Clinical trials: Computer-aided Diagnosis
Supernumerary Teeth
Computer-Assisted Removal of Supernumerary Teeth vs Freehand Surgery
While CBCT imaging enables the surgeon to precisely map the position of impacted supernumerary teeth relative to neighboring structures, traditional extraction methods for impacted supernumerary teeth can involve extensive bone…
- Trial name
- NCT07416851
- Testing
- extraction, extraction of impaction
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
TB - Tuberculosis, PTLD
Intergrated Service Delivery for Lung Health Conditions
The Advancing Lung Health in Zambia project aims to improve access to integrated screening, diagnosis, and management of tuberculosis (TB) and other priority respiratory diseases at community and primary healthcare levels.
- Conditions
- TB - Tuberculosis, PTLD, COPD (Chronic Obstructive Pulmonary Disease), Computer Aided Diagnosis
- Trial name
- TB REACH W11 (NCT07816523)
- Testing
- Intergrated lung health screening, AI-Enabled Cough Sound Screening for Tuberculosis, Post-TB Lung Disease evaluation
- Where
- Zambia
- Volunteers
- 20,300 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Diagnosis
Physician Reasoning on Diagnostic Cases With Large Language Models
This study will evaluate the effect of providing access to GPT-4, a large language model, compared to traditional diagnostic decision support tools on performance on case-based diagnostic reasoning tasks.
- Trial name
- NCT06157944
- Testing
- GPT-4
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Stanford University
Heart Murmurs, Mitral Valve Prolapse
Automated Algorithm Based Analysis of Phonocardiograms of Newborns
The purpose of this double-blind pivotal clinical utility study is to determine on a large patient population whether heart murmurs can be reliably detected with high sensitivity and specificity using a locked, automated…
- Conditions
- Heart Murmurs, Mitral Valve Prolapse, Systolic Murmurs
- Trial name
- NCT02105480
- Testing
- Computer aided auscultation (CAA)
- Where
- Austria
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- CSD Labs GmbH
Genetic Disorders
Face Anthropometric Pattern Recognition Technology for Computer Aided Diagnosis of Human Genetic Disorders.
The hypothesis to be tested: After the construction of a database of anthropometric measurements, the system would extract important features of a given facial surface and be able to match it with existing morphometric figures.
- Trial name
- DW-6/2007 (NCT00705055)
- Where
- 2 sites in Israel
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Pathologic Processes, Disease
Diagnostic Reasoning With Customized GPT-4 Model
This study will assess the impact of immediate access to a customized version of GPT-4, a large language model, on performance in case-based diagnostic reasoning tasks.
- Trial name
- NCT06911645
- Testing
- Immediate access to customized version of GPT-4, Access to customized version of GPT-4 following use of conventional resources
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Stanford University
Denture, Complete, Jaw, Edentulous
Milled Versus Printed CAD/CAM Complete Dentures
A crossover clinical trial investigates two novel CAD/CAM techniques for complete removable dental prostheses for edentulous patients, milling and rapid prototyping (3D-printing) in a clinical setting of an undergraduate student…
- Trial name
- MILLPRINT (NCT04873219)
- Testing
- manufacturing a complete dental prosthesis
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Diagnosis
Mitigating Automation Bias in Physician-LLM Diagnostic Reasoning Using Behavioral Nudges
The goal of this randomized controlled trial is to evaluate whether behavioral nudges can reduce automation bias, the uncritical acceptance of automated output, in physicians using large language models (LLM) like ChatGPT-5.1 for…
- Trial name
- NCT07328815
- Testing
- Behavioral Nudge Intervention
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
Diagnosis
The Impact of Large Language Models on Diagnostic Reasoning Among LLM-Trained Medical Doctors
This study aims to evaluate whether large language model-trained medical doctors demonstrate enhanced diagnostic reasoning performance when utilizing ChatGPT-4o alongside conventional resources compared to using conventional…
- Trial name
- NCT06774612
- Testing
- ChatGPT-4o
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
Diagnosis, Tuberculosis
Active Close Contact Investigation of Tuberculosis Through Computer-aided Detection and Stool Xpert MTB/RIF Among People Living in Ethiopia
Tuberculosis is the 13th cause of death from all causes, infecting roughly the 25% of the world population, and Ethiopia is listed among the 30 high-burden countries both for TB and for HIV/TB.
- Conditions
- Diagnosis, Tuberculosis, geneXpert
- Trial name
- CADOOL (NCT05818059)
- Testing
- Diagnosis of Tuberculosis with computer-aided detection (CAD) software
- Where
- Ethiopia
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Doctors with Africa - CUAMM
Tuberculosis, Pulmonary
Comparative Efficacy of CUS, CXR and CAD in TB Diagnosis in LMIC
Pulmonary Tuberculosis (TB) remains a significant global health concern, particularly in low- and middle-income countries (LMIC), where resources for healthcare are often limited.
