Clinical trials: Colitis
Ulcerative Colitis
The Use of Butyrate Therapy in Pediatric Ulcerative Colitis
Butyrate is an important metabolite produced by the gut microbiome and has been shown as a helpful therapy in ulcerative colitis.
- Trial name
- NCT05218850
- Testing
- Butyrate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital Los Angeles
Ulcerative Colitis
Lactobacillus GG in Pediatric Ulcerative Colitis (UC)
Abstract: Current evidence suggests that the enteric flora is the primary trigger for chronic mucosal inflammation in the Inflammatory Bowel Diseases (IBD), Crohn's Disease (CD) and Ulcerative Colitis (UC).
- Trial name
- NCT00895336
- Testing
- Lactobacillus GG
- Where
- United States
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Arthritis, Rheumatoid, Spondylitis, Ankylosing
One-year Persistence to Treatment of Participants Receiving Flixabi or Imraldi: a French Cohort Study
A study to describe the one-year persistence in participants treated by Flixabi (infliximab) or Imraldi (Adalimumab) as prescribed by the physician for each of the 5 following indications: Rheumatoid Arthritis (RA), Ankylosing…
- Conditions
- Arthritis, Rheumatoid, Spondylitis, Ankylosing, Arthritis, Psoriatic, Crohn's Disease
- Trial name
- PERFUSE (NCT03662919)
- Testing
- Infliximab, Adalimumab
- Where
- 60 sites in France
- Volunteers
- 2,274 people
- Sponsor
- Biogen
Inflammatory Bowel Diseases, Crohn Disease
Therapeutic Effect of New Biologics in Crohn's Disease
New types of biologics have brought advantages in therapy strategies for Crohn's disease. However, clinical data evaluating their efficacy and adverse in China is lacking.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Treatment Side Effects
- Trial name
- NCT04923100
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Ulcerative Colitis
Safety and Pharmacokinetics of MMX Mesalamine in Children and Adolescents With Ulcerative Colitis
The purpose of this study is to determine the safety and pharmacokinetics of MMX mesalamine following administration in children and adolescents with ulcerative colitis.
- Trial name
- NCT01130844
- Testing
- MMX Mesalamine
- Where
- 19 sites in United States, Australia and 3 more
- Volunteers
- 52 people
- Sponsor
- Shire
Inflammatory Bowel Diseases, Colitis, Ulcerative
Initial Experience With a Novel Single-Balloon Enteroscopy System in Children With IBD
To evaluate the safety and efficacy of the NaviAid™ AB in children with known or suspected IBD.
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease
- Trial name
- NCT02629211
- Testing
- NaviAid™ AB
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Smart Medical Systems Ltd.
Eosinophilic Esophagitis, Gastritis
Data Bank for Eosinophilic Disorders
The purpose of this study is to conduct a translational study in patients with primary eosinophil associated gastrointestinal disorders [EGID] (e.g.
- Conditions
- Eosinophilic Esophagitis, Gastritis, Enteritis, Eosinophilic Colitis
- Trial name
- NCT00267475
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Marc Rothenberg
Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis)
Analysis of Barriers and Facilitators to Adapted Physical Activity for Pediatric Patients With Chronic Inflammatory Bowel Diseases
This study aims to identify perceived barriers and facilitators to regular physical activity among children and adolescents with inflammatory bowel disease (IBD) followed in pediatric gastroenterology.
