Clinical trials: Complicated Appendicitis
Abscess, Intra-Abdominal, Abdominal Abscess
A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections
The purpose of the study is to evaluate the safety and tolerability of doripenem compared with meropenem in children hospitalized with complicated intra-abdominal infections.
- Conditions
- Abscess, Intra-Abdominal, Abdominal Abscess, Abdomen, Acute, Abdominal Pain
- Trial name
- NCT01110382
- Testing
- Doripenem, Meropenem, Amoxicillin/clavulanate potassium
- Where
- 19 sites in United States, Argentina and 6 more
- Volunteers
- 41 people
- Sponsor
- Janssen Research & Development, LLC
Appendicitis, Surgical Wound Infection
Primary Versus Delayed Wound Closure in Complicated Appendectomy (The HIEDI-Yemen Trial)
The goal of this clinical trial is to compare primary wound closure (PC) versus delayed primary closure (DPC) after standardized wound decontamination using the High-Efficiency Incision and Drainage with Irrigation (HIEDI)…
- Conditions
- Appendicitis, Surgical Wound Infection, Postoperative Complications, Wound Healing
- Trial name
- HIEDI-Yemen (NCT07688109)
- Testing
- Primary Closure with HIEDI, Delayed Primary Closure with HIEDI
- Where
- 3 sites in Yemen
- Volunteers
- 200 people
- Sponsor
- Sana'a University
Complicated Appendicitis
Safety and Efficacy of Single Daily Dose of Ceftriaxone and Metronidazole for Treatment of Complicated Appendicitis in Children
A prospective open randomized study conducted between July 1st 2008 and June 30th, 2009. Included were children younger than 14 years with Complicated appendicitis randomly assigned either to a single daily dose of Ceftriaxone…
- Trial name
- NCT01678365
- Testing
- ceftriaxone, metronidazole/ampicillin, gentamicin, and metronidazole
- Where
- Israel
- Volunteers
- 43 people
- Sponsor
- HaEmek Medical Center, Israel
Surgery
Acute Appendicitis in Foreign Workers of Northern Israel
To Compare the outcome to acute appendicitis in foreign workers to the native patients.
- Trial name
- NCT04895163
- Testing
- Laparoscopic appendectomy
- Where
- Israel
- Volunteers
- 117 people
- Sponsor
- HaEmek Medical Center, Israel
Complicated Appendicitis, Intra-Abdominal Abscess
Laparoscopic Antibiotic Lavage to Prevent Intra-abdominal Abscess Formation in Complicated Appendicitis
Appendicitis is one of the most common causes of acute surgical admission. Presently, two types of appendicitis are distinguished: complicated and uncomplicated (phlegmonous).
- Trial name
- ALPACA (NCT06841003)
- Testing
- Laparoscopic antibiotic peritoneal lavage with gentamicin / clindamycin
- Where
- 11 sites in Netherlands
- Volunteers
- 752 people
- Sponsor
- Spaarne Gasthuis
Appendicitis
Laparoscopic Clipping Versus Extracorporeal Ligation in Complicated Appendicitis Upper Egypt Overview
The investigators aim to compare between laparoscopic clipping and extracorporeal ligation in complicated appendicitis regarding safety, efficacy, operative time, postoperative outcome, hospital stay and complications.
- Trial name
- NCT05637554
- Testing
- Laparoscopic appendectomy using clipping., Laparoscopic appendectomy using extracorporeal ligation to secure the base of the appendix.
- Volunteers
- 40 people
- Sponsor
- Assiut University
Acute Appendicitis, Acute Appendicitis With Rupture
Prioritisation of Acute Appendicitis Using Appendistat Score
Introduction Although non-operative management of acute appendicitis may be appropriate in selected cases, surgery remains the gold standard treatment.
- Trial name
- APEX (NCT07197489)
- Where
- 2 sites in United Kingdom
- Volunteers
- 592 people
- Sponsor
- University College, London
Laparoscopic Appendectomy, Complicated Appendicitis
Fast Track Therapeutic Model in Acute Complicated Appendicitis in Pediatrics
To evaluate whether a postoperative therapeutic strategy, Fast Track, aimed at shortening hospital stay in pediatric patients undergoing laparoscopic appendectomy for complicated acute appendicitis, yields outcomes that are not…
- Conditions
- Laparoscopic Appendectomy, Complicated Appendicitis, Periappendicular Abscess
- Trial name
- FTAA (NCT05761080)
- Testing
- Oral amoxicillin-clavulanic acid (40mg/kg in 3 times/day; maximum dose 3g/day), Inpatient postpoperative intravenous antibiotic treatment according to the established protocol in each center
- Where
- 12 sites in Spain
- Volunteers
- 772 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Appendicitis, Appendicitis; Perforation
Probiotics and Antibiotic Associated Diarrhea in Pediatric Complicated Appendicitis
To determine the effectiveness of the use of probiotics in patients with a diagnosis of complicated appendicitis on antibiotic associated diarrhea (AAD).
