Clinical trials: Cognitive Functions
Cognitive Intervention to Promote Healthy Development of Executive Function (EF) Skills in Young Children
Parent-Child EF Intervention
Koronis Biomedical Technologies Corporation (KBT) is developing a cognitive intervention to promote healthy development of Executive Function (EF) skills in young children by leveraging a smartphone-based training regime designed…
- Trial name
- NCT06924307
- Testing
- Executive Function Intervention
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Koronis Biomedical Technologies
Autism Spectrum Disorder
Biomarker-Driven Pharmacological Treatment of Adolescents With Autism Spectrum Disorder With Gabapentin
The social cognitive deficits associated with autism spectrum disorder (ASD) are related to an imbalance in excitatory and inhibitory neurotransmission, specifically a deficit in the inhibitory neurotransmitter GABA.
- Trial name
- NCT05063656
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- David Cochran
BECTS, Epilepsy, Rolandic
Emotion Recognition in Benign Epilepsy of Childhood With Centro-Temporal Spikes (BECTS)
The social processes depend on complex cognitive mechanisms, which involve mainly the frontal and temporal lobe regions. Patients with early onset frontal and temporal lobe lesions might later develop important deficits in social…
- Trial name
- BECTS (NCT03465566)
- Testing
- IDS;MMSPE;CDI 2;CBCL;tests of facial expression evaluation
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Alzheimer's Disease
Development and Decline of Brain and Cognition Through the Life Span
The protocol objectives are to enable prospective IRB review of research using human MRI scans and data collected under other branch protocols or extramural sources.
- Trial name
- NCT00880451
- Where
- United States
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy, Adolescent
Physical Activity on Motor Competence, Cognitive Function and Mood in Adolescents
The study aimed to determine the effect of coordinative-based physical activity practices on motor competence, cognitive function and mood levels of adolescent boys.
- Trial name
- NCT07111780
- Testing
- "Coordinative-Based Physical Activity Practices" training group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University
Alzheimer Disease, Dementia Alzheimers
Optical Coherence Tomography in Cerebral Amyloidosis
In this observational study, the investigators aim to evaluate whether changes in the retinal and choroidal circulation, as assessed by Optical Coherence Tomography (OCT) and the quantification of retinal amyloid deposits using…
- Conditions
- Alzheimer Disease, Dementia Alzheimers, Dementia, Lewy Body Disease
- Trial name
- NCT03472482
- Testing
- non-invasive retinal imaging
- Where
- Belgium
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Epilepsy
Management Strategies For Electrical Status Epilepticus During Sleep
Electrical status epilepticus during slow wave sleep is a condition in which the epileptic patient starts to develop neurocognitive deterioration, any type of seizures and continuous electrical activity in the EEG during non…
- Trial name
- NCT03251820
- Testing
- corticosteroid
- Volunteers
- 50 people
- Sponsor
- Randa Abdelbadie Abdelaleem
Brain and Central Nervous System Tumors, Cognitive/Functional Effects
Modafinil in Treating Children With Memory and Attention Problems Caused by Cancer Treatment for a Brain Tumor
RATIONALE: Modafinil may help improve memory, attention, and fatigue caused by cancer treatment. PURPOSE: This phase II randomized trial studies how well modafinil works in treating children with memory and attention problems…
- Conditions
- Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Fatigue, Neurotoxicity
- Trial name
- NCT01381718
- Testing
- modafinil
- Where
- 60 sites in United States
- Volunteers
- 112 people
- Sponsor
- University of South Florida
Major Depressive Disorder, Remission
Quality of Life in Chinese Working and School Age Population With MDD
Major depressive disorder (MDD) is a common mental illness with high prevalence and global burden. Previous studies revealed that over 70% patients in remission still had decreased quality of life, severe function impairment, low…
- Trial name
- NCT04986124
- Testing
- treatment as usual
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai Mental Health Center
Brain Health, Cognition
Exercise Effects on Cognition in School-Aged Children
Recent trends have identified decreasing levels of physical activity, fitness, and health in preadolescent children. Examining factors, such as physical activity behavior and aerobic fitness that positively influence cognitive…
- Conditions
- Brain Health, Cognition, Scholastic Achievement
- Trial name
- FITKids (NCT01334359)
- Testing
- Physical Activity
- Where
- United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Autism Spectrum Disorder
High School SUCCESS: Vocational Soft Skills Program for Transition-Age ASD Youth
By utilizing community-based participatory research methods, this research was conducted in collaboration with the community through our partnership of researchers, educators, providers and consumers (Active Collaborative Hub for…
- Trial name
- TAY SUCCESS (NCT04953793)
- Testing
- TAY SUCCESS, Usual Care
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Rady Children's Hospital, San Diego
Neurofibromatosis 1 (NF1), Executive Function (Cognition)
Cognitive Intervention for Children and Adolescents With NF1
Psychological interventions have been shown to be effective for managing cognitive and mental health challenges in different patient populations.