- Trial name
- CUSTB (NCT06409780)
- Testing
- Comparative analysis of CUS, CAD and CXR in pulmonary TB
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Bari
Colorectal Polyp, Linked Color Imaging
Computer-assisted Diagnosis System Based on Linked Colour Imaging
Linked color imaging (LCI)，a new endoscopy modality, creates clear and bright images by using short wavelength narrow band laser light. LCI can make red area appear redder and white areas appear whiter.
- Conditions
- Colorectal Polyp, Linked Color Imaging, Computer-aided Diagnosis
- Trial name
- NCT03359343
- Where
- 2 sites in China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Tuberculosis (TB)
Effectiveness of Computer-Aided Detection Chest X-Ray Screening for Improving Tuberculosis Diagnostic Yield in Chinese Primary Health Care Settings: Study Protocol for a Prospective Cluster Randomized Controlled Trial
The global incidence rate and mortality of tuberculosis (TB) pose a challenge to achieving the goals set out in the tuberculosis eradication strategy and the SDGs by 2030.
- Trial name
- NCT06963606
- Testing
- Artificial intelligence-assisted chest X-ray in TB screening, Routine doctors analyze the process of chest X-rays
- Where
- China
- Volunteers
- 22,000 people, healthy volunteers welcome
- Sponsor
- Xuelin Yang
Heart Murmurs, Mitral Valve Prolapse
Automatic Differentiation of Innocent and Pathologic Murmurs in Pediatrics
The purpose of this preliminary clinical study is to assess the quality of a computational algorithm that automatically classifies murmurs of phonocardiograms (PCGs) as either pathologic (AHA class I) or as no- or innocent (AHA…
- Conditions
- Heart Murmurs, Mitral Valve Prolapse, Systolic Murmurs
- Trial name
- NCT02512341
- Testing
- Computer Aided Auscultation (CAA)
- Where
- Canada
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- CSD Labs GmbH
Lung Cancer
Testing of Computer Aided Detection Software for Riverain Medical Group
This is a clinical trial using retrospective data of two different software devices developed by Riverain Medical Group: Softview and OnGuard 5.0. The two studies will be run concurrently.
- Trial name
- NCT00906789
- Testing
- Software
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Diagnosis
Automation Bias in Physician-LLM Diagnostic Reasoning
This study aims to systematically measure the extent and patterns of automation bias among physicians when utilizing ChatGPT-4o in clinical decision-making.
- Trial name
- NCT06963957
- Testing
- ChatGPT-4o Recommendations with Hallucinations
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
Small Bowel Disease, Gastrointestinal Diseases
Anonymous Data Sharing for Small Bowel
Crohn's disease is characterised by an abnormal immunological response within the bowel wall leading to abnormal wall thickening, stricturing (narrowing), fistulation (abnormal connections) to adjacent organs and strictures…
- Trial name
- NCT06868875
- Where
- United Kingdom
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University College, London
Molar Hypomineralization, Dental Restoration Failure of Marginal Integrity
CAD-CAM or Adhesive Approaches for MIH Treatment
Aim: This randomized controlled clinical study aimed to compare direct composite resin restorations and Computer Aided Design-Computer Aided Manufacturing (CAD-CAM) supported inlay or onlay restorations in young permanent molar…
- Trial name
- NCT06456619
- Testing
- Tooth restoration
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Baskent University
Pregnancy, Sexually Transmitted Diseases
The S.A.F.E. Study : Computer-Aided Counseling to Prevent Teen Pregnancy/Sexually Transmitted Diseases (STDs)
This is a randomized clinical trial assessing the efficacy of two types of counseling (Computer-Assisted Motivational Intervention [CAMI] versus Didactic Educational Counseling [DEC]) to see which can better reduce female…
- Trial name
- NCT00151151
- Testing
- Computer-Assisted Motivational Intervention, Didactic Educational Counseling
- Where
- United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Covid19
Detection of SARS-CoV-2 in Nasopharyngeal Swabs by Using Multi-Spectral Screening System
The aim of this research is to use the Multi-Spectral method to measure the biomolecular fingerprint of the virus directly instead of the virus's RNA (RT-PCR) or the body's immune response (antibody) measurement methods to…
- Trial name
- NCT04860895
- Testing
- AP-23
- Where
- Turkey (Türkiye)
- Volunteers
- 4,400 people, healthy volunteers welcome
- Sponsor
- Fable Biyoteknoloji San ve Tic A.S