Clinical trials: Cohort Studies
Solid Tumor, Osteosarcoma
Metronomic Chemotherapy in Patients With Advanced Solid Tumor With Bone Metastasis and Advanced Pretreated Osteosarcoma
This is a prospective open-labeled phase I trial based on a dose escalating study design assessing two dose levels of sirolimus when prescribed in combination with metronomic cyclophosphamide (CP), methotrexate (MT) and…
- Trial name
- METZOLIMOS (NCT02517918)
- Testing
- Sirolimus combined with CP, MT and ZA
- Where
- 3 sites in France
- Volunteers
- 23 people
- Sponsor
- Institut Bergonié
Fullterm Birth, Neonate
Assessment of Autonomic Maturation in Neonatal Period and Early Neural Development From a Longitudinal Prospective Cohort
The heart rate variability assessment of the sympathetic-parasympathetic balance is a strong analytical tool in the autonomic nervous system (ANS) physiology, at each end of life.
- Conditions
- Fullterm Birth, Neonate, Prematurity
- Trial name
- AUBE (NCT00951860)
- Testing
- Autonomic Nervous System activity
- Where
- France
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Amputation, Surgical, Walking, Difficulty
Outcome of a Cohort of Patients Fitted With a SYME Type Prosthesis in the Context of a Hindfoot Amputation With Distal Support
The purpose of this study is to see outcome of patients with syme prothesis in order to comment the handfoot amputation.
- Trial name
- DEVSYME (NCT06448260)
- Testing
- Questionnary
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Institut Robert Merle d'aubigné
Lung Neoplasms, Family Research
A Prospective Cohort of Pulmonary Ground Glass Nodules Patients With Family History.
The aim of the present prospective cohort study (GGN-F) is to study the family aggregation of pulmonary ground glass nodules via the questionnaire survey and to investigate the underlying genetic mechanism via the biobank.
- Trial name
- GGN-F (NCT04220268)
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Guangdong Provincial People's Hospital
Hepatitis C, Chronic, Liver Diseases
Patterns of Early Hepatitis C Virus Decline Predict the Outcome of Interferon Therapy (sIFN-pred2)
The purpose of this study is to validate the first round HCV early dynamics discovery within a larger population.
- Conditions
- Hepatitis C, Chronic, Liver Diseases, Interferon Deficiency
- Trial name
- sIFN-pred2 (NCT01760148)
- Testing
- interferon alpha 2b
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Junqi Niu
Bloodstream Infection, Salmonella Bacteremia
Clinical Decision Support in Non-typhoidal Salmonella Bloodstream Infections in Children
In sub-Saharan Africa, non-typhoidal Salmonella (NTS) are a frequent cause of bloodstream infection, display high levels of antibiotic resistance and have a high case fatality rate (15%).
- Conditions
- Bloodstream Infection, Salmonella Bacteremia, Malaria,Falciparum, Severe Malaria
- Trial name
- DeNTS (NCT04473768)
- Where
- Belgium
- Volunteers
- 1,880 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Refraction Error, Myopia
Age and Refraction in Predicting Myopia Progression in COVID-19
To determine the longitudinal changes of age and refraction in predicting myopia progression with risk under the coronavirus disease 2019 (COVID-19) pandemic in a 3-year follow-up of a Chinese cohort.
- Trial name
- NCT05305274
- Testing
- screening
- Where
- China
- Volunteers
- 34,400 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Body Weight, Obesity
Meta-analyses of Food Sources of Fructose-Containing Sugars and Obesity
Sugars have been implicated in the epidemics of overweight and obesity. This view is supported by lower quality evidence from ecological observations, animal models, and select human trials.
- Conditions
- Body Weight, Obesity, Overweight, Adiposity
- Trial name
- NCT02558920
- Testing
- Fructose-containing Sugars
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Alagille Syndrome (ALGS), Progressive Familial Intrahepatic Cholestasis (PFIC)
A Database Study of Maralixibat (TAK-625) in Participants With Alagille Syndrome (ALGS) and Progressive Familial Intrahepatic Cholestasis (PFIC)
This study is a database study in Japan for maralixibat (TAK-625) used to treat participants with Alagille Syndrome (ALGS) and Progressive Familial Intrahepatic Cholestasis (PFIC).
- Trial name
- NCT07293897
- Testing
- Maralixibat
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Takeda
Small Bowel Obstruction
SnapSBO - Small Bowel Obstruction Snapshot Audit
Small bowel obstruction (SBO) and its complications are frequently seen in patients admitted through the Emergency Departments of all acute care hospitals2.
