Clinical trials: Colonisation
Orthodontic Appliance Complication
Microbial Colonisation On Vacuum-Formed Retainers Constructed On Conventional Models And Three Dimensional (3D) Reconstructed Models
Vacuum-formed retainers are clear or transparent retainers, that hold the teeth in the new position after active orthodontic treatment.
- Trial name
- NCT03844425
- Testing
- Conventional VFR, VFR from SLA, VFR from FDM
- Where
- Malaysia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Risk Factor
Digestive Colonisation by Highly Resistant Bacteria (CODBAHRE)
The aim of this study is to identify in hospitalized patients, the risk factors associated with the digestive colonisation by emergent extensively drug-resistant bacteria (eXDR), to optimize their detection and the medical care…
- Trial name
- CODBAHRE (NCT04085380)
- Where
- France
- Volunteers
- 2,396 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infection, Bacterial, Infection Prevention
Optimising Kangaroo Care to Reduce Neonatal Severe Infection/Sepsis and Resistant Bacterial Colonisation Among High-risk Infants in NICU.
NeoDeco is a pragmatic, multicenter, parallel-group, cluster-randomised hybrid effectiveness-implementation trial designed to evaluate the impact of implementing optimised Kangaroo Care (KC) at the unit level compared to standard…
- Trial name
- NeoDeco (NCT05993442)
- Testing
- Optimised kangaroo care
- Where
- 24 sites in Greece, Italy and 3 more
- Volunteers
- 3,080 people
- Sponsor
- PENTA Foundation
Clostridium Difficile
Influence of a New Polycationic Disinfectant on Clostridium Difficile Incidence and Environmental Colonisation
The aim of this study is to 1) test the efficacy of PHMG-based disinfectant against C. difficile spores, 2) test whether it reduces the incidence of C. difficile associated disease (CDAD) and 3) evaluate cost.
- Trial name
- NCT00566306
- Testing
- Polyhexamethyleneguanidine (PHMG)
- Volunteers
- 200 people
- Sponsor
- University of Helsinki
Streptococcus Agalactiae (Streptococcus Group B)
The Clinical and Molecular Epidemiology of Streptococcus Agalactiae Colonisation on the Kenyan Coast
Sub-Saharan Africa (sSA) has the highest regional rates of perinatal mortality worldwide. Group B Streptococcus (GBS) has been identified as a leading cause of early onset neonatal sepsis (EOS, in <7 days of life) in sSA.
- Trial name
- GBS (NCT01757041)
- Where
- 4 sites in Kenya
- Volunteers
- 7,967 people
- Sponsor
- University of Oxford
Neonatal Sepsis
Use of Probiotics to Reduce Infections, Death and ESBL Colonisation
This study examines the effect of oral probiotic treatment to newborns on preventing hospitalizations, death and colonization with Extended-spectrum beta-lactamase-producing Gram negative bacteria.
- Trial name
- ProRIDE (NCT04172012)
- Testing
- Labinic (R) probiotic mixture
- Where
- Tanzania
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Haydom Lutheran Hospital
Bronchopulmonary Dysplasia
Clarithromycin Prophylaxis in Preterm Infants Colonisation With Ureaplasma Urealyticum and Mycoplasma Hominis
The purpose of this study is to determine of clarithromycin effect on developing of bronchopulmonary dysplasia in preterm babies.
- Trial name
- Claprum (NCT01652118)
- Testing
- clarithromycin treatment for prophylaxis of bronchopulmonary dysplasia, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Ventilation, Mechanical, Ventilation-Associated Pneumonia
Surveillance of Neonatal Endotracheal Tube Colonisation
Babies in neonatal intensive care units (NICUs) sometimes need help breathing using a breathing tube (endotracheal tube, or ETT) connected to a breathing machine (ventilator).
- Trial name
- NETT (NCT07664449)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Respiratory Tract; Infection, Upper (Acute), Colonization, Asymptomatic
Studying Respiratory Infections and Colonisation in Children Using Daily Minimally-invasive Nasal Sampling
Rationale: Respiratory tract infections (RTI) are a major cause of morbidity in young children in high- income countries and the major cause of mortality in developing countries.
