Clinical trials: Colitis, Ulcerative
Ulcerative Colitis, Dysplasia
Development of Dysplasia in the Pelvic Pouch in Patients With Ulcerative Colitis (UC) and Risk Factors
The purpose of this study is to study development of dysplasia in the ileal mucosa among patients with Ulcerative Colitis and who previous have hade risk factors for developing cellular changes/dysplasia, i.e.
- Conditions
- Ulcerative Colitis, Dysplasia, Surgery
- Trial name
- NCT01764542
- Testing
- Endoscopy and biopsy
- Where
- Sweden
- Volunteers
- 56 people
- Sponsor
- Mattias Block
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Inflammatory Bowel Disease, Crohn's Disease
Efficacy and Safety of Upadacitinib in Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD), which encompasses ulcerative Colitis (UC) and Crohn's Disease (CD), has seen significant improvements in patient outcomes with biologic treatments.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- EaseUpIBD (NCT06780683)
- Testing
- Upadacitinib
- Where
- 6 sites in China
- Volunteers
- 174 people
- Sponsor
- Xiang Gao
Ulcerative Colitis (UC)
Use of the Ulcerative Colitis Diet for Induction of Remission
The goal of the study is to evaluate the use of Ulcerative Colitis Diet for Induction of Remission. The investigators have postulated that we developed could be beneficial for patients with Ulcerative Colitis.
- Trial name
- NCT02217722
- Testing
- Ulcerative Colitis Diet, Antibiotic cocktail
- Where
- Israel
- Volunteers
- 9 people
- Sponsor
- Prof. Arie Levine
Crohn Disease, Ulcerative Colitis
OptiMized REsistaNt Starch in Inflammatory Bowel Disease: The MEND Trial
The purpose of the study is to determine if a plant-based resistant starch that is optimized for the individual will target the underlying cause of inflammatory bowel disease and restore a "healthier" gut microbiome in pediatric…
- Conditions
- Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
- Trial name
- NCT04520594
- Testing
- Resistant Starch
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Children's Hospital of Eastern Ontario
Ulcerative Colitis (UC)
A Study to Assess Adverse Events and Change in Disease Condition of Mesalamine Capsules in Children Aged 5 to 17 Years With Ulcerative Colitis
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) characterized by diffuse, continuous inflammation of the colon.
- Trial name
- NCT05316220
- Testing
- Mesalamine
- Where
- 10 sites in United States, Puerto Rico
- Sponsor
- AbbVie
Ulcerative Colitis, Crohn Disease
Evaluation of the Diagnostic Value of microRNAs for Inflammatory Bowel Diseases
The purpose of this study is to assess the diagnostic value of microRNAs in IBD colon (ulcerative colitis or Crohn's disease) in adults as compared to healthy controls (and non-IBD colitis)
- Conditions
- Ulcerative Colitis, Crohn Disease, Healthy, Non-IBD Colitis
- Trial name
- MicroMICI (NCT02020382)
- Testing
- qPCR diagnostic KIT of microRNAS
- Where
- 5 sites in France
- Volunteers
- 325 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ulcerative Colitis
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis
This is a multinational, multicenter, randomized, double-blind, placebo-controlled, Phase 3 induction study to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active Ulcerative Colitis…
- Trial name
- SUNSCAPE-1 (NCT07184996)
- Testing
- Duvakitug
- Where
- 240 sites in United States, Argentina and 23 more
- Volunteers
- 980 people
- Sponsor
- Sanofi
Ulcerative Colitis
Assessment of 5-Aminosalicylic Acid Prescription Patterns and Treatment Outcomes in Patients With Ulcerative Colitis in Korea
The prevalence of ulcerative colitis (UC), which is one of the inflammatory bowel diseases, is known to be increasing and the majority of patients (≥ 85%) have experienced mild or moderate severity.
- Trial name
- NCT04499495
- Testing
- PENTASA (mesalamine/ 5-Aminosalicylic acid (5-ASA)
- Where
- South Korea
- Volunteers
- 11,385 people
- Sponsor
- Ferring Pharmaceuticals
Colon Cancer, Diverticulitis
General Surgical Outcomes Quality Improvement Database (UH-SOCRATES)
A database has been established to track the outcomes of all cases performed in the University Hospitals Department of Surgery in an effort to improve quality of surgical performance and case management.
- Conditions
- Colon Cancer, Diverticulitis, Colorectal Polyps, Crohn's Disease
- Trial name
- SOCRATES (NCT00622557)
- Where
- United States
- Volunteers
- 200,000 people
- Sponsor
- University Hospitals Cleveland Medical Center
Inflammatory Bowel Diseases, Ulcerative Colitis
Personalized B-fructan Diet in Inflammatory Bowel Disease Patients
This study aims to examine patient tolerability of personalized dietary fibre consumption recommendations (high-pectin diet versus high-B-fructan diet based on personalized responses), provided by an IBD dietician, based on our…
- Trial name
- NCT05615779
- Testing
- Randomized B-fructan diet, Personalized pectin diet, Personalized B-fructan diet
- Where
- 2 sites in Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Ulcerative Colitis
Fecal Microbiota Transplantation in Patients With Ulcerative Colitis
The purpose of this study is to find out whether a single fecal microbiota transplantation is an effective and safe treatment as an adjunct to standard therapy in patients with ulcerative colitis.
- Trial name
- NCT01961492
- Testing
- Fecal microbiota transplantation
- Where
- Finland
- Sponsor
- Turku University Hospital
Prospective Study, Ulcerative Colitis in Remission
A Multicenter Prospective Cohort Study on the Clinical Prognosis of Ulcerative Colitis
Mucosal healing or histological remission is an important target for the treatment of inflammatory bowel disease. In this study, patients with mucosal healing are defined as a control group, observing their clinical outcomes for…
- Trial name
- NCT03698812
- Testing
- Colonoscope
- Where
- China
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Colitis, Ulcerative
A Study to Evaluate the Safety and Efficacy of AJM300 in Participants With Active Ulcerative Colitis
The study will investigate the efficacy and safety of an oral dose of AJM300 960 milligram (mg)/dose administered three times daily for 8 weeks in participants with active ulcerative colitis.
- Trial name
- NCT03531892
- Testing
- AJM300
- Where
- 82 sites in Japan
- Volunteers
- 198 people
- Sponsor
- EA Pharma Co., Ltd.
Crohn's Disease, Ulcerative Colitis
Long-term Scheduled Therapy With Infliximab in Inflammatory Bowel Disease
The primary objective of this study is to evaluate sustained clinical remission (for the definition see below) in patients with inflammatory bowel disease receiving long-term (> 2 years) scheduled treatment with infliximab.
- Trial name
- NCT02057016
- Where
- Italy
- Volunteers
- 258 people
- Sponsor
- Catholic University of the Sacred Heart
Ulcerative Colitis, Ulcerative Colitis Chronic
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Ulcerative Colitis
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Ulcerative Colitis
- Trial name
- NCT04148274
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)
Spiritual Needs of European Patients With Inflammatory Bowel Disease and Their Caregivers
A European-wide cross-sectional non-interventional study, initiated by a pilot study in Italy, will be conducted. The first phase of the pilot study is a 6-step translation, adaptation, and validation of the extended version of…
- Trial name
- Spirit@IBD (NCT07020481)
- Volunteers
- 1,000 people
- Sponsor
- University of Padova
Inflammatory Bowel Disease, Crohn's Disease
Bacteriotherapy in Pediatric Inflammatory Bowel Disease
In this study, the investigators want to see if Bacteriotherapy (also referred to as stool transplantation) improves the symptoms and decreases inflammation in children with Inflammatory Bowel Disease (IBD).
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis, CD
- Trial name
- NCT01757964
- Testing
- Bacteriotherapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- David Suskind
Ulcerative Colitis, Crohn's Disease
Nasal Calcitonin in the Treatment of Bone Mineral Loss in Children and Adolescents With Inflammatory Bowel Disease
The hypothesis underlying this study is that nasally administered calcitonin will stabilize or improve bone mineral density in young patients with ulcerative colitis or Crohn's disease.
- Trial name
- NCT00114803
- Testing
- Calcitonin nasal spray (salmon)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Boston Children's Hospital
Ulcerative Colitis
A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)
The purpose of this protocol is to evaluate the efficacy of tulisokibart in participants with moderately to severely active ulcerative colitis.
- Trial name
- NCT06052059
- Testing
- IV Tulisokibart, SC Tulisokibart
- Where
- 476 sites in United States, Argentina and 43 more
- Volunteers
- 1,109 people
- Sponsor
- Merck Sharp & Dohme LLC