- Trial name
- SnapSBO (NCT05843097)
- Where
- Spain
- Volunteers
- 1,900 people
- Sponsor
- European Society for Trauma and Emergency Surgery
HIV
The Study of the Prevalence of Helicobacter Pylori Infection Among HIV/AIDS Cohort
The purpose of the Study is to investigate the prevalence of Helicobacter Pylori infection among the HIV/AIDS group. The study will screen the patients who were confirmed HIV/AIDS in Kaohsiung Medical University Hospital and…
- Trial name
- NCT01261208
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Traumatic Brain Injury, Blunt Abdominal Trauma
Impact of Traumatic Brain Injury on Hemodynamic Instability in Patients With Blunt Bowel and Mesenteric Injuries
This retrospective cohort study aims to evaluate the impact of traumatic brain injury (TBI) on hemodynamic status in trauma patients with surgically confirmed blunt bowel and mesenteric injuries (BBMI).
- Conditions
- Traumatic Brain Injury, Blunt Abdominal Trauma, Hemodynamic Instability, Shock
- Trial name
- NCT06942091
- Testing
- Traumatic Brain Injury (TBI)
- Volunteers
- 169 people
- Sponsor
- Chang Gung Memorial Hospital
Cardiovascular Diseases, Heart Diseases
Childhood Passive Smoking: Cohort Study of Cardiac Risk
To determine the effects of long-term exposure to passive smoking on the cardiovascular and oxygen transport systems in pre-adolescent twins.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Lung Diseases, Coronary Arteriosclerosis
- Trial name
- NCT00005242
- Sponsor
- Virginia Commonwealth University
Autoimmune Liver Diseases, Immunological Mechanisms
The MAI-FOIE Cohort
The MAI-FOIE cohort will be a French multicenter cohort with the development of a biobank including patients with autoimmune, metabolic and medicated liver diseases
- Trial name
- NCT07594990
- Where
- 13 sites in France
- Volunteers
- 800 people
- Sponsor
- Nantes University Hospital
SARS-CoV-2, COVID-19
A Cohort of Patients With Possible or Confirmed SARS-CoV-2 (COVID-19)
SARV-CoV-2 infection was considered pandemic on March 11, 2020. The SARV-CoV-2 epidemic affected France from the beginning of March, spreading in particular from a 4-day large evangelical meeting of 2500 people on February 17 in…
- Trial name
- COVIDothèque (NCT04347850)
- Testing
- blood sample
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Covid19, Surgery
The Effect of the Covid-19 Pandemic Among Operated Patients
This project covers several research aims and uses different research methods, such as cohort analyses.
- Trial name
- NCT04525716
- Testing
- COVID-19 infection status, Socioeconomic status
- Where
- Sweden
- Volunteers
- 300,000 people
- Sponsor
- Karolinska Institutet
Congenital Mitral Insufficiency
Study of Innovative Strategies for Mitral Valve Repair
The goal of this observational study is to compare the safety and effectiveness of a 3-steps standardized repair-oriented strategy with annuloplasty only in pediatric patients with mild to moderate mitral valve regurgitation.
- Trial name
- NCT06037447
- Testing
- 3-steps standardized repair-oriented strategy
- Where
- China
- Volunteers
- 256 people
- Sponsor
- China National Center for Cardiovascular Diseases
Radiofrequency Can be Used to Treat Splenic Trauma Because of Its Excellent Coagulation Hemostasis
RF-assisted Splenic Preservation VS Conventional Treatment of Blunt Splenic Injury.
Radiofrequency (RF) can be used to treat splenic trauma because of its excellent coagulation hemostasis. This study aimed to compare the efficacy of RF-assisted spleen-preserving surgery with that of conventional…
- Trial name
- NCT03890328
- Testing
- radiofrequency ablation
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Southwest Hospital, China
Macular Disease
Cohort Study of the Clinical Course of Macular Diseases in Kagawa
Macular diseases often cases severe visual impairment. Recent clinical introduction of anti-vascular endothelial growth factor agents may change the clinical course of various macular diseases, including age-related macular…
- Trial name
- NCT02321267
- Testing
- ranibizumab, aflibercept, pegaptanib, verteporphin
- Where
- Japan
- Volunteers
- 1,000 people
- Sponsor
- Kagawa University
Respiratory Function Tests，Heart Function Tests, Cardiopulmonary Function
Xiangya Cardiopulmonary Health and Disease Cohort
Xiangya Cardiopulmonary Health and Disease Cohort (XY-CPHDC) is a non-intervention study grounded in real-world data. It is designed as a bidrectional clinical cohort combined retrospective and prospective design, in order to…
- Trial name
- XY-CPHDC (NCT06972784)
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
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