- Trial name
- Feels-Mici (NCT07383844)
- Testing
- IMPACT-III questionnaires, Data collection: CAPAS-Q, semi-structured interview
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Lenval
Ulcerative Colitis
Combination of Diet and 5ASA ( 5-aminosalicylic Acid) for Ulcerative Colitis
Combination Therapy with Drug and Diet for Induction of Remission in Mild to Moderate Active Pediatric Ulcerative colitis: A Single Blinded, International Randomized Controlled Trial
- Trial name
- INDUCT (NCT03980405)
- Testing
- Group 1- Control Diet, Group 2- UCD Diet
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Prof. Arie Levine
Ulcerative Colitis, Crohn's Disease
A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease
The main aim of this study is to learn how the body of a child or teenager with moderately to severely active ulcerative colitis (UC) or Crohn's disease (CD) processes vedolizumab (pharmacokinetics) given just under the skin…
- Trial name
- NCT06100289
- Testing
- Vedolizumab IV, Vedolizumab SC
- Where
- 54 sites in United States, Belgium and 14 more
- Volunteers
- 70 people
- Sponsor
- Takeda
Ulcerative Colitis
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis
This is a multinational, multicenter, randomized, double-blind, placebo-controlled, Phase 3 induction study to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active Ulcerative Colitis…
- Trial name
- SUNSCAPE-1 (NCT07184996)
- Testing
- Duvakitug
- Where
- 240 sites in United States, Argentina and 23 more
- Volunteers
- 980 people
- Sponsor
- Sanofi
Colitis, Ulcerative
A Study of How the Medicine Called "Etrasimod" Works in Children With the Gut Disease Called Ulcerative Colitis
The purpose of this study is to determine the safety, efficacy, and pharmacokinetics (PK) of etrasimod for the treatment of moderately to severely active ulcerative colitis in pediatrics participants (≥ 2 years up to < 12 years…
- Trial name
- ELEVATE-UCkids (NCT07470879)
- Testing
- Etrasimod
- Where
- 46 sites in United States, Australia and 8 more
- Volunteers
- 24 people
- Sponsor
- Pfizer
Inflammatory Bowel Diseases, Crohn Disease
Conventional vs Biologic Therapy in Pediatric IBD
This combined retrospective-prospective cohort study aims to evaluate the effectiveness, safety, and adverse events of conventional versus biologic therapy in children and adolescents with inflammatory bowel disease at Assiut…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT07818473
- Volunteers
- 100 people
- Sponsor
- Assiut University
Crohn's Enteritis, Crohn Disease
Physical Fitness Levels in Children and Adolescents With Chronic Inflammatory Bowel Disease (CIBD): Crohn's Disease, Ulcerative Colitis, Chronic Unclassified Colitis
Inflammatory bowel diseases (IBDs), including Crohn's disease (CD), ulcerative colitis (UC) and IBD-unclassified (IBD-U), are characterised by chronic inflammation of the gastrointestinal tract.
- Conditions
- Crohn's Enteritis, Crohn Disease, Inflammatory Bowel Diseases, Colitis, Ulcerative
- Trial name
- MICI-FIT (NCT04647578)
- Testing
- GT3X Actigraph accelerometer.
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Crohn Disease, Ulcerative Colitis
Safety and Efficacy of Fecal Microbiota Transplantation
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease…
- Conditions
- Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome
- Trial name
- NCT04014413
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Chinese University of Hong Kong
Colitis, Gastrointestinal Diseases
Efficacy of a Low Fiber Diet for Pediatric Colonoscopy Prep
This study is designed to evaluate if pediatric patients who are undergoing a bowel preparation in anticipation of a colonoscopy may be able to take in a low fiber diet instead of a standard, clear liquid diet, while still…
- Conditions
- Colitis, Gastrointestinal Diseases, Pediatric Disorder, Pediatric Crohns Disease
- Trial name
- NCT05918562
- Testing
- Low fiber diet, Standard clear liquid diet
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Rhode Island Hospital
Ulcerative Colitis
Special Drug-Use Surveillance Study on Vedolizumab for IV Infusion 300 mg [Ulcerative Colitis]
The purpose of this survey is to evaluate the long-term safety and effectiveness of vedolizumab for intravenous (IV) infusion 300 milligrams (mg) in ulcerative colitis (UC) patients in the routine clinical setting.
- Trial name
- NCT03824561
- Testing
- Vedolizumab
- Where
- Japan
- Volunteers
- 1,110 people
- Sponsor
- Takeda
Ulcerative Colitis (Disorder)
Efficacy and Safety of Etrasimod in Elderly Patients With Ulcerative Colitis
Eligible patients will be identified in regular clinical practice. After providing thorough explanation and obtaining voluntary written informed consent, the clinical course, adverse events, endoscopic findings, and…
- Trial name
- NCT07243639
- Testing
- Etrasimod administration
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Showa Inan General Hospital
Infectious, Colitis
A Two-Arm, Multi-Centre Clinical Evaluation of the xTAG Gastrointestinal Pathogen Panel
The xTAG Gastrointestinal Pathogen Panel (xTAG GPP) is a PCR-based assay to detect the presence or absence of gastrointestinal (GI) pathogens from human stool specimens.
- Conditions
- Infectious, Colitis, Gastroenteritis
- Trial name
- NCT01326013
- Where
- 6 sites in United States, Canada
- Volunteers
- 1,534 people
- Sponsor
- Luminex Molecular Diagnostics
Inflammatory Bowel Diseases
Individualized Infiximab Dosing-Proof of Concept Study
The purpose of this study is to determine which early infliximab pharmacokinetic level is most associated with clinical remission at weeks 30 and 54 in pediatric IBD patients.
- Trial name
- NCT02027727
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Cedars-Sinai Medical Center