- Conditions
- Neurofibromatosis 1 (NF1), Executive Function (Cognition), Cognitive Intervention
- Trial name
- NCT07869914
- Testing
- Unstuck and On Target!
- Volunteers
- 60 people
- Sponsor
- The Hospital for Sick Children
Chediak Higashi Syndrome, Chronic Granulomatous Disease
Learning and Behavior Problems in Children With Chronic Granulomatous Disease and Related Disorders
This study will try to determine what causes learning, behavioral and emotional problems in children with chronic granulomatous disease (GCD) and other phagocyte disorders.
- Conditions
- Chediak Higashi Syndrome, Chronic Granulomatous Disease, Job's Syndrome, Leukocyte Disorder
- Trial name
- NCT00005933
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Stroke
The Acute and Chronic Effects of a Heel Raise Programme on Central Blood Pressure, Arterial Compliance and Oxygen Perfusion After Stroke
Physical inactivity and increased sedentary time are linked to increased blood pressure and may cause decreases in peripheral and cerebral oxygen perfusion in stroke survivors.
- Trial name
- NCT03423433
- Testing
- Heel raise intervention
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Winchester
Cognitive Impairment
Family-Centered Songwriting in Pediatric Palliative Care
This study evaluates the feasibility and efficacy of a family-centered songwriting intervention for cognitively-impaired children referred to a palliative care service.
- Trial name
- NCT04198038
- Testing
- Songwriting with licensed music therapist
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt University
Pediatric Obesity, Executive Function
Cognitive Aspects of Response to Treatment for Weight-related Health to Improve Eating and Exercise Earlier in Life
We plan to examine whether child and parental cognitive/executive function predict body composition outcomes and adherence to a 6-month protocol of Family-Based Behavioral Treatment (FBT), for pediatric obesity.
- Trial name
- CARTWHEEL (NCT03329300)
- Testing
- Family-based Behavioral Treatment (FBT)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Alabama at Birmingham
Cognitive Decline
Flortaucipir 18F PET Imaging in BIOCARD Study
This study is designed to assess the imaging characteristics of Flortaucipir (18F-AV-1451) in subjects who participated in the Biomarkers of Cognitive Decline Among Normal Individuals (BIOCARD) study at Johns Hopkins University.
- Trial name
- NCT03052972
- Testing
- Flortaucipir F18, Brain PET scan
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Obesity, Childhood, Overweight, Childhood
Sleep and Stigma: Novel Moderators in the Relationship Between Weight Status and Cognitive Function
The investigators aim to assess the relationship between overweight/obesity and decreased cognitive function in adolescents. While this relationship has been seen in past literature, the causal mechanisms are still unclear.
- Trial name
- NCT04346433
- Testing
- Restricted Sleep, Adequate Sleep
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cognitive Function, Growth
Long-term Effects of Iron and Zinc Supplementation During Infancy on Cognitive Performance and Growth
The hypotheses of this study are: 1. Compared to children who received a placebo, children who received iron or zinc or iron and zinc combined will perform better on cognitive tests and will have better growth status at ages 8 to…
- Trial name
- FeZn_FU (NCT00824304)
- Where
- Thailand
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Healthy
Nutrition and Cognition in Indian Children
Nutritional deficiencies are a major problem in school children in India and have a variety of adverse effects on their cognitive development and growth, and increase susceptibility to infections.
- Trial name
- CHAMPION (NCT00467909)
- Testing
- micronutrients
- Where
- India
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- St. John's Research Institute
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