Clinical trials: Colitis
Diabetes Mellitus, Type 1, Ulcerative Colitis
Machine Learning Approach to Study the Interactions Between Environment and Intestinal Tissue Homeostasis in IBD
The intestinal epithelial barrier is one of the most important security checkpoints of our body that constrains harmful factors from invading mucosal surfaces and facilitates the absorption of nutrients and water.
- Trial name
- NCT06120322
- Testing
- Environmental factor monitoring; collection of blood, feces and urine. For UC: collection of 8 additional biopsies
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele
Crohn Disease, Ulcerative Colitis
Monitoring of Pediatric Inflammatory Bowel Diseases Using Multispectral Optoacoustic Tomography
In this clinical trial, the intestinal wall of pediatric patients with Crohns disease and Ulcerative Colitis will be assessed with multispectral optoacoustic tomography (MSOT) to characterize the optoacoustic signal of the…
- Conditions
- Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
- Trial name
- NCT06107179
- Testing
- Multispectral Optoacoustic Tomography
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Ulcerative Colitis, Cytomegalovirus Infections
Assessment of CMV-specific ELISPOT Assay for Predicting CMV Colitis in Patient With Ulcerative Colitis
Consequences of latent cytomegalovirus (CMV) infection reactivation on ulcerative colitis flare, as a flare-worsening factor or simple bystander, are debated.
- Conditions
- Ulcerative Colitis, Cytomegalovirus Infections, Disease Exacerbation
- Trial name
- ACE-UC (NCT02439372)
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Asan Medical Center
Inflammatory Bowel Diseases, Crohn's Disease
Thalidomide in Pediatric Inflammatory Bowel Diseases.
Several open-label studies reported thalidomide efficacy in inducing clinical remission and steroid tapering in refractory Inflammatory Bowel diseases (IBD), both in adults and in children.
- Conditions
- Inflammatory Bowel Diseases, Crohn's Disease, Ulcerative Colitis
- Trial name
- TALIBDP (NCT00720538)
- Testing
- Thalidomide
- Where
- 7 sites in Italy
- Volunteers
- 84 people
- Sponsor
- IRCCS Burlo Garofolo
Inflammatory Bowel Diseases
Butyrate in Pediatric Inflammatory Bowel Disease
The first prospective randomised placebo-controlled study in the IBD pediatric population was conducted to evaluate the effectiveness of oral sodium butyrate as add-on therapy in IBD.
- Trial name
- NCT05456763
- Testing
- sodium butyrate
- Volunteers
- 100 people
- Sponsor
- Centre of Postgraduate Medical Education
Colitis,Ulcerative, Adenomatous Polyposis Coli
Registry With Information About Colitis Ulcerosa and Familial Adenomatous Polyposis Patients
The purpose of this registry is to collect information about patients in which a pouch has been created to improve in the future the quality of the surgery of the pouch.
- Conditions
- Colitis,Ulcerative, Adenomatous Polyposis Coli, Reservoir, Ileoanal
- Trial name
- KOPOF (NCT01604564)
- Where
- Belgium
- Volunteers
- 207 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ulcerative Colitis, Flare Up, Symptom
Effectiveness of Golimumab in Patients With Ulcerative Colitis: Results of a Real-life Study in Switzerland
TNF inhibitors have improved treatment options for patients with inflammatory bowel disease (IBD) and three TNF inhibitors, infliximab, adalimumab and golimumab are available for treatment of ulcerative colitis in Switzerland.
- Trial name
- NCT05405465
- Testing
- Exposure to golimumab
- Where
- Switzerland
- Volunteers
- 103 people
- Sponsor
- University of Zurich
Colitis, Ulcerative
Localized Therapeutics for the Treatment of Gastrointestinal Disorders II
The purpose of this study is to investigate a novel thermosensitive topical gel formulation for the treatment of inflammatory bowel disease (IBD), specifically ulcerative colitis.
- Trial name
- NCT02745678
- Testing
- Thermosensitive gel rectal formulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Stanford University
Inflammatory Bowel Diseases, Crohn Disease
De-escalation of Anti-TNF Therapy in Inflammatory Bowel Disease
BACKGROUND/RATIONALE: Treatment outcomes of patients with inflammatory bowel disease (IBD) have improved enormously during the past decade due to the use of anti-tumour necrosis factor (anti-TNF) therapy.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Colitis, Ulcerative
- Trial name
- FREE (NCT04646187)
- Testing
- Infliximab, Adalimumab
- Where
- 7 sites in Belgium, Netherlands and 1 more
- Volunteers
- 148 people
- Sponsor
- University Medical Center Groningen
Chronic Inflammatory Bowel Diseases
Digestive Evolution of Children With Crohn's Disease or Ulcerative Colitis Whose Anti-TNFα Treatment Was Switched to Ustekinumab Due to Paradoxical Psoriasis,
Inflammatory bowel diseases (IBD) include Crohn's disease (CD) and ulcerative colitis (UC). They cause abdominal pain and chronic diarrhea and/or rectal bleeding, which can lead to weight loss and malnutrition.
- Trial name
- INFLISWITCH (NCT07529236)
- Testing
- switch of anti TNF for ustekinumab for paradoxical psoriasis.
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Colitis, Ulcerative
A Study to Assess the Safety and Pharmacokinetics of Subcutaneously Administered Golimumab, a Human Anti-TNFα Antibody, in Pediatric Patients With Moderate to Severe Active Ulcerative Colitis
The purpose of this study is to evaluate the pharmacokinetics (what the body does to the study medication) and safety of subcutaneously (under the skin) administered golimumab in pediatric participants (aged 2 to 17 years) with…
- Trial name
- NCT01900574
- Testing
- Golimumab
- Where
- 27 sites in United States, Austria and 8 more
- Volunteers
- 35 people
- Sponsor
- Janssen Research & Development, LLC
Crohn Disease, Ulcerative Colitis
Expanded Access to Upadacitinib
This is an expanded access program (EAP) for eligible participants. This program is designed to provide access to upadacitinib prior to approval by the local regulatory agency. Availability will depend on territory eligibility.
- Conditions
- Crohn Disease, Ulcerative Colitis, Idiopathic Arthritis (Including sJIA, pJIA, or JPsA), Atopic Dermatitis
- Trial name
- NCT04159597
- Testing
- Upadacitinib
- Sponsor
- AbbVie
Crohn's Disease, Ulcerative Colitis
Disease Course in an IBD Cohort in the Era of Biological Treatment
The aim of the study is to do a 7-year follow-up of a consecutive inception cohort of 562 adults and children diagnosed and registered with inflammatory bowel disease in 2003-04 in order to evaluate the consequences of biological…
- Trial name
- NCT01468090
- Where
- 2 sites in Denmark
- Volunteers
- 192 people
- Sponsor
- Hvidovre University Hospital
Ulcerative Colitis, Crohn's Disease
A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease
The main aim of this study is to learn how the body of a child or teenager with moderately to severely active ulcerative colitis (UC) or Crohn's disease (CD) processes vedolizumab (pharmacokinetics) given just under the skin…
- Trial name
- NCT06100289
- Testing
- Vedolizumab IV, Vedolizumab SC
- Where
- 54 sites in United States, Belgium and 14 more
- Volunteers
- 70 people
- Sponsor
- Takeda
Ulcerative Colitis, Ulcerative Colitis Chronic
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
The main purpose of this study is to evaluate the long-term efficacy of mirikizumab in pediatric participants with ulcerative colitis (UC) or Crohn's disease (CD).
- Conditions
- Ulcerative Colitis, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases, Crohn's Disease
- Trial name
- SHINE-ON (NCT04844606)
- Testing
- Mirikizumab
- Where
- 69 sites in United States, Austria and 14 more
- Volunteers
- 150 people
- Sponsor
- Eli Lilly and Company
Ulcerative Colitis, Crohn's Disease
Probiotics in GastroIntestinal Disorders
All of us have millions of bacteria living in our gut. These bacteria are very important to our health providing us with protection against infections of the gut, allowing us to gain extra nutritional value from food we eat and…
- Trial name
- PROGID (NCT00510978)
- Testing
- Bifidobacterium infantis 35624, Lactobacillus salivarius UCC118
- Where
- Ireland
- Volunteers
- 360 people
- Sponsor
- University College Cork
Pediatric Ulcerative Colitis
Clinical Study of TA-650 in Pediatric Patients With Ulcerative Colitis
The purpose of this study is to evaluate the the efficacy of TA-650 using Clinical activity index (CAI) score and other evaluation indicators in pediatric patients with moderate to severe ulcerative colitis after TA-650…
- Trial name
- NCT01585155
- Testing
- TA-650
- Where
- 7 sites in Japan
- Volunteers
- 21 people
- Sponsor
- Tanabe Pharma Corporation
Inflammatory Bowel Diseases, Crohn Disease
Nutrition and Clinical Outcomes in IBD
The goal of this observational study is to demonstrate that nutritional status and body composition have an impact on clinical outcomes in inflammatory bowel disease (IBD). The main objectives are: 1.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Malnutrition
- Trial name
- NUTRICO-IBD (NCT06550310)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Barts & The London NHS Trust
Ulcerative Colitis, Pouchitis
Clotrimazole Enemas for Pouchitis in Children and Adults
Colectomy with creation of an ileal pouch (IPAA) is now the treatment of choice for patients with ulcerative colitis that is resistant to existing medical therapies.
- Conditions
- Ulcerative Colitis, Pouchitis, Ileitis, Inflammatory Bowel Disease
- Trial name
- CAPTURE (NCT00061282)
- Testing
- Clotrimazole
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Web
Inflammatory Bowel Diseases, Crohn Disease
Epidemiology of IBD in Hong Kong: An Inception Cohort and Follow up Study
Crohn's disease and ulcerative colitis are inflammatory disorders of the gut which cause major life-long disability. They affect males and females, with the commonest age of onset in childhood, teens and early adult life.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- ACCESS (NCT02131168)
- Where
- Hong Kong
- Volunteers
- 300 people
- Sponsor
- Chinese University of Hong Kong