- Trial name
- SAMSAM (NCT06049537)
- Where
- Netherlands
- Volunteers
- 46 people
- Sponsor
- Leiden University Medical Center
Sepsis, Septic Shock
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract.
- Conditions
- Sepsis, Septic Shock, Post-cardiac Surgery, Post-Cardiorespiratory Arrest Coma
- Trial name
- NCT03270774
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makerere University
Infections
Effect of Antibiotic Rotation in the ICU on the Prevalence of Antibiotic Resistant Gram-negative Colonisation
The SATURN ICU-trial studies the effect of antibiotic rotation on the prevalence of antibiotic resistant Gram-negative colonisation.
- Trial name
- SATURN (NCT01293071)
- Testing
- Antibiotic rotation
- Where
- Netherlands
- Volunteers
- 10,000 people
- Sponsor
- UMC Utrecht
Burns
Study on the Infection Risk of Long Dwell Period Catheters in High Risk Intensive Care Unit (ICU) Patients
This is an evaluation of the use of silver impregnated catheters in burn patients to reduce catheter colonisation compared to the standard central venous catheter without antiseptic activity.
- Trial name
- NCT00136097
- Testing
- Placement of a silver impregnated central venous catheter
- Where
- Belgium
- Volunteers
- 142 people
- Sponsor
- University Hospital, Ghent
Staphylococcal Infection
Safety and Efficacy of Mupirocin in Eradicating Colonization With S. Aureus in Critically Ill Infants
The objective of this trial is 1) to evaluate the safety and clinical acceptability of a 5-day course of mupirocin applied every 8 hours (± 2 hours) to the nares, umbilical and perianal areas of infants residing in the ICU.
- Trial name
- NCT01827358
- Testing
- Mupirocin calcium
- Where
- 6 sites in United States
- Volunteers
- 155 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Streptococcal Pneumonia
A Study of Streptococcus Pneumonia Colonisation and Invasive Disease in Cambodian Children
Streptococcus pneumoniae (the pneumococcus) remains a leading cause of childhood mortality and morbidity. Between 2007 and 2012, Angkor Hospital for Children (AHC), Siem Reap, Cambodia documented that S.
- Trial name
- PCV (NCT03331952)
- Testing
- Prospective study, Cross-sectional surveys
- Where
- Cambodia
- Volunteers
- 4,111 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy Infants
Colonisation Resistance Study
This study is initiated to investigate the effect of infant formulas with added specific prebiotic oligosaccharides on the reduction of specific potential pathogens and/or toxins.
- Trial name
- ColoR (NCT01507935)
- Testing
- Regular non-hydrolysed cow's milk
- Where
- 2 sites in Thailand
- Volunteers
- healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Microbial Colonization, Infection, Bacterial
Microorganisms on Reusable Tourniquets
The purpose of this study was to compare microbial contamination on the surface of reusable stasis after indefinite use, 2 weeks and 4 weeks.
- Conditions
- Microbial Colonization, Infection, Bacterial, HAI, Nurse's Role
- Trial name
- NCT06566495
- Testing
- collection of microbiological material from reusable tourniquets
- Where
- Poland
- Volunteers
- 53 people
- Sponsor
- Medical University of Gdansk
Bacteria Infection Mechanism
Study of Factors Influencing the Dynamics of Colonisation and Decolonisation of the Digestive Tract by Clostridioides Difficile in Infants
Clostridioides difficile (formerly C. difficile) is a bacterium found in the form of spores (a resistant form) to which patients may be exposed in a hospital environment.
- Trial name
- BBDIFF (NCT07512908)
- Testing
- cohort follow up
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fondation Hôpital Saint-Joseph
Multi-resistant Enterobacteriaceae Colonisation, Pregnancy
Multi-resistant Enterobacteriaceae Colonisation in Less Than 32 Weeks Pregnant Women Admitted to the Hospital.
The purpose of this study is to determine the prevalence and risk factors for multi-resistant enterobacteriaceae colonization in less than 32 weeks pregnant women admitted to the hospital and its transmission to the newborn, in…
- Conditions
- Multi-resistant Enterobacteriaceae Colonisation, Pregnancy, Nosocomial Outbreaks
- Trial name
- EME (NCT02631226)
- Where
- Spain
- Volunteers
- 580 people
- Sponsor
- Corporacion Parc Tauli