCT03333512)
- Testing
- Nap
- Where
- Singapore
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Autism Spectrum Disorder, Anxiety
Effect of Cognitive Behavioural Therapy (CBT) for Children With Autistic Spectrum Disorders
Cognitive Behavioural Therapy is an effective intervention program for children with High-Functioning Autistic Spectrum Disorder to remediate anxiety issues.
- Trial name
- NCT01031511
- Testing
- Cognitive Behavioural Therapy, Social Recreational
- Where
- Singapore
- Volunteers
- 73 people
- Sponsor
- National Healthcare Group, Singapore
Cognitive Change, Well-Being, Psychological
Trout Consumption in Young Children and Families and Brain Health
Regular fish consumption may support brain health. Trout lines developed in Idaho contain higher levels of omega-3 fatty acids, nutrients important for human cognition and mental wellbeing.
- Trial name
- NCT06721468
- Testing
- Trout, Child-centered nutrition phrases, Puzzle
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Idaho
Mild Cognitive Impairment
An Intergenerational, Cognitively Enriched Intervention for MCI Patients and Their Children.
In 2018, approximately 50 million people received a diagnosis of dementia, which is projected to triple by 2050. To mitigate the increase in dementia, it is crucial to prevent cognitive decline in at risk groups, such as older…
- Trial name
- MCI-project (NCT06221579)
- Testing
- No intervention, interviews with MCI patients as part of the development phase
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- University Ghent
Autistic Disorders Spectrum
Neurostimulation for Cognitive Rehabilitation in Autistic Spectrum Disorders
This study is a clinical trial aims investigate the effects of neurostimulation in the treatment of children with mild ASD, specifically the action of tDCS on social cognition skills.
- Trial name
- NCT03947086
- Testing
- Transcranial Direct Current Stimulation (TDCS)- Active, Cognitive Training
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- Federal University of Paraíba
Dysmenorrhea, Primary Dysmenorrhea
The Effect of Cognitive Exercise Therapy Approach and Yoga in Adolescents With Dysmenorrhoea
Dysmenorrhoea is a condition that negatively affects the quality of life in women of many age groups. In girls with dysmenorrhoea in adolescence, there is an effect on school performance, self-confidence-depression problems and a…
- Trial name
- NCT06398990
- Testing
- Cognitive Exercise Therapy Approach, Yoga, Routine Medical Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Acibadem University
Attention Deficit Disorder With Hyperactivity
Long-term Effects of Medication for ADHD
Single-centre open-label prospective study, enrolling 127 children and adolescents aged 6-17 years, who receive medication for ADHD of any subtype (presentation).
- Trial name
- LMA (NCT03250013)
- Testing
- ADHD medications
- Where
- Sweden
- Volunteers
- 128 people
- Sponsor
- Göteborg University
Pediatric Epilepsy
Social Cognition in Pediatric Epilepsy
The purpose of this study is to investigate the development of social cognition skills in pediatric epilepsy compared to healthy children.
- Trial name
- TOMEPI (NCT04253379)
- Testing
- Neuropsychological evaluation , Evaluation of theory of mind, Evaluation of executive functions, Evaluation of verbal skills
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
22q11.2 Deletion Syndrome, Velo-Cardio-Facial Syndrome
Cognitive Remediation in 22q11DS
The goal of this study is to collect preliminary data on the efficacy of a cognitive remediation program in improving the neurocognitive deficits in children with chromosome 22q11.2 deletion syndrome (22q11DS).
- Trial name
- NCT01781923
- Testing
- Cognitive remediation program, Small group social skills training
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Diabetes Mellitus, Type 1, Epilepsy
Impact of Parental Perfectionistic Cognitions Self-compassion Intervention Effects on Shame in Child Health Context
Parents of children with long-term health conditions (LTCs) can experience shame related to parenting. Whilst self-compassion interventions (SCIs) can reduce parental shame, this has not been studied with parents of children with…
- Conditions
- Diabetes Mellitus, Type 1, Epilepsy, Asthma, Shame
- Trial name
- NCT03504605
- Testing
- Online self-compassion intervention
- Where
- United Kingdom
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Tuberous Sclerosis Complex, Aspirin
Aspirin as an add-on Treatment of Refractory Epilepsy in Tuberous Sclerosis Complex
There had been much evidence in aspirin controlling tumorous conditions conducted by basic researches, especially through mammilian target of rapamycin (mTOR) pathway.
- Conditions
- Tuberous Sclerosis Complex, Aspirin, Epilepsy, Cognitive Decline
- Trial name
- NCT03356769
- Testing
- Aspirin, AED
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Peking Union Medical College Hospital
Attention-Deficit/Hyperactivity Disorder (ADHD)
Reward Effects on Cognition, Motor Skills, and Motivation in Children
This interventional study aimed to aimed to evaluate the effects of rewards on cognitive function, motor skills, and motivation in 8- to 10-year-old children with ADHD following 3- and 6-week interventions.
- Trial name
- ADHD (NCT06798337)
- Testing
- Conventional Physiotherapy group, Reward based physiotherapy group
- Where
- Lithuania
- Volunteers
- 67 people
- Sponsor
- Lithuanian Sports University
Alzheimer Disease, Mild Cognitive Impairment (MCI)
Prospective Cohort Study of Patients With Early Alzheimer's Disease Treated With Lecanemab
As the population increases and aging intensifies, cognitive disorders represented by Alzheimer's disease (AD) not only pose a severe threat to public health but also bring significant social and economic burdens.
- Trial name
- NCT06741553
- Testing
- Lecanemab 10 mg/kg
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Physical Activity, Obesity
Effectiveness of MOVI Interventions on Adiposity, Cognition and Subclinical Atherosclerosis: MOVI-daFit!
Project which objective is to test the effectiveness of an extracurricular physical activity intervention based on high intensity interval training (MOVI-daFit!) on improving cardiorespiratory fitness (CRF), cardiometabolic risk…
- Conditions
- Physical Activity, Obesity, Children, Cardiovascular
- Trial name
- NCT03236337
- Testing
- MOVI intervention
- Where
- 2 sites in Spain
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Overweight, Childhood, Obesity, Childhood
Prevalence of Obesity and Overweight in Primary School Children in the Rhein-Neckar Region in Germany
The study will determine the weight status in primary school children in the Rhein-Neckar Region in Germany and will analyse the development of height and weight in these children during the time of COVID-19 related restrictions…
- Conditions
- Overweight, Childhood, Obesity, Childhood, Child Development, Overweight and Obesity
- Trial name
- NCT05077059
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Adipositasnetzwerk Rhein-Neckar e.V.
Huntington Disease, Juvenile
REGISTRY-JHD - an Observational Study of the European Huntington's Disease Network (EHDN)
The study aims to monitor the progression of symptoms and signs of those affected by JHD using modified UHDRS scales of motor and function (functional assessment, TFC).
- Trial name
- JHD (NCT01590602)
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 78 people
- Sponsor
- European Huntington's Disease Network
Preterm Birth, Cognitive Dysfunction
Building the Path to Resilience in Preterm Infants: Mindfulness-based Intervention
Yearly 15 million babies worldwide are born too soon. 10% of these preterm births occur very early before 32 weeks of gestation and these newborns are at high risk for neurodevelopmental disorders later in life.
- Conditions
- Preterm Birth, Cognitive Dysfunction, Behavioral Problem
- Trial name
- NCT04638101
- Testing
- Mindfulness-based intervention
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pediatric Clinical Research Platform
Mucopolysaccharidosis Type II, Metabolic Diseases
A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II
This is phase 2/3 study to evaluate the safety, pharmacokinetics, pharmacodynamics, and efficacy of the investigational product GNR-055 in MPS II (Hunter syndrome) patients of different age groups.
- Trial name
- NCT05208281
- Testing
- GNR-055 1.0-2.0-3.0 mg/kg, GNR-055 2.0 mg/kg, GNR-055 3.0 mg/kg
- Where
- 5 sites in Russia
- Volunteers
- 32 people
- Sponsor
- AO GENERIUM
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