- Trial name
- NCT04529980
- Testing
- Lactobacillus rhamnosus GG (LGG) Probiotic
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Children's Health
Appendicitis, Perforated Appendicitis
Comparative Study Between Laparoscopic and Open Appendectomy of Complicated Appendicitis
Acute appendicitis is one of the most common surgical emergencies in children. In complicated cases, where the appendix has perforated, become gangrenous, or caused peritonitis and purulent contamination, determining the optimal…
- Conditions
- Appendicitis, Perforated Appendicitis, Gangrenous Appendicitis, Peritonitis
- Trial name
- NCT07879235
- Testing
- Laparoscopic Appendectomy, Open Appendectomy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Appendicitis, Surgery
Serum Hyperbilirubinemia as an Early Predictive Factor for Complicated Appendicitis: Single Center Experience
Serum total bilirubin provides a practical guide to early assessment of suspected appendicitis, supporting faster and more proportionate decisions-earlier escalation when overall risk is high and safe observation when it is low.
- Trial name
- NCT07291882
- Testing
- Appendectomy
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Minia University
Conservative Management
Risk Factors of Failure of Conservative Treatment in Acute Non Complicated Appendicitis
From this study, it can be concluded that patients who meet the following criteria are more likely to fail expectant management and thus should not be considered for the NOM of uncomplicated acute appendicitis.
- Trial name
- appendicitis (NCT06828952)
- Testing
- ceftriaxone, ceftriaxone 1 gm/12 hourly and IV metronidazole 500 mg/8 hourly
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ahmed Mohammed Hussein Sayed
Perforated Appendicitis
Initial Versus Delayed Operation for Treatment of Complicated Appendicitis In Children
To determine the most cost effective way to treat children with perforated appendicitis we will randomize all children presenting with perforated appendicitis to initial operation, with in 24 hours of admission, or to initial…
- Trial name
- NCT00540189
- Testing
- Initial appendectomy, Interval appendectomy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Michigan
Complicated Appendicitis, Perforated Appendicitis
Antibiotic Duration in Post-appendectomy Abscess
This is a randomized study of patients 2-17 years old who are diagnosed with perforated appendicitis and develop an abscess after laparoscopy that is subsequently drained.
- Trial name
- NCT03795194
- Testing
- ampicillin/clavulanate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Phoenix Children's Hospital
Enhanced Recovery After Surgery, Appendicitis
Safety and Efficacy of ERAS Therapeutic Protocol for Complicated Appendicitis in Children
Complicated appendicitis in pediatrics is frequent, potentially serious and complex to manage. The implementation of a ERAS model would allow optimizing perioperative care, offering a shorter hospital stay, reducing complications…
- Conditions
- Enhanced Recovery After Surgery, Appendicitis, Children, Only
- Trial name
- ERAS (NCT05511194)
- Testing
- Enhanced Recovery After Surgery therapeutic protocol, Conventional management
- Volunteers
- 40 people
- Sponsor
- Instituto Mexicano del Seguro Social
Complicated Appendicitis, Acute Appendicitis
Antibiotic Instillation in Appendicitis
Appendicitis (inflammation of the wall of the appendix, causing pain and tenderness in the abdomen) has a range of severity that goes from simple to complicated.
- Trial name
- NCT05470517
- Testing
- Ceftriaxone, Intra-peritoneal Fluid Aspiration
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- Johns Hopkins All Children's Hospital
Pediatric Disorder, Complicated Appendicitis
ERAS for Pediatric Acute Appendicitis
This multicenter, prospective randomized controlled study is designed to applicate perioperative Enhanced recovery after surgery (ERAS) management for children with acute complicated appendicitis, the aim is to promote…
- Trial name
- EPAA (NCT03712657)
- Testing
- ERAS
- Where
- China
- Volunteers
- 893 people
- Sponsor
- Feng Jiexiong
Appendicitis, Perforated Appendicitis
Optimal Care of Complicated Appendicitis
When the appendix becomes infected and inflamed, it is called appendicitis. Sometimes, if the infection and inflammation get worse, the appendix can die or burst, leading to a larger infection or even pus pockets around the…
- Conditions
- Appendicitis, Perforated Appendicitis, Ruptured Appendicitis, Complicated Appendicitis
- Trial name
- NCT03159754
- Testing
- Early Appendectomy, Interval Appendectomy, Antibiotics
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Complicated Appendicitis
Causes of Complicated Appendicitis at Referral Hospital
The study was conducted on a medical record of previously treated patients for acute appendicitis at HFSUH, Harar, Ethiopia. The study design was case-control with a total sample size of 402.
- Trial name
- AA (NCT05005104)
- Where
- Ethiopia
- Volunteers
- 402 people
- Sponsor
- Haramaya Unversity
COVID-19, Complicated Appendicitis
Complicated Appendicitis During the COVID-19 Pandemic in Jordan
Comparing the incidence of complicated appendicitis between two groups, the pandemic and pre-pandemic groups.
- Trial name
- NCT05375058
- Testing
- Observational Study
- Where
- Jordan
- Volunteers
- 257 people
- Sponsor
- Jordan